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Q5VT66

- MARC1_HUMAN

UniProt

Q5VT66 - MARC1_HUMAN

Protein

Mitochondrial amidoxime-reducing component 1

Gene

MARC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.1 Publication

    Cofactori

    Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit.2 Publications

    Kineticsi

    1. KM=180 µM for benzamidoxime2 Publications
    2. KM=86 µM for NOHA2 Publications
    3. KM=272 µM for NHAM2 Publications

    Vmax=34 nmol/min/mg enzyme toward benzamidoxime2 Publications

    Vmax=105 nmol/min/mg enzyme toward benzamidoxime (PubMed:24423752, at pH 6.0 and 37 degrees Celsius)2 Publications

    Vmax=55 nmol/min/mg enzyme toward NOHA2 Publications

    Vmax=43 nmol/min/mg enzyme toward NHAM2 Publications

    GO - Molecular functioni

    1. molybdenum ion binding Source: UniProtKB
    2. molybdopterin cofactor binding Source: UniProtKB
    3. nitrate reductase activity Source: UniProtKB
    4. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. detoxification of nitrogen compound Source: UniProtKB
    2. nitrate metabolic process Source: UniProtKB
    3. oxidation-reduction process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Molybdenum

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial amidoxime-reducing component 1 (EC:1.-.-.-)
    Short name:
    mARC1
    Alternative name(s):
    Molybdenum cofactor sulfurase C-terminal domain-containing protein 1
    Short name:
    MOSC domain-containing protein 1
    Short name:
    Moco sulfurase C-terminal domain-containing protein 1
    Gene namesi
    Name:MARC1
    Synonyms:MOSC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:26189. MARC1.

    Subcellular locationi

    Mitochondrion outer membrane 1 Publication; Single-pass type II membrane protein 1 Publication
    Note: Mitochondrial import is mediated by AA 1-40 and requires ATP.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: Ensembl
    3. mitochondrial outer membrane Source: UniProtKB-SubCell
    4. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671344.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337Mitochondrial amidoxime-reducing component 1PRO_0000273335Add
    BLAST

    Proteomic databases

    MaxQBiQ5VT66.
    PaxDbiQ5VT66.
    PRIDEiQ5VT66.

    PTM databases

    PhosphoSiteiQ5VT66.

    Expressioni

    Gene expression databases

    BgeeiQ5VT66.
    CleanExiHS_MOSC1.
    GenevestigatoriQ5VT66.

    Organism-specific databases

    HPAiHPA028702.

    Interactioni

    Subunit structurei

    Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase and MARC1.

    Protein-protein interaction databases

    BioGridi122271. 13 interactions.
    STRINGi9606.ENSP00000355877.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VT66.
    SMRiQ5VT66. Positions 58-188.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020Mitochondrial matrix1 PublicationAdd
    BLAST
    Topological domaini41 – 337297Cytoplasmic1 PublicationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4020Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini187 – 335149MOSCPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MOSC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3217.
    HOVERGENiHBG081982.
    InParanoidiQ5VT66.
    OMAiHKCRVHG.
    OrthoDBiEOG7WT41P.
    PhylomeDBiQ5VT66.
    TreeFamiTF316807.

    Family and domain databases

    InterProiIPR005302. MoCF_Sase_C.
    IPR005303. MOSC_N.
    IPR011037. Pyrv_Knase-like_insert_dom.
    [Graphical view]
    PfamiPF03473. MOSC. 1 hit.
    PF03476. MOSC_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50800. SSF50800. 2 hits.
    PROSITEiPS51340. MOSC. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5VT66-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGAAGSSALA RFVLLAQSRP GWLGVAALGL TAVALGAVAW RRAWPTRRRR    50
    LLQQVGTVAQ LWIYPVKSCK GVPVSEAECT AMGLRSGNLR DRFWLVINQE 100
    GNMVTARQEP RLVLISLTCD GDTLTLSAAY TKDLLLPIKT PTTNAVHKCR 150
    VHGLEIEGRD CGEATAQWIT SFLKSQPYRL VHFEPHMRPR RPHQIADLFR 200
    PKDQIAYSDT SPFLILSEAS LADLNSRLEK KVKATNFRPN IVISGCDVYA 250
    EDSWDELLIG DVELKRVMAC SRCILTTVDP DTGVMSRKEP LETLKSYRQC 300
    DPSERKLYGK SPLFGQYFVL ENPGTIKVGD PVYLLGQ 337
    Length:337
    Mass (Da):37,499
    Last modified:December 7, 2004 - v1
    Checksum:iF983AB08F3D646C4
    GO
    Isoform 2 (identifier: Q5VT66-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         251-251: E → EVTLCPFGSFLGFDFFFK

    Note: No experimental confirmation available.

    Show »
    Length:354
    Mass (Da):39,454
    Checksum:iCC368AD4B543AD51
    GO
    Isoform 3 (identifier: Q5VT66-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-102: Missing.
         251-251: E → EVTLCPFGSFLGFDFFFK

    Note: No experimental confirmation available.

    Show »
    Length:252
    Mass (Da):28,439
    Checksum:i0FEF88317AF6C9D2
    GO

    Sequence cautioni

    The sequence BAB15333.1 differs from that shown. Reason: Frameshift at position 139.
    The sequence CAH72118.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151L → H.1 Publication
    VAR_062273
    Natural varianti96 – 961V → L Common polymorphism in Caucasian population; no effect on binding of the molybdenum cofactor; no significant effect on catalytic efficiency toward benzamidoxime; no significant effect on affinity for benzamidoxime. 1 Publication
    Corresponds to variant rs12023067 [ dbSNP | Ensembl ].
    VAR_056941
    Natural varianti165 – 1651T → A No effect on binding of the molybdenum cofactor; no significant effect on catalytic efficiency toward benzamidoxime; no significant effect on affinity for benzamidoxime. 5 Publications
    Corresponds to variant rs2642438 [ dbSNP | Ensembl ].
    VAR_030129
    Natural varianti187 – 1871M → K No effect on binding of the molybdenum cofactor; no significant effect on catalytic efficiency toward benzamidoxime; no significant effect on affinity for benzamidoxime. 2 Publications
    Corresponds to variant rs17850677 [ dbSNP | Ensembl ].
    VAR_030130
    Natural varianti246 – 2461C → S No effect on binding of the molybdenum cofactor; no significant effect on catalytic efficiency toward benzamidoxime; no significant effect on affinity for benzamidoxime. 2 Publications
    Corresponds to variant rs3738178 [ dbSNP | Ensembl ].
    VAR_030131
    Natural varianti247 – 2471D → H No effect on binding of the molybdenum cofactor; no significant effect on catalytic efficiency toward benzamidoxime; no significant effect on affinity for benzamidoxime. 2 Publications
    Corresponds to variant rs72470601 [ dbSNP | Ensembl ].
    VAR_062274
    Natural varianti268 – 2681M → I No effect on binding of the molybdenum cofactor; no significant effect on catalytic efficiency toward benzamidoxime; no significant effect on affinity for benzamidoxime.
    Corresponds to variant rs2642419 [ dbSNP | Ensembl ].
    VAR_030132

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 102102Missing in isoform 3. 1 PublicationVSP_022511Add
    BLAST
    Alternative sequencei251 – 2511E → EVTLCPFGSFLGFDFFFK in isoform 2 and isoform 3. 1 PublicationVSP_022512

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK026043 mRNA. Translation: BAB15333.1. Frameshift.
    AK094105 mRNA. Translation: BAC04286.1.
    AK290812 mRNA. Translation: BAF83501.1.
    EU563849 Genomic DNA. Translation: ACB21046.1.
    AL606726, AL445423 Genomic DNA. Translation: CAH71881.1.
    AL445423 Genomic DNA. Translation: CAH72116.1.
    AL445423 Genomic DNA. Translation: CAH72118.1. Sequence problems.
    AL445423, AL606726 Genomic DNA. Translation: CAH72119.1.
    CH471100 Genomic DNA. Translation: EAW93291.1.
    BC010619 mRNA. Translation: AAH10619.1.
    CCDSiCCDS1526.1. [Q5VT66-1]
    RefSeqiNP_073583.3. NM_022746.3. [Q5VT66-1]
    UniGeneiHs.497816.

    Genome annotation databases

    EnsembliENST00000366910; ENSP00000355877; ENSG00000186205. [Q5VT66-1]
    GeneIDi64757.
    KEGGihsa:64757.
    UCSCiuc001hms.3. human. [Q5VT66-1]
    uc001hmt.3. human. [Q5VT66-2]

    Polymorphism databases

    DMDMi74746896.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK026043 mRNA. Translation: BAB15333.1 . Frameshift.
    AK094105 mRNA. Translation: BAC04286.1 .
    AK290812 mRNA. Translation: BAF83501.1 .
    EU563849 Genomic DNA. Translation: ACB21046.1 .
    AL606726 , AL445423 Genomic DNA. Translation: CAH71881.1 .
    AL445423 Genomic DNA. Translation: CAH72116.1 .
    AL445423 Genomic DNA. Translation: CAH72118.1 . Sequence problems.
    AL445423 , AL606726 Genomic DNA. Translation: CAH72119.1 .
    CH471100 Genomic DNA. Translation: EAW93291.1 .
    BC010619 mRNA. Translation: AAH10619.1 .
    CCDSi CCDS1526.1. [Q5VT66-1 ]
    RefSeqi NP_073583.3. NM_022746.3. [Q5VT66-1 ]
    UniGenei Hs.497816.

    3D structure databases

    ProteinModelPortali Q5VT66.
    SMRi Q5VT66. Positions 58-188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122271. 13 interactions.
    STRINGi 9606.ENSP00000355877.

    PTM databases

    PhosphoSitei Q5VT66.

    Polymorphism databases

    DMDMi 74746896.

    Proteomic databases

    MaxQBi Q5VT66.
    PaxDbi Q5VT66.
    PRIDEi Q5VT66.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366910 ; ENSP00000355877 ; ENSG00000186205 . [Q5VT66-1 ]
    GeneIDi 64757.
    KEGGi hsa:64757.
    UCSCi uc001hms.3. human. [Q5VT66-1 ]
    uc001hmt.3. human. [Q5VT66-2 ]

    Organism-specific databases

    CTDi 64757.
    GeneCardsi GC01P220961.
    H-InvDB HIX0001608.
    HGNCi HGNC:26189. MARC1.
    HPAi HPA028702.
    MIMi 614126. gene.
    neXtProti NX_Q5VT66.
    PharmGKBi PA142671344.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3217.
    HOVERGENi HBG081982.
    InParanoidi Q5VT66.
    OMAi HKCRVHG.
    OrthoDBi EOG7WT41P.
    PhylomeDBi Q5VT66.
    TreeFami TF316807.

    Miscellaneous databases

    GenomeRNAii 64757.
    NextBioi 66731.
    PROi Q5VT66.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5VT66.
    CleanExi HS_MOSC1.
    Genevestigatori Q5VT66.

    Family and domain databases

    InterProi IPR005302. MoCF_Sase_C.
    IPR005303. MOSC_N.
    IPR011037. Pyrv_Knase-like_insert_dom.
    [Graphical view ]
    Pfami PF03473. MOSC. 1 hit.
    PF03476. MOSC_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50800. SSF50800. 2 hits.
    PROSITEi PS51340. MOSC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ALA-165.
      Tissue: Adrenal gland and Kidney.
    2. NIEHS SNPs program
      Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-15; LEU-96; ALA-165; SER-246 AND HIS-247.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-165.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-165 AND LYS-187.
      Tissue: Eye.
    6. "The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs."
      Gruenewald S., Wahl B., Bittner F., Hungeling H., Kanzow S., Kotthaus J., Schwering U., Mendel R.R., Clement B.
      J. Med. Chem. 51:8173-8177(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, COFACTOR.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Reduction of N(omega)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC)."
      Kotthaus J., Wahl B., Havemeyer A., Kotthaus J., Schade D., Garbe-Schonberg D., Mendel R., Bittner F., Clement B.
      Biochem. J. 433:383-391(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: BIOPHYSICOCHEMICAL PROPERTIES.
    9. "The mitochondrial amidoxime-reducing component (mARC1) is a novel signal-anchored protein of the outer mitochondrial membrane."
      Klein J.M., Busch J.D., Potting C., Baker M.J., Langer T., Schwarz G.
      J. Biol. Chem. 287:42795-42803(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TOPOLOGY.
    10. "Functional characterization of protein variants encoded by non-synonymous SNPs in MARC1 and MARC2 in healthy Caucasians."
      Ott G., Reichmann D., Boerger C., Cascorbi I., Bittner F., Mendel R.R., Kunze T., Clement B., Havemeyer A.
      Drug Metab. Dispos. 42:718-725(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ALA-165; LYS-187; SER-246 AND HIS-247, CHARACTERIZATION OF VARIANTS LEU-96; ALA-165; LYS-187; SER-246; HIS-247 AND ILE-268, BIOPHYSICOCHEMICAL PROPERTIES, COFACTOR.

    Entry informationi

    Entry nameiMARC1_HUMAN
    AccessioniPrimary (citable) accession number: Q5VT66
    Secondary accession number(s): A8K447
    , B2D078, Q5VVS9, Q5VVT0, Q5VVT1, Q8N9P5, Q96FN8, Q9H6C7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3