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Q5VTD9

- GFI1B_HUMAN

UniProt

Q5VTD9 - GFI1B_HUMAN

Protein

Zinc finger protein Gfi-1b

Gene

GFI1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.7 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri163 – 18624C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri192 – 21423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri220 – 24223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri248 – 27023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri276 – 29823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri304 – 32724C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB
    4. RNA polymerase II transcription factor binding Source: BHF-UCL

    GO - Biological processi

    1. cell proliferation Source: ProtInc
    2. chromatin modification Source: UniProtKB-KW
    3. multicellular organismal development Source: UniProtKB-KW
    4. negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
    5. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Developmental protein, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    SignaLinkiQ5VTD9.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein Gfi-1b
    Alternative name(s):
    Growth factor independent protein 1B
    Potential regulator of CDKN1A translocated in CML
    Gene namesi
    Name:GFI1B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:4238. GFI1B.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nuclear matrix Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. transcription factor complex Source: BHF-UCL

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Bleeding disorder, platelet-type 17 (BDPLT17) [MIM:187900]: An autosomal dominant disorder characterized by increased bleeding tendency due to platelet dysfunction, and associated with macrothrombocytopenia and red cell anisopoikilocytosis. Platelets appear abnormal on light microscopy, while electron microscopy shows a heterogeneous decrease of alpha granules within platelets. Bone marrow biopsy shows increased numbers of abnormal megakaryocytes, suggesting a defect in megakaryopoiesis and platelet production. The severity of bleeding is variable with some affected individuals experiencing spontaneous bleeding while other exhibit only abnormal bleeding with surgery.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi290 – 2901N → S: Prevents DNA-binding. 1 Publication

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    MIMi187900. phenotype.
    Orphaneti721. Gray platelet syndrome.
    PharmGKBiPA28649.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330Zinc finger protein Gfi-1bPRO_0000306327Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei8 – 81N6,N6-dimethyllysine1 Publication

    Post-translational modificationi

    Methylation at Lys-8 in the SNAG domain seems required for the recruitment of the corepressor complex.1 Publication

    Keywords - PTMi

    Methylation

    Proteomic databases

    PaxDbiQ5VTD9.
    PRIDEiQ5VTD9.

    PTM databases

    PhosphoSiteiQ5VTD9.

    Expressioni

    Tissue specificityi

    Expressed in bone marrow and fetal liver, but also detectable in fetal spleen, fetal thymus, and testes. Detected in hematopoietic stem cells, erythroblasts, and megakaryocytes. Overexpressed in bone marrow of patients with erythroleukemia and megakaryocytic leukemia as well as in their corresponding leukemic cell lines, and markedly repressed in severe aplastic anemia (SAA).3 Publications

    Inductioni

    By GATA1 which binds to GFI1B promoter in cooperation with the transcription factor NFYA. Target gene of transcription factor E2-alpha/TCF3 that promotes growth arrest and apoptosis in lymphomas.1 Publication

    Gene expression databases

    BgeeiQ5VTD9.
    CleanExiHS_GFI1B.
    GenevestigatoriQ5VTD9.

    Organism-specific databases

    HPAiHPA007012.

    Interactioni

    Subunit structurei

    Component of a RCOR-GFI-KDM1A-HDAC complex. Interacts directly with RCOR1, KDM1A and HDAC2 By similarity. Forms a complex with GATA1. Interacts with histone methyltransferases EHMT2 and SUV39H1. Interacts with ARIH2 (via RING-type 2). Interacts with RUNX1T1.By similarity5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CENPJQ9HC772EBI-946212,EBI-946194
    JAG2Q9Y2192EBI-946212,EBI-946223
    NELL2Q994352EBI-946212,EBI-946274

    Protein-protein interaction databases

    BioGridi113924. 76 interactions.
    IntActiQ5VTD9. 71 interactions.
    MINTiMINT-2798741.
    STRINGi9606.ENSP00000344782.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VTD9.
    SMRiQ5VTD9. Positions 163-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2020SNAG domainAdd
    BLAST
    Regioni91 – 330240Interaction with ARIH2Add
    BLAST
    Regioni164 – 330167Mediates interaction with GATA1Add
    BLAST

    Domaini

    The zinc finger domains are essential for erythroid expansion and acts as an activation domain whereas non finger domain serves as repression domain.By similarity
    The SNAG domain of GFIs is required for nuclear location and for interaction with some corepressors.By similarity

    Sequence similaritiesi

    Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri163 – 18624C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri192 – 21423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri220 – 24223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri248 – 27023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri276 – 29823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri304 – 32724C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000067832.
    HOVERGENiHBG106655.
    InParanoidiQ5VTD9.
    KOiK09223.
    OMAiYGHSYRQ.
    OrthoDBiEOG72RN05.
    PhylomeDBiQ5VTD9.
    TreeFamiTF350784.

    Family and domain databases

    Gene3Di3.30.160.60. 6 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 6 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5VTD9-1) [UniParc]FASTAAdd to Basket

    Also known as: p37

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPRSFLVKSK KAHTYHQPRV QEDEPLWPPA LTPVPRDQAP SNSPVLSTLF    50
    PNQCLDWTNL KREPELEQDQ NLARMAPAPE GPIVLSRPQD GDSPLSDSPP 100
    FYKPSFSWDT LATTYGHSYR QAPSTMQSAF LEHSVSLYGS PLVPSTEPAL 150
    DFSLRYSPGM DAYHCVKCNK VFSTPHGLEV HVRRSHSGTR PFACDICGKT 200
    FGHAVSLEQH THVHSQERSF ECRMCGKAFK RSSTLSTHLL IHSDTRPYPC 250
    QFCGKRFHQK SDMKKHTYIH TGEKPHKCQV CGKAFSQSSN LITHSRKHTG 300
    FKPFSCELCT KGFQRKVDLR RHRESQHNLK 330
    Length:330
    Mass (Da):37,492
    Last modified:December 7, 2004 - v1
    Checksum:i947DD9C34B5BD962
    GO
    Isoform 2 (identifier: Q5VTD9-2) [UniParc]FASTAAdd to Basket

    Also known as: p32

    The sequence of this isoform differs from the canonical sequence as follows:
         171-216: Missing.

    Note: Essential for erythroid differentiation. Binds to target gene promoters and associates with the LSD1-CoREST repressor complex more efficiently than the major isoform 1.

    Show »
    Length:284
    Mass (Da):32,419
    Checksum:i36498895611B0E20
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 111K → M in AAR06639. (PubMed:15280509)Curated
    Sequence conflicti27 – 271W → R in CAG38783. 1 PublicationCurated
    Sequence conflicti29 – 291P → H in AAD08672. (PubMed:9878267)Curated
    Sequence conflicti190 – 1901R → W in AAR06639. (PubMed:15280509)Curated
    Sequence conflicti219 – 2191S → N in AAD08672. (PubMed:9878267)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti231 – 2311R → H in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035556

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei171 – 21646Missing in isoform 2. 1 PublicationVSP_028459Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF081946 mRNA. Translation: AAD08672.1.
    AY428733 mRNA. Translation: AAR06639.1.
    CR536546 mRNA. Translation: CAG38783.1.
    AL593851 Genomic DNA. Translation: CAH73618.1.
    AL593851 Genomic DNA. Translation: CAH73619.1.
    CH471090 Genomic DNA. Translation: EAW88025.1.
    BC043371 mRNA. Translation: AAH43371.1.
    BC035626 mRNA. No translation available.
    CCDSiCCDS48049.1. [Q5VTD9-2]
    CCDS6957.1. [Q5VTD9-1]
    RefSeqiNP_001128503.1. NM_001135031.1. [Q5VTD9-2]
    NP_004179.3. NM_004188.4. [Q5VTD9-1]
    UniGeneiHs.553160.

    Genome annotation databases

    EnsembliENST00000339463; ENSP00000344782; ENSG00000165702. [Q5VTD9-1]
    ENST00000372122; ENSP00000361195; ENSG00000165702. [Q5VTD9-1]
    ENST00000372123; ENSP00000361196; ENSG00000165702. [Q5VTD9-2]
    ENST00000534944; ENSP00000446134; ENSG00000165702. [Q5VTD9-2]
    GeneIDi8328.
    KEGGihsa:8328.
    UCSCiuc004ccg.3. human. [Q5VTD9-1]
    uc010mzy.3. human. [Q5VTD9-2]

    Polymorphism databases

    DMDMi74756792.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF081946 mRNA. Translation: AAD08672.1 .
    AY428733 mRNA. Translation: AAR06639.1 .
    CR536546 mRNA. Translation: CAG38783.1 .
    AL593851 Genomic DNA. Translation: CAH73618.1 .
    AL593851 Genomic DNA. Translation: CAH73619.1 .
    CH471090 Genomic DNA. Translation: EAW88025.1 .
    BC043371 mRNA. Translation: AAH43371.1 .
    BC035626 mRNA. No translation available.
    CCDSi CCDS48049.1. [Q5VTD9-2 ]
    CCDS6957.1. [Q5VTD9-1 ]
    RefSeqi NP_001128503.1. NM_001135031.1. [Q5VTD9-2 ]
    NP_004179.3. NM_004188.4. [Q5VTD9-1 ]
    UniGenei Hs.553160.

    3D structure databases

    ProteinModelPortali Q5VTD9.
    SMRi Q5VTD9. Positions 163-327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113924. 76 interactions.
    IntActi Q5VTD9. 71 interactions.
    MINTi MINT-2798741.
    STRINGi 9606.ENSP00000344782.

    PTM databases

    PhosphoSitei Q5VTD9.

    Polymorphism databases

    DMDMi 74756792.

    Proteomic databases

    PaxDbi Q5VTD9.
    PRIDEi Q5VTD9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339463 ; ENSP00000344782 ; ENSG00000165702 . [Q5VTD9-1 ]
    ENST00000372122 ; ENSP00000361195 ; ENSG00000165702 . [Q5VTD9-1 ]
    ENST00000372123 ; ENSP00000361196 ; ENSG00000165702 . [Q5VTD9-2 ]
    ENST00000534944 ; ENSP00000446134 ; ENSG00000165702 . [Q5VTD9-2 ]
    GeneIDi 8328.
    KEGGi hsa:8328.
    UCSCi uc004ccg.3. human. [Q5VTD9-1 ]
    uc010mzy.3. human. [Q5VTD9-2 ]

    Organism-specific databases

    CTDi 8328.
    GeneCardsi GC09P135821.
    HGNCi HGNC:4238. GFI1B.
    HPAi HPA007012.
    MIMi 187900. phenotype.
    604383. gene.
    neXtProti NX_Q5VTD9.
    Orphaneti 721. Gray platelet syndrome.
    PharmGKBi PA28649.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000067832.
    HOVERGENi HBG106655.
    InParanoidi Q5VTD9.
    KOi K09223.
    OMAi YGHSYRQ.
    OrthoDBi EOG72RN05.
    PhylomeDBi Q5VTD9.
    TreeFami TF350784.

    Enzyme and pathway databases

    SignaLinki Q5VTD9.

    Miscellaneous databases

    GeneWikii GFI1B.
    GenomeRNAii 8328.
    NextBioi 31186.
    PROi Q5VTD9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5VTD9.
    CleanExi HS_GFI1B.
    Genevestigatori Q5VTD9.

    Family and domain databases

    Gene3Di 3.30.160.60. 6 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 6 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases."
      Roedel B., Wagner T., Zoernig M., Niessing J., Moeroey T.
      Genomics 54:580-582(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Umbilical cord blood.
    2. "GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene."
      Huang D.Y., Kuo Y.Y., Lai J.S., Suzuki Y., Sugano S., Chang Z.F.
      Nucleic Acids Res. 32:3935-3946(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION BY GATA1.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    7. "Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis."
      Osawa M., Yamaguchi T., Nakamura Y., Kaneko S., Onodera M., Sawada K., Jegalian A., Wu H., Nakauchi H., Iwama A.
      Blood 100:2769-2777(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    8. "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism."
      McGhee L., Bryan J., Elliott L., Grimes H.L., Kazanjian A., Davis J.N., Meyers S.
      J. Cell. Biochem. 89:1005-1018(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RUNX1T1.
    9. "GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells."
      Huang D.-Y., Kuo Y.-Y., Chang Z.-F.
      Nucleic Acids Res. 33:5331-5342(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DNA-BINDING, INTERACTION WITH GATA1.
    10. "Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin."
      Vassen L., Fiolka K., Moeroey T.
      EMBO J. 25:2409-2419(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH EHMT2 AND SUV39H1.
    11. "Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development."
      Schwartz R., Engel I., Fallahi-Sichani M., Petrie H.T., Murre C.
      Proc. Natl. Acad. Sci. U.S.A. 103:9976-9981(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1."
      Marteijn J.A., van der Meer L.T., van Emst L., van Reijmersdal S., Wissink W., de Witte T., Jansen J.H., Van der Reijden B.A.
      Blood 110:3128-3135(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARIH2.
    13. "Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas."
      Wei X., Kee B.L.
      Blood 109:4406-4414(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DNA-BINDING, MUTAGENESIS OF ASN-290.
    14. "Growth factor-independent 1B gene (GFI1B) is overexpressed in erythropoietic and megakaryocytic malignancies and increases their proliferation rate."
      Elmaagacli A.H., Koldehoff M., Zakrzewski J.L., Steckel N.K., Ottinger H., Beelen D.W.
      Br. J. Haematol. 136:212-219(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    15. "GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription."
      Kuo Y.-Y., Chang Z.-F.
      Mol. Cell. Biol. 27:4261-4272(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GATA1.
    16. "A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1-CoREST complex through the dimethylation of its SNAG domain."
      Laurent B., Randrianarison-Huetz V., Frisan E., Andrieu-Soler C., Soler E., Fontenay M., Dusanter-Fourt I., Dumenil D.
      J. Cell Sci. 125:993-1002(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION (ISOFORM 2), METHYLATION AT LYS-8.
    17. Cited for: INVOLVEMENT IN BDPLT17.
    18. Cited for: INVOLVEMENT IN BDPLT17.
    19. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-231.

    Entry informationi

    Entry nameiGFI1B_HUMAN
    AccessioniPrimary (citable) accession number: Q5VTD9
    Secondary accession number(s): O95270
    , Q5VTD8, Q6FHZ2, Q6T888
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3