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Protein

Protein angel homolog 2

Gene

ANGEL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: HGNC

GO - Biological processi

  • 3'-UTR-mediated mRNA stabilization Source: HGNC
  • negative regulation of mitotic cell cycle Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein angel homolog 2
Gene namesi
Name:ANGEL2
Synonyms:KIAA0759L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30534. ANGEL2.

Subcellular locationi

GO - Cellular componenti

  • Cajal body Source: HGNC
  • cytoplasm Source: HGNC
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672620.

Polymorphism and mutation databases

BioMutaiANGEL2.
DMDMi74746929.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 544544Protein angel homolog 2PRO_0000305080Add
BLAST

Proteomic databases

EPDiQ5VTE6.
MaxQBiQ5VTE6.
PaxDbiQ5VTE6.
PeptideAtlasiQ5VTE6.
PRIDEiQ5VTE6.

PTM databases

iPTMnetiQ5VTE6.
PhosphoSiteiQ5VTE6.

Expressioni

Gene expression databases

BgeeiENSG00000174606.
CleanExiHS_ANGEL2.
ExpressionAtlasiQ5VTE6. baseline and differential.
GenevisibleiQ5VTE6. HS.

Organism-specific databases

HPAiHPA030796.

Interactioni

Protein-protein interaction databases

BioGridi124763. 16 interactions.
IntActiQ5VTE6. 1 interaction.
STRINGi9606.ENSP00000355929.

Structurei

3D structure databases

ProteinModelPortaliQ5VTE6.
SMRiQ5VTE6. Positions 170-369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CCR4/nocturin family.Curated

Phylogenomic databases

eggNOGiKOG0620. Eukaryota.
KOG2338. Eukaryota.
COG5239. LUCA.
GeneTreeiENSGT00550000074364.
HOGENOMiHOG000033940.
HOVERGENiHBG057379.
InParanoidiQ5VTE6.
KOiK18729.
OMAiRRKHQGT.
OrthoDBiEOG091G0BJF.
PhylomeDBiQ5VTE6.
TreeFamiTF316126.

Family and domain databases

Gene3Di3.60.10.10. 2 hits.
InterProiIPR005135. Endo/exonuclease/phosphatase.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VTE6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAWRCVRKG YGHCVVGRGR YPMFPHHSRS LGRDWTTPWE NLQRCCWNRH
60 70 80 90 100
ISSCMRWPGH YSRAPYPYFS SRHFSLNWRP PCLFESRTQF QYCNWRPDNL
110 120 130 140 150
SQTSLIHLSS YVMNAEGDEP SSKRRKHQGV IKRNWEYICS HDKEKTKILG
160 170 180 190 200
DKNVDPKCED SENKFDFSVM SYNILSQDLL EDNSHLYRHC RRPVLHWSFR
210 220 230 240 250
FPNILKEIKH FDADVLCLQE VQEDHYGAEI RPSLESLGYH CEYKMRTGRK
260 270 280 290 300
PDGCAICFKH SKFSLLSVNP VEFFRPDISL LDRDNVGLVL LLQPKIPYAA
310 320 330 340 350
CPAICVANTH LLYNPRRGDI KLTQLAMLLA EISSVAHQKD GSFCPIVMCG
360 370 380 390 400
DFNSVPGSPL YSFIKEGKLN YEGLPIGKVS GQEQSSRGQR ILSIPIWPPN
410 420 430 440 450
LGISQNCVYE VQQVPKVEKT DSDLTQTQLK QTEVLVTAEK LSSNLQHHFS
460 470 480 490 500
LSSVYSHYFP DTGIPEVTTC HSRSAITVDY IFYSAEKEDV AGHPGAEVAL
510 520 530 540
VGGLKLLARL SLLTEQDLWT VNGLPNENNS SDHLPLLAKF RLEL
Length:544
Mass (Da):62,339
Last modified:December 7, 2004 - v1
Checksum:i89F33A8A357E10A7
GO
Isoform 2 (identifier: Q5VTE6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-169: Missing.

Show »
Length:375
Mass (Da):42,106
Checksum:i34881761BC8FA432
GO

Sequence cautioni

The sequence AAH47469 differs from that shown. Reason: Erroneous termination at position 456. Translated as Ser.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971P → S.
Corresponds to variant rs11542154 [ dbSNP | Ensembl ].
VAR_050290

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 169169Missing in isoform 2. 2 PublicationsVSP_028216Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510741 mRNA. Translation: AAM44053.1.
AK295116 mRNA. Translation: BAH11980.1.
AL592449 Genomic DNA. Translation: CAH71919.1.
AL592449 Genomic DNA. Translation: CAH71920.1.
CH471100 Genomic DNA. Translation: EAW93366.1.
CH471100 Genomic DNA. Translation: EAW93368.1.
CH471100 Genomic DNA. Translation: EAW93369.1.
BC047469 mRNA. Translation: AAH47469.1. Sequence problems.
CCDSiCCDS1512.1. [Q5VTE6-1]
CCDS73027.1. [Q5VTE6-2]
RefSeqiNP_001287682.1. NM_001300753.1.
NP_001287684.1. NM_001300755.1.
NP_001287686.1. NM_001300757.1. [Q5VTE6-2]
NP_001287687.1. NM_001300758.1. [Q5VTE6-2]
NP_653168.2. NM_144567.4. [Q5VTE6-1]
UniGeneiHs.157078.

Genome annotation databases

EnsembliENST00000360506; ENSP00000353696; ENSG00000174606. [Q5VTE6-2]
ENST00000366962; ENSP00000355929; ENSG00000174606. [Q5VTE6-1]
ENST00000535388; ENSP00000438141; ENSG00000174606. [Q5VTE6-2]
GeneIDi90806.
KEGGihsa:90806.
UCSCiuc001hjz.3. human. [Q5VTE6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510741 mRNA. Translation: AAM44053.1.
AK295116 mRNA. Translation: BAH11980.1.
AL592449 Genomic DNA. Translation: CAH71919.1.
AL592449 Genomic DNA. Translation: CAH71920.1.
CH471100 Genomic DNA. Translation: EAW93366.1.
CH471100 Genomic DNA. Translation: EAW93368.1.
CH471100 Genomic DNA. Translation: EAW93369.1.
BC047469 mRNA. Translation: AAH47469.1. Sequence problems.
CCDSiCCDS1512.1. [Q5VTE6-1]
CCDS73027.1. [Q5VTE6-2]
RefSeqiNP_001287682.1. NM_001300753.1.
NP_001287684.1. NM_001300755.1.
NP_001287686.1. NM_001300757.1. [Q5VTE6-2]
NP_001287687.1. NM_001300758.1. [Q5VTE6-2]
NP_653168.2. NM_144567.4. [Q5VTE6-1]
UniGeneiHs.157078.

3D structure databases

ProteinModelPortaliQ5VTE6.
SMRiQ5VTE6. Positions 170-369.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124763. 16 interactions.
IntActiQ5VTE6. 1 interaction.
STRINGi9606.ENSP00000355929.

PTM databases

iPTMnetiQ5VTE6.
PhosphoSiteiQ5VTE6.

Polymorphism and mutation databases

BioMutaiANGEL2.
DMDMi74746929.

Proteomic databases

EPDiQ5VTE6.
MaxQBiQ5VTE6.
PaxDbiQ5VTE6.
PeptideAtlasiQ5VTE6.
PRIDEiQ5VTE6.

Protocols and materials databases

DNASUi90806.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360506; ENSP00000353696; ENSG00000174606. [Q5VTE6-2]
ENST00000366962; ENSP00000355929; ENSG00000174606. [Q5VTE6-1]
ENST00000535388; ENSP00000438141; ENSG00000174606. [Q5VTE6-2]
GeneIDi90806.
KEGGihsa:90806.
UCSCiuc001hjz.3. human. [Q5VTE6-1]

Organism-specific databases

CTDi90806.
GeneCardsiANGEL2.
HGNCiHGNC:30534. ANGEL2.
HPAiHPA030796.
neXtProtiNX_Q5VTE6.
PharmGKBiPA142672620.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0620. Eukaryota.
KOG2338. Eukaryota.
COG5239. LUCA.
GeneTreeiENSGT00550000074364.
HOGENOMiHOG000033940.
HOVERGENiHBG057379.
InParanoidiQ5VTE6.
KOiK18729.
OMAiRRKHQGT.
OrthoDBiEOG091G0BJF.
PhylomeDBiQ5VTE6.
TreeFamiTF316126.

Miscellaneous databases

ChiTaRSiANGEL2. human.
GenomeRNAii90806.
PROiQ5VTE6.

Gene expression databases

BgeeiENSG00000174606.
CleanExiHS_ANGEL2.
ExpressionAtlasiQ5VTE6. baseline and differential.
GenevisibleiQ5VTE6. HS.

Family and domain databases

Gene3Di3.60.10.10. 2 hits.
InterProiIPR005135. Endo/exonuclease/phosphatase.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiANGE2_HUMAN
AccessioniPrimary (citable) accession number: Q5VTE6
Secondary accession number(s): B7Z2U4
, D3DTA3, Q86X13, Q8NHH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 7, 2004
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.