Reviewed, UniProtKB/Swiss-Prot Q5VTM2 (AGAP9_HUMAN)

Names and origin

Protein names

Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9
      Short name=AGAP-9
Alternative name(s):
    Centaurin-gamma-like family member 6

Gene names

Name:	AGAP9
Synonyms:	CTGLF6

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	703 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Putative GTPase-activating protein Potential.
Miscellaneous	Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.
Sequence similarities	Belongs to the centaurin gamma-like family. Contains 1 ANK repeat. Contains 1 Arf-GAP domain. Contains 1 PH domain.
Sequence caution	The sequence CAH72201.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Domain	ANK repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	GTPase activation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of ARF GTPase activity Inferred from electronic annotation. Source: InterPro
Molecular function	ARF GTPase activator activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 703	703	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9		PRO_0000284677
Regions
	Domain	327 – 488	162	PH
	Domain	509 – 629	121	Arf-GAP
	Repeat	631 – 700	70	ANK
	Zinc finger	524 – 547	24	C4-type

Sequences

	Sequence		Length	Mass (Da)
	Q5VTM2-1 [UniParc]. Last modified April 17, 2007. Version 2. Checksum: 28D84F589E15A0EB	FASTA	703	77,972
	10 20 30 40 50 60 MFEDVFSDSG NTGNFDRGKK RRLTIIECGC DINMMIDLAK VADLVLMLID ASFGFEMEMF 70 80 90 100 110 120 EFLNICQAHG FPKILGVLTH LDSFKHNKQL KKTKKRLKHR FWTEVYQDKV GLTHELVQSL 130 140 150 160 170 180 ISTYSTIDAK MASSRVTLLS NSKPLGSEAI DNQGVSLEFD QQQGSVCPSE SEIYEAGAED 190 200 210 220 230 240 RMAGAPMAAA VQPAEVTVEV GEDLHMHQVR DREMPEVVEI RRSNCTNHCD LGDTSSYHTK 250 260 270 280 290 300 VSTVHIMKKR NGGGSLNNYS SSIPPTPSTS QEDPQFSVPP TANTPTPVCK RSMRWSNLFT 310 320 330 340 350 360 SEKGSDPDKE RKAPENHADT IGSGRAIPIK QGMLLKRSGK WLKTWKKKYV TLCSNGVLTY 370 380 390 400 410 420 YSSLGDYMKN IHKKEIDLRT STIKVPGKWP SLATSACAPI SSSKSNGLSK DMDTGLGDSI 430 440 450 460 470 480 CFSPGISSTT SPKLNPPPSP HANKKKHLKK KSTNNFMIVS ATGQTWHFEA TTYEERDAWV 490 500 510 520 530 540 QAIQSQILAS LQSCKSSKSK SQLTSQSEAM ALQSIQNMRG NAHCVDCETQ NPKWASLNLG 550 560 570 580 590 600 VLMCIECSGI HRSFGTRLSR VRSLELDDWP VELRKVMSSI GNELANSIWE GSSQGQTKPS 610 620 630 640 650 660 IKSTREEKEW WIRSKYEEKL FLAPLPCTEL SLGQQLLRAT TDEDLQTAIL LLAHGSREEV 670 680 690 700 NETCGEGDGC TALHLACRKG NVVLEQLLTG WTSWPEMPTG TQR

References

[1]

"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL591684 Genomic DNA. Translation: CAH72201.1. Sequence problems.
IPI	IPI00747142.
UniGene	Hs.645346
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENST00000453919; ENSP00000396454; ENSG00000198035; Homo sapiens. [Genome view]
Organism-specific databases
HGNC	HGNC:23463. AGAP9.
PharmGKB	PA134960401.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG505242.
HOVERGEN	Q5VTM2.
Gene expression databases
CleanEx	HS_AGAP9.
Genevestigator	Q5VTM2.
Family and domain databases
InterPro	IPR020683. Ankyrin_rpt-contain_dom. IPR001164. ArfGAP. IPR011993. PH_type. IPR001849. Pleckstrin_homology. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit.
Pfam	PF01412. ArfGap. 1 hit. PF00169. PH. 1 hit. [Graphical view]
PRINTS	PR00405. REVINTRACTNG.
SMART	SM00105. ArfGap. 1 hit. SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. False negative. PS50115. ARFGAP. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AGAP9_HUMAN

Accession

Primary (citable) accession number: Q5VTM2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	April 17, 2007
Last modified:	December 15, 2009
This is version 39 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.