Q5VT52 (RPRD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulation of nuclear pre-mRNA domain-containing protein 2

Gene names

Name:	RPRD2
Synonyms:	KIAA0460
ORF Names:	HSPC099

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1461 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Associates with the RNA polymerase II complex. Ref.17
Sequence similarities	Contains 1 CID domain.
Sequence caution	The sequence AAF28922.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH45623.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	DNA-directed RNA polymerase II, holoenzyme Inferred from direct assay Ref.17. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5VT52-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5VT52-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q5VT52-3)

The sequence of this isoform differs from the canonical sequence as follows:
     146-171: Missing.

Isoform 4 (identifier: Q5VT52-4)

The sequence of this isoform differs from the canonical sequence as follows:
     147-152: TTFKTQ → KCLFLS
     153-1461: Missing.

Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1461

1461

Regulation of nuclear pre-mRNA domain-containing protein 2

PRO_0000244355

Regions

Domain

19 – 149

131

CID

Compositional bias

4 – 19

16

Gly/Ser-rich

Compositional bias

457 – 950

494

Ser-rich

Compositional bias

1054 – 1057

4

Poly-Gln

Compositional bias

1152 – 1158

7

Poly-Gly

Compositional bias

1195 – 1459

265

Pro-rich

Amino acid modifications

Modified residue

356

1

Phosphoserine Ref.16

Modified residue

358

1

Phosphothreonine Ref.16

Modified residue

374

1

Phosphoserine Ref.9 Ref.11 Ref.12 Ref.13 Ref.14 Ref.16

Modified residue

473

1

Phosphoserine Ref.13 Ref.14

Modified residue

476

1

Phosphoserine Ref.13

Modified residue

479

1

Phosphoserine Ref.12

Modified residue

482

1

Phosphothreonine Ref.13 Ref.14

Modified residue

485

1

Phosphoserine Ref.12 Ref.13

Modified residue

517

1

Phosphothreonine Ref.12 Ref.14

Modified residue

593

1

Phosphoserine Ref.12 Ref.13 Ref.14 Ref.16

Modified residue

598

1

Phosphothreonine Ref.13

Modified residue

614

1

Phosphoserine Ref.10 Ref.12 Ref.13 Ref.14

Modified residue

665

1

Phosphoserine Ref.13

Modified residue

723

1

Phosphothreonine Ref.9 Ref.12 Ref.14

Modified residue

730

1

Phosphoserine By similarity

Modified residue

732

1

Phosphothreonine Ref.13

Modified residue

758

1

Phosphoserine Ref.10 Ref.12

Modified residue

762

1

Phosphoserine Ref.10

Modified residue

826

1

Phosphoserine Ref.13

Modified residue

900

1

Phosphoserine Ref.12

Modified residue

909

1

Phosphoserine Ref.12 Ref.13

Modified residue

928

1

Phosphoserine Ref.12 Ref.14

Modified residue

1021

1

Phosphoserine By similarity

Modified residue

1099

1

Phosphoserine Ref.9 Ref.12 Ref.13 Ref.14

Natural variations

Alternative sequence

1 – 37

37

Missing in isoform 2.

VSP_019546

Alternative sequence

146 – 171

26

Missing in isoform 3.

VSP_019547

Alternative sequence

147 – 152

6

TTFKTQ → KCLFLS in isoform 4.

VSP_035574

Alternative sequence

153 – 1461

1309

Missing in isoform 4.

VSP_035575

Natural variant

351

1

M → V.
Corresponds to variant rs41273537 [ dbSNP | Ensembl ].

VAR_061700

Experimental info

Sequence conflict

167

1

W → C in AAF28922. Ref.6

Sequence conflict

174

1

T → A in BAG51793. Ref.1

Sequence conflict

1297

1

P → L in BAG51793. Ref.1

Sequence conflict

1385

1

G → R in BAG51793. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1461

Helix Strand Turn

Details...

Helix

20 – 33

14

Helix

38 – 50

13

Helix

52 – 54

3

Helix

55 – 68

14

Helix

71 – 87

17

Turn

88 – 92

5

Helix

95 – 101

7

Helix

104 – 109

6

Turn

114 – 116

3

Helix

117 – 130

14

Helix

135 – 144

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: E08CAF3148F89F67	FASTA	1,461	156,020
	10 20 30 40 50 60 MAAGGGGGSS KASSSSASSA GALESSLDRK FQSVTNTMES IQGLSSWCIE NKKHHSTIVY 70 80 90 100 110 120 HWMKWLRRSA YPHRLNLFYL ANDVIQNCKR KNAIIFRESF ADVLPEAAAL VKDPSVSKSV 130 140 150 160 170 180 ERIFKIWEDR NVYPEEMIVA LREALSTTFK TQKQLKENLN KQPNKQWKKS QTSTNPKAAL 190 200 210 220 230 240 KSKIVAEFRS QALIEELLLY KRSEDQIELK EKQLSTMRVD VCSTETLKCL KDKTGGKKFS 250 260 270 280 290 300 KEFEEASSKL EEFVNGLDKQ VKNGPSLTEA LENAGIFYEA QYKEVKVVAN AYKTFANRVN 310 320 330 340 350 360 NLKKKLDQLK STLPDPEESP VPSPSMDAPS PTGSESPFQG MGGEESQSPT MESEKSATPE 370 380 390 400 410 420 PVTDNRDVED MELSDVEDDG SKIIVEDRKE KPAEKSAVST SVPTKPTENI SKASSCTPVP 430 440 450 460 470 480 VTMTATPPLP KPVNTSLSPS PALALPNLAN VDLAKISSIL SSLTSVMKNT GVSPASRPSP 490 500 510 520 530 540 GTPTSPSNLT SGLKTPAPAT TTSHNPLANI LSKVEITPES ILSALSKTQT QSAPALQGLS 550 560 570 580 590 600 SLLQSVTGNP VPASEAASQS TSASPANTTV STIKGRNLPS SAQPFIPKSF NYSPNSSTSE 610 620 630 640 650 660 VSSTSASKAS IGQSPGLPST TFKLPSNSLG FTATHNTSPA APPTEVTICQ SSEVSKPKLE 670 680 690 700 710 720 SESTSPSLEM KIHNFLKGNP GFSGLNLNIP ILSSLGSSAP SESHPSDFQR GPTSTSIDNI 730 740 750 760 770 780 DGTPVRDERS GTPTQDEMMD KPTSSSVDTM SLLSKIISPG SSTPSSTRSP PPGRDESYPR 790 800 810 820 830 840 ELSNSVSTYR PFGLGSESPY KQPSDGMERP SSLMDSSQEK FYPDTSFQED EDYRDFEYSG 850 860 870 880 890 900 PPPSAMMNLE KKPAKSILKS SKLSDTTEYQ PILSSYSHRA QEFGVKSAFP PSVRALLDSS 910 920 930 940 950 960 ENCDRLSSSP GLFGAFSVRG NEPGSDRSPS PSKNDSFFTP DSNHNSLSQS TTGHLSLPQK 970 980 990 1000 1010 1020 QYPDSPHPVP HRSLFSPQNT LAAPTGHPPT SGVEKVLAST ISTTSTIEFK NMLKNASRKP 1030 1040 1050 1060 1070 1080 SDDKHFGQAP SKGTPSDGVS LSNLTQPSLT ATDQQQQEEH YRIETRVSSS CLDLPDSTEE 1090 1100 1110 1120 1130 1140 KGAPIETLGY HSASNRRMSG EPIQTVESIR VPGKGNRGHG REASRVGWFD LSTSGSSFDN 1150 1160 1170 1180 1190 1200 GPSSASELAS LGGGGSGGLT GFKTAPYKER APQFQESVGS FRSNSFNSTF EHHLPPSPLE 1210 1220 1230 1240 1250 1260 HGTPFQREPV GPSSAPPVPP KDHGGIFSRD APTHLPSVDL SNPFTKEAAL AHAAPPPPPG 1270 1280 1290 1300 1310 1320 EHSGIPFPTP PPPPPPGEHS SSGGSGVPFS TPPPPPPPVD HSGVVPFPAP PLAEHGVAGA 1330 1340 1350 1360 1370 1380 VAVFPKDHSS LLQGTLAEHF GVLPGPRDHG GPTQRDLNGP GLSRVRESLT LPSHSLEHLG 1390 1400 1410 1420 1430 1440 PPHGGGGGGG SNSSSGPPLG PSHRDTISRS GIILRSPRPD FRPREPFLSR DPFHSLKRPR 1450 1460 PPFARGPPFF APKRPFFPPR Y
	Isoform 2 [UniParc]. Checksum: EFB18C42C73F5B93	FASTA	1,424	152,588
	10 20 30 40 50 60 MESIQGLSSW CIENKKHHST IVYHWMKWLR RSAYPHRLNL FYLANDVIQN CKRKNAIIFR 70 80 90 100 110 120 ESFADVLPEA AALVKDPSVS KSVERIFKIW EDRNVYPEEM IVALREALST TFKTQKQLKE 130 140 150 160 170 180 NLNKQPNKQW KKSQTSTNPK AALKSKIVAE FRSQALIEEL LLYKRSEDQI ELKEKQLSTM 190 200 210 220 230 240 RVDVCSTETL KCLKDKTGGK KFSKEFEEAS SKLEEFVNGL DKQVKNGPSL TEALENAGIF 250 260 270 280 290 300 YEAQYKEVKV VANAYKTFAN RVNNLKKKLD QLKSTLPDPE ESPVPSPSMD APSPTGSESP 310 320 330 340 350 360 FQGMGGEESQ SPTMESEKSA TPEPVTDNRD VEDMELSDVE DDGSKIIVED RKEKPAEKSA 370 380 390 400 410 420 VSTSVPTKPT ENISKASSCT PVPVTMTATP PLPKPVNTSL SPSPALALPN LANVDLAKIS 430 440 450 460 470 480 SILSSLTSVM KNTGVSPASR PSPGTPTSPS NLTSGLKTPA PATTTSHNPL ANILSKVEIT 490 500 510 520 530 540 PESILSALSK TQTQSAPALQ GLSSLLQSVT GNPVPASEAA SQSTSASPAN TTVSTIKGRN 550 560 570 580 590 600 LPSSAQPFIP KSFNYSPNSS TSEVSSTSAS KASIGQSPGL PSTTFKLPSN SLGFTATHNT 610 620 630 640 650 660 SPAAPPTEVT ICQSSEVSKP KLESESTSPS LEMKIHNFLK GNPGFSGLNL NIPILSSLGS 670 680 690 700 710 720 SAPSESHPSD FQRGPTSTSI DNIDGTPVRD ERSGTPTQDE MMDKPTSSSV DTMSLLSKII 730 740 750 760 770 780 SPGSSTPSST RSPPPGRDES YPRELSNSVS TYRPFGLGSE SPYKQPSDGM ERPSSLMDSS 790 800 810 820 830 840 QEKFYPDTSF QEDEDYRDFE YSGPPPSAMM NLEKKPAKSI LKSSKLSDTT EYQPILSSYS 850 860 870 880 890 900 HRAQEFGVKS AFPPSVRALL DSSENCDRLS SSPGLFGAFS VRGNEPGSDR SPSPSKNDSF 910 920 930 940 950 960 FTPDSNHNSL SQSTTGHLSL PQKQYPDSPH PVPHRSLFSP QNTLAAPTGH PPTSGVEKVL 970 980 990 1000 1010 1020 ASTISTTSTI EFKNMLKNAS RKPSDDKHFG QAPSKGTPSD GVSLSNLTQP SLTATDQQQQ 1030 1040 1050 1060 1070 1080 EEHYRIETRV SSSCLDLPDS TEEKGAPIET LGYHSASNRR MSGEPIQTVE SIRVPGKGNR 1090 1100 1110 1120 1130 1140 GHGREASRVG WFDLSTSGSS FDNGPSSASE LASLGGGGSG GLTGFKTAPY KERAPQFQES 1150 1160 1170 1180 1190 1200 VGSFRSNSFN STFEHHLPPS PLEHGTPFQR EPVGPSSAPP VPPKDHGGIF SRDAPTHLPS 1210 1220 1230 1240 1250 1260 VDLSNPFTKE AALAHAAPPP PPGEHSGIPF PTPPPPPPPG EHSSSGGSGV PFSTPPPPPP 1270 1280 1290 1300 1310 1320 PVDHSGVVPF PAPPLAEHGV AGAVAVFPKD HSSLLQGTLA EHFGVLPGPR DHGGPTQRDL 1330 1340 1350 1360 1370 1380 NGPGLSRVRE SLTLPSHSLE HLGPPHGGGG GGGSNSSSGP PLGPSHRDTI SRSGIILRSP 1390 1400 1410 1420 RPDFRPREPF LSRDPFHSLK RPRPPFARGP PFFAPKRPFF PPRY
	Isoform 3 [UniParc]. Checksum: 3425769AF329312E	FASTA	1,435	152,876
	10 20 30 40 50 60 MAAGGGGGSS KASSSSASSA GALESSLDRK FQSVTNTMES IQGLSSWCIE NKKHHSTIVY 70 80 90 100 110 120 HWMKWLRRSA YPHRLNLFYL ANDVIQNCKR KNAIIFRESF ADVLPEAAAL VKDPSVSKSV 130 140 150 160 170 180 ERIFKIWEDR NVYPEEMIVA LREALTSTNP KAALKSKIVA EFRSQALIEE LLLYKRSEDQ 190 200 210 220 230 240 IELKEKQLST MRVDVCSTET LKCLKDKTGG KKFSKEFEEA SSKLEEFVNG LDKQVKNGPS 250 260 270 280 290 300 LTEALENAGI FYEAQYKEVK VVANAYKTFA NRVNNLKKKL DQLKSTLPDP EESPVPSPSM 310 320 330 340 350 360 DAPSPTGSES PFQGMGGEES QSPTMESEKS ATPEPVTDNR DVEDMELSDV EDDGSKIIVE 370 380 390 400 410 420 DRKEKPAEKS AVSTSVPTKP TENISKASSC TPVPVTMTAT PPLPKPVNTS LSPSPALALP 430 440 450 460 470 480 NLANVDLAKI SSILSSLTSV MKNTGVSPAS RPSPGTPTSP SNLTSGLKTP APATTTSHNP 490 500 510 520 530 540 LANILSKVEI TPESILSALS KTQTQSAPAL QGLSSLLQSV TGNPVPASEA ASQSTSASPA 550 560 570 580 590 600 NTTVSTIKGR NLPSSAQPFI PKSFNYSPNS STSEVSSTSA SKASIGQSPG LPSTTFKLPS 610 620 630 640 650 660 NSLGFTATHN TSPAAPPTEV TICQSSEVSK PKLESESTSP SLEMKIHNFL KGNPGFSGLN 670 680 690 700 710 720 LNIPILSSLG SSAPSESHPS DFQRGPTSTS IDNIDGTPVR DERSGTPTQD EMMDKPTSSS 730 740 750 760 770 780 VDTMSLLSKI ISPGSSTPSS TRSPPPGRDE SYPRELSNSV STYRPFGLGS ESPYKQPSDG 790 800 810 820 830 840 MERPSSLMDS SQEKFYPDTS FQEDEDYRDF EYSGPPPSAM MNLEKKPAKS ILKSSKLSDT 850 860 870 880 890 900 TEYQPILSSY SHRAQEFGVK SAFPPSVRAL LDSSENCDRL SSSPGLFGAF SVRGNEPGSD 910 920 930 940 950 960 RSPSPSKNDS FFTPDSNHNS LSQSTTGHLS LPQKQYPDSP HPVPHRSLFS PQNTLAAPTG 970 980 990 1000 1010 1020 HPPTSGVEKV LASTISTTST IEFKNMLKNA SRKPSDDKHF GQAPSKGTPS DGVSLSNLTQ 1030 1040 1050 1060 1070 1080 PSLTATDQQQ QEEHYRIETR VSSSCLDLPD STEEKGAPIE TLGYHSASNR RMSGEPIQTV 1090 1100 1110 1120 1130 1140 ESIRVPGKGN RGHGREASRV GWFDLSTSGS SFDNGPSSAS ELASLGGGGS GGLTGFKTAP 1150 1160 1170 1180 1190 1200 YKERAPQFQE SVGSFRSNSF NSTFEHHLPP SPLEHGTPFQ REPVGPSSAP PVPPKDHGGI 1210 1220 1230 1240 1250 1260 FSRDAPTHLP SVDLSNPFTK EAALAHAAPP PPPGEHSGIP FPTPPPPPPP GEHSSSGGSG 1270 1280 1290 1300 1310 1320 VPFSTPPPPP PPVDHSGVVP FPAPPLAEHG VAGAVAVFPK DHSSLLQGTL AEHFGVLPGP 1330 1340 1350 1360 1370 1380 RDHGGPTQRD LNGPGLSRVR ESLTLPSHSL EHLGPPHGGG GGGGSNSSSG PPLGPSHRDT 1390 1400 1410 1420 1430 ISRSGIILRS PRPDFRPREP FLSRDPFHSL KRPRPPFARG PPFFAPKRPF FPPRY
	Isoform 4 [UniParc]. Checksum: 4FFBE10E974AC878	FASTA	152	17,001
	10 20 30 40 50 60 MAAGGGGGSS KASSSSASSA GALESSLDRK FQSVTNTMES IQGLSSWCIE NKKHHSTIVY 70 80 90 100 110 120 HWMKWLRRSA YPHRLNLFYL ANDVIQNCKR KNAIIFRESF ADVLPEAAAL VKDPSVSKSV 130 140 150 ERIFKIWEDR NVYPEEMIVA LREALSKCLF LS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Salivary gland.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Testis.
[6]	"Human partial CDS cloned from CD34+ stem cells." Zhang Q.H., Ye M., Zhou J., Shen Y., Wu X.Y., Guan Z.Q., Wang L., Fan H.Y., Mao Y.F., Dai M., Huang Q.H., Chen S.J., Chen Z. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-167 (ISOFORM 1). Tissue: Umbilical cord blood.
[7]	"Characterization of cDNA clones in size-fractionated cDNA libraries from human brain." Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O. DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-1461 (ISOFORM 1). Tissue: Brain.
[8]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374; THR-723 AND SER-1099, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-614; SER-758 AND SER-762, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374, MASS SPECTROMETRY. Tissue: T-cell.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374; SER-479; SER-485; THR-517; SER-593; SER-614; THR-723; SER-758; SER-900; SER-909; SER-928 AND SER-1099, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374; SER-473; SER-476; THR-482; SER-485; SER-593; THR-598; SER-614; SER-665; THR-732; SER-826; SER-909 AND SER-1099, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[14]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374; SER-473; THR-482; THR-517; SER-593; SER-614; THR-723; SER-928 AND SER-1099, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356; THR-358; SER-374 AND SER-593, MASS SPECTROMETRY.
[17]	"Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B." Ni Z., Olsen J.B., Guo X., Zhong G., Ruan E.D., Marcon E., Young P., Guo H., Li J., Moffat J., Emili A., Greenblatt J.F. Transcription 2:237-242(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE RNA POLYMERASE II COMPLEX.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK056707 mRNA. Translation: BAG51793.1.
AK291703 mRNA. Translation: BAF84392.1.
BX641025 mRNA. Translation: CAE46016.1.
AL356356, AL611942, BX284695 Genomic DNA. Translation: CAI15496.1.
AL356356, AL611942, BX284695 Genomic DNA. Translation: CAI15497.1.
AL611942, AL356356, BX284695 Genomic DNA. Translation: CAH70313.1.
AL611942, AL356356, BX284695 Genomic DNA. Translation: CAH70314.1.
AL611942 Genomic DNA. Translation: CAH70315.1.
BX284695, AL356356, AL611942 Genomic DNA. Translation: CAI17373.1.
BX284695, AL356356, AL611942 Genomic DNA. Translation: CAI17374.1.
CH471121 Genomic DNA. Translation: EAW53552.1.
BC045623 mRNA. Translation: AAH45623.2. Different initiation.
AF161362 mRNA. Translation: AAF28922.1. Different initiation.
AB007929 mRNA. Translation: BAA32305.2.

IPI

IPI00384541.
IPI00639879.
IPI00647267.
IPI00760919.

PIR

T00074.

RefSeq

NP_056018.2. NM_015203.3.

UniGene

Hs.213666.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4FLB	X-ray	1.80	A	19-149	[»]

ProteinModelPortal

Q5VT52.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q5VT52. 4 interactions.

MINT

MINT-1603162.

PTM databases

PhosphoSite

Q5VT52.

Polymorphism databases

DMDM

74746888.

Proteomic databases

PaxDb

Q5VT52.

PRIDE

Q5VT52.

Protocols and materials databases

DNASU

23248.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000369067; ENSP00000358063; ENSG00000163125.
ENST00000369068; ENSP00000358064; ENSG00000163125.
ENST00000401000; ENSP00000383785; ENSG00000163125.
ENST00000579067; ENSP00000462536; ENSG00000266562.
ENST00000584319; ENSP00000464492; ENSG00000266562.
ENST00000584841; ENSP00000463897; ENSG00000266562.

GeneID

23248.

KEGG

hsa:23248.

UCSC

uc001eup.4. human.
uc009wlr.3. human.

Organism-specific databases

CTD

23248.

GeneCards

GC01P150335.

H-InvDB

HIX0019981.

HGNC

HGNC:29039. RPRD2.

HPA

HPA045778.

MIM

614695. gene.

neXtProt

NX_Q5VT52.

PharmGKB

PA162402062.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG331230.

HOVERGEN

HBG104176.

InParanoid

Q5VT52.

OMA

GKGNRGH.

Gene expression databases

ArrayExpress

Q5VT52.

Bgee

Q5VT52.

CleanEx

HS_RPRD2.

Genevestigator

Q5VT52.

GermOnline

ENSG00000163125. Homo sapiens.

Family and domain databases

Gene3D

1.25.40.90. 1 hit.

InterPro

IPR006569. CID_dom.
IPR008942. ENTH_VHS.
IPR006903. RNA_pol_II-bd.
[Graphical view]

Pfam

PF04818. CTD_bind. 1 hit.
[Graphical view]

SMART

SM00582. RPR. 1 hit.
[Graphical view]

SUPFAM

SSF48464. ENTH_VHS. 1 hit.

PROSITE

PS51391. CID. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

RPRD2. human.

GenomeRNAi

23248.

NextBio

44942.

SOURCE

Search...

Entry information

Entry name

RPRD2_HUMAN

Accession

Primary (citable) accession number: Q5VT52
Secondary accession number(s): A8K6N8 , B3KPT1, O75048, Q5VT51, Q5VT53, Q6MZL4, Q86XD2, Q9P0D7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.