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Q5VT52

- RPRD2_HUMAN

UniProt

Q5VT52 - RPRD2_HUMAN

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Protein

Regulation of nuclear pre-mRNA domain-containing protein 2

Gene

RPRD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Regulation of nuclear pre-mRNA domain-containing protein 2
Gene namesi
Name:RPRD2
Synonyms:KIAA0460
ORF Names:HSPC099
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:29039. RPRD2.

Subcellular locationi

GO - Cellular componenti

  1. DNA-directed RNA polymerase II, holoenzyme Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162402062.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14611461Regulation of nuclear pre-mRNA domain-containing protein 2PRO_0000244355Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei356 – 3561Phosphoserine1 Publication
Modified residuei358 – 3581Phosphothreonine1 Publication
Modified residuei374 – 3741Phosphoserine6 Publications
Modified residuei473 – 4731Phosphoserine2 Publications
Modified residuei476 – 4761Phosphoserine1 Publication
Modified residuei479 – 4791Phosphoserine1 Publication
Modified residuei482 – 4821Phosphothreonine2 Publications
Modified residuei485 – 4851Phosphoserine2 Publications
Modified residuei517 – 5171Phosphothreonine2 Publications
Modified residuei593 – 5931Phosphoserine4 Publications
Modified residuei598 – 5981Phosphothreonine1 Publication
Modified residuei614 – 6141Phosphoserine4 Publications
Modified residuei665 – 6651Phosphoserine1 Publication
Modified residuei723 – 7231Phosphothreonine3 Publications
Modified residuei732 – 7321Phosphothreonine1 Publication
Modified residuei758 – 7581Phosphoserine2 Publications
Modified residuei762 – 7621Phosphoserine1 Publication
Modified residuei826 – 8261Phosphoserine1 Publication
Modified residuei900 – 9001Phosphoserine1 Publication
Modified residuei909 – 9091Phosphoserine2 Publications
Modified residuei928 – 9281Phosphoserine2 Publications
Modified residuei1068 – 10681PhosphoserineBy similarity
Modified residuei1099 – 10991Phosphoserine4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5VT52.
PaxDbiQ5VT52.
PRIDEiQ5VT52.

PTM databases

PhosphoSiteiQ5VT52.

Expressioni

Gene expression databases

BgeeiQ5VT52.
CleanExiHS_RPRD2.
GenevestigatoriQ5VT52.

Organism-specific databases

HPAiHPA045778.

Interactioni

Subunit structurei

Associates with the RNA polymerase II complex.1 Publication

Protein-protein interaction databases

BioGridi116852. 16 interactions.
IntActiQ5VT52. 4 interactions.
MINTiMINT-1603162.

Structurei

Secondary structure

1
1461
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi20 – 3314Combined sources
Helixi38 – 5013Combined sources
Helixi52 – 543Combined sources
Helixi55 – 6814Combined sources
Helixi71 – 8717Combined sources
Turni88 – 925Combined sources
Helixi95 – 1017Combined sources
Helixi104 – 1096Combined sources
Turni114 – 1163Combined sources
Helixi117 – 13014Combined sources
Helixi135 – 14410Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FLBX-ray1.80A19-149[»]
ProteinModelPortaliQ5VT52.
SMRiQ5VT52. Positions 19-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 149131CIDPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 1916Gly/Ser-richAdd
BLAST
Compositional biasi457 – 950494Ser-richAdd
BLAST
Compositional biasi1054 – 10574Poly-Gln
Compositional biasi1152 – 11587Poly-Gly
Compositional biasi1195 – 1459265Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 CID domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG331230.
GeneTreeiENSGT00400000022016.
HOVERGENiHBG104176.
InParanoidiQ5VT52.
OMAiTLGYHNA.
PhylomeDBiQ5VT52.
TreeFamiTF320926.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR006569. CID_dom.
IPR008942. ENTH_VHS.
IPR006903. RNA_pol_II-bd.
[Graphical view]
PfamiPF04818. CTD_bind. 1 hit.
[Graphical view]
SMARTiSM00582. RPR. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS51391. CID. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VT52-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGGGGGSS KASSSSASSA GALESSLDRK FQSVTNTMES IQGLSSWCIE
60 70 80 90 100
NKKHHSTIVY HWMKWLRRSA YPHRLNLFYL ANDVIQNCKR KNAIIFRESF
110 120 130 140 150
ADVLPEAAAL VKDPSVSKSV ERIFKIWEDR NVYPEEMIVA LREALSTTFK
160 170 180 190 200
TQKQLKENLN KQPNKQWKKS QTSTNPKAAL KSKIVAEFRS QALIEELLLY
210 220 230 240 250
KRSEDQIELK EKQLSTMRVD VCSTETLKCL KDKTGGKKFS KEFEEASSKL
260 270 280 290 300
EEFVNGLDKQ VKNGPSLTEA LENAGIFYEA QYKEVKVVAN AYKTFANRVN
310 320 330 340 350
NLKKKLDQLK STLPDPEESP VPSPSMDAPS PTGSESPFQG MGGEESQSPT
360 370 380 390 400
MESEKSATPE PVTDNRDVED MELSDVEDDG SKIIVEDRKE KPAEKSAVST
410 420 430 440 450
SVPTKPTENI SKASSCTPVP VTMTATPPLP KPVNTSLSPS PALALPNLAN
460 470 480 490 500
VDLAKISSIL SSLTSVMKNT GVSPASRPSP GTPTSPSNLT SGLKTPAPAT
510 520 530 540 550
TTSHNPLANI LSKVEITPES ILSALSKTQT QSAPALQGLS SLLQSVTGNP
560 570 580 590 600
VPASEAASQS TSASPANTTV STIKGRNLPS SAQPFIPKSF NYSPNSSTSE
610 620 630 640 650
VSSTSASKAS IGQSPGLPST TFKLPSNSLG FTATHNTSPA APPTEVTICQ
660 670 680 690 700
SSEVSKPKLE SESTSPSLEM KIHNFLKGNP GFSGLNLNIP ILSSLGSSAP
710 720 730 740 750
SESHPSDFQR GPTSTSIDNI DGTPVRDERS GTPTQDEMMD KPTSSSVDTM
760 770 780 790 800
SLLSKIISPG SSTPSSTRSP PPGRDESYPR ELSNSVSTYR PFGLGSESPY
810 820 830 840 850
KQPSDGMERP SSLMDSSQEK FYPDTSFQED EDYRDFEYSG PPPSAMMNLE
860 870 880 890 900
KKPAKSILKS SKLSDTTEYQ PILSSYSHRA QEFGVKSAFP PSVRALLDSS
910 920 930 940 950
ENCDRLSSSP GLFGAFSVRG NEPGSDRSPS PSKNDSFFTP DSNHNSLSQS
960 970 980 990 1000
TTGHLSLPQK QYPDSPHPVP HRSLFSPQNT LAAPTGHPPT SGVEKVLAST
1010 1020 1030 1040 1050
ISTTSTIEFK NMLKNASRKP SDDKHFGQAP SKGTPSDGVS LSNLTQPSLT
1060 1070 1080 1090 1100
ATDQQQQEEH YRIETRVSSS CLDLPDSTEE KGAPIETLGY HSASNRRMSG
1110 1120 1130 1140 1150
EPIQTVESIR VPGKGNRGHG REASRVGWFD LSTSGSSFDN GPSSASELAS
1160 1170 1180 1190 1200
LGGGGSGGLT GFKTAPYKER APQFQESVGS FRSNSFNSTF EHHLPPSPLE
1210 1220 1230 1240 1250
HGTPFQREPV GPSSAPPVPP KDHGGIFSRD APTHLPSVDL SNPFTKEAAL
1260 1270 1280 1290 1300
AHAAPPPPPG EHSGIPFPTP PPPPPPGEHS SSGGSGVPFS TPPPPPPPVD
1310 1320 1330 1340 1350
HSGVVPFPAP PLAEHGVAGA VAVFPKDHSS LLQGTLAEHF GVLPGPRDHG
1360 1370 1380 1390 1400
GPTQRDLNGP GLSRVRESLT LPSHSLEHLG PPHGGGGGGG SNSSSGPPLG
1410 1420 1430 1440 1450
PSHRDTISRS GIILRSPRPD FRPREPFLSR DPFHSLKRPR PPFARGPPFF
1460
APKRPFFPPR Y
Length:1,461
Mass (Da):156,020
Last modified:December 7, 2004 - v1
Checksum:iE08CAF3148F89F67
GO
Isoform 2 (identifier: Q5VT52-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.

Note: No experimental confirmation available.

Show »
Length:1,424
Mass (Da):152,588
Checksum:iEFB18C42C73F5B93
GO
Isoform 3 (identifier: Q5VT52-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-171: Missing.

Show »
Length:1,435
Mass (Da):152,876
Checksum:i3425769AF329312E
GO
Isoform 4 (identifier: Q5VT52-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-152: TTFKTQ → KCLFLS
     153-1461: Missing.

Note: Gene prediction based on EST data.

Show »
Length:152
Mass (Da):17,001
Checksum:i4FFBE10E974AC878
GO
Isoform 5 (identifier: Q5VT52-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-171: Missing.
     932-960: SKNDSFFTPDSNHNSLSQSTTGHLSLPQK → KHPCRSHGSPTHVRRGESPGLHHFHHVDD
     961-1461: Missing.

Note: No experimental confirmation available.

Show »
Length:934
Mass (Da):100,272
Checksum:iA3D3BB446939BB42
GO

Sequence cautioni

The sequence AAF28922.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH45623.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti167 – 1671W → C in AAF28922. 1 PublicationCurated
Sequence conflicti174 – 1741T → A in BAG51793. (PubMed:14702039)Curated
Sequence conflicti1297 – 12971P → L in BAG51793. (PubMed:14702039)Curated
Sequence conflicti1385 – 13851G → R in BAG51793. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti351 – 3511M → V.
Corresponds to variant rs41273537 [ dbSNP | Ensembl ].
VAR_061700

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3737Missing in isoform 2. 1 PublicationVSP_019546Add
BLAST
Alternative sequencei146 – 17126Missing in isoform 3 and isoform 5. 2 PublicationsVSP_019547Add
BLAST
Alternative sequencei147 – 1526TTFKTQ → KCLFLS in isoform 4. CuratedVSP_035574
Alternative sequencei153 – 14611309Missing in isoform 4. CuratedVSP_035575Add
BLAST
Alternative sequencei932 – 96029SKNDS…SLPQK → KHPCRSHGSPTHVRRGESPG LHHFHHVDD in isoform 5. 1 PublicationVSP_053733Add
BLAST
Alternative sequencei961 – 1461501Missing in isoform 5. 1 PublicationVSP_053734Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056707 mRNA. Translation: BAG51793.1.
AK291703 mRNA. Translation: BAF84392.1.
AK304380 mRNA. Translation: BAG65218.1.
BX641025 mRNA. Translation: CAE46016.1.
AL356356, AL611942, BX284695 Genomic DNA. Translation: CAI15496.1.
AL356356, AL611942, BX284695 Genomic DNA. Translation: CAI15497.1.
AL611942, AL356356, BX284695 Genomic DNA. Translation: CAH70313.1.
AL611942, AL356356, BX284695 Genomic DNA. Translation: CAH70314.1.
AL611942 Genomic DNA. Translation: CAH70315.1.
BX284695, AL356356, AL611942 Genomic DNA. Translation: CAI17373.1.
BX284695, AL356356, AL611942 Genomic DNA. Translation: CAI17374.1.
CH471121 Genomic DNA. Translation: EAW53552.1.
BC045623 mRNA. Translation: AAH45623.2. Different initiation.
AF161362 mRNA. Translation: AAF28922.1. Different initiation.
AB007929 mRNA. Translation: BAA32305.2.
CCDSiCCDS44216.1. [Q5VT52-1]
CCDS72907.1. [Q5VT52-3]
PIRiT00074.
RefSeqiNP_001284602.1. NM_001297673.1. [Q5VT52-5]
NP_001284603.1. NM_001297674.1. [Q5VT52-3]
NP_056018.2. NM_015203.4. [Q5VT52-1]
UniGeneiHs.213666.

Genome annotation databases

EnsembliENST00000369067; ENSP00000358063; ENSG00000163125. [Q5VT52-4]
ENST00000369068; ENSP00000358064; ENSG00000163125. [Q5VT52-1]
ENST00000401000; ENSP00000383785; ENSG00000163125. [Q5VT52-3]
GeneIDi23248.
KEGGihsa:23248.
UCSCiuc001eup.4. human. [Q5VT52-3]
uc009wlr.3. human. [Q5VT52-1]
uc010pcc.1. human.

Polymorphism databases

DMDMi74746888.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056707 mRNA. Translation: BAG51793.1 .
AK291703 mRNA. Translation: BAF84392.1 .
AK304380 mRNA. Translation: BAG65218.1 .
BX641025 mRNA. Translation: CAE46016.1 .
AL356356 , AL611942 , BX284695 Genomic DNA. Translation: CAI15496.1 .
AL356356 , AL611942 , BX284695 Genomic DNA. Translation: CAI15497.1 .
AL611942 , AL356356 , BX284695 Genomic DNA. Translation: CAH70313.1 .
AL611942 , AL356356 , BX284695 Genomic DNA. Translation: CAH70314.1 .
AL611942 Genomic DNA. Translation: CAH70315.1 .
BX284695 , AL356356 , AL611942 Genomic DNA. Translation: CAI17373.1 .
BX284695 , AL356356 , AL611942 Genomic DNA. Translation: CAI17374.1 .
CH471121 Genomic DNA. Translation: EAW53552.1 .
BC045623 mRNA. Translation: AAH45623.2 . Different initiation.
AF161362 mRNA. Translation: AAF28922.1 . Different initiation.
AB007929 mRNA. Translation: BAA32305.2 .
CCDSi CCDS44216.1. [Q5VT52-1 ]
CCDS72907.1. [Q5VT52-3 ]
PIRi T00074.
RefSeqi NP_001284602.1. NM_001297673.1. [Q5VT52-5 ]
NP_001284603.1. NM_001297674.1. [Q5VT52-3 ]
NP_056018.2. NM_015203.4. [Q5VT52-1 ]
UniGenei Hs.213666.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4FLB X-ray 1.80 A 19-149 [» ]
ProteinModelPortali Q5VT52.
SMRi Q5VT52. Positions 19-149.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116852. 16 interactions.
IntActi Q5VT52. 4 interactions.
MINTi MINT-1603162.

PTM databases

PhosphoSitei Q5VT52.

Polymorphism databases

DMDMi 74746888.

Proteomic databases

MaxQBi Q5VT52.
PaxDbi Q5VT52.
PRIDEi Q5VT52.

Protocols and materials databases

DNASUi 23248.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369067 ; ENSP00000358063 ; ENSG00000163125 . [Q5VT52-4 ]
ENST00000369068 ; ENSP00000358064 ; ENSG00000163125 . [Q5VT52-1 ]
ENST00000401000 ; ENSP00000383785 ; ENSG00000163125 . [Q5VT52-3 ]
GeneIDi 23248.
KEGGi hsa:23248.
UCSCi uc001eup.4. human. [Q5VT52-3 ]
uc009wlr.3. human. [Q5VT52-1 ]
uc010pcc.1. human.

Organism-specific databases

CTDi 23248.
GeneCardsi GC01P150335.
H-InvDB HIX0019981.
HGNCi HGNC:29039. RPRD2.
HPAi HPA045778.
MIMi 614695. gene.
neXtProti NX_Q5VT52.
PharmGKBi PA162402062.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG331230.
GeneTreei ENSGT00400000022016.
HOVERGENi HBG104176.
InParanoidi Q5VT52.
OMAi TLGYHNA.
PhylomeDBi Q5VT52.
TreeFami TF320926.

Miscellaneous databases

ChiTaRSi RPRD2. human.
GeneWikii KIAA0460.
GenomeRNAii 23248.
NextBioi 35477341.
PROi Q5VT52.
SOURCEi Search...

Gene expression databases

Bgeei Q5VT52.
CleanExi HS_RPRD2.
Genevestigatori Q5VT52.

Family and domain databases

Gene3Di 1.25.40.90. 1 hit.
InterProi IPR006569. CID_dom.
IPR008942. ENTH_VHS.
IPR006903. RNA_pol_II-bd.
[Graphical view ]
Pfami PF04818. CTD_bind. 1 hit.
[Graphical view ]
SMARTi SM00582. RPR. 1 hit.
[Graphical view ]
SUPFAMi SSF48464. SSF48464. 1 hit.
PROSITEi PS51391. CID. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
    Tissue: Placenta and Trachea.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Salivary gland.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  6. "Human partial CDS cloned from CD34+ stem cells."
    Zhang Q.H., Ye M., Zhou J., Shen Y., Wu X.Y., Guan Z.Q., Wang L., Fan H.Y., Mao Y.F., Dai M., Huang Q.H., Chen S.J., Chen Z.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-167 (ISOFORM 1).
    Tissue: Umbilical cord blood.
  7. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
    Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
    DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-1461 (ISOFORM 1).
    Tissue: Brain.
  8. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374; THR-723 AND SER-1099, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-614; SER-758 AND SER-762, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
    Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
    J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: T-cell.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374; SER-479; SER-485; THR-517; SER-593; SER-614; THR-723; SER-758; SER-900; SER-909; SER-928 AND SER-1099, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374; SER-473; SER-476; THR-482; SER-485; SER-593; THR-598; SER-614; SER-665; THR-732; SER-826; SER-909 AND SER-1099, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374; SER-473; THR-482; THR-517; SER-593; SER-614; THR-723; SER-928 AND SER-1099, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356; THR-358; SER-374 AND SER-593, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B."
    Ni Z., Olsen J.B., Guo X., Zhong G., Ruan E.D., Marcon E., Young P., Guo H., Li J., Moffat J., Emili A., Greenblatt J.F.
    Transcription 2:237-242(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RNA POLYMERASE II COMPLEX.
  19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRPRD2_HUMAN
AccessioniPrimary (citable) accession number: Q5VT52
Secondary accession number(s): A8K6N8
, B3KPT1, B4E2Q6, O75048, Q5VT51, Q5VT53, Q6MZL4, Q86XD2, Q9P0D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 7, 2004
Last modified: November 26, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3