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Protein

Mitochondrial amidoxime-reducing component 1

Gene

MARC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.1 Publication

Cofactori

Mo-molybdopterin2 PublicationsNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.2 Publications

Kineticsi

  1. KM=180 µM for benzamidoxime2 Publications
  2. KM=86 µM for NOHA2 Publications
  3. KM=272 µM for NHAM2 Publications
  1. Vmax=34 nmol/min/mg enzyme toward benzamidoxime2 Publications
  2. Vmax=105 nmol/min/mg enzyme toward benzamidoxime (PubMed:24423752, at pH 6.0 and 37 degrees Celsius)2 Publications
  3. Vmax=55 nmol/min/mg enzyme toward NOHA2 Publications
  4. Vmax=43 nmol/min/mg enzyme toward NHAM2 Publications

GO - Molecular functioni

  • molybdenum ion binding Source: UniProtKB
  • molybdopterin cofactor binding Source: UniProtKB
  • nitrate reductase activity Source: UniProtKB
  • pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  • detoxification of nitrogen compound Source: UniProtKB
  • nitrate metabolic process Source: UniProtKB
  • oxidation-reduction process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Molybdenum

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial amidoxime-reducing component 1 (EC:1.-.-.-)
Short name:
mARC1
Alternative name(s):
Molybdenum cofactor sulfurase C-terminal domain-containing protein 1
Short name:
MOSC domain-containing protein 1
Short name:
Moco sulfurase C-terminal domain-containing protein 1
Gene namesi
Name:MARC1
Synonyms:MOSC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26189. MARC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020Mitochondrial matrix1 PublicationAdd
BLAST
Transmembranei21 – 4020Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini41 – 337297Cytoplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: Ensembl
  • mitochondrial outer membrane Source: UniProtKB-SubCell
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671344.

Polymorphism and mutation databases

BioMutaiMARC1.
DMDMi74746896.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Mitochondrial amidoxime-reducing component 1PRO_0000273335Add
BLAST

Proteomic databases

MaxQBiQ5VT66.
PaxDbiQ5VT66.
PRIDEiQ5VT66.

PTM databases

PhosphoSiteiQ5VT66.

Expressioni

Gene expression databases

BgeeiQ5VT66.
CleanExiHS_MOSC1.
ExpressionAtlasiQ5VT66. baseline and differential.
GenevisibleiQ5VT66. HS.

Organism-specific databases

HPAiHPA028702.

Interactioni

Subunit structurei

Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase and MARC1.

Protein-protein interaction databases

BioGridi122271. 16 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ5VT66.
SMRiQ5VT66. Positions 58-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini187 – 335149MOSCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MOSC domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3217.
GeneTreeiENSGT00530000063150.
HOVERGENiHBG081982.
InParanoidiQ5VT66.
OMAiQCDPSER.
OrthoDBiEOG7WT41P.
PhylomeDBiQ5VT66.
TreeFamiTF316807.

Family and domain databases

InterProiIPR005302. MoCF_Sase_C.
IPR005303. MOSC_N.
IPR011037. Pyrv_Knase-like_insert_dom.
[Graphical view]
PfamiPF03473. MOSC. 1 hit.
PF03476. MOSC_N. 1 hit.
[Graphical view]
SUPFAMiSSF50800. SSF50800. 2 hits.
PROSITEiPS51340. MOSC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VT66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAAGSSALA RFVLLAQSRP GWLGVAALGL TAVALGAVAW RRAWPTRRRR
60 70 80 90 100
LLQQVGTVAQ LWIYPVKSCK GVPVSEAECT AMGLRSGNLR DRFWLVINQE
110 120 130 140 150
GNMVTARQEP RLVLISLTCD GDTLTLSAAY TKDLLLPIKT PTTNAVHKCR
160 170 180 190 200
VHGLEIEGRD CGEATAQWIT SFLKSQPYRL VHFEPHMRPR RPHQIADLFR
210 220 230 240 250
PKDQIAYSDT SPFLILSEAS LADLNSRLEK KVKATNFRPN IVISGCDVYA
260 270 280 290 300
EDSWDELLIG DVELKRVMAC SRCILTTVDP DTGVMSRKEP LETLKSYRQC
310 320 330
DPSERKLYGK SPLFGQYFVL ENPGTIKVGD PVYLLGQ
Length:337
Mass (Da):37,499
Last modified:December 7, 2004 - v1
Checksum:iF983AB08F3D646C4
GO
Isoform 2 (identifier: Q5VT66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     251-251: E → EVTLCPFGSFLGFDFFFK

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):39,454
Checksum:iCC368AD4B543AD51
GO
Isoform 3 (identifier: Q5VT66-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.
     251-251: E → EVTLCPFGSFLGFDFFFK

Note: No experimental confirmation available.
Show »
Length:252
Mass (Da):28,439
Checksum:i0FEF88317AF6C9D2
GO

Sequence cautioni

The sequence BAB15333.1 differs from that shown. Reason: Frameshift at position 139. Curated
The sequence CAH72118.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151L → H.1 Publication
VAR_062273
Natural varianti96 – 961V → L Common polymorphism in Caucasian population; no effect on binding of the molybdenum cofactor; no significant effect on catalytic efficiency toward benzamidoxime; no significant effect on affinity for benzamidoxime. 2 Publications
Corresponds to variant rs12023067 [ dbSNP | Ensembl ].
VAR_056941
Natural varianti165 – 1651T → A No effect on binding of the molybdenum cofactor; no significant effect on catalytic efficiency toward benzamidoxime; no significant effect on affinity for benzamidoxime. 5 Publications
Corresponds to variant rs2642438 [ dbSNP | Ensembl ].
VAR_030129
Natural varianti187 – 1871M → K No effect on binding of the molybdenum cofactor; no significant effect on catalytic efficiency toward benzamidoxime; no significant effect on affinity for benzamidoxime. 2 Publications
Corresponds to variant rs17850677 [ dbSNP | Ensembl ].
VAR_030130
Natural varianti246 – 2461C → S No effect on binding of the molybdenum cofactor; no significant effect on catalytic efficiency toward benzamidoxime; no significant effect on affinity for benzamidoxime. 2 Publications
Corresponds to variant rs3738178 [ dbSNP | Ensembl ].
VAR_030131
Natural varianti247 – 2471D → H No effect on binding of the molybdenum cofactor; no significant effect on catalytic efficiency toward benzamidoxime; no significant effect on affinity for benzamidoxime. 2 Publications
Corresponds to variant rs72470601 [ dbSNP | Ensembl ].
VAR_062274
Natural varianti268 – 2681M → I No effect on binding of the molybdenum cofactor; no significant effect on catalytic efficiency toward benzamidoxime; no significant effect on affinity for benzamidoxime. 1 Publication
Corresponds to variant rs2642419 [ dbSNP | Ensembl ].
VAR_030132

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 102102Missing in isoform 3. 1 PublicationVSP_022511Add
BLAST
Alternative sequencei251 – 2511E → EVTLCPFGSFLGFDFFFK in isoform 2 and isoform 3. 1 PublicationVSP_022512

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026043 mRNA. Translation: BAB15333.1. Frameshift.
AK094105 mRNA. Translation: BAC04286.1.
AK290812 mRNA. Translation: BAF83501.1.
EU563849 Genomic DNA. Translation: ACB21046.1.
AL606726, AL445423 Genomic DNA. Translation: CAH71881.1.
AL445423 Genomic DNA. Translation: CAH72116.1.
AL445423 Genomic DNA. Translation: CAH72118.1. Sequence problems.
AL445423, AL606726 Genomic DNA. Translation: CAH72119.1.
CH471100 Genomic DNA. Translation: EAW93291.1.
BC010619 mRNA. Translation: AAH10619.1.
CCDSiCCDS1526.1. [Q5VT66-1]
RefSeqiNP_073583.3. NM_022746.3. [Q5VT66-1]
UniGeneiHs.497816.

Genome annotation databases

EnsembliENST00000366910; ENSP00000355877; ENSG00000186205. [Q5VT66-1]
GeneIDi64757.
KEGGihsa:64757.
UCSCiuc001hms.3. human. [Q5VT66-1]
uc001hmt.3. human. [Q5VT66-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026043 mRNA. Translation: BAB15333.1. Frameshift.
AK094105 mRNA. Translation: BAC04286.1.
AK290812 mRNA. Translation: BAF83501.1.
EU563849 Genomic DNA. Translation: ACB21046.1.
AL606726, AL445423 Genomic DNA. Translation: CAH71881.1.
AL445423 Genomic DNA. Translation: CAH72116.1.
AL445423 Genomic DNA. Translation: CAH72118.1. Sequence problems.
AL445423, AL606726 Genomic DNA. Translation: CAH72119.1.
CH471100 Genomic DNA. Translation: EAW93291.1.
BC010619 mRNA. Translation: AAH10619.1.
CCDSiCCDS1526.1. [Q5VT66-1]
RefSeqiNP_073583.3. NM_022746.3. [Q5VT66-1]
UniGeneiHs.497816.

3D structure databases

ProteinModelPortaliQ5VT66.
SMRiQ5VT66. Positions 58-188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122271. 16 interactions.

PTM databases

PhosphoSiteiQ5VT66.

Polymorphism and mutation databases

BioMutaiMARC1.
DMDMi74746896.

Proteomic databases

MaxQBiQ5VT66.
PaxDbiQ5VT66.
PRIDEiQ5VT66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366910; ENSP00000355877; ENSG00000186205. [Q5VT66-1]
GeneIDi64757.
KEGGihsa:64757.
UCSCiuc001hms.3. human. [Q5VT66-1]
uc001hmt.3. human. [Q5VT66-2]

Organism-specific databases

CTDi64757.
GeneCardsiGC01P220961.
H-InvDBHIX0001608.
HGNCiHGNC:26189. MARC1.
HPAiHPA028702.
MIMi614126. gene.
neXtProtiNX_Q5VT66.
PharmGKBiPA142671344.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG3217.
GeneTreeiENSGT00530000063150.
HOVERGENiHBG081982.
InParanoidiQ5VT66.
OMAiQCDPSER.
OrthoDBiEOG7WT41P.
PhylomeDBiQ5VT66.
TreeFamiTF316807.

Miscellaneous databases

GenomeRNAii64757.
NextBioi66731.
PROiQ5VT66.
SOURCEiSearch...

Gene expression databases

BgeeiQ5VT66.
CleanExiHS_MOSC1.
ExpressionAtlasiQ5VT66. baseline and differential.
GenevisibleiQ5VT66. HS.

Family and domain databases

InterProiIPR005302. MoCF_Sase_C.
IPR005303. MOSC_N.
IPR011037. Pyrv_Knase-like_insert_dom.
[Graphical view]
PfamiPF03473. MOSC. 1 hit.
PF03476. MOSC_N. 1 hit.
[Graphical view]
SUPFAMiSSF50800. SSF50800. 2 hits.
PROSITEiPS51340. MOSC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ALA-165.
    Tissue: Adrenal gland and Kidney.
  2. NIEHS SNPs program
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-15; LEU-96; ALA-165; SER-246 AND HIS-247.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-165.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-165 AND LYS-187.
    Tissue: Eye.
  6. "The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs."
    Gruenewald S., Wahl B., Bittner F., Hungeling H., Kanzow S., Kotthaus J., Schwering U., Mendel R.R., Clement B.
    J. Med. Chem. 51:8173-8177(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, COFACTOR.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Reduction of N(omega)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC)."
    Kotthaus J., Wahl B., Havemeyer A., Kotthaus J., Schade D., Garbe-Schonberg D., Mendel R., Bittner F., Clement B.
    Biochem. J. 433:383-391(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: BIOPHYSICOCHEMICAL PROPERTIES.
  9. "The mitochondrial amidoxime-reducing component (mARC1) is a novel signal-anchored protein of the outer mitochondrial membrane."
    Klein J.M., Busch J.D., Potting C., Baker M.J., Langer T., Schwarz G.
    J. Biol. Chem. 287:42795-42803(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TOPOLOGY.
  10. "Functional characterization of protein variants encoded by non-synonymous SNPs in MARC1 and MARC2 in healthy Caucasians."
    Ott G., Reichmann D., Boerger C., Cascorbi I., Bittner F., Mendel R.R., Kunze T., Clement B., Havemeyer A.
    Drug Metab. Dispos. 42:718-725(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ALA-165; LYS-187; SER-246 AND HIS-247, CHARACTERIZATION OF VARIANTS LEU-96; ALA-165; LYS-187; SER-246; HIS-247 AND ILE-268, BIOPHYSICOCHEMICAL PROPERTIES, COFACTOR.

Entry informationi

Entry nameiMARC1_HUMAN
AccessioniPrimary (citable) accession number: Q5VT66
Secondary accession number(s): A8K447
, B2D078, Q5VVS9, Q5VVT0, Q5VVT1, Q8N9P5, Q96FN8, Q9H6C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 7, 2004
Last modified: June 24, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.