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Q5VTD9 (GFI1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein Gfi-1b
Alternative name(s):
Growth factor independent protein 1B
Potential regulator of CDKN1A translocated in CML
Gene names
Name:GFI1B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation. Ref.7 Ref.9 Ref.10 Ref.11 Ref.13 Ref.14 Ref.15 Ref.16

Subunit structure

Component of a RCOR-GFI-KDM1A-HDAC complex. Interacts directly with RCOR1, KDM1A and HDAC2 By similarity. Forms a complex with GATA1. Interacts with histone methyltransferases EHMT2 and SUV39H1. Interacts with ARIH2 (via RING-type 2). Interacts with RUNX1T1. Ref.8 Ref.9 Ref.10 Ref.12 Ref.15

Subcellular location

Nucleus Ref.10.

Tissue specificity

Expressed in bone marrow and fetal liver, but also detectable in fetal spleen, fetal thymus, and testes. Detected in hematopoietic stem cells, erythroblasts, and megakaryocytes. Overexpressed in bone marrow of patients with erythroleukemia and megakaryocytic leukemia as well as in their corresponding leukemic cell lines, and markedly repressed in severe aplastic anemia (SAA). Ref.1 Ref.7 Ref.14

Induction

By GATA1 which binds to GFI1B promoter in cooperation with the transcription factor NFYA. Target gene of transcription factor E2-alpha/TCF3 that promotes growth arrest and apoptosis in lymphomas. Ref.2

Domain

The zinc finger domains are essential for erythroid expansion and acts as an activation domain whereas non finger domain serves as repression domain By similarity.

The SNAG domain of GFIs is required for nuclear location and for interaction with some corepressors By similarity.

Post-translational modification

Methylation at Lys-8 in the SNAG domain seems required for the recruitment of the corepressor complex. Ref.16

Involvement in disease

Bleeding disorder, platelet-type 17 (BDPLT17) [MIM:187900]: An autosomal dominant disorder characterized by increased bleeding tendency due to platelet dysfunction, and associated with macrothrombocytopenia and red cell anisopoikilocytosis. Platelets appear abnormal on light microscopy, while electron microscopy shows a heterogeneous decrease of alpha granules within platelets. Bone marrow biopsy shows increased numbers of abnormal megakaryocytes, suggesting a defect in megakaryopoiesis and platelet production. The severity of bleeding is variable with some affected individuals experiencing spontaneous bleeding while other exhibit only abnormal bleeding with surgery.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.17 Ref.18

Sequence similarities

Contains 6 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseProto-oncogene
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
Chromatin regulator
Developmental protein
Repressor
   PTMMethylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell proliferation

Traceable author statement PubMed 9566867. Source: ProtInc

chromatin modification

Inferred from electronic annotation. Source: UniProtKB-KW

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of transcription from RNA polymerase II promoter

Traceable author statement PubMed 9566867. Source: ProtInc

transcription from RNA polymerase II promoter

Traceable author statement PubMed 9566867. Source: ProtInc

   Cellular_componentnuclear matrix

Inferred from direct assay Ref.8. Source: UniProtKB

nucleus

Inferred from direct assay Ref.8. Source: UniProtKB

transcription factor complex

Inferred from direct assay PubMed 15920471. Source: BHF-UCL

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

RNA polymerase II transcription factor binding

Inferred from physical interaction PubMed 15920471. Source: BHF-UCL

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction Ref.8. Source: UniProtKB

Complete GO annotation...

Binary interactions

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5VTD9-1)

Also known as: p37;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5VTD9-2)

Also known as: p32;

The sequence of this isoform differs from the canonical sequence as follows:
     171-216: Missing.
Note: Essential for erythroid differentiation. Binds to target gene promoters and associates with the LSD1-CoREST repressor complex more efficiently than the major isoform 1.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330Zinc finger protein Gfi-1b
PRO_0000306327

Regions

Zinc finger163 – 18624C2H2-type 1
Zinc finger192 – 21423C2H2-type 2
Zinc finger220 – 24223C2H2-type 3
Zinc finger248 – 27023C2H2-type 4
Zinc finger276 – 29823C2H2-type 5
Zinc finger304 – 32724C2H2-type 6
Region1 – 2020SNAG domain
Region91 – 330240Interaction with ARIH2
Region164 – 330167Mediates interaction with GATA1

Amino acid modifications

Modified residue81N6,N6-dimethyllysine Ref.16

Natural variations

Alternative sequence171 – 21646Missing in isoform 2.
VSP_028459
Natural variant2311R → H in a colorectal cancer sample; somatic mutation. Ref.19
VAR_035556

Experimental info

Mutagenesis2901N → S: Prevents DNA-binding. Ref.13
Sequence conflict111K → M in AAR06639. Ref.2
Sequence conflict271W → R in CAG38783. Ref.3
Sequence conflict291P → H in AAD08672. Ref.1
Sequence conflict1901R → W in AAR06639. Ref.2
Sequence conflict2191S → N in AAD08672. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (p37) [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 947DD9C34B5BD962

FASTA33037,492
        10         20         30         40         50         60 
MPRSFLVKSK KAHTYHQPRV QEDEPLWPPA LTPVPRDQAP SNSPVLSTLF PNQCLDWTNL 

        70         80         90        100        110        120 
KREPELEQDQ NLARMAPAPE GPIVLSRPQD GDSPLSDSPP FYKPSFSWDT LATTYGHSYR 

       130        140        150        160        170        180 
QAPSTMQSAF LEHSVSLYGS PLVPSTEPAL DFSLRYSPGM DAYHCVKCNK VFSTPHGLEV 

       190        200        210        220        230        240 
HVRRSHSGTR PFACDICGKT FGHAVSLEQH THVHSQERSF ECRMCGKAFK RSSTLSTHLL 

       250        260        270        280        290        300 
IHSDTRPYPC QFCGKRFHQK SDMKKHTYIH TGEKPHKCQV CGKAFSQSSN LITHSRKHTG 

       310        320        330 
FKPFSCELCT KGFQRKVDLR RHRESQHNLK 

« Hide

Isoform 2 (p32) [UniParc].

Checksum: 36498895611B0E20
Show »

FASTA28432,419

References

« Hide 'large scale' references
[1]"The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases."
Roedel B., Wagner T., Zoernig M., Niessing J., Moeroey T.
Genomics 54:580-582(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Tissue: Umbilical cord blood.
[2]"GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene."
Huang D.Y., Kuo Y.Y., Lai J.S., Suzuki Y., Sugano S., Chang Z.F.
Nucleic Acids Res. 32:3935-3946(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION BY GATA1.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain.
[7]"Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis."
Osawa M., Yamaguchi T., Nakamura Y., Kaneko S., Onodera M., Sawada K., Jegalian A., Wu H., Nakauchi H., Iwama A.
Blood 100:2769-2777(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[8]"Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism."
McGhee L., Bryan J., Elliott L., Grimes H.L., Kazanjian A., Davis J.N., Meyers S.
J. Cell. Biochem. 89:1005-1018(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RUNX1T1.
[9]"GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells."
Huang D.-Y., Kuo Y.-Y., Chang Z.-F.
Nucleic Acids Res. 33:5331-5342(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DNA-BINDING, INTERACTION WITH GATA1.
[10]"Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin."
Vassen L., Fiolka K., Moeroey T.
EMBO J. 25:2409-2419(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH EHMT2 AND SUV39H1.
[11]"Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development."
Schwartz R., Engel I., Fallahi-Sichani M., Petrie H.T., Murre C.
Proc. Natl. Acad. Sci. U.S.A. 103:9976-9981(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[12]"Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1."
Marteijn J.A., van der Meer L.T., van Emst L., van Reijmersdal S., Wissink W., de Witte T., Jansen J.H., Van der Reijden B.A.
Blood 110:3128-3135(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ARIH2.
[13]"Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas."
Wei X., Kee B.L.
Blood 109:4406-4414(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DNA-BINDING, MUTAGENESIS OF ASN-290.
[14]"Growth factor-independent 1B gene (GFI1B) is overexpressed in erythropoietic and megakaryocytic malignancies and increases their proliferation rate."
Elmaagacli A.H., Koldehoff M., Zakrzewski J.L., Steckel N.K., Ottinger H., Beelen D.W.
Br. J. Haematol. 136:212-219(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[15]"GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription."
Kuo Y.-Y., Chang Z.-F.
Mol. Cell. Biol. 27:4261-4272(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH GATA1.
[16]"A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1-CoREST complex through the dimethylation of its SNAG domain."
Laurent B., Randrianarison-Huetz V., Frisan E., Andrieu-Soler C., Soler E., Fontenay M., Dusanter-Fourt I., Dumenil D.
J. Cell Sci. 125:993-1002(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION (ISOFORM 2), METHYLATION AT LYS-8.
[17]"GFI1B mutation causes a bleeding disorder with abnormal platelet function."
Stevenson W.S., Morel-Kopp M.C., Chen Q., Liang H.P., Bromhead C.J., Wright S., Turakulov R., Ng A.P., Roberts A.W., Bahlo M., Ward C.M.
J. Thromb. Haemost. 11:2039-2047(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN BDPLT17.
[18]"A dominant-negative GFI1B mutation in the gray platelet syndrome."
Monteferrario D., Bolar N.A., Marneth A.E., Hebeda K.M., Bergevoet S.M., Veenstra H., Laros-van Gorkom B.A., MacKenzie M.A., Khandanpour C., Botezatu L., Fransen E., Van Camp G., Duijnhouwer A.L., Salemink S., Willemsen B., Huls G., Preijers F., Van Heerde W. expand/collapse author list , Jansen J.H., Kempers M.J., Loeys B.L., Van Laer L., Van der Reijden B.A.
N. Engl. J. Med. 370:245-253(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN BDPLT17.
[19]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-231.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF081946 mRNA. Translation: AAD08672.1.
AY428733 mRNA. Translation: AAR06639.1.
CR536546 mRNA. Translation: CAG38783.1.
AL593851 Genomic DNA. Translation: CAH73618.1.
AL593851 Genomic DNA. Translation: CAH73619.1.
CH471090 Genomic DNA. Translation: EAW88025.1.
BC043371 mRNA. Translation: AAH43371.1.
BC035626 mRNA. No translation available.
CCDSCCDS48049.1. [Q5VTD9-2]
CCDS6957.1. [Q5VTD9-1]
RefSeqNP_001128503.1. NM_001135031.1. [Q5VTD9-2]
NP_004179.3. NM_004188.4. [Q5VTD9-1]
UniGeneHs.553160.

3D structure databases

ProteinModelPortalQ5VTD9.
SMRQ5VTD9. Positions 163-327.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113924. 76 interactions.
IntActQ5VTD9. 71 interactions.
MINTMINT-2798741.
STRING9606.ENSP00000344782.

PTM databases

PhosphoSiteQ5VTD9.

Polymorphism databases

DMDM74756792.

Proteomic databases

PaxDbQ5VTD9.
PRIDEQ5VTD9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339463; ENSP00000344782; ENSG00000165702. [Q5VTD9-1]
ENST00000372122; ENSP00000361195; ENSG00000165702. [Q5VTD9-1]
ENST00000372123; ENSP00000361196; ENSG00000165702. [Q5VTD9-2]
ENST00000372124; ENSP00000361197; ENSG00000165702. [Q5VTD9-2]
ENST00000450530; ENSP00000409546; ENSG00000165702. [Q5VTD9-1]
ENST00000534944; ENSP00000446134; ENSG00000165702. [Q5VTD9-2]
GeneID8328.
KEGGhsa:8328.
UCSCuc004ccg.3. human. [Q5VTD9-1]
uc010mzy.3. human. [Q5VTD9-2]

Organism-specific databases

CTD8328.
GeneCardsGC09P135821.
HGNCHGNC:4238. GFI1B.
HPAHPA007012.
MIM187900. phenotype.
604383. gene.
neXtProtNX_Q5VTD9.
Orphanet721. Gray platelet syndrome.
PharmGKBPA28649.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000067832.
HOVERGENHBG106655.
InParanoidQ5VTD9.
KOK09223.
OMAYGHSYRQ.
OrthoDBEOG72RN05.
PhylomeDBQ5VTD9.
TreeFamTF350784.

Enzyme and pathway databases

SignaLinkQ5VTD9.

Gene expression databases

BgeeQ5VTD9.
CleanExHS_GFI1B.
GenevestigatorQ5VTD9.

Family and domain databases

Gene3D3.30.160.60. 6 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGFI1B.
GenomeRNAi8328.
NextBio31186.
PROQ5VTD9.
SOURCESearch...

Entry information

Entry nameGFI1B_HUMAN
AccessionPrimary (citable) accession number: Q5VTD9
Secondary accession number(s): O95270 expand/collapse secondary AC list , Q5VTD8, Q6FHZ2, Q6T888
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM