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Protein

Centrosome-associated protein 350

Gene

CEP350

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity.5 Publications

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SIGNORiQ5VT06.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosome-associated protein 350
Short name:
Cep350
Alternative name(s):
Centrosome-associated protein of 350 kDa
Gene namesi
Name:CEP350
Synonyms:CAP350, KIAA0480
ORF Names:GM133
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24238. CEP350.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: HPA
  • membrane Source: UniProtKB
  • nucleoplasm Source: HPA
  • spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi762 – 763LL → AA: Abolishes recruitment of PPARA to specific nuclear foci. No effect on interaction with PPARA (in vitro). 1 Publication2

Organism-specific databases

DisGeNETi9857.
OpenTargetsiENSG00000135837.
PharmGKBiPA143485434.

Polymorphism and mutation databases

BioMutaiCEP350.
DMDMi74746869.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332911 – 3117Centrosome-associated protein 350Add BLAST3117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86PhosphoserineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Modified residuei218PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei507PhosphoserineCombined sources1
Modified residuei695PhosphoserineCombined sources1
Modified residuei878PhosphothreonineCombined sources1
Modified residuei939PhosphoserineCombined sources1
Modified residuei1061PhosphoserineCombined sources1
Modified residuei1253PhosphothreonineCombined sources1
Modified residuei1256PhosphoserineCombined sources1
Modified residuei1259PhosphoserineCombined sources1
Modified residuei1648PhosphoserineCombined sources1
Modified residuei1653PhosphoserineCombined sources1
Modified residuei1818PhosphoserineCombined sources1
Modified residuei2115PhosphoserineCombined sources1
Modified residuei2204PhosphothreonineCombined sources1
Modified residuei2206PhosphoserineCombined sources1
Modified residuei2460PhosphoserineCombined sources1
Modified residuei2689PhosphothreonineCombined sources1
Modified residuei2839PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated during mitosis.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5VT06.
MaxQBiQ5VT06.
PaxDbiQ5VT06.
PeptideAtlasiQ5VT06.
PRIDEiQ5VT06.

PTM databases

iPTMnetiQ5VT06.
PhosphoSitePlusiQ5VT06.

Expressioni

Tissue specificityi

Detected in heart, brain, skeletal muscle, testis, placenta, lung, liver, kidney and pancreas.2 Publications

Gene expression databases

BgeeiENSG00000135837.
CleanExiHS_CEP350.
ExpressionAtlasiQ5VT06. baseline and differential.
GenevisibleiQ5VT06. HS.

Organism-specific databases

HPAiHPA028355.
HPA028357.
HPA030845.

Interactioni

Subunit structurei

Part of a ternary complex composed of SASS6, CENPJ and CEP350. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with FGFR1OP via its C-terminus. Interacts with NR1H3, PPARA, PPARD and PPARG. Interacts directly with microtubules. Interacts with the fusion protein FGFR1OP-FGFR1, and by doing so recruits and activates PI3K and PLC-gamma. Interacts with CYLD (PubMed:25134987).6 Publications

Protein-protein interaction databases

BioGridi115191. 63 interactors.
DIPiDIP-49946N.
IntActiQ5VT06. 47 interactors.
MINTiMINT-2867672.
STRINGi9606.ENSP00000356579.

Structurei

Secondary structure

13117
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2483 – 2486Combined sources4
Beta strandi2501 – 2505Combined sources5
Turni2506 – 2508Combined sources3
Beta strandi2509 – 2518Combined sources10
Beta strandi2520 – 2533Combined sources14
Beta strandi2536 – 2538Combined sources3
Beta strandi2540 – 2542Combined sources3
Beta strandi2555 – 2558Combined sources4
Helixi2560 – 2562Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2COZNMR-A2473-2581[»]
ProteinModelPortaliQ5VT06.
SMRiQ5VT06.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5VT06.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2517 – 2559CAP-GlyPROSITE-ProRule annotationAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili598 – 645Sequence analysisAdd BLAST48
Coiled coili1369 – 1411Sequence analysisAdd BLAST43
Coiled coili1707 – 1800Sequence analysisAdd BLAST94
Coiled coili1856 – 1899Sequence analysisAdd BLAST44
Coiled coili2051 – 2110Sequence analysisAdd BLAST60
Coiled coili2719 – 2752Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1112 – 1281Ser-richAdd BLAST170
Compositional biasi1502 – 1556Ser-richAdd BLAST55

Sequence similaritiesi

Contains 1 CAP-Gly domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410ISTJ. Eukaryota.
ENOG410YQD7. LUCA.
GeneTreeiENSGT00760000119173.
HOGENOMiHOG000111528.
HOVERGENiHBG095435.
InParanoidiQ5VT06.
KOiK16768.
OMAiQWEHSEE.
OrthoDBiEOG091G0038.
PhylomeDBiQ5VT06.
TreeFamiTF329845.

Family and domain databases

Gene3Di2.30.30.190. 1 hit.
InterProiIPR000938. CAP-Gly_domain.
IPR028750. CEP350.
[Graphical view]
PANTHERiPTHR13958. PTHR13958. 1 hit.
PfamiPF01302. CAP_GLY. 1 hit.
[Graphical view]
SMARTiSM01052. CAP_GLY. 1 hit.
[Graphical view]
SUPFAMiSSF74924. SSF74924. 1 hit.
PROSITEiPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VT06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSSKSKEVP LPNPRNSQSK DTVQADITTS WDALSQTKAA LRHIENKLEV
60 70 80 90 100
APTSTAVCDS VMDTKKSSTS ATRKISRKDG RYLDDSWVNA PISKSTKSRK
110 120 130 140 150
EKSRSPLRAT TLESNVKKNN RVEFREPLVS YREIHGAPSN FSSSHLESKH
160 170 180 190 200
VYCVDVNEEK TESGNWMIGS REERNIRSCD FESSQSSVIN DTVVRFLNDR
210 220 230 240 250
PAIDALQNSE CLIRMGASMR TEEEMPNRTK GSENNLKLSV NNMAHDTDPK
260 270 280 290 300
ALRLTDSSPS STSTSNSQRL DILKRRQHDV KLEKLKERIR KQWEHSEETN
310 320 330 340 350
GRGQKLGHID HPVMVVNVDN SVTAKVRKVA TAPPAPAYKG FNPSETKIRT
360 370 380 390 400
PDGKVWQEAE FQNMSRELYR DLALHFADDI SIKEKPAEKS KEKKVVKPVR
410 420 430 440 450
KVQKVAQLSS TECRTGSSHL ISTSSWRDGQ KLVKKILGPA PRMEPKEQRT
460 470 480 490 500
ASSDRGGRER TAKSGGHIGR AESDPRLDVL HRHLQRNSER SRSKSRSENN
510 520 530 540 550
IKKLASSLPD NKQEENTALN KDFLPIEIRG ILDDLQLDST AHTAKQDTVE
560 570 580 590 600
LQNQKSSAPV HAPRSHSPVK RKPDKITANE DPPVISKRRH YDTDEVRQYI
610 620 630 640 650
VRQQEERKRK QNEEKKAQKE ATEQKNKRLQ ELYRKQKEAF TKVKNVPPSE
660 670 680 690 700
PSATRRLQET YSKLLLEKTL LEEPSHQHVT QETQAKPGYQ PSGESDKENK
710 720 730 740 750
VQERPPSASS SSDMSLSEPP QPLARKDLME STWMQPERLS PQVHHSQPQP
760 770 780 790 800
FAGTAGSLLS HLLSLEHVGI LHKDFESILP TRKNHNMASR PLTFTPQPYV
810 820 830 840 850
TSPAAYTDAL LKPSASQYKS KLDRIEALKA TAASLSSRIE SEAKKLAGAS
860 870 880 890 900
INYGSAWNTE YDVQQAPQED GPWTKAVTPP VKDDNEDVFS ARIQKMLGSC
910 920 930 940 950
VSHATFDDDL PGVGNLSEFK KLPEMIRPQS AISSFRVRSP GPKPEGLLAQ
960 970 980 990 1000
LCKRQTDSSS SDMQACSQDK AKISLGSSID SVSEGPLLSE GSLSEEEGDQ
1010 1020 1030 1040 1050
DGQPLLKVAE ILKEKEFCPG ERNSYEPIKE FQKEAEKFLP LFGHIGGTQS
1060 1070 1080 1090 1100
KGPWEELAKG SPHSVINIFT KSYQLYGKGF EDKLDRGTST SRPLNATATP
1110 1120 1130 1140 1150
LSGVSYEDDF VSSPGTGTST EKKSTLEPHS TLSPQEDHSN RKSAYDPSSV
1160 1170 1180 1190 1200
DVTSQHSSGA QSAASSRSST SSKGKKGKKE KTEWLDSFTG NVQNSLLDEE
1210 1220 1230 1240 1250
KAERGSHQGK KSGTSSKLSV KDFEQTLDTD STLEDLSGHS VSVSSDKGRS
1260 1270 1280 1290 1300
QKTPTSPLSP SSQKSLQFDV AGTSSERSKS SVMPPTITGF KPNAPLTDLN
1310 1320 1330 1340 1350
PAASRTTTEN MAPIPGSKRF SPAGLHHRMA AELSYLNAIE ESVRQLSDVE
1360 1370 1380 1390 1400
RVRGISLAQQ ESVSLAQIIK AQQQRHERDL ALLKLKAEQE ALESQRQLEE
1410 1420 1430 1440 1450
TRNKAAQVHA ESLQQVVQSQ REVTEVLQEA TCKIAAQQSE TARLTTDAAR
1460 1470 1480 1490 1500
QICEMAELTR THISDAVVAS GAPLAILYDH QRQHLPDFVK QLRTRTETDR
1510 1520 1530 1540 1550
KSPSVSLSQS KEGTLDSKHQ KYSASYDSYS ESSGYKNHDR RSSSGSSRQE
1560 1570 1580 1590 1600
SPSVPSCKEN EKKLNGEKIE SSIDEQVQTA ADDSLRSDSV PSLPDEKDST
1610 1620 1630 1640 1650
SIATEYSLKF DESMTEDEIE EQSFRSLLPS ESHRRFNMEK RRGHHDDSDE
1660 1670 1680 1690 1700
EASPEKTTLS TAKELNMPFS GGQDSFSKFT MEMVRQYMKE EEMRAAHQSS
1710 1720 1730 1740 1750
LLRLREKALK EKTKAELAWL EHQKKHLRDK GEDDKMPPLR KKQRGLLLRL
1760 1770 1780 1790 1800
QQEKAEIKRL QEANKAARKE RQLILKQQEE IEKIRQTTIK LQEKLKSAGE
1810 1820 1830 1840 1850
SKLDSHSDDD TKDNKATSPG PTDLETRSPS PISISSSETS SIMQKLKKMR
1860 1870 1880 1890 1900
SRMDEKFLTK REQKLMQRRQ HAEELLEWKR RLDAEEAEIR QMEKQALAAW
1910 1920 1930 1940 1950
DKELIKPKTP KKELEDQRTE QKEIASEEES PVPLYSHLNS ESSIPEELGS
1960 1970 1980 1990 2000
PAVEYVPSES IGQEQPGSPD HSILTEEMIC SQELESSTSP SKHSLPKSCT
2010 2020 2030 2040 2050
SVSKQESSKG SHRTGGQCHL PIKSHQHCYS WSDESLSMTQ SETTSDQSDI
2060 2070 2080 2090 2100
EGRIRALKDE LRKRKSVVNQ LKKEQKKRQK ERLKAQEASL IKQLESYDEF
2110 2120 2130 2140 2150
IKKTEAELSQ DLETSPTAKP QIKTLSSASE KPKIKPLTPL HRSETAKNWK
2160 2170 2180 2190 2200
SLTESERSRG SLESIAEHVD ASLSGSERSV SERSLSAYAK RVNEWDSRTE
2210 2220 2230 2240 2250
DFQTPSPVLR SSRKIREESG DSLENVPALH LLKELNATSR ILDMSDGKVG
2260 2270 2280 2290 2300
ESSKKSEIKE IEYTKLKKSK IEDAFSKEGK SDVLLKLVLE QGDSSEILSK
2310 2320 2330 2340 2350
KDLPLDSENV QKDLVGLAIE NLHKSEEMLK ERQSDQDMNH SPNIQSGKDI
2360 2370 2380 2390 2400
HEQKNTKEKD LSWSEHLFAP KEIPYSEDFE VSSFKKEISA ELYKDDFEVS
2410 2420 2430 2440 2450
SLLSLRKDSQ SCRDKPQPMR SSTSGATSFG SNEEISECLS EKSLSIHSNV
2460 2470 2480 2490 2500
HSDRLLELKS PTELMKSKER SDVEHEQQVT ESPSLASVPT ADELFDFHIG
2510 2520 2530 2540 2550
DRVLIGNVQP GILRFKGETS FAKGFWAGVE LDKPEGNNNG TYDGIAYFEC
2560 2570 2580 2590 2600
KEKHGIFAPP QKISHIPENF DDYVDINEDE DCYSDERYQC YNQEQNDTEG
2610 2620 2630 2640 2650
PKDREKDVSE YFYEKSLPSV NDIEASVNRS RSLKIETDNV QDISGVLEAH
2660 2670 2680 2690 2700
VHQQSSVDSQ ISSKENKDLI SDATEKVSIA AEDDTLDNTF SEELEKQQQF
2710 2720 2730 2740 2750
TEEEDNLYAE ASEKLCTPLL DLLTREKNQL EAQLKSSLNE EKKSKQQLEK
2760 2770 2780 2790 2800
ISLLTDSLLK VFVKDTVNQL QQIKKTRDEK IQLSNQELLG DDQKKVTPQD
2810 2820 2830 2840 2850
LSQNVEEQSP SISGCFLSSE LEDEKEEISS PDMCPRPESP VFGASGQEEL
2860 2870 2880 2890 2900
AKRLAELELS REFLSALGDD QDWFDEDFGL SSSHKIQKNK AEETIVPLMA
2910 2920 2930 2940 2950
EPKRVTQQPC ETLLAVPHTA EEVEILVHNA AEELWKWKEL GHDLHSISIP
2960 2970 2980 2990 3000
TKLLGCASKG LDIESTSKRV YKQAVFDLTK EIFEEIFAED PNLNQPVWMK
3010 3020 3030 3040 3050
PCRINSSYFR RVKNPNNLDE IKSFIASEVL KLFSLKKEPN HKTDWQKMMK
3060 3070 3080 3090 3100
FGRKKRDRVD HILVQELHEE EAQWVNYDED ELCVKMQLAD GIFETLIKDT
3110
IDVLNQISEK QGRMLLV
Length:3,117
Mass (Da):350,930
Last modified:December 7, 2004 - v1
Checksum:iDD0E03EA96DA319E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25Missing in AAL91355 (PubMed:11891061).Curated1
Sequence conflicti114S → G in AAL55733 (Ref. 1) Curated1
Sequence conflicti459E → R in AAL55733 (Ref. 1) Curated1
Sequence conflicti2164S → P in AAL55733 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059202892R → T.Corresponds to variant rs6692219dbSNPEnsembl.1
Natural variantiVAR_026126945E → Q.1 PublicationCorresponds to variant rs2477120dbSNPEnsembl.1
Natural variantiVAR_0592031213G → V.Corresponds to variant rs12125245dbSNPEnsembl.1
Natural variantiVAR_0486711445T → A.Corresponds to variant rs16855164dbSNPEnsembl.1
Natural variantiVAR_0592041446T → A.Corresponds to variant rs16855164dbSNPEnsembl.1
Natural variantiVAR_0592051517S → A.Corresponds to variant rs12124336dbSNPEnsembl.1
Natural variantiVAR_0610922044T → P.Corresponds to variant rs56173179dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287356 mRNA. Translation: AAL55733.1.
AL645487, AL390718, AL590632 Genomic DNA. Translation: CAH72345.1.
AL590632, AL390718, AL645487 Genomic DNA. Translation: CAI15177.1.
AL390718, AL590632, AL645487 Genomic DNA. Translation: CAI14833.1.
AF387614 mRNA. Translation: AAL91355.1.
CCDSiCCDS1336.1.
PIRiT00263.
RefSeqiNP_055625.4. NM_014810.4.
UniGeneiHs.413045.

Genome annotation databases

EnsembliENST00000367607; ENSP00000356579; ENSG00000135837.
GeneIDi9857.
KEGGihsa:9857.
UCSCiuc001gnt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287356 mRNA. Translation: AAL55733.1.
AL645487, AL390718, AL590632 Genomic DNA. Translation: CAH72345.1.
AL590632, AL390718, AL645487 Genomic DNA. Translation: CAI15177.1.
AL390718, AL590632, AL645487 Genomic DNA. Translation: CAI14833.1.
AF387614 mRNA. Translation: AAL91355.1.
CCDSiCCDS1336.1.
PIRiT00263.
RefSeqiNP_055625.4. NM_014810.4.
UniGeneiHs.413045.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2COZNMR-A2473-2581[»]
ProteinModelPortaliQ5VT06.
SMRiQ5VT06.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115191. 63 interactors.
DIPiDIP-49946N.
IntActiQ5VT06. 47 interactors.
MINTiMINT-2867672.
STRINGi9606.ENSP00000356579.

PTM databases

iPTMnetiQ5VT06.
PhosphoSitePlusiQ5VT06.

Polymorphism and mutation databases

BioMutaiCEP350.
DMDMi74746869.

Proteomic databases

EPDiQ5VT06.
MaxQBiQ5VT06.
PaxDbiQ5VT06.
PeptideAtlasiQ5VT06.
PRIDEiQ5VT06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367607; ENSP00000356579; ENSG00000135837.
GeneIDi9857.
KEGGihsa:9857.
UCSCiuc001gnt.4. human.

Organism-specific databases

CTDi9857.
DisGeNETi9857.
GeneCardsiCEP350.
H-InvDBHIX0001384.
HGNCiHGNC:24238. CEP350.
HPAiHPA028355.
HPA028357.
HPA030845.
neXtProtiNX_Q5VT06.
OpenTargetsiENSG00000135837.
PharmGKBiPA143485434.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISTJ. Eukaryota.
ENOG410YQD7. LUCA.
GeneTreeiENSGT00760000119173.
HOGENOMiHOG000111528.
HOVERGENiHBG095435.
InParanoidiQ5VT06.
KOiK16768.
OMAiQWEHSEE.
OrthoDBiEOG091G0038.
PhylomeDBiQ5VT06.
TreeFamiTF329845.

Enzyme and pathway databases

SIGNORiQ5VT06.

Miscellaneous databases

ChiTaRSiCEP350. human.
EvolutionaryTraceiQ5VT06.
GeneWikiiCEP350.
GenomeRNAii9857.
PROiQ5VT06.

Gene expression databases

BgeeiENSG00000135837.
CleanExiHS_CEP350.
ExpressionAtlasiQ5VT06. baseline and differential.
GenevisibleiQ5VT06. HS.

Family and domain databases

Gene3Di2.30.30.190. 1 hit.
InterProiIPR000938. CAP-Gly_domain.
IPR028750. CEP350.
[Graphical view]
PANTHERiPTHR13958. PTHR13958. 1 hit.
PfamiPF01302. CAP_GLY. 1 hit.
[Graphical view]
SMARTiSM01052. CAP_GLY. 1 hit.
[Graphical view]
SUPFAMiSSF74924. SSF74924. 1 hit.
PROSITEiPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCE350_HUMAN
AccessioniPrimary (citable) accession number: Q5VT06
Secondary accession number(s): O75068, Q8TDK3, Q8WY20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 7, 2004
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.