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Q5VT52

- RPRD2_HUMAN

UniProt

Q5VT52 - RPRD2_HUMAN

Protein

Regulation of nuclear pre-mRNA domain-containing protein 2

Gene

RPRD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulation of nuclear pre-mRNA domain-containing protein 2
    Gene namesi
    Name:RPRD2
    Synonyms:KIAA0460
    ORF Names:HSPC099
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:29039. RPRD2.

    Subcellular locationi

    GO - Cellular componenti

    1. DNA-directed RNA polymerase II, holoenzyme Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162402062.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14611461Regulation of nuclear pre-mRNA domain-containing protein 2PRO_0000244355Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei356 – 3561Phosphoserine1 Publication
    Modified residuei358 – 3581Phosphothreonine1 Publication
    Modified residuei374 – 3741Phosphoserine6 Publications
    Modified residuei473 – 4731Phosphoserine2 Publications
    Modified residuei476 – 4761Phosphoserine1 Publication
    Modified residuei479 – 4791Phosphoserine1 Publication
    Modified residuei482 – 4821Phosphothreonine2 Publications
    Modified residuei485 – 4851Phosphoserine2 Publications
    Modified residuei517 – 5171Phosphothreonine2 Publications
    Modified residuei593 – 5931Phosphoserine4 Publications
    Modified residuei598 – 5981Phosphothreonine1 Publication
    Modified residuei614 – 6141Phosphoserine4 Publications
    Modified residuei665 – 6651Phosphoserine1 Publication
    Modified residuei723 – 7231Phosphothreonine3 Publications
    Modified residuei732 – 7321Phosphothreonine1 Publication
    Modified residuei758 – 7581Phosphoserine2 Publications
    Modified residuei762 – 7621Phosphoserine1 Publication
    Modified residuei826 – 8261Phosphoserine1 Publication
    Modified residuei900 – 9001Phosphoserine1 Publication
    Modified residuei909 – 9091Phosphoserine2 Publications
    Modified residuei928 – 9281Phosphoserine2 Publications
    Modified residuei1068 – 10681PhosphoserineBy similarity
    Modified residuei1099 – 10991Phosphoserine4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ5VT52.
    PaxDbiQ5VT52.
    PRIDEiQ5VT52.

    PTM databases

    PhosphoSiteiQ5VT52.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5VT52.
    BgeeiQ5VT52.
    CleanExiHS_RPRD2.
    GenevestigatoriQ5VT52.

    Organism-specific databases

    HPAiHPA045778.

    Interactioni

    Subunit structurei

    Associates with the RNA polymerase II complex.1 Publication

    Protein-protein interaction databases

    BioGridi116852. 14 interactions.
    IntActiQ5VT52. 4 interactions.
    MINTiMINT-1603162.

    Structurei

    Secondary structure

    1
    1461
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi20 – 3314
    Helixi38 – 5013
    Helixi52 – 543
    Helixi55 – 6814
    Helixi71 – 8717
    Turni88 – 925
    Helixi95 – 1017
    Helixi104 – 1096
    Turni114 – 1163
    Helixi117 – 13014
    Helixi135 – 14410

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4FLBX-ray1.80A19-149[»]
    ProteinModelPortaliQ5VT52.
    SMRiQ5VT52. Positions 19-149, 190-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 149131CIDPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi4 – 1916Gly/Ser-richAdd
    BLAST
    Compositional biasi457 – 950494Ser-richAdd
    BLAST
    Compositional biasi1054 – 10574Poly-Gln
    Compositional biasi1152 – 11587Poly-Gly
    Compositional biasi1195 – 1459265Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CID domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG331230.
    HOVERGENiHBG104176.
    InParanoidiQ5VT52.
    OMAiTLGYHNA.
    PhylomeDBiQ5VT52.
    TreeFamiTF320926.

    Family and domain databases

    Gene3Di1.25.40.90. 1 hit.
    InterProiIPR006569. CID_dom.
    IPR008942. ENTH_VHS.
    IPR006903. RNA_pol_II-bd.
    [Graphical view]
    PfamiPF04818. CTD_bind. 1 hit.
    [Graphical view]
    SMARTiSM00582. RPR. 1 hit.
    [Graphical view]
    SUPFAMiSSF48464. SSF48464. 1 hit.
    PROSITEiPS51391. CID. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5VT52-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAGGGGGSS KASSSSASSA GALESSLDRK FQSVTNTMES IQGLSSWCIE     50
    NKKHHSTIVY HWMKWLRRSA YPHRLNLFYL ANDVIQNCKR KNAIIFRESF 100
    ADVLPEAAAL VKDPSVSKSV ERIFKIWEDR NVYPEEMIVA LREALSTTFK 150
    TQKQLKENLN KQPNKQWKKS QTSTNPKAAL KSKIVAEFRS QALIEELLLY 200
    KRSEDQIELK EKQLSTMRVD VCSTETLKCL KDKTGGKKFS KEFEEASSKL 250
    EEFVNGLDKQ VKNGPSLTEA LENAGIFYEA QYKEVKVVAN AYKTFANRVN 300
    NLKKKLDQLK STLPDPEESP VPSPSMDAPS PTGSESPFQG MGGEESQSPT 350
    MESEKSATPE PVTDNRDVED MELSDVEDDG SKIIVEDRKE KPAEKSAVST 400
    SVPTKPTENI SKASSCTPVP VTMTATPPLP KPVNTSLSPS PALALPNLAN 450
    VDLAKISSIL SSLTSVMKNT GVSPASRPSP GTPTSPSNLT SGLKTPAPAT 500
    TTSHNPLANI LSKVEITPES ILSALSKTQT QSAPALQGLS SLLQSVTGNP 550
    VPASEAASQS TSASPANTTV STIKGRNLPS SAQPFIPKSF NYSPNSSTSE 600
    VSSTSASKAS IGQSPGLPST TFKLPSNSLG FTATHNTSPA APPTEVTICQ 650
    SSEVSKPKLE SESTSPSLEM KIHNFLKGNP GFSGLNLNIP ILSSLGSSAP 700
    SESHPSDFQR GPTSTSIDNI DGTPVRDERS GTPTQDEMMD KPTSSSVDTM 750
    SLLSKIISPG SSTPSSTRSP PPGRDESYPR ELSNSVSTYR PFGLGSESPY 800
    KQPSDGMERP SSLMDSSQEK FYPDTSFQED EDYRDFEYSG PPPSAMMNLE 850
    KKPAKSILKS SKLSDTTEYQ PILSSYSHRA QEFGVKSAFP PSVRALLDSS 900
    ENCDRLSSSP GLFGAFSVRG NEPGSDRSPS PSKNDSFFTP DSNHNSLSQS 950
    TTGHLSLPQK QYPDSPHPVP HRSLFSPQNT LAAPTGHPPT SGVEKVLAST 1000
    ISTTSTIEFK NMLKNASRKP SDDKHFGQAP SKGTPSDGVS LSNLTQPSLT 1050
    ATDQQQQEEH YRIETRVSSS CLDLPDSTEE KGAPIETLGY HSASNRRMSG 1100
    EPIQTVESIR VPGKGNRGHG REASRVGWFD LSTSGSSFDN GPSSASELAS 1150
    LGGGGSGGLT GFKTAPYKER APQFQESVGS FRSNSFNSTF EHHLPPSPLE 1200
    HGTPFQREPV GPSSAPPVPP KDHGGIFSRD APTHLPSVDL SNPFTKEAAL 1250
    AHAAPPPPPG EHSGIPFPTP PPPPPPGEHS SSGGSGVPFS TPPPPPPPVD 1300
    HSGVVPFPAP PLAEHGVAGA VAVFPKDHSS LLQGTLAEHF GVLPGPRDHG 1350
    GPTQRDLNGP GLSRVRESLT LPSHSLEHLG PPHGGGGGGG SNSSSGPPLG 1400
    PSHRDTISRS GIILRSPRPD FRPREPFLSR DPFHSLKRPR PPFARGPPFF 1450
    APKRPFFPPR Y 1461
    Length:1,461
    Mass (Da):156,020
    Last modified:December 7, 2004 - v1
    Checksum:iE08CAF3148F89F67
    GO
    Isoform 2 (identifier: Q5VT52-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-37: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,424
    Mass (Da):152,588
    Checksum:iEFB18C42C73F5B93
    GO
    Isoform 3 (identifier: Q5VT52-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         146-171: Missing.

    Show »
    Length:1,435
    Mass (Da):152,876
    Checksum:i3425769AF329312E
    GO
    Isoform 4 (identifier: Q5VT52-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         147-152: TTFKTQ → KCLFLS
         153-1461: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:152
    Mass (Da):17,001
    Checksum:i4FFBE10E974AC878
    GO
    Isoform 5 (identifier: Q5VT52-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         146-171: Missing.
         932-960: SKNDSFFTPDSNHNSLSQSTTGHLSLPQK → KHPCRSHGSPTHVRRGESPGLHHFHHVDD
         961-1461: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:934
    Mass (Da):100,272
    Checksum:iA3D3BB446939BB42
    GO

    Sequence cautioni

    The sequence AAF28922.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH45623.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti167 – 1671W → C in AAF28922. 1 PublicationCurated
    Sequence conflicti174 – 1741T → A in BAG51793. (PubMed:14702039)Curated
    Sequence conflicti1297 – 12971P → L in BAG51793. (PubMed:14702039)Curated
    Sequence conflicti1385 – 13851G → R in BAG51793. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti351 – 3511M → V.
    Corresponds to variant rs41273537 [ dbSNP | Ensembl ].
    VAR_061700

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3737Missing in isoform 2. 1 PublicationVSP_019546Add
    BLAST
    Alternative sequencei146 – 17126Missing in isoform 3 and isoform 5. 2 PublicationsVSP_019547Add
    BLAST
    Alternative sequencei147 – 1526TTFKTQ → KCLFLS in isoform 4. CuratedVSP_035574
    Alternative sequencei153 – 14611309Missing in isoform 4. CuratedVSP_035575Add
    BLAST
    Alternative sequencei932 – 96029SKNDS…SLPQK → KHPCRSHGSPTHVRRGESPG LHHFHHVDD in isoform 5. 1 PublicationVSP_053733Add
    BLAST
    Alternative sequencei961 – 1461501Missing in isoform 5. 1 PublicationVSP_053734Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056707 mRNA. Translation: BAG51793.1.
    AK291703 mRNA. Translation: BAF84392.1.
    AK304380 mRNA. Translation: BAG65218.1.
    BX641025 mRNA. Translation: CAE46016.1.
    AL356356, AL611942, BX284695 Genomic DNA. Translation: CAI15496.1.
    AL356356, AL611942, BX284695 Genomic DNA. Translation: CAI15497.1.
    AL611942, AL356356, BX284695 Genomic DNA. Translation: CAH70313.1.
    AL611942, AL356356, BX284695 Genomic DNA. Translation: CAH70314.1.
    AL611942 Genomic DNA. Translation: CAH70315.1.
    BX284695, AL356356, AL611942 Genomic DNA. Translation: CAI17373.1.
    BX284695, AL356356, AL611942 Genomic DNA. Translation: CAI17374.1.
    CH471121 Genomic DNA. Translation: EAW53552.1.
    BC045623 mRNA. Translation: AAH45623.2. Different initiation.
    AF161362 mRNA. Translation: AAF28922.1. Different initiation.
    AB007929 mRNA. Translation: BAA32305.2.
    CCDSiCCDS44216.1. [Q5VT52-1]
    PIRiT00074.
    RefSeqiNP_056018.2. NM_015203.3. [Q5VT52-1]
    XP_005245088.1. XM_005245031.2. [Q5VT52-3]
    XP_005245089.1. XM_005245032.2. [Q5VT52-5]
    UniGeneiHs.213666.

    Genome annotation databases

    EnsembliENST00000369067; ENSP00000358063; ENSG00000163125. [Q5VT52-4]
    ENST00000369068; ENSP00000358064; ENSG00000163125. [Q5VT52-1]
    ENST00000401000; ENSP00000383785; ENSG00000163125. [Q5VT52-3]
    GeneIDi23248.
    KEGGihsa:23248.
    UCSCiuc001eup.4. human. [Q5VT52-3]
    uc009wlr.3. human. [Q5VT52-1]

    Polymorphism databases

    DMDMi74746888.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056707 mRNA. Translation: BAG51793.1 .
    AK291703 mRNA. Translation: BAF84392.1 .
    AK304380 mRNA. Translation: BAG65218.1 .
    BX641025 mRNA. Translation: CAE46016.1 .
    AL356356 , AL611942 , BX284695 Genomic DNA. Translation: CAI15496.1 .
    AL356356 , AL611942 , BX284695 Genomic DNA. Translation: CAI15497.1 .
    AL611942 , AL356356 , BX284695 Genomic DNA. Translation: CAH70313.1 .
    AL611942 , AL356356 , BX284695 Genomic DNA. Translation: CAH70314.1 .
    AL611942 Genomic DNA. Translation: CAH70315.1 .
    BX284695 , AL356356 , AL611942 Genomic DNA. Translation: CAI17373.1 .
    BX284695 , AL356356 , AL611942 Genomic DNA. Translation: CAI17374.1 .
    CH471121 Genomic DNA. Translation: EAW53552.1 .
    BC045623 mRNA. Translation: AAH45623.2 . Different initiation.
    AF161362 mRNA. Translation: AAF28922.1 . Different initiation.
    AB007929 mRNA. Translation: BAA32305.2 .
    CCDSi CCDS44216.1. [Q5VT52-1 ]
    PIRi T00074.
    RefSeqi NP_056018.2. NM_015203.3. [Q5VT52-1 ]
    XP_005245088.1. XM_005245031.2. [Q5VT52-3 ]
    XP_005245089.1. XM_005245032.2. [Q5VT52-5 ]
    UniGenei Hs.213666.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4FLB X-ray 1.80 A 19-149 [» ]
    ProteinModelPortali Q5VT52.
    SMRi Q5VT52. Positions 19-149, 190-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116852. 14 interactions.
    IntActi Q5VT52. 4 interactions.
    MINTi MINT-1603162.

    PTM databases

    PhosphoSitei Q5VT52.

    Polymorphism databases

    DMDMi 74746888.

    Proteomic databases

    MaxQBi Q5VT52.
    PaxDbi Q5VT52.
    PRIDEi Q5VT52.

    Protocols and materials databases

    DNASUi 23248.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369067 ; ENSP00000358063 ; ENSG00000163125 . [Q5VT52-4 ]
    ENST00000369068 ; ENSP00000358064 ; ENSG00000163125 . [Q5VT52-1 ]
    ENST00000401000 ; ENSP00000383785 ; ENSG00000163125 . [Q5VT52-3 ]
    GeneIDi 23248.
    KEGGi hsa:23248.
    UCSCi uc001eup.4. human. [Q5VT52-3 ]
    uc009wlr.3. human. [Q5VT52-1 ]

    Organism-specific databases

    CTDi 23248.
    GeneCardsi GC01P150335.
    H-InvDB HIX0019981.
    HGNCi HGNC:29039. RPRD2.
    HPAi HPA045778.
    MIMi 614695. gene.
    neXtProti NX_Q5VT52.
    PharmGKBi PA162402062.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG331230.
    HOVERGENi HBG104176.
    InParanoidi Q5VT52.
    OMAi TLGYHNA.
    PhylomeDBi Q5VT52.
    TreeFami TF320926.

    Miscellaneous databases

    ChiTaRSi RPRD2. human.
    GeneWikii KIAA0460.
    GenomeRNAii 23248.
    NextBioi 35477341.
    PROi Q5VT52.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5VT52.
    Bgeei Q5VT52.
    CleanExi HS_RPRD2.
    Genevestigatori Q5VT52.

    Family and domain databases

    Gene3Di 1.25.40.90. 1 hit.
    InterProi IPR006569. CID_dom.
    IPR008942. ENTH_VHS.
    IPR006903. RNA_pol_II-bd.
    [Graphical view ]
    Pfami PF04818. CTD_bind. 1 hit.
    [Graphical view ]
    SMARTi SM00582. RPR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48464. SSF48464. 1 hit.
    PROSITEi PS51391. CID. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
      Tissue: Placenta and Trachea.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Salivary gland.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Testis.
    6. "Human partial CDS cloned from CD34+ stem cells."
      Zhang Q.H., Ye M., Zhou J., Shen Y., Wu X.Y., Guan Z.Q., Wang L., Fan H.Y., Mao Y.F., Dai M., Huang Q.H., Chen S.J., Chen Z.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-167 (ISOFORM 1).
      Tissue: Umbilical cord blood.
    7. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
      Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
      DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-1461 (ISOFORM 1).
      Tissue: Brain.
    8. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374; THR-723 AND SER-1099, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-614; SER-758 AND SER-762, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
      Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
      J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: T-cell.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374; SER-479; SER-485; THR-517; SER-593; SER-614; THR-723; SER-758; SER-900; SER-909; SER-928 AND SER-1099, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374; SER-473; SER-476; THR-482; SER-485; SER-593; THR-598; SER-614; SER-665; THR-732; SER-826; SER-909 AND SER-1099, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374; SER-473; THR-482; THR-517; SER-593; SER-614; THR-723; SER-928 AND SER-1099, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356; THR-358; SER-374 AND SER-593, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B."
      Ni Z., Olsen J.B., Guo X., Zhong G., Ruan E.D., Marcon E., Young P., Guo H., Li J., Moffat J., Emili A., Greenblatt J.F.
      Transcription 2:237-242(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE RNA POLYMERASE II COMPLEX.
    19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRPRD2_HUMAN
    AccessioniPrimary (citable) accession number: Q5VT52
    Secondary accession number(s): A8K6N8
    , B3KPT1, B4E2Q6, O75048, Q5VT51, Q5VT53, Q6MZL4, Q86XD2, Q9P0D7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3