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Protein

Rho GTPase-activating protein SYDE2

Gene

SYDE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein SYDE2
Alternative name(s):
Synapse defective protein 1 homolog 2
Short name:
Protein syd-1 homolog 2
Gene namesi
Name:SYDE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25841. SYDE2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiSYDE2.
DMDMi325511351.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11941194Rho GTPase-activating protein SYDE2PRO_0000312160Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei315 – 3151PhosphoserineCombined sources
Modified residuei317 – 3171PhosphoserineCombined sources
Modified residuei622 – 6221PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5VT97.
PaxDbiQ5VT97.
PeptideAtlasiQ5VT97.
PRIDEiQ5VT97.

PTM databases

iPTMnetiQ5VT97.
PhosphoSiteiQ5VT97.

Expressioni

Gene expression databases

BgeeiENSG00000097096.
CleanExiHS_SYDE2.

Organism-specific databases

HPAiHPA027138.
HPA058378.

Interactioni

Protein-protein interaction databases

BioGridi123912. 1 interaction.
STRINGi9606.ENSP00000340594.

Structurei

3D structure databases

ProteinModelPortaliQ5VT97.
SMRiQ5VT97. Positions 832-987.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini681 – 781101C2Add
BLAST
Domaini816 – 1031216Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.Curated
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1452. Eukaryota.
ENOG410XYAD. LUCA.
GeneTreeiENSGT00840000129703.
HOGENOMiHOG000154470.
HOVERGENiHBG094587.
InParanoidiQ5VT97.
OMAiEENKKCQ.
OrthoDBiEOG091G01HK.
PhylomeDBiQ5VT97.
TreeFamiTF323458.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VT97-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHDLPPDSGA RRGGRGLADH SFPAGARAPG QPPSRGAAYR RACPRDGERG
60 70 80 90 100
GGGRPRQQVS PPRSPQREPR GGQLRTPRMR PSCSRSLESL RVGAKPPPFQ
110 120 130 140 150
RWPSDSWIRC GAHRDWDEPP PRGGRMDGWS GDRARAAAPT GLQPPGCKDH
160 170 180 190 200
GCSSGSPFRD PAGSSVIRSG KGDRQEGPSF LRPPAVTVKK LQKWMYKGRL
210 220 230 240 250
LSLGMKGRAR GTAPKVTGTQ AASPNVGALK VRENRVLSVP PDQRITLTDL
260 270 280 290 300
FENAYGSSMK GRELEELKDN IEFRGHKPLN SITVSKKRNW LYQSTLRPLN
310 320 330 340 350
LEEENKKCQD RSHLSISPVS LPKHQLSQSF LKSSKEYCTY VVCNATNSSL
360 370 380 390 400
SKNCALDFNE ENDADDEGEI WYNPIPEDDD LGISSALSFG EADSAVLKLP
410 420 430 440 450
AVNLSMLSGS DLMKAERHTE DSLCSSEHAG DIQTTRSNGM NPIHPAHSTE
460 470 480 490 500
FVQQYKQKLG HKTQEGIMVE DSPMLKSPFA GSGILAATNS TELGIMEPSS
510 520 530 540 550
PNPSPVKKGS SINWSLPDKI KSPRTVRKLS MKMKKLPEFS RKLSVKGTLN
560 570 580 590 600
YINSPDNTPS LSKYNCREVH HTDILPSGNT TTAAKRNVIS RYHLDTSVSS
610 620 630 640 650
QQSYQKKNSM SSKYSCKGGY LSDGDSPELT TKASKHGSEN KFGKGKEIIS
660 670 680 690 700
NSCSKNEIDI DAFRHYSFSD QPKCSQYISG LMSVHFYGAE DLKPPRIDSK
710 720 730 740 750
DVFCAIQVDS VNKARTALLT CRTTFLDMDH TFNIEIENAQ HLKLVVFSWE
760 770 780 790 800
PTPRKNRVCC HGTVVLPTLF RVTKTHQLAV KLEPRGLIYV KVTLMEQWEN
810 820 830 840 850
SLHGLDINQE PIIFGVDIQK VVEKENIGLM VPLLIQKCIM EIEKRGCQVV
860 870 880 890 900
GLYRLCGSAA VKKELREAFE RDSKAVGLCE NQYPDINVIT GVLKDYLREL
910 920 930 940 950
PSPLITKQLY EAVLDAMAKS PLKMSSNGCE NDPGDSKYTV DLLDCLPEIE
960 970 980 990 1000
KATLKMLLDH LKLVASYHEV NKMTCQNLAV CFGPVLLSQR QEPSTHNNRV
1010 1020 1030 1040 1050
FTDSEELASA LDFKKHIEVL HYLLQLWPVQ RLTVKKSTDN LFPEQKSSLN
1060 1070 1080 1090 1100
YLRQKKERPH MLNLSGTDSS GVLRPRQNRL DSPLSNRYAG DWSSCGENYF
1110 1120 1130 1140 1150
LNTKENLNDV DYDDVPSEDR KIGENYSKMD GPEVMIEQPI PMSKECTFQT
1160 1170 1180 1190
YLTMQTVEST VDRKNNLKDL QESIDTLIGN LERELNKNKL NMSF
Length:1,194
Mass (Da):133,230
Last modified:March 8, 2011 - v2
Checksum:i592A8A0D29BC02BE
GO
Isoform 2 (identifier: Q5VT97-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     850-863: VGLYRLCGSAAVKK → LSYYGSLLLPLLID
     864-1194: Missing.

Show »
Length:863
Mass (Da):95,471
Checksum:iB7F274BEE137EEFD
GO

Sequence cautioni

The sequence BAB14711 differs from that shown.Probable cloning artifact.Curated
The sequence BAB14711 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAH72669 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAH72670 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701R → A in BF196265 (Ref. 2) Curated
Sequence conflicti118 – 1181E → K in BF196265 (Ref. 2) Curated
Sequence conflicti175 – 1751Q → P in BAB14711 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti484 – 4841I → M.
Corresponds to variant rs12090608 [ dbSNP | Ensembl ].
VAR_037419
Natural varianti569 – 5691V → I.2 Publications
Corresponds to variant rs817443 [ dbSNP | Ensembl ].
VAR_037420
Natural varianti1157 – 11571V → I.
Corresponds to variant rs709786 [ dbSNP | Ensembl ].
VAR_037421

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei850 – 86314VGLYR…AAVKK → LSYYGSLLLPLLID in isoform 2. 1 PublicationVSP_029718Add
BLAST
Alternative sequencei864 – 1194331Missing in isoform 2. 1 PublicationVSP_029719Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL603750 Genomic DNA. Translation: CAH72669.1. Different initiation.
AL603750 Genomic DNA. Translation: CAH72670.1. Different initiation.
BF196265 mRNA. No translation available.
AK023877 mRNA. Translation: BAB14711.1. Sequence problems.
AL834286 mRNA. Translation: CAD38960.1.
CCDSiCCDS44169.1. [Q5VT97-1]
RefSeqiNP_115560.1. NM_032184.1. [Q5VT97-1]
UniGeneiHs.533853.
Hs.670497.

Genome annotation databases

EnsembliENST00000341460; ENSP00000340594; ENSG00000097096. [Q5VT97-1]
GeneIDi84144.
KEGGihsa:84144.
UCSCiuc009wcm.4. human. [Q5VT97-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL603750 Genomic DNA. Translation: CAH72669.1. Different initiation.
AL603750 Genomic DNA. Translation: CAH72670.1. Different initiation.
BF196265 mRNA. No translation available.
AK023877 mRNA. Translation: BAB14711.1. Sequence problems.
AL834286 mRNA. Translation: CAD38960.1.
CCDSiCCDS44169.1. [Q5VT97-1]
RefSeqiNP_115560.1. NM_032184.1. [Q5VT97-1]
UniGeneiHs.533853.
Hs.670497.

3D structure databases

ProteinModelPortaliQ5VT97.
SMRiQ5VT97. Positions 832-987.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123912. 1 interaction.
STRINGi9606.ENSP00000340594.

PTM databases

iPTMnetiQ5VT97.
PhosphoSiteiQ5VT97.

Polymorphism and mutation databases

BioMutaiSYDE2.
DMDMi325511351.

Proteomic databases

MaxQBiQ5VT97.
PaxDbiQ5VT97.
PeptideAtlasiQ5VT97.
PRIDEiQ5VT97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341460; ENSP00000340594; ENSG00000097096. [Q5VT97-1]
GeneIDi84144.
KEGGihsa:84144.
UCSCiuc009wcm.4. human. [Q5VT97-1]

Organism-specific databases

CTDi84144.
GeneCardsiSYDE2.
H-InvDBHIX0000742.
HGNCiHGNC:25841. SYDE2.
HPAiHPA027138.
HPA058378.
neXtProtiNX_Q5VT97.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1452. Eukaryota.
ENOG410XYAD. LUCA.
GeneTreeiENSGT00840000129703.
HOGENOMiHOG000154470.
HOVERGENiHBG094587.
InParanoidiQ5VT97.
OMAiEENKKCQ.
OrthoDBiEOG091G01HK.
PhylomeDBiQ5VT97.
TreeFamiTF323458.

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiSYDE2. human.
GenomeRNAii84144.
PROiQ5VT97.

Gene expression databases

BgeeiENSG00000097096.
CleanExiHS_SYDE2.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYDE2_HUMAN
AccessioniPrimary (citable) accession number: Q5VT97
Secondary accession number(s): Q5VT96, Q8NDB8, Q9H8A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 8, 2011
Last modified: September 7, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-79 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.