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Protein

Fibronectin type III domain-containing protein 7

Gene

FNDC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin type III domain-containing protein 7
Gene namesi
Name:FNDC7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26668. FNDC7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671756.

Polymorphism and mutation databases

BioMutaiFNDC7.
DMDMi380865465.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 733708Fibronectin type III domain-containing protein 7PRO_0000328880Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi230 – 2301N-linked (GlcNAc...)Sequence analysis
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5VTL7.
PRIDEiQ5VTL7.

PTM databases

PhosphoSiteiQ5VTL7.

Expressioni

Gene expression databases

BgeeiQ5VTL7.
CleanExiHS_FNDC7.
ExpressionAtlasiQ5VTL7. baseline and differential.
GenevisibleiQ5VTL7. HS.

Organism-specific databases

HPAiHPA028079.
HPA054297.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000359034.

Structurei

3D structure databases

ProteinModelPortaliQ5VTL7.
SMRiQ5VTL7. Positions 28-186, 207-280, 372-453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 11588Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini116 – 20287Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini203 – 28886Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini289 – 37385Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini374 – 45986Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini460 – 54485Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini545 – 63288Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Domaini631 – 71585Fibronectin type-III 8PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IJIZ. Eukaryota.
ENOG410ZVQP. LUCA.
GeneTreeiENSGT00390000004674.
HOGENOMiHOG000112623.
HOVERGENiHBG107925.
InParanoidiQ5VTL7.
OMAiITVEWAT.
OrthoDBiEOG7X6KZH.
TreeFamiTF331331.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 7 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5VTL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGRETCLP LIGFILICLK MVASAKSAPE IPTIDQAYSK LSNSITVEWA
60 70 80 90 100
TVPGATSYLL TAEDGDTVIE TTVANSPGTV TGLKAATWYE ITIRSISAAG
110 120 130 140 150
RSQASPPKQA KTVLAAPILE VSSPSSDSIL VQWEAVYMAI AFSVSIMRAN
160 170 180 190 200
GLGSIWKENT TNTSLTFTSL EAGTLYTIKA YAWNANRIPG DDSTCNQRTS
210 220 230 240 250
PRAPANIQVS FDSGALKASF SWARAEGAFN YTVMALSDSS ELTCSTTFSS
260 270 280 290 300
CTISSLQCGT EYLISVLASN DAGSSKSSSA MTLKTVACAP GRVTIQEDPP
310 320 330 340 350
GHLSVAWSSV DLGDYYVVFV KSDDGLEVHC NTSLTQCNFL SECGFTYFIS
360 370 380 390 400
VFVYNKAGQS PLGDIFNYTT APCCPSDINP VLVSSDRVEI VWSPVRGAEL
410 420 430 440 450
YETKAVDGYN MVECNDTTPA CTLSALECDT KYNITVYSFN EVRGSNMSCT
460 470 480 490 500
PQFITTAPCS PEIKNVSRDA FSMINVHWRS TNDDATYTVT AQGEKGLYQC
510 520 530 540 550
SSTGESCTMR GLPCGSVFSV TAVAETQAGR SLPSYSVPLE TVPCCPTGLT
560 570 580 590 600
VTQITQSVIN VSWTIGRVAQ THVAVLESHT GQSKCHTHQN HCLLGCITCG
610 620 630 640 650
INYTVTLKAI SATGLTADCS YQSYFSGACC PLGVKLYRLG PNGIRIYWQA
660 670 680 690 700
SRGSANYSTD LYGSKGIFTC TPSAGLSFCD VTEIPCGDVY TVMVSPVAKT
710 720 730
GLKLTFCPKK IYSVTCSGST LGMVIYRGKR NEE
Length:733
Mass (Da):78,236
Last modified:March 21, 2012 - v3
Checksum:i5D0E0EDBEAF2C630
GO

Sequence cautioni

The sequence AAH57762.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI30422.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC04077.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAH72065.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti210 – 2101S → F in AAH57762 (PubMed:15489334).Curated
Sequence conflicti224 – 2241R → L in AAH57762 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti309 – 3091S → N.
Corresponds to variant rs11582005 [ dbSNP | Ensembl ].
VAR_042570
Natural varianti353 – 3531V → A.1 Publication
Corresponds to variant rs4494160 [ dbSNP | Ensembl ].
VAR_042571
Natural varianti367 – 3671N → S.
Corresponds to variant rs3006870 [ dbSNP | Ensembl ].
VAR_042572
Natural varianti685 – 6851P → L.
Corresponds to variant rs1277017 [ dbSNP | Ensembl ].
VAR_042573

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591719 Genomic DNA. Translation: CAH72065.1. Sequence problems.
BC057762 mRNA. Translation: AAH57762.1. Different initiation.
BC130421 mRNA. Translation: AAI30422.1. Different initiation.
AK093157 mRNA. Translation: BAC04077.1. Different initiation.
CCDSiCCDS44185.1.
RefSeqiNP_001138409.1. NM_001144937.1.
UniGeneiHs.258253.

Genome annotation databases

EnsembliENST00000370017; ENSP00000359034; ENSG00000143107.
GeneIDi163479.
KEGGihsa:163479.
UCSCiuc001dvx.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591719 Genomic DNA. Translation: CAH72065.1. Sequence problems.
BC057762 mRNA. Translation: AAH57762.1. Different initiation.
BC130421 mRNA. Translation: AAI30422.1. Different initiation.
AK093157 mRNA. Translation: BAC04077.1. Different initiation.
CCDSiCCDS44185.1.
RefSeqiNP_001138409.1. NM_001144937.1.
UniGeneiHs.258253.

3D structure databases

ProteinModelPortaliQ5VTL7.
SMRiQ5VTL7. Positions 28-186, 207-280, 372-453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000359034.

PTM databases

PhosphoSiteiQ5VTL7.

Polymorphism and mutation databases

BioMutaiFNDC7.
DMDMi380865465.

Proteomic databases

PaxDbiQ5VTL7.
PRIDEiQ5VTL7.

Protocols and materials databases

DNASUi163479.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370017; ENSP00000359034; ENSG00000143107.
GeneIDi163479.
KEGGihsa:163479.
UCSCiuc001dvx.4. human.

Organism-specific databases

CTDi163479.
GeneCardsiFNDC7.
HGNCiHGNC:26668. FNDC7.
HPAiHPA028079.
HPA054297.
neXtProtiNX_Q5VTL7.
PharmGKBiPA142671756.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJIZ. Eukaryota.
ENOG410ZVQP. LUCA.
GeneTreeiENSGT00390000004674.
HOGENOMiHOG000112623.
HOVERGENiHBG107925.
InParanoidiQ5VTL7.
OMAiITVEWAT.
OrthoDBiEOG7X6KZH.
TreeFamiTF331331.

Miscellaneous databases

GenomeRNAii163479.
NextBioi88360.
PROiQ5VTL7.

Gene expression databases

BgeeiQ5VTL7.
CleanExiHS_FNDC7.
ExpressionAtlasiQ5VTL7. baseline and differential.
GenevisibleiQ5VTL7. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 7 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 210-733, VARIANT ALA-353.
    Tissue: Brain and Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 226-733.
    Tissue: Testis.

Entry informationi

Entry nameiFNDC7_HUMAN
AccessioniPrimary (citable) accession number: Q5VTL7
Secondary accession number(s): A1L468
, E9PAZ5, Q6PF16, Q8NA51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 21, 2012
Last modified: March 16, 2016
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.