Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pre-mRNA-splicing factor 38B

Gene

PRPF38B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be required for pre-mRNA splicing.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor 38B
Alternative name(s):
Sarcoma antigen NY-SAR-27
Gene namesi
Name:PRPF38B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000134186.11
HGNCiHGNC:25512 PRPF38B
neXtProtiNX_Q5VTL8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi55119
OpenTargetsiENSG00000134186
PharmGKBiPA142671126

Polymorphism and mutation databases

BioMutaiPRPF38B
DMDMi74746965

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002872352 – 546Pre-mRNA-splicing factor 38BAdd BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei5PhosphoserineBy similarity1
Modified residuei227N6-acetyllysineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Modified residuei318PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei448PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei475PhosphoserineCombined sources1
Modified residuei481PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
Modified residuei529PhosphoserineCombined sources1
Modified residuei534PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5VTL8
MaxQBiQ5VTL8
PaxDbiQ5VTL8
PeptideAtlasiQ5VTL8
PRIDEiQ5VTL8

PTM databases

iPTMnetiQ5VTL8
PhosphoSitePlusiQ5VTL8
SwissPalmiQ5VTL8

Expressioni

Gene expression databases

BgeeiENSG00000134186
CleanExiHS_PRPF38B
ExpressionAtlasiQ5VTL8 baseline and differential
GenevisibleiQ5VTL8 HS

Organism-specific databases

HPAiHPA053255

Interactioni

Protein-protein interaction databases

BioGridi120428, 18 interactors
IntActiQ5VTL8, 11 interactors
MINTiQ5VTL8
STRINGi9606.ENSP00000359042

Structurei

3D structure databases

ProteinModelPortaliQ5VTL8
SMRiQ5VTL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili292 – 321Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi253 – 451Arg-richAdd BLAST199

Sequence similaritiesi

Belongs to the PRP38 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2888 Eukaryota
ENOG410XS5N LUCA
GeneTreeiENSGT00730000111145
HOVERGENiHBG101033
InParanoidiQ5VTL8
KOiK12850
OMAiHGPSFDR
OrthoDBiEOG091G0EEY
PhylomeDBiQ5VTL8
TreeFamiTF313626

Family and domain databases

InterProiView protein in InterPro
IPR005037 PRP38
PANTHERiPTHR23142 PTHR23142, 2 hits
PfamiView protein in Pfam
PF03371 PRP38, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VTL8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANNSPALTG NSQPQHQAAA AAAQQQQQCG GGGATKPAVS GKQGNVLPLW
60 70 80 90 100
GNEKTMNLNP MILTNILSSP YFKVQLYELK TYHEVVDEIY FKVTHVEPWE
110 120 130 140 150
KGSRKTAGQT GMCGGVRGVG TGGIVSTAFC LLYKLFTLKL TRKQVMGLIT
160 170 180 190 200
HTDSPYIRAL GFMYIRYTQP PTDLWDWFES FLDDEEDLDV KAGGGCVMTI
210 220 230 240 250
GEMLRSFLTK LEWFSTLFPR IPVPVQKNID QQIKTRPRKI KKDGKEGAEE
260 270 280 290 300
IDRHVERRRS RSPRRSLSPR RSPRRSRSRS HHREGHGSSS FDRELEREKE
310 320 330 340 350
RQRLEREAKE REKERRRSRS IDRGLERRRS RSRERHRSRS RSRDRKGDRR
360 370 380 390 400
DRDREREKEN ERGRRRDRDY DKERGNEREK ERERSRERSK EQRSRGEVEE
410 420 430 440 450
KKHKEDKDDR RHRDDKRDSK KEKKHSRSRS RERKHRSRSR SRNAGKRSRS
460 470 480 490 500
RSKEKSSKHK NESKEKSNKR SRSGSQGRTD SVEKSKKREH SPSKEKSRKR
510 520 530 540
SRSKERSHKR DHSDSKDQSD KHDRRRSQSI EQESQEKQHK NKDETV
Length:546
Mass (Da):64,468
Last modified:December 7, 2004 - v1
Checksum:iA3082DCF491F88F8
GO
Isoform 2 (identifier: Q5VTL8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-190: DLDV → FFTL
     191-546: Missing.

Show »
Length:190
Mass (Da):21,061
Checksum:iBA711597136F2BBD
GO

Sequence cautioni

The sequence AAO65168 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAH72070 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI12934 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52N → S in BAA91546 (PubMed:14702039).Curated1
Sequence conflicti294 – 295EL → DR in AAH40127 (PubMed:15489334).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025408187 – 190DLDV → FFTL in isoform 2. 1 Publication4
Alternative sequenceiVSP_025409191 – 546Missing in isoform 2. 1 PublicationAdd BLAST356

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001192 mRNA Translation: BAA91546.1
AL591719, AL160171 Genomic DNA Translation: CAH72068.1
AL591719, AL160171 Genomic DNA Translation: CAH72069.1
AL591719, AL160171 Genomic DNA Translation: CAH72070.1 Sequence problems.
AL160171, AL591719 Genomic DNA Translation: CAI12932.1
AL160171, AL591719 Genomic DNA Translation: CAI12933.1
AL160171, AL591719 Genomic DNA Translation: CAI12934.1 Sequence problems.
BC007757 mRNA Translation: AAH07757.1 Different termination.
BC016296 mRNA Translation: AAH16296.1 Different termination.
BC024275 mRNA Translation: AAH24275.1 Different termination.
BC040127 mRNA Translation: AAH40127.1 Different termination.
BC053838 mRNA Translation: AAH53838.1
BC107801 mRNA Translation: AAI07802.1 Different termination.
BC130346 mRNA Translation: AAI30347.1
BC132963 mRNA Translation: AAI32964.1
AY211915 mRNA Translation: AAO65168.1 Different initiation.
CCDSiCCDS788.1 [Q5VTL8-1]
RefSeqiNP_060531.2, NM_018061.2 [Q5VTL8-1]
UniGeneiHs.342307

Genome annotation databases

EnsembliENST00000370022; ENSP00000359039; ENSG00000134186 [Q5VTL8-2]
ENST00000370025; ENSP00000359042; ENSG00000134186 [Q5VTL8-1]
GeneIDi55119
KEGGihsa:55119
UCSCiuc001dvv.5 human [Q5VTL8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPR38B_HUMAN
AccessioniPrimary (citable) accession number: Q5VTL8
Secondary accession number(s): Q05DD6
, Q32Q58, Q5VTL9, Q6PK39, Q7Z6E2, Q86WF3, Q8IWG9, Q9NW40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health