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Protein

Pre-mRNA-splicing factor 38B

Gene

PRPF38B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be required for pre-mRNA splicing.Curated

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor 38B
Alternative name(s):
Sarcoma antigen NY-SAR-27
Gene namesi
Name:PRPF38B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25512. PRPF38B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi55119.
OpenTargetsiENSG00000134186.
PharmGKBiPA142671126.

Polymorphism and mutation databases

BioMutaiPRPF38B.
DMDMi74746965.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002872352 – 546Pre-mRNA-splicing factor 38BAdd BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei5PhosphoserineBy similarity1
Modified residuei227N6-acetyllysineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Modified residuei318PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei448PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei475PhosphoserineCombined sources1
Modified residuei481PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
Modified residuei529PhosphoserineCombined sources1
Modified residuei534PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5VTL8.
MaxQBiQ5VTL8.
PaxDbiQ5VTL8.
PeptideAtlasiQ5VTL8.
PRIDEiQ5VTL8.

PTM databases

iPTMnetiQ5VTL8.
PhosphoSitePlusiQ5VTL8.
SwissPalmiQ5VTL8.

Expressioni

Gene expression databases

BgeeiENSG00000134186.
CleanExiHS_PRPF38B.
ExpressionAtlasiQ5VTL8. baseline and differential.
GenevisibleiQ5VTL8. HS.

Organism-specific databases

HPAiHPA053255.

Interactioni

Protein-protein interaction databases

BioGridi120428. 15 interactors.
IntActiQ5VTL8. 11 interactors.
MINTiMINT-4654815.
STRINGi9606.ENSP00000359042.

Structurei

3D structure databases

ProteinModelPortaliQ5VTL8.
SMRiQ5VTL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili292 – 321Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi253 – 451Arg-richAdd BLAST199

Sequence similaritiesi

Belongs to the PRP38 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2888. Eukaryota.
ENOG410XS5N. LUCA.
GeneTreeiENSGT00730000111145.
HOVERGENiHBG101033.
InParanoidiQ5VTL8.
KOiK12850.
OMAiDRRHRED.
OrthoDBiEOG091G0EEY.
PhylomeDBiQ5VTL8.
TreeFamiTF313626.

Family and domain databases

InterProiIPR005037. PRP38.
[Graphical view]
PANTHERiPTHR23142. PTHR23142. 1 hit.
PfamiPF03371. PRP38. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VTL8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANNSPALTG NSQPQHQAAA AAAQQQQQCG GGGATKPAVS GKQGNVLPLW
60 70 80 90 100
GNEKTMNLNP MILTNILSSP YFKVQLYELK TYHEVVDEIY FKVTHVEPWE
110 120 130 140 150
KGSRKTAGQT GMCGGVRGVG TGGIVSTAFC LLYKLFTLKL TRKQVMGLIT
160 170 180 190 200
HTDSPYIRAL GFMYIRYTQP PTDLWDWFES FLDDEEDLDV KAGGGCVMTI
210 220 230 240 250
GEMLRSFLTK LEWFSTLFPR IPVPVQKNID QQIKTRPRKI KKDGKEGAEE
260 270 280 290 300
IDRHVERRRS RSPRRSLSPR RSPRRSRSRS HHREGHGSSS FDRELEREKE
310 320 330 340 350
RQRLEREAKE REKERRRSRS IDRGLERRRS RSRERHRSRS RSRDRKGDRR
360 370 380 390 400
DRDREREKEN ERGRRRDRDY DKERGNEREK ERERSRERSK EQRSRGEVEE
410 420 430 440 450
KKHKEDKDDR RHRDDKRDSK KEKKHSRSRS RERKHRSRSR SRNAGKRSRS
460 470 480 490 500
RSKEKSSKHK NESKEKSNKR SRSGSQGRTD SVEKSKKREH SPSKEKSRKR
510 520 530 540
SRSKERSHKR DHSDSKDQSD KHDRRRSQSI EQESQEKQHK NKDETV
Length:546
Mass (Da):64,468
Last modified:December 7, 2004 - v1
Checksum:iA3082DCF491F88F8
GO
Isoform 2 (identifier: Q5VTL8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-190: DLDV → FFTL
     191-546: Missing.

Show »
Length:190
Mass (Da):21,061
Checksum:iBA711597136F2BBD
GO

Sequence cautioni

The sequence AAO65168 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAH72070 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI12934 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52N → S in BAA91546 (PubMed:14702039).Curated1
Sequence conflicti294 – 295EL → DR in AAH40127 (PubMed:15489334).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025408187 – 190DLDV → FFTL in isoform 2. 1 Publication4
Alternative sequenceiVSP_025409191 – 546Missing in isoform 2. 1 PublicationAdd BLAST356

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001192 mRNA. Translation: BAA91546.1.
AL591719, AL160171 Genomic DNA. Translation: CAH72068.1.
AL591719, AL160171 Genomic DNA. Translation: CAH72069.1.
AL591719, AL160171 Genomic DNA. Translation: CAH72070.1. Sequence problems.
AL160171, AL591719 Genomic DNA. Translation: CAI12932.1.
AL160171, AL591719 Genomic DNA. Translation: CAI12933.1.
AL160171, AL591719 Genomic DNA. Translation: CAI12934.1. Sequence problems.
BC007757 mRNA. Translation: AAH07757.1. Different termination.
BC016296 mRNA. Translation: AAH16296.1. Different termination.
BC024275 mRNA. Translation: AAH24275.1. Different termination.
BC040127 mRNA. Translation: AAH40127.1. Different termination.
BC053838 mRNA. Translation: AAH53838.1.
BC107801 mRNA. Translation: AAI07802.1. Different termination.
BC130346 mRNA. Translation: AAI30347.1.
BC132963 mRNA. Translation: AAI32964.1.
AY211915 mRNA. Translation: AAO65168.1. Different initiation.
CCDSiCCDS788.1. [Q5VTL8-1]
RefSeqiNP_060531.2. NM_018061.2. [Q5VTL8-1]
UniGeneiHs.342307.

Genome annotation databases

EnsembliENST00000370022; ENSP00000359039; ENSG00000134186. [Q5VTL8-2]
ENST00000370025; ENSP00000359042; ENSG00000134186. [Q5VTL8-1]
GeneIDi55119.
KEGGihsa:55119.
UCSCiuc001dvv.5. human. [Q5VTL8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001192 mRNA. Translation: BAA91546.1.
AL591719, AL160171 Genomic DNA. Translation: CAH72068.1.
AL591719, AL160171 Genomic DNA. Translation: CAH72069.1.
AL591719, AL160171 Genomic DNA. Translation: CAH72070.1. Sequence problems.
AL160171, AL591719 Genomic DNA. Translation: CAI12932.1.
AL160171, AL591719 Genomic DNA. Translation: CAI12933.1.
AL160171, AL591719 Genomic DNA. Translation: CAI12934.1. Sequence problems.
BC007757 mRNA. Translation: AAH07757.1. Different termination.
BC016296 mRNA. Translation: AAH16296.1. Different termination.
BC024275 mRNA. Translation: AAH24275.1. Different termination.
BC040127 mRNA. Translation: AAH40127.1. Different termination.
BC053838 mRNA. Translation: AAH53838.1.
BC107801 mRNA. Translation: AAI07802.1. Different termination.
BC130346 mRNA. Translation: AAI30347.1.
BC132963 mRNA. Translation: AAI32964.1.
AY211915 mRNA. Translation: AAO65168.1. Different initiation.
CCDSiCCDS788.1. [Q5VTL8-1]
RefSeqiNP_060531.2. NM_018061.2. [Q5VTL8-1]
UniGeneiHs.342307.

3D structure databases

ProteinModelPortaliQ5VTL8.
SMRiQ5VTL8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120428. 15 interactors.
IntActiQ5VTL8. 11 interactors.
MINTiMINT-4654815.
STRINGi9606.ENSP00000359042.

PTM databases

iPTMnetiQ5VTL8.
PhosphoSitePlusiQ5VTL8.
SwissPalmiQ5VTL8.

Polymorphism and mutation databases

BioMutaiPRPF38B.
DMDMi74746965.

Proteomic databases

EPDiQ5VTL8.
MaxQBiQ5VTL8.
PaxDbiQ5VTL8.
PeptideAtlasiQ5VTL8.
PRIDEiQ5VTL8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370022; ENSP00000359039; ENSG00000134186. [Q5VTL8-2]
ENST00000370025; ENSP00000359042; ENSG00000134186. [Q5VTL8-1]
GeneIDi55119.
KEGGihsa:55119.
UCSCiuc001dvv.5. human. [Q5VTL8-1]

Organism-specific databases

CTDi55119.
DisGeNETi55119.
GeneCardsiPRPF38B.
HGNCiHGNC:25512. PRPF38B.
HPAiHPA053255.
neXtProtiNX_Q5VTL8.
OpenTargetsiENSG00000134186.
PharmGKBiPA142671126.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2888. Eukaryota.
ENOG410XS5N. LUCA.
GeneTreeiENSGT00730000111145.
HOVERGENiHBG101033.
InParanoidiQ5VTL8.
KOiK12850.
OMAiDRRHRED.
OrthoDBiEOG091G0EEY.
PhylomeDBiQ5VTL8.
TreeFamiTF313626.

Miscellaneous databases

ChiTaRSiPRPF38B. human.
GenomeRNAii55119.
PROiQ5VTL8.

Gene expression databases

BgeeiENSG00000134186.
CleanExiHS_PRPF38B.
ExpressionAtlasiQ5VTL8. baseline and differential.
GenevisibleiQ5VTL8. HS.

Family and domain databases

InterProiIPR005037. PRP38.
[Graphical view]
PANTHERiPTHR23142. PTHR23142. 1 hit.
PfamiPF03371. PRP38. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPR38B_HUMAN
AccessioniPrimary (citable) accession number: Q5VTL8
Secondary accession number(s): Q05DD6
, Q32Q58, Q5VTL9, Q6PK39, Q7Z6E2, Q86WF3, Q8IWG9, Q9NW40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.