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Protein

Fibronectin type III domain-containing protein 7

Gene

FNDC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin type III domain-containing protein 7
Gene namesi
Name:FNDC7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143107.8
HGNCiHGNC:26668 FNDC7
neXtProtiNX_Q5VTL7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143107
PharmGKBiPA142671756

Polymorphism and mutation databases

BioMutaiFNDC7
DMDMi380865465

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000032888026 – 733Fibronectin type III domain-containing protein 7Add BLAST708

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi230N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5VTL7
PeptideAtlasiQ5VTL7
PRIDEiQ5VTL7

PTM databases

iPTMnetiQ5VTL7
PhosphoSitePlusiQ5VTL7

Expressioni

Gene expression databases

BgeeiENSG00000143107
CleanExiHS_FNDC7
ExpressionAtlasiQ5VTL7 baseline and differential
GenevisibleiQ5VTL7 HS

Organism-specific databases

HPAiHPA028079
HPA054297

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000359034

Structurei

3D structure databases

ProteinModelPortaliQ5VTL7
SMRiQ5VTL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 115Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST88
Domaini116 – 202Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST87
Domaini203 – 288Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST86
Domaini289 – 373Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST85
Domaini374 – 459Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST86
Domaini460 – 544Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST85
Domaini545 – 632Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST88
Domaini631 – 715Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST85

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IJIZ Eukaryota
ENOG410ZVQP LUCA
GeneTreeiENSGT00390000004674
HOGENOMiHOG000112623
HOVERGENiHBG107925
InParanoidiQ5VTL7
OMAiITVEWAT
OrthoDBiEOG091G01OV
TreeFamiTF331331

Family and domain databases

CDDicd00063 FN3, 5 hits
Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
SMARTiView protein in SMART
SM00060 FN3, 7 hits
SUPFAMiSSF49265 SSF49265, 4 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 7 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5VTL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGRETCLP LIGFILICLK MVASAKSAPE IPTIDQAYSK LSNSITVEWA
60 70 80 90 100
TVPGATSYLL TAEDGDTVIE TTVANSPGTV TGLKAATWYE ITIRSISAAG
110 120 130 140 150
RSQASPPKQA KTVLAAPILE VSSPSSDSIL VQWEAVYMAI AFSVSIMRAN
160 170 180 190 200
GLGSIWKENT TNTSLTFTSL EAGTLYTIKA YAWNANRIPG DDSTCNQRTS
210 220 230 240 250
PRAPANIQVS FDSGALKASF SWARAEGAFN YTVMALSDSS ELTCSTTFSS
260 270 280 290 300
CTISSLQCGT EYLISVLASN DAGSSKSSSA MTLKTVACAP GRVTIQEDPP
310 320 330 340 350
GHLSVAWSSV DLGDYYVVFV KSDDGLEVHC NTSLTQCNFL SECGFTYFIS
360 370 380 390 400
VFVYNKAGQS PLGDIFNYTT APCCPSDINP VLVSSDRVEI VWSPVRGAEL
410 420 430 440 450
YETKAVDGYN MVECNDTTPA CTLSALECDT KYNITVYSFN EVRGSNMSCT
460 470 480 490 500
PQFITTAPCS PEIKNVSRDA FSMINVHWRS TNDDATYTVT AQGEKGLYQC
510 520 530 540 550
SSTGESCTMR GLPCGSVFSV TAVAETQAGR SLPSYSVPLE TVPCCPTGLT
560 570 580 590 600
VTQITQSVIN VSWTIGRVAQ THVAVLESHT GQSKCHTHQN HCLLGCITCG
610 620 630 640 650
INYTVTLKAI SATGLTADCS YQSYFSGACC PLGVKLYRLG PNGIRIYWQA
660 670 680 690 700
SRGSANYSTD LYGSKGIFTC TPSAGLSFCD VTEIPCGDVY TVMVSPVAKT
710 720 730
GLKLTFCPKK IYSVTCSGST LGMVIYRGKR NEE
Length:733
Mass (Da):78,236
Last modified:March 21, 2012 - v3
Checksum:i5D0E0EDBEAF2C630
GO

Sequence cautioni

The sequence AAH57762 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI30422 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC04077 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAH72065 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti210S → F in AAH57762 (PubMed:15489334).Curated1
Sequence conflicti224R → L in AAH57762 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042570309S → N. Corresponds to variant dbSNP:rs11582005Ensembl.1
Natural variantiVAR_042571353V → A1 PublicationCorresponds to variant dbSNP:rs4494160Ensembl.1
Natural variantiVAR_042572367N → S. Corresponds to variant dbSNP:rs3006870Ensembl.1
Natural variantiVAR_042573685P → L. Corresponds to variant dbSNP:rs1277017Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591719 Genomic DNA Translation: CAH72065.1 Sequence problems.
BC057762 mRNA Translation: AAH57762.1 Different initiation.
BC130421 mRNA Translation: AAI30422.1 Different initiation.
AK093157 mRNA Translation: BAC04077.1 Different initiation.
CCDSiCCDS44185.1
RefSeqiNP_001138409.1, NM_001144937.1
UniGeneiHs.258253

Genome annotation databases

EnsembliENST00000370017; ENSP00000359034; ENSG00000143107
GeneIDi163479
KEGGihsa:163479
UCSCiuc001dvx.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFNDC7_HUMAN
AccessioniPrimary (citable) accession number: Q5VTL7
Secondary accession number(s): A1L468
, E9PAZ5, Q6PF16, Q8NA51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 21, 2012
Last modified: February 28, 2018
This is version 109 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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