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Q5VTE0

- EF1A3_HUMAN

UniProt

Q5VTE0 - EF1A3_HUMAN

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Protein

Putative elongation factor 1-alpha-like 3

Gene
EEF1A1P5, EEF1AL3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Protein uncertaini

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 218GTP By similarity
Nucleotide bindingi91 – 955GTP By similarity
Nucleotide bindingi153 – 1564GTP By similarity

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-KW
  3. translation elongation factor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_1477. Eukaryotic Translation Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative elongation factor 1-alpha-like 3
Short name:
EF-1-alpha-like 3
Alternative name(s):
Eukaryotic elongation factor 1 A-like 3
Short name:
eEF1A-like 3
Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5
Gene namesi
Synonyms:EEF1AL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:3200. EEF1A1P5.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular space Source: UniProt
  3. extracellular vesicular exosome Source: UniProt
  4. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Putative elongation factor 1-alpha-like 3UniRule annotationPRO_0000340262Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361N6,N6,N6-trimethyllysine By similarity
Modified residuei55 – 551N6,N6-dimethyllysine2 Publications
Modified residuei79 – 791N6,N6,N6-trimethyllysine By similarity
Modified residuei165 – 1651N6,N6,N6-trimethyllysine; alternate2 Publications
Modified residuei165 – 1651N6,N6-dimethyllysine; alternate2 Publications
Modified residuei165 – 1651N6-methyllysine; alternate2 Publications
Modified residuei300 – 3001Phosphoserine By similarity
Modified residuei301 – 30115-glutamyl glycerylphosphorylethanolamine By similarity
Modified residuei318 – 3181N6,N6,N6-trimethyllysine By similarity
Modified residuei374 – 37415-glutamyl glycerylphosphorylethanolamine By similarity
Modified residuei432 – 4321Phosphothreonine By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PRIDEiQ5VTE0.

Expressioni

Gene expression databases

GenevestigatoriQ5VTE0.

Interactioni

Protein-protein interaction databases

IntActiQ5VTE0. 14 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ5VTE0.
SMRiQ5VTE0. Positions 2-443.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 242238tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni14 – 218G1 By similarity
Regioni70 – 745G2 By similarity
Regioni91 – 944G3 By similarity
Regioni153 – 1564G4 By similarity
Regioni194 – 1963G5 By similarity

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000179.
InParanoidiQ5VTE0.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_A. EF_Tu_A.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004539. Transl_elong_EF1A_euk/arc.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00483. EF-1_alpha. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VTE0-1 [UniParc]FASTAAdd to Basket

« Hide

MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG    50
KGSFKYAWVL DKLKAERERG ITIDISLWKF ETSKYYVTII DAPGHRDFIK 100
NMITGTSQAD CAVLIVAAGV GEFEAGISKN GQTREHALLA YTLGVKQLIV 150
GVNKMDSTEP PYSQKRYEEI VKEVSTYIKK IGYNPDTVAF VPISGWNGDN 200
MLEPSANMPW FKGWKVTRKD GNASGTTLLE ALDCILPPTR PTDKPLRLPL 250
QDVYKIGGIG TVPVGRVETG VLKPGMVVTF APVNVTTEVK SVEMHHEALS 300
EALPGDNVGF KVKNVSVKDV RRGNVAGDSK NDPPMEAAGF TAQVIILNHP 350
GQISAGYAPV LDCHMAHIAC KFAELKEKID RRSGKKLEDG PKFLKSGDAA 400
IVDMVPGKPM CVESFSDYPP LGRFAVRDMR QTVAVGVIKA VDKKAAGAGK 450
VTKSAQKAQK AK 462
Length:462
Mass (Da):50,185
Last modified:December 7, 2004 - v1
Checksum:i7E53152607CE1E68
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL593851 Genomic DNA. No translation available.
CR595753 mRNA. No translation available.
CR609311 mRNA. No translation available.

Polymorphism databases

DMDMi74746925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL593851 Genomic DNA. No translation available.
CR595753 mRNA. No translation available.
CR609311 mRNA. No translation available.

3D structure databases

ProteinModelPortali Q5VTE0.
SMRi Q5VTE0. Positions 2-443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q5VTE0. 14 interactions.

Polymorphism databases

DMDMi 74746925.

Proteomic databases

PRIDEi Q5VTE0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC09P135910.
HGNCi HGNC:3200. EEF1A1P5.
neXtProti NX_Q5VTE0.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG000179.
InParanoidi Q5VTE0.

Enzyme and pathway databases

Reactomei REACT_1477. Eukaryotic Translation Elongation.

Gene expression databases

Genevestigatori Q5VTE0.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00118_A. EF_Tu_A.
InterProi IPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004539. Transl_elong_EF1A_euk/arc.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00483. EF-1_alpha. 1 hit.
PROSITEi PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Bienvenut W.V., Lilla S., von Kriegsheim A., Lempens A., Kolch W.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 6-30; 52-62; 85-96; 135-166; 173-179; 248-290 AND 431-439, METHYLATION AT LYS-55 AND LYS-165, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Colon carcinoma and Ovarian carcinoma.
  3. Bienvenut W.V., Waridel P., Quadroni M.
    Submitted (MAR-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 6-30; 52-62; 85-96; 101-129; 135-179; 220-244; 248-290; 396-423 AND 431-439, METHYLATION AT LYS-55 AND LYS-165, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma and Embryonic kidney.
  4. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 258-462.
  5. "Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3."
    Lund A., Knudsen S.M., Vissing H., Clark B., Tommerup N.
    Genomics 36:359-361(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiEF1A3_HUMAN
AccessioniPrimary (citable) accession number: Q5VTE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 7, 2004
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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