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Q5VTD9

- GFI1B_HUMAN

UniProt

Q5VTD9 - GFI1B_HUMAN

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Protein

Zinc finger protein Gfi-1b

Gene
GFI1B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.8 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri163 – 18624C2H2-type 1Add
BLAST
Zinc fingeri192 – 21423C2H2-type 2Add
BLAST
Zinc fingeri220 – 24223C2H2-type 3Add
BLAST
Zinc fingeri248 – 27023C2H2-type 4Add
BLAST
Zinc fingeri276 – 29823C2H2-type 5Add
BLAST
Zinc fingeri304 – 32724C2H2-type 6Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: UniProtKB
  4. RNA polymerase II transcription factor binding Source: BHF-UCL

GO - Biological processi

  1. cell proliferation Source: ProtInc
  2. chromatin modification Source: UniProtKB-KW
  3. multicellular organismal development Source: UniProtKB-KW
  4. negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
  5. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ5VTD9.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein Gfi-1b
Alternative name(s):
Growth factor independent protein 1B
Potential regulator of CDKN1A translocated in CML
Gene namesi
Name:GFI1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:4238. GFI1B.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nuclear matrix Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. transcription factor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Bleeding disorder, platelet-type 17 (BDPLT17) [MIM:187900]: An autosomal dominant disorder characterized by increased bleeding tendency due to platelet dysfunction, and associated with macrothrombocytopenia and red cell anisopoikilocytosis. Platelets appear abnormal on light microscopy, while electron microscopy shows a heterogeneous decrease of alpha granules within platelets. Bone marrow biopsy shows increased numbers of abnormal megakaryocytes, suggesting a defect in megakaryopoiesis and platelet production. The severity of bleeding is variable with some affected individuals experiencing spontaneous bleeding while other exhibit only abnormal bleeding with surgery.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi290 – 2901N → S: Prevents DNA-binding. 1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

MIMi187900. phenotype.
Orphaneti721. Gray platelet syndrome.
PharmGKBiPA28649.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Zinc finger protein Gfi-1bPRO_0000306327Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81N6,N6-dimethyllysine1 Publication

Post-translational modificationi

Methylation at Lys-8 in the SNAG domain seems required for the recruitment of the corepressor complex.1 Publication

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ5VTD9.
PRIDEiQ5VTD9.

PTM databases

PhosphoSiteiQ5VTD9.

Expressioni

Tissue specificityi

Expressed in bone marrow and fetal liver, but also detectable in fetal spleen, fetal thymus, and testes. Detected in hematopoietic stem cells, erythroblasts, and megakaryocytes. Overexpressed in bone marrow of patients with erythroleukemia and megakaryocytic leukemia as well as in their corresponding leukemic cell lines, and markedly repressed in severe aplastic anemia (SAA).3 Publications

Inductioni

By GATA1 which binds to GFI1B promoter in cooperation with the transcription factor NFYA. Target gene of transcription factor E2-alpha/TCF3 that promotes growth arrest and apoptosis in lymphomas.1 Publication

Gene expression databases

BgeeiQ5VTD9.
CleanExiHS_GFI1B.
GenevestigatoriQ5VTD9.

Organism-specific databases

HPAiHPA007012.

Interactioni

Subunit structurei

Component of a RCOR-GFI-KDM1A-HDAC complex. Interacts directly with RCOR1, KDM1A and HDAC2 By similarity. Forms a complex with GATA1. Interacts with histone methyltransferases EHMT2 and SUV39H1. Interacts with ARIH2 (via RING-type 2). Interacts with RUNX1T1.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CENPJQ9HC772EBI-946212,EBI-946194
JAG2Q9Y2192EBI-946212,EBI-946223
NELL2Q994352EBI-946212,EBI-946274

Protein-protein interaction databases

BioGridi113924. 76 interactions.
IntActiQ5VTD9. 71 interactions.
MINTiMINT-2798741.
STRINGi9606.ENSP00000344782.

Structurei

3D structure databases

ProteinModelPortaliQ5VTD9.
SMRiQ5VTD9. Positions 163-327.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2020SNAG domainAdd
BLAST
Regioni91 – 330240Interaction with ARIH2Add
BLAST
Regioni164 – 330167Mediates interaction with GATA1Add
BLAST

Domaini

The zinc finger domains are essential for erythroid expansion and acts as an activation domain whereas non finger domain serves as repression domain By similarity.
The SNAG domain of GFIs is required for nuclear location and for interaction with some corepressors By similarity.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri163 – 18624C2H2-type 1Add
BLAST
Zinc fingeri192 – 21423C2H2-type 2Add
BLAST
Zinc fingeri220 – 24223C2H2-type 3Add
BLAST
Zinc fingeri248 – 27023C2H2-type 4Add
BLAST
Zinc fingeri276 – 29823C2H2-type 5Add
BLAST
Zinc fingeri304 – 32724C2H2-type 6Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000067832.
HOVERGENiHBG106655.
InParanoidiQ5VTD9.
KOiK09223.
OMAiYGHSYRQ.
OrthoDBiEOG72RN05.
PhylomeDBiQ5VTD9.
TreeFamiTF350784.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VTD9-1) [UniParc]FASTAAdd to Basket

Also known as: p37

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPRSFLVKSK KAHTYHQPRV QEDEPLWPPA LTPVPRDQAP SNSPVLSTLF    50
PNQCLDWTNL KREPELEQDQ NLARMAPAPE GPIVLSRPQD GDSPLSDSPP 100
FYKPSFSWDT LATTYGHSYR QAPSTMQSAF LEHSVSLYGS PLVPSTEPAL 150
DFSLRYSPGM DAYHCVKCNK VFSTPHGLEV HVRRSHSGTR PFACDICGKT 200
FGHAVSLEQH THVHSQERSF ECRMCGKAFK RSSTLSTHLL IHSDTRPYPC 250
QFCGKRFHQK SDMKKHTYIH TGEKPHKCQV CGKAFSQSSN LITHSRKHTG 300
FKPFSCELCT KGFQRKVDLR RHRESQHNLK 330
Length:330
Mass (Da):37,492
Last modified:December 7, 2004 - v1
Checksum:i947DD9C34B5BD962
GO
Isoform 2 (identifier: Q5VTD9-2) [UniParc]FASTAAdd to Basket

Also known as: p32

The sequence of this isoform differs from the canonical sequence as follows:
     171-216: Missing.

Note: Essential for erythroid differentiation. Binds to target gene promoters and associates with the LSD1-CoREST repressor complex more efficiently than the major isoform 1.

Show »
Length:284
Mass (Da):32,419
Checksum:i36498895611B0E20
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti231 – 2311R → H in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035556

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei171 – 21646Missing in isoform 2. VSP_028459Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111K → M in AAR06639. 1 Publication
Sequence conflicti27 – 271W → R in CAG38783. 1 Publication
Sequence conflicti29 – 291P → H in AAD08672. 1 Publication
Sequence conflicti190 – 1901R → W in AAR06639. 1 Publication
Sequence conflicti219 – 2191S → N in AAD08672. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF081946 mRNA. Translation: AAD08672.1.
AY428733 mRNA. Translation: AAR06639.1.
CR536546 mRNA. Translation: CAG38783.1.
AL593851 Genomic DNA. Translation: CAH73618.1.
AL593851 Genomic DNA. Translation: CAH73619.1.
CH471090 Genomic DNA. Translation: EAW88025.1.
BC043371 mRNA. Translation: AAH43371.1.
BC035626 mRNA. No translation available.
CCDSiCCDS48049.1. [Q5VTD9-2]
CCDS6957.1. [Q5VTD9-1]
RefSeqiNP_001128503.1. NM_001135031.1. [Q5VTD9-2]
NP_004179.3. NM_004188.4. [Q5VTD9-1]
UniGeneiHs.553160.

Genome annotation databases

EnsembliENST00000339463; ENSP00000344782; ENSG00000165702. [Q5VTD9-1]
ENST00000372122; ENSP00000361195; ENSG00000165702. [Q5VTD9-1]
ENST00000372123; ENSP00000361196; ENSG00000165702. [Q5VTD9-2]
ENST00000372124; ENSP00000361197; ENSG00000165702. [Q5VTD9-2]
ENST00000450530; ENSP00000409546; ENSG00000165702. [Q5VTD9-1]
ENST00000534944; ENSP00000446134; ENSG00000165702. [Q5VTD9-2]
GeneIDi8328.
KEGGihsa:8328.
UCSCiuc004ccg.3. human. [Q5VTD9-1]
uc010mzy.3. human. [Q5VTD9-2]

Polymorphism databases

DMDMi74756792.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF081946 mRNA. Translation: AAD08672.1 .
AY428733 mRNA. Translation: AAR06639.1 .
CR536546 mRNA. Translation: CAG38783.1 .
AL593851 Genomic DNA. Translation: CAH73618.1 .
AL593851 Genomic DNA. Translation: CAH73619.1 .
CH471090 Genomic DNA. Translation: EAW88025.1 .
BC043371 mRNA. Translation: AAH43371.1 .
BC035626 mRNA. No translation available.
CCDSi CCDS48049.1. [Q5VTD9-2 ]
CCDS6957.1. [Q5VTD9-1 ]
RefSeqi NP_001128503.1. NM_001135031.1. [Q5VTD9-2 ]
NP_004179.3. NM_004188.4. [Q5VTD9-1 ]
UniGenei Hs.553160.

3D structure databases

ProteinModelPortali Q5VTD9.
SMRi Q5VTD9. Positions 163-327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113924. 76 interactions.
IntActi Q5VTD9. 71 interactions.
MINTi MINT-2798741.
STRINGi 9606.ENSP00000344782.

PTM databases

PhosphoSitei Q5VTD9.

Polymorphism databases

DMDMi 74756792.

Proteomic databases

PaxDbi Q5VTD9.
PRIDEi Q5VTD9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339463 ; ENSP00000344782 ; ENSG00000165702 . [Q5VTD9-1 ]
ENST00000372122 ; ENSP00000361195 ; ENSG00000165702 . [Q5VTD9-1 ]
ENST00000372123 ; ENSP00000361196 ; ENSG00000165702 . [Q5VTD9-2 ]
ENST00000372124 ; ENSP00000361197 ; ENSG00000165702 . [Q5VTD9-2 ]
ENST00000450530 ; ENSP00000409546 ; ENSG00000165702 . [Q5VTD9-1 ]
ENST00000534944 ; ENSP00000446134 ; ENSG00000165702 . [Q5VTD9-2 ]
GeneIDi 8328.
KEGGi hsa:8328.
UCSCi uc004ccg.3. human. [Q5VTD9-1 ]
uc010mzy.3. human. [Q5VTD9-2 ]

Organism-specific databases

CTDi 8328.
GeneCardsi GC09P135821.
HGNCi HGNC:4238. GFI1B.
HPAi HPA007012.
MIMi 187900. phenotype.
604383. gene.
neXtProti NX_Q5VTD9.
Orphaneti 721. Gray platelet syndrome.
PharmGKBi PA28649.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000067832.
HOVERGENi HBG106655.
InParanoidi Q5VTD9.
KOi K09223.
OMAi YGHSYRQ.
OrthoDBi EOG72RN05.
PhylomeDBi Q5VTD9.
TreeFami TF350784.

Enzyme and pathway databases

SignaLinki Q5VTD9.

Miscellaneous databases

GeneWikii GFI1B.
GenomeRNAii 8328.
NextBioi 31186.
PROi Q5VTD9.
SOURCEi Search...

Gene expression databases

Bgeei Q5VTD9.
CleanExi HS_GFI1B.
Genevestigatori Q5VTD9.

Family and domain databases

Gene3Di 3.30.160.60. 6 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 6 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases."
    Roedel B., Wagner T., Zoernig M., Niessing J., Moeroey T.
    Genomics 54:580-582(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Umbilical cord blood.
  2. "GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene."
    Huang D.Y., Kuo Y.Y., Lai J.S., Suzuki Y., Sugano S., Chang Z.F.
    Nucleic Acids Res. 32:3935-3946(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION BY GATA1.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  7. "Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis."
    Osawa M., Yamaguchi T., Nakamura Y., Kaneko S., Onodera M., Sawada K., Jegalian A., Wu H., Nakauchi H., Iwama A.
    Blood 100:2769-2777(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  8. "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism."
    McGhee L., Bryan J., Elliott L., Grimes H.L., Kazanjian A., Davis J.N., Meyers S.
    J. Cell. Biochem. 89:1005-1018(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RUNX1T1.
  9. "GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells."
    Huang D.-Y., Kuo Y.-Y., Chang Z.-F.
    Nucleic Acids Res. 33:5331-5342(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING, INTERACTION WITH GATA1.
  10. "Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin."
    Vassen L., Fiolka K., Moeroey T.
    EMBO J. 25:2409-2419(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH EHMT2 AND SUV39H1.
  11. "Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development."
    Schwartz R., Engel I., Fallahi-Sichani M., Petrie H.T., Murre C.
    Proc. Natl. Acad. Sci. U.S.A. 103:9976-9981(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1."
    Marteijn J.A., van der Meer L.T., van Emst L., van Reijmersdal S., Wissink W., de Witte T., Jansen J.H., Van der Reijden B.A.
    Blood 110:3128-3135(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARIH2.
  13. "Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas."
    Wei X., Kee B.L.
    Blood 109:4406-4414(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING, MUTAGENESIS OF ASN-290.
  14. "Growth factor-independent 1B gene (GFI1B) is overexpressed in erythropoietic and megakaryocytic malignancies and increases their proliferation rate."
    Elmaagacli A.H., Koldehoff M., Zakrzewski J.L., Steckel N.K., Ottinger H., Beelen D.W.
    Br. J. Haematol. 136:212-219(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  15. "GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription."
    Kuo Y.-Y., Chang Z.-F.
    Mol. Cell. Biol. 27:4261-4272(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GATA1.
  16. "A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1-CoREST complex through the dimethylation of its SNAG domain."
    Laurent B., Randrianarison-Huetz V., Frisan E., Andrieu-Soler C., Soler E., Fontenay M., Dusanter-Fourt I., Dumenil D.
    J. Cell Sci. 125:993-1002(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION (ISOFORM 2), METHYLATION AT LYS-8.
  17. Cited for: INVOLVEMENT IN BDPLT17.
  18. Cited for: INVOLVEMENT IN BDPLT17.
  19. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-231.

Entry informationi

Entry nameiGFI1B_HUMAN
AccessioniPrimary (citable) accession number: Q5VTD9
Secondary accession number(s): O95270
, Q5VTD8, Q6FHZ2, Q6T888
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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