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Protein

Protein Flattop

Gene

CFAP126

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear.By similarity

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FlattopCurated
Alternative name(s):
Cilia- and flagella-associated protein 126Imported
Gene namesi
Name:CFAP126Imported
Synonyms:C1orf192Imported, FLTPBy similarity
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000188931.3
HGNCiHGNC:32325 CFAP126
MIMi616119 gene
neXtProtiNX_Q5VTH2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188931
PharmGKBiPA142672403

Polymorphism and mutation databases

DMDMi74746942

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003169721 – 177Protein FlattopAdd BLAST177

Proteomic databases

PaxDbiQ5VTH2
PeptideAtlasiQ5VTH2
PRIDEiQ5VTH2
ProteomicsDBi65328

PTM databases

iPTMnetiQ5VTH2
PhosphoSitePlusiQ5VTH2

Expressioni

Gene expression databases

BgeeiENSG00000188931
CleanExiHS_C1orf192
GenevisibleiQ5VTH2 HS

Organism-specific databases

HPAiHPA045904

Interactioni

Subunit structurei

Interacts with DLG3.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000356951

Structurei

3D structure databases

ProteinModelPortaliQ5VTH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Flattop family.Curated

Phylogenomic databases

eggNOGiENOG410J0RM Eukaryota
ENOG41129F8 LUCA
GeneTreeiENSGT00390000001092
HOGENOMiHOG000111270
HOVERGENiHBG059083
InParanoidiQ5VTH2
OMAiQARSPTI
OrthoDBiEOG091G0SJX
PhylomeDBiQ5VTH2
TreeFamiTF329474

Family and domain databases

InterProiView protein in InterPro
IPR038797 Fltp
PANTHERiPTHR34639 PTHR34639, 1 hit

Sequencei

Sequence statusi: Complete.

Q5VTH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATNYSANQY EKAFSSKYLQ NWSPTKPTKE SISSHEGYTQ IIANDRGHLL
60 70 80 90 100
PSVPRSKANP WGSFMGTWQM PLKIPPARVT LTSRTTAGAA SLTKWIQKNP
110 120 130 140 150
DLLKASNGLC PEILGKPHDP DSQKKLRKKS ITKTVQQARS PTIIPSSPAA
160 170
NLNSPDELQS SHPSAGHTPG PQRPAKS
Length:177
Mass (Da):19,293
Last modified:December 7, 2004 - v1
Checksum:i3D50FC792F5A8AF9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37G → A in BU688150 (PubMed:8889548).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592295 Genomic DNA No translation available.
BU688150 mRNA No translation available.
CCDSiCCDS30921.1
RefSeqiNP_001013647.2, NM_001013625.3
UniGeneiHs.534593

Genome annotation databases

EnsembliENST00000367974; ENSP00000356951; ENSG00000188931
GeneIDi257177
KEGGihsa:257177
UCSCiuc001gal.5 human

Similar proteinsi

Entry informationi

Entry nameiFLTOP_HUMAN
AccessioniPrimary (citable) accession number: Q5VTH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 7, 2004
Last modified: June 20, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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