Q5VT06 (CE350_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Centrosome-associated protein 350
Short name=Cep350

Alternative name(s):
Centrosome-associated protein of 350 kDa

Gene names

Name:	CEP350
Synonyms:	CAP350, KIAA0480
ORF Names:	GM133

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	3117 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Ref.5 Ref.7 Ref.8 Ref.9 Ref.10
Subunit structure	Part of a ternary complex composed of SASS6, CENPJ and CEP350. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with FGFR1OP via its C-terminus. Interacts with NR1H3, PPARA, PPARD and PPARG. Interacts directly with microtubules. Interacts with the fusion protein FGFR1OP-FGFR1, and by doing so recruits and activates PI3K and PLC-gamma. Ref.5 Ref.7 Ref.8 Ref.9 Ref.10
Subcellular location	Cytoplasm › cytoskeleton › centrosome. Cytoplasm › cytoskeleton › spindle. Nucleus. Note: Associated with mitotic spindles. Nuclear, in discrete foci. Associated with intermediate filaments. Also present in the pericentrosomal area. Ref.4 Ref.5 Ref.7 Ref.8 Ref.10
Tissue specificity	Detected in heart, brain, skeletal muscle, testis, placenta, lung, liver, kidney and pancreas. Ref.3 Ref.5
Post-translational modification	Phosphorylated during mitosis. Ref.7
Sequence similarities	Contains 1 CAP-Gly domain.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Nucleus
Coding sequence diversity	Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	centrosome Inferred from direct assay PubMed 21399614. Source: UniProtKB cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA spindle Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 3117

3117

Centrosome-associated protein 350

PRO_0000233291

Regions

Domain

2517 – 2559

43

CAP-Gly

Coiled coil

598 – 645

48

Potential

Coiled coil

1369 – 1411

43

Potential

Coiled coil

1707 – 1800

94

Potential

Coiled coil

1856 – 1899

44

Potential

Coiled coil

2051 – 2110

60

Potential

Coiled coil

2719 – 2752

34

Potential

Compositional bias

1112 – 1281

170

Ser-rich

Compositional bias

1502 – 1556

55

Ser-rich

Amino acid modifications

Modified residue

878

1

Phosphothreonine Ref.11

Modified residue

1061

1

Phosphoserine Ref.12

Modified residue

1253

1

Phosphothreonine Ref.11

Modified residue

1256

1

Phosphoserine Ref.11

Modified residue

1259

1

Phosphoserine Ref.11

Modified residue

2204

1

Phosphothreonine Ref.11

Modified residue

2206

1

Phosphoserine Ref.11

Modified residue

2460

1

Phosphoserine Ref.11

Modified residue

2839

1

Phosphoserine Ref.6

Natural variations

Natural variant

892

1

R → T.
Corresponds to variant rs6692219 [ dbSNP | Ensembl ].

VAR_059202

Natural variant

945

1

E → Q. Ref.1
Corresponds to variant rs2477120 [ dbSNP | Ensembl ].

VAR_026126

Natural variant

1213

1

G → V.
Corresponds to variant rs12125245 [ dbSNP | Ensembl ].

VAR_059203

Natural variant

1445

1

T → A.
Corresponds to variant rs16855164 [ dbSNP | Ensembl ].

VAR_048671

Natural variant

1446

1

T → A.
Corresponds to variant rs16855164 [ dbSNP | Ensembl ].

VAR_059204

Natural variant

1517

1

S → A.
Corresponds to variant rs12124336 [ dbSNP | Ensembl ].

VAR_059205

Natural variant

2044

1

T → P.
Corresponds to variant rs56173179 [ dbSNP | Ensembl ].

VAR_061092

Experimental info

Mutagenesis

762 – 763

2

LL → AA: Abolishes recruitment of PPARA to specific nuclear foci. No effect on interaction with PPARA (in vitro). Ref.5

Sequence conflict

25

1

Missing in AAL91355. Ref.3

Sequence conflict

114

1

S → G in AAL55733. Ref.1

Sequence conflict

459

1

E → R in AAL55733. Ref.1

Sequence conflict

2164

1

S → P in AAL55733. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

3117

Helix Strand Turn

Details...

Beta strand

2483 – 2486

4

Beta strand

2501 – 2505

5

Turn

2506 – 2508

3

Beta strand

2509 – 2518

10

Beta strand

2520 – 2533

14

Beta strand

2536 – 2538

3

Beta strand

2540 – 2542

3

Beta strand

2555 – 2558

4

Helix

2560 – 2562

3

Sequences

	Sequence		Length	Mass (Da)
	Q5VT06 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: DD0E03EA96DA319E	FASTA	3,117	350,930
	10 20 30 40 50 60 MRSSKSKEVP LPNPRNSQSK DTVQADITTS WDALSQTKAA LRHIENKLEV APTSTAVCDS 70 80 90 100 110 120 VMDTKKSSTS ATRKISRKDG RYLDDSWVNA PISKSTKSRK EKSRSPLRAT TLESNVKKNN 130 140 150 160 170 180 RVEFREPLVS YREIHGAPSN FSSSHLESKH VYCVDVNEEK TESGNWMIGS REERNIRSCD 190 200 210 220 230 240 FESSQSSVIN DTVVRFLNDR PAIDALQNSE CLIRMGASMR TEEEMPNRTK GSENNLKLSV 250 260 270 280 290 300 NNMAHDTDPK ALRLTDSSPS STSTSNSQRL DILKRRQHDV KLEKLKERIR KQWEHSEETN 310 320 330 340 350 360 GRGQKLGHID HPVMVVNVDN SVTAKVRKVA TAPPAPAYKG FNPSETKIRT PDGKVWQEAE 370 380 390 400 410 420 FQNMSRELYR DLALHFADDI SIKEKPAEKS KEKKVVKPVR KVQKVAQLSS TECRTGSSHL 430 440 450 460 470 480 ISTSSWRDGQ KLVKKILGPA PRMEPKEQRT ASSDRGGRER TAKSGGHIGR AESDPRLDVL 490 500 510 520 530 540 HRHLQRNSER SRSKSRSENN IKKLASSLPD NKQEENTALN KDFLPIEIRG ILDDLQLDST 550 560 570 580 590 600 AHTAKQDTVE LQNQKSSAPV HAPRSHSPVK RKPDKITANE DPPVISKRRH YDTDEVRQYI 610 620 630 640 650 660 VRQQEERKRK QNEEKKAQKE ATEQKNKRLQ ELYRKQKEAF TKVKNVPPSE PSATRRLQET 670 680 690 700 710 720 YSKLLLEKTL LEEPSHQHVT QETQAKPGYQ PSGESDKENK VQERPPSASS SSDMSLSEPP 730 740 750 760 770 780 QPLARKDLME STWMQPERLS PQVHHSQPQP FAGTAGSLLS HLLSLEHVGI LHKDFESILP 790 800 810 820 830 840 TRKNHNMASR PLTFTPQPYV TSPAAYTDAL LKPSASQYKS KLDRIEALKA TAASLSSRIE 850 860 870 880 890 900 SEAKKLAGAS INYGSAWNTE YDVQQAPQED GPWTKAVTPP VKDDNEDVFS ARIQKMLGSC 910 920 930 940 950 960 VSHATFDDDL PGVGNLSEFK KLPEMIRPQS AISSFRVRSP GPKPEGLLAQ LCKRQTDSSS 970 980 990 1000 1010 1020 SDMQACSQDK AKISLGSSID SVSEGPLLSE GSLSEEEGDQ DGQPLLKVAE ILKEKEFCPG 1030 1040 1050 1060 1070 1080 ERNSYEPIKE FQKEAEKFLP LFGHIGGTQS KGPWEELAKG SPHSVINIFT KSYQLYGKGF 1090 1100 1110 1120 1130 1140 EDKLDRGTST SRPLNATATP LSGVSYEDDF VSSPGTGTST EKKSTLEPHS TLSPQEDHSN 1150 1160 1170 1180 1190 1200 RKSAYDPSSV DVTSQHSSGA QSAASSRSST SSKGKKGKKE KTEWLDSFTG NVQNSLLDEE 1210 1220 1230 1240 1250 1260 KAERGSHQGK KSGTSSKLSV KDFEQTLDTD STLEDLSGHS VSVSSDKGRS QKTPTSPLSP 1270 1280 1290 1300 1310 1320 SSQKSLQFDV AGTSSERSKS SVMPPTITGF KPNAPLTDLN PAASRTTTEN MAPIPGSKRF 1330 1340 1350 1360 1370 1380 SPAGLHHRMA AELSYLNAIE ESVRQLSDVE RVRGISLAQQ ESVSLAQIIK AQQQRHERDL 1390 1400 1410 1420 1430 1440 ALLKLKAEQE ALESQRQLEE TRNKAAQVHA ESLQQVVQSQ REVTEVLQEA TCKIAAQQSE 1450 1460 1470 1480 1490 1500 TARLTTDAAR QICEMAELTR THISDAVVAS GAPLAILYDH QRQHLPDFVK QLRTRTETDR 1510 1520 1530 1540 1550 1560 KSPSVSLSQS KEGTLDSKHQ KYSASYDSYS ESSGYKNHDR RSSSGSSRQE SPSVPSCKEN 1570 1580 1590 1600 1610 1620 EKKLNGEKIE SSIDEQVQTA ADDSLRSDSV PSLPDEKDST SIATEYSLKF DESMTEDEIE 1630 1640 1650 1660 1670 1680 EQSFRSLLPS ESHRRFNMEK RRGHHDDSDE EASPEKTTLS TAKELNMPFS GGQDSFSKFT 1690 1700 1710 1720 1730 1740 MEMVRQYMKE EEMRAAHQSS LLRLREKALK EKTKAELAWL EHQKKHLRDK GEDDKMPPLR 1750 1760 1770 1780 1790 1800 KKQRGLLLRL QQEKAEIKRL QEANKAARKE RQLILKQQEE IEKIRQTTIK LQEKLKSAGE 1810 1820 1830 1840 1850 1860 SKLDSHSDDD TKDNKATSPG PTDLETRSPS PISISSSETS SIMQKLKKMR SRMDEKFLTK 1870 1880 1890 1900 1910 1920 REQKLMQRRQ HAEELLEWKR RLDAEEAEIR QMEKQALAAW DKELIKPKTP KKELEDQRTE 1930 1940 1950 1960 1970 1980 QKEIASEEES PVPLYSHLNS ESSIPEELGS PAVEYVPSES IGQEQPGSPD HSILTEEMIC 1990 2000 2010 2020 2030 2040 SQELESSTSP SKHSLPKSCT SVSKQESSKG SHRTGGQCHL PIKSHQHCYS WSDESLSMTQ 2050 2060 2070 2080 2090 2100 SETTSDQSDI EGRIRALKDE LRKRKSVVNQ LKKEQKKRQK ERLKAQEASL IKQLESYDEF 2110 2120 2130 2140 2150 2160 IKKTEAELSQ DLETSPTAKP QIKTLSSASE KPKIKPLTPL HRSETAKNWK SLTESERSRG 2170 2180 2190 2200 2210 2220 SLESIAEHVD ASLSGSERSV SERSLSAYAK RVNEWDSRTE DFQTPSPVLR SSRKIREESG 2230 2240 2250 2260 2270 2280 DSLENVPALH LLKELNATSR ILDMSDGKVG ESSKKSEIKE IEYTKLKKSK IEDAFSKEGK 2290 2300 2310 2320 2330 2340 SDVLLKLVLE QGDSSEILSK KDLPLDSENV QKDLVGLAIE NLHKSEEMLK ERQSDQDMNH 2350 2360 2370 2380 2390 2400 SPNIQSGKDI HEQKNTKEKD LSWSEHLFAP KEIPYSEDFE VSSFKKEISA ELYKDDFEVS 2410 2420 2430 2440 2450 2460 SLLSLRKDSQ SCRDKPQPMR SSTSGATSFG SNEEISECLS EKSLSIHSNV HSDRLLELKS 2470 2480 2490 2500 2510 2520 PTELMKSKER SDVEHEQQVT ESPSLASVPT ADELFDFHIG DRVLIGNVQP GILRFKGETS 2530 2540 2550 2560 2570 2580 FAKGFWAGVE LDKPEGNNNG TYDGIAYFEC KEKHGIFAPP QKISHIPENF DDYVDINEDE 2590 2600 2610 2620 2630 2640 DCYSDERYQC YNQEQNDTEG PKDREKDVSE YFYEKSLPSV NDIEASVNRS RSLKIETDNV 2650 2660 2670 2680 2690 2700 QDISGVLEAH VHQQSSVDSQ ISSKENKDLI SDATEKVSIA AEDDTLDNTF SEELEKQQQF 2710 2720 2730 2740 2750 2760 TEEEDNLYAE ASEKLCTPLL DLLTREKNQL EAQLKSSLNE EKKSKQQLEK ISLLTDSLLK 2770 2780 2790 2800 2810 2820 VFVKDTVNQL QQIKKTRDEK IQLSNQELLG DDQKKVTPQD LSQNVEEQSP SISGCFLSSE 2830 2840 2850 2860 2870 2880 LEDEKEEISS PDMCPRPESP VFGASGQEEL AKRLAELELS REFLSALGDD QDWFDEDFGL 2890 2900 2910 2920 2930 2940 SSSHKIQKNK AEETIVPLMA EPKRVTQQPC ETLLAVPHTA EEVEILVHNA AEELWKWKEL 2950 2960 2970 2980 2990 3000 GHDLHSISIP TKLLGCASKG LDIESTSKRV YKQAVFDLTK EIFEEIFAED PNLNQPVWMK 3010 3020 3030 3040 3050 3060 PCRINSSYFR RVKNPNNLDE IKSFIASEVL KLFSLKKEPN HKTDWQKMMK FGRKKRDRVD 3070 3080 3090 3100 3110 HILVQELHEE EAQWVNYDED ELCVKMQLAD GIFETLIKDT IDVLNQISEK QGRMLLV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a cDNA encoding a protein of 350 kDa (CAP350) associated with centrosomes." Klein-Hitpass L., Esser F., Michels D., Schwerk C., Vassen L. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLN-945.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Identification of six novel genes by experimental validation of GeneMachine predicted genes." Makalowska I., Sood R., Faruque M.U., Hu P., Robbins C.M., Eddings E.M., Mestre J.D., Baxevanis A.D., Carpten J.D. Gene 284:203-213(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-131, IDENTIFICATION, TISSUE SPECIFICITY.
[4]	"Proteomic characterization of the human centrosome by protein correlation profiling." Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M. Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract] Cited for: MASS SPECTROMETRY, SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. Tissue: Lymphoblast.
[5]	"Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350." Patel H., Truant R., Rachubinski R.A., Capone J.P. J. Cell Sci. 118:175-186(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF 762-LEU-LEU-763, INTERACTION WITH NR1H3; PPARA; PPARD AND PPARG.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2839, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring." Yan X., Habedanck R., Nigg E.A. Mol. Biol. Cell 17:634-644(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, INTERACTION WITH FGFR1OP.
[8]	"Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex." Hoppeler-Lebel A., Celati C., Bellett G., Mogensen M.M., Klein-Hitpass L., Bornens M., Tassin A.-M. J. Cell Sci. 120:3299-3308(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MICROTUBULE.
[9]	"Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cgamma at the centrosome." Lelievre H., Chevrier V., Tassin A.-M., Birnbaum D. Mol. Cancer 7:30-30(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH FGFR1OP-FGFR1 FUSION PROTEIN.
[10]	"Role of CAP350 in centriolar tubule stability and centriole assembly." Le Clech M. PLoS ONE 3:E3855-E3855(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH SASS6 AND CENPJ.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-878; THR-1253; SER-1256; SER-1259; THR-2204; SER-2206 AND SER-2460, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1061, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"Solution structure of the CAP-Gly domain in human centrosome-associated protein Cap350." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 2473-2581.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF287356 mRNA. Translation: AAL55733.1.
AL645487, AL390718, AL590632 Genomic DNA. Translation: CAH72345.1.
AL590632, AL390718, AL645487 Genomic DNA. Translation: CAI15177.1.
AL390718, AL590632, AL645487 Genomic DNA. Translation: CAI14833.1.
AF387614 mRNA. Translation: AAL91355.1.

IPI

IPI00103595.

PIR

T00263.

RefSeq

NP_055625.4. NM_014810.4.

UniGene

Hs.413045.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2COZ	NMR	-	A	2473-2581	[»]

ProteinModelPortal

Q5VT06.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q5VT06. 3 interactions.

MINT

MINT-2867672.

STRING

9606.ENSP00000356579.

PTM databases

PhosphoSite

Q5VT06.

Polymorphism databases

DMDM

74746869.

Proteomic databases

PaxDb

Q5VT06.

PRIDE

Q5VT06.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000367607; ENSP00000356579; ENSG00000135837.

GeneID

9857.

KEGG

hsa:9857.

UCSC

uc001gnt.3. human.

Organism-specific databases

CTD

9857.

GeneCards

GC01P179923.

H-InvDB

HIX0001384.

HGNC

HGNC:24238. CEP350.

HPA

HPA028355.
HPA028357.

neXtProt

NX_Q5VT06.

PharmGKB

PA143485434.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5244.

HOGENOM

HOG000111528.

HOVERGEN

HBG095435.

InParanoid

Q5VT06.

KO

K16768.

OMA

WDALSQT.

OrthoDB

EOG4M0F0T.

PhylomeDB

Q5VT06.

Gene expression databases

ArrayExpress

Q5VT06.

Bgee

Q5VT06.

CleanEx

HS_CEP350.

Genevestigator

Q5VT06.

GermOnline

ENSG00000135837. Homo sapiens.

Family and domain databases

Gene3D

2.30.30.190. 1 hit.

InterPro

IPR000938. CAP-Gly_domain.
[Graphical view]

Pfam

PF01302. CAP_GLY. 1 hit.
[Graphical view]

SMART

SM01052. CAP_GLY. 1 hit.
[Graphical view]

SUPFAM

SSF74924. CAP-Gly_domain. 1 hit.

PROSITE

PS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

CEP350. human.

EvolutionaryTrace

Q5VT06.

GenomeRNAi

9857.

NextBio

37150.

Entry information

Entry name

CE350_HUMAN

Accession

Primary (citable) accession number: Q5VT06
Secondary accession number(s): O75068, Q8TDK3, Q8WY20

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.