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Protein

G kinase-anchoring protein 1

Gene

GKAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Enzyme and pathway databases

SIGNORiQ5VSY0

Names & Taxonomyi

Protein namesi
Recommended name:
G kinase-anchoring protein 1
Alternative name(s):
cGMP-dependent protein kinase-anchoring protein of 42 kDa
Gene namesi
Name:GKAP1
Synonyms:GKAP42
ORF Names:FKSG21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000165113.12
HGNCiHGNC:17496 GKAP1
MIMi611356 gene
neXtProtiNX_Q5VSY0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165113
PharmGKBiPA134880503

Polymorphism and mutation databases

BioMutaiGKAP1
DMDMi166224631

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003156541 – 366G kinase-anchoring protein 1Add BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphoserineBy similarity1
Modified residuei25PhosphoserineBy similarity1
Modified residuei27PhosphoserineCombined sources1
Modified residuei106Phosphoserine; by PKGBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5VSY0
MaxQBiQ5VSY0
PaxDbiQ5VSY0
PeptideAtlasiQ5VSY0
PRIDEiQ5VSY0
ProteomicsDBi65286
65287 [Q5VSY0-2]

PTM databases

iPTMnetiQ5VSY0
PhosphoSitePlusiQ5VSY0

Expressioni

Gene expression databases

BgeeiENSG00000165113
CleanExiHS_GKAP1
ExpressionAtlasiQ5VSY0 baseline and differential
GenevisibleiQ5VSY0 HS

Organism-specific databases

HPAiHPA035117
HPA035118
HPA066173

Interactioni

Subunit structurei

Interacts with PRKG1.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi123231, 27 interactors
DIPiDIP-47324N
IntActiQ5VSY0, 28 interactors
STRINGi9606.ENSP00000365550

Structurei

3D structure databases

ProteinModelPortaliQ5VSY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili47 – 77Sequence analysisAdd BLAST31
Coiled coili128 – 160Sequence analysisAdd BLAST33
Coiled coili243 – 353Sequence analysisAdd BLAST111

Sequence similaritiesi

Belongs to the GKAP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF7C Eukaryota
ENOG410YKPT LUCA
GeneTreeiENSGT00390000008742
HOGENOMiHOG000088604
HOVERGENiHBG107948
InParanoidiQ5VSY0
OMAiQGEMKDK
OrthoDBiEOG091G0IVX
PhylomeDBiQ5VSY0
TreeFamiTF328459

Family and domain databases

InterProiView protein in InterPro
IPR026109 GKAP1
PANTHERiPTHR14899 PTHR14899, 1 hit
PRINTSiPR02083 GKINASEAP1

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VSY0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASAVLSSVP TTASRFALLQ VDSGSGSDSE PGKGKGRNTG KSQTLGSKST
60 70 80 90 100
TNEKKREKRR KKKEQQQSEA NELRNLAFKK IPQKSSHAVC NAQHDLPLSN
110 120 130 140 150
PVQKDSREEN WQEWRQRDEQ LTSEMFEADL EKALLLSKLE YEEHKKEYED
160 170 180 190 200
AENTSTQSKV MNKKDKRKNH QGKDRPLTVS LKDFHSEDHI SKKTEELSSS
210 220 230 240 250
QTLSHDGGFF NRLEDDVHKI LIREKRREQL TEYNGTDNCT AHEHNQEVVL
260 270 280 290 300
KDGRIERLKL ELERKDAEIQ KLKNVITQWE AKYKEVKARN AQLLKMLQEG
310 320 330 340 350
EMKDKAEILL QVDESQSIKN ELTIQVTSLH AALEQERSKV KVLQAELAKY
360
QGGRKGKRNS ESDQCR
Length:366
Mass (Da):42,078
Last modified:January 15, 2008 - v2
Checksum:i973D16361756691B
GO
Isoform 2 (identifier: Q5VSY0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     196-246: Missing.

Show »
Length:315
Mass (Da):36,126
Checksum:i90AEB71AF18F1CEE
GO

Sequence cautioni

The sequence BAB71712 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAH70734 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI16011 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAW62665 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti325Q → R in AAG40320 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030596196 – 246Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033131 mRNA Translation: BAB40454.1
AB033132 mRNA Translation: BAB40455.1
AF319476 mRNA Translation: AAG40320.1
AL662787, AL354733 Genomic DNA Translation: CAH70734.1 Sequence problems.
AL662787, AL354733 Genomic DNA Translation: CAH70735.1
AL354733, AL662787 Genomic DNA Translation: CAI16010.1
AL354733, AL662787 Genomic DNA Translation: CAI16011.1 Sequence problems.
CH471089 Genomic DNA Translation: EAW62665.1 Sequence problems.
CH471089 Genomic DNA Translation: EAW62666.1
BC014476 mRNA Translation: AAH14476.1
AK058198 mRNA Translation: BAB71712.1 Different initiation.
CCDSiCCDS35049.1 [Q5VSY0-1]
CCDS47988.1 [Q5VSY0-2]
RefSeqiNP_001129425.1, NM_001135953.1 [Q5VSY0-2]
NP_079487.2, NM_025211.3 [Q5VSY0-1]
XP_005252298.1, XM_005252241.2 [Q5VSY0-1]
XP_011517360.1, XM_011519058.2 [Q5VSY0-1]
UniGeneiHs.522255

Genome annotation databases

EnsembliENST00000376365; ENSP00000365544; ENSG00000165113 [Q5VSY0-2]
ENST00000376371; ENSP00000365550; ENSG00000165113 [Q5VSY0-1]
GeneIDi80318
KEGGihsa:80318
UCSCiuc004amy.4 human [Q5VSY0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGKAP1_HUMAN
AccessioniPrimary (citable) accession number: Q5VSY0
Secondary accession number(s): Q96LI0
, Q9BYI1, Q9BYI2, Q9H225
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 20, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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