Q5VTE6 (ANGE2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein angel homolog 2

Gene names

Name:	ANGEL2
Synonyms:	KIAA0759L

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	544 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the CCR4/nocturin family.
Sequence caution	The sequence AAH47469.1 differs from that shown. Reason: Erroneous termination at position 456. Translated as Ser.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5VTE6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5VTE6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-169: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 544	544	Protein angel homolog 2		PRO_0000305080
Natural variations
	Alternative sequence	1 – 169	169	Missing in isoform 2.		VSP_028216
	Natural variant	97	1	P → S. Corresponds to variant rs11542154 [ dbSNP | Ensembl ].		VAR_050290

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 89F33A8A357E10A7	FASTA	544	62,339
	10 20 30 40 50 60 MEAWRCVRKG YGHCVVGRGR YPMFPHHSRS LGRDWTTPWE NLQRCCWNRH ISSCMRWPGH 70 80 90 100 110 120 YSRAPYPYFS SRHFSLNWRP PCLFESRTQF QYCNWRPDNL SQTSLIHLSS YVMNAEGDEP 130 140 150 160 170 180 SSKRRKHQGV IKRNWEYICS HDKEKTKILG DKNVDPKCED SENKFDFSVM SYNILSQDLL 190 200 210 220 230 240 EDNSHLYRHC RRPVLHWSFR FPNILKEIKH FDADVLCLQE VQEDHYGAEI RPSLESLGYH 250 260 270 280 290 300 CEYKMRTGRK PDGCAICFKH SKFSLLSVNP VEFFRPDISL LDRDNVGLVL LLQPKIPYAA 310 320 330 340 350 360 CPAICVANTH LLYNPRRGDI KLTQLAMLLA EISSVAHQKD GSFCPIVMCG DFNSVPGSPL 370 380 390 400 410 420 YSFIKEGKLN YEGLPIGKVS GQEQSSRGQR ILSIPIWPPN LGISQNCVYE VQQVPKVEKT 430 440 450 460 470 480 DSDLTQTQLK QTEVLVTAEK LSSNLQHHFS LSSVYSHYFP DTGIPEVTTC HSRSAITVDY 490 500 510 520 530 540 IFYSAEKEDV AGHPGAEVAL VGGLKLLARL SLLTEQDLWT VNGLPNENNS SDHLPLLAKF RLEL
	Isoform 2 [UniParc]. Checksum: 34881761BC8FA432	FASTA	375	42,106
	10 20 30 40 50 60 MSYNILSQDL LEDNSHLYRH CRRPVLHWSF RFPNILKEIK HFDADVLCLQ EVQEDHYGAE 70 80 90 100 110 120 IRPSLESLGY HCEYKMRTGR KPDGCAICFK HSKFSLLSVN PVEFFRPDIS LLDRDNVGLV 130 140 150 160 170 180 LLLQPKIPYA ACPAICVANT HLLYNPRRGD IKLTQLAMLL AEISSVAHQK DGSFCPIVMC 190 200 210 220 230 240 GDFNSVPGSP LYSFIKEGKL NYEGLPIGKV SGQEQSSRGQ RILSIPIWPP NLGISQNCVY 250 260 270 280 290 300 EVQQVPKVEK TDSDLTQTQL KQTEVLVTAE KLSSNLQHHF SLSSVYSHYF PDTGIPEVTT 310 320 330 340 350 360 CHSRSAITVD YIFYSAEKED VAGHPGAEVA LVGGLKLLAR LSLLTEQDLW TVNGLPNENN 370 SSDHLPLLAK FRLEL

References

[1]	Guo J.H., Yu L. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF510741 mRNA. Translation: AAM44053.1. AK295116 mRNA. Translation: BAH11980.1. AL592449 Genomic DNA. Translation: CAH71919.1. AL592449 Genomic DNA. Translation: CAH71920.1. CH471100 Genomic DNA. Translation: EAW93366.1. CH471100 Genomic DNA. Translation: EAW93368.1. CH471100 Genomic DNA. Translation: EAW93369.1. BC047469 mRNA. Translation: AAH47469.1. Sequence problems.
IPI	IPI00375317. IPI00478899.
RefSeq	NP_653168.2. NM_144567.3.
UniGene	Hs.157078.
3D structure databases
ProteinModelPortal	Q5VTE6.
ModBase	Search...
PTM databases
PhosphoSite	Q5VTE6.
Polymorphism databases
DMDM	74746929.
Proteomic databases
PRIDE	Q5VTE6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000366962; ENSP00000355929; ENSG00000174606.
GeneID	90806.
KEGG	hsa:90806.
NMPDR	fig|9606.3.peg.3059.
UCSC	uc001hjz.1. human. uc001hka.1. human.
Organism-specific databases
CTD	90806.
GeneCards	GC01M213165.
HGNC	HGNC:30534. ANGEL2.
HPA	HPA030796.
neXtProt	NX_Q5VTE6.
PharmGKB	PA142672620.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00550000074364.
HOGENOM	HBG444702.
HOVERGEN	HBG057379.
InParanoid	Q5VTE6.
OMA	EDHYGTE.
OrthoDB	EOG4255SF.
PhylomeDB	Q5VTE6.
Gene expression databases
ArrayExpress	Q5VTE6.
Bgee	Q5VTE6.
CleanEx	HS_ANGEL2.
Genevestigator	Q5VTE6.
Family and domain databases
InterPro	IPR005135. Endo/exonuclease/phosphatase. [Graphical view]
Pfam	PF03372. Exo_endo_phos. 1 hit. [Graphical view]
SUPFAM	SSF56219. Exo_endo_phos. 1 hit.
ProtoNet	Search...
Other
NextBio	76965.

Entry information

Entry name

ANGE2_HUMAN

Accession

Primary (citable) accession number: Q5VTE6
Secondary accession number(s): B7Z2U4 , D3DTA3, Q86X13, Q8NHH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	December 7, 2004
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.