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Q5VSY0 (GKAP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G kinase-anchoring protein 1
Alternative name(s):
cGMP-dependent protein kinase-anchoring protein of 42 kDa
Gene names
Name:GKAP1
Synonyms:GKAP42
ORF Names:FKSG21
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with PRKG1 By similarity.

Subcellular location

Golgi apparatus By similarity.

Sequence similarities

Belongs to the GKAP1 family.

Sequence caution

The sequence BAB71712.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAH70734.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI16011.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence EAW62665.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentGolgi apparatus
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsignal transduction

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentGolgi apparatus

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5VSY0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5VSY0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     196-246: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366G kinase-anchoring protein 1
PRO_0000315654

Regions

Coiled coil47 – 7731 Potential
Coiled coil128 – 16033 Potential
Coiled coil243 – 353111 Potential

Amino acid modifications

Modified residue271Phosphoserine Ref.8 Ref.9
Modified residue1061Phosphoserine; by PKG By similarity

Natural variations

Alternative sequence196 – 24651Missing in isoform 2.
VSP_030596

Experimental info

Sequence conflict3251Q → R in AAG40320. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: 973D16361756691B

FASTA36642,078
        10         20         30         40         50         60 
MASAVLSSVP TTASRFALLQ VDSGSGSDSE PGKGKGRNTG KSQTLGSKST TNEKKREKRR 

        70         80         90        100        110        120 
KKKEQQQSEA NELRNLAFKK IPQKSSHAVC NAQHDLPLSN PVQKDSREEN WQEWRQRDEQ 

       130        140        150        160        170        180 
LTSEMFEADL EKALLLSKLE YEEHKKEYED AENTSTQSKV MNKKDKRKNH QGKDRPLTVS 

       190        200        210        220        230        240 
LKDFHSEDHI SKKTEELSSS QTLSHDGGFF NRLEDDVHKI LIREKRREQL TEYNGTDNCT 

       250        260        270        280        290        300 
AHEHNQEVVL KDGRIERLKL ELERKDAEIQ KLKNVITQWE AKYKEVKARN AQLLKMLQEG 

       310        320        330        340        350        360 
EMKDKAEILL QVDESQSIKN ELTIQVTSLH AALEQERSKV KVLQAELAKY QGGRKGKRNS 


ESDQCR 

« Hide

Isoform 2 [UniParc].

Checksum: 90AEB71AF18F1CEE
Show »

FASTA31536,126

References

« Hide 'large scale' references
[1]"Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha."
Yuasa K., Omori K., Yanaka N.
J. Biol. Chem. 275:4897-4905(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]"Cloning of FKSG21, a novel gene located on human chromosome 9."
Wang Y.-G., Gong L.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Skin.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 145-366 (ISOFORM 1).
Tissue: Testis.
[7]"Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia."
Sweetser D.A., Peniket A.J., Haaland C., Blomberg A.A., Zhang Y., Zaidi S.T., Dayyani F., Zhao Z., Heerema N.A., Boultwood J., Dewald G.W., Paietta E., Slovak M.L., Willman C.L., Wainscoat J.S., Bernstein I.D., Daly S.B.
Genes Chromosomes Cancer 44:279-291(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB033131 mRNA. Translation: BAB40454.1.
AB033132 mRNA. Translation: BAB40455.1.
AF319476 mRNA. Translation: AAG40320.1.
AL662787, AL354733 Genomic DNA. Translation: CAH70734.1. Sequence problems.
AL662787, AL354733 Genomic DNA. Translation: CAH70735.1.
AL354733, AL662787 Genomic DNA. Translation: CAI16010.1.
AL354733, AL662787 Genomic DNA. Translation: CAI16011.1. Sequence problems.
CH471089 Genomic DNA. Translation: EAW62665.1. Sequence problems.
CH471089 Genomic DNA. Translation: EAW62666.1.
BC014476 mRNA. Translation: AAH14476.1.
AK058198 mRNA. Translation: BAB71712.1. Different initiation.
CCDSCCDS35049.1. [Q5VSY0-1]
CCDS47988.1. [Q5VSY0-2]
RefSeqNP_001129425.1. NM_001135953.1. [Q5VSY0-2]
NP_079487.2. NM_025211.3. [Q5VSY0-1]
XP_005252298.1. XM_005252241.1. [Q5VSY0-1]
UniGeneHs.522255.

3D structure databases

ProteinModelPortalQ5VSY0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123231. 7 interactions.
DIPDIP-47324N.
IntActQ5VSY0. 7 interactions.
MINTMINT-1455843.
STRING9606.ENSP00000365550.

PTM databases

PhosphoSiteQ5VSY0.

Polymorphism databases

DMDM166224631.

Proteomic databases

MaxQBQ5VSY0.
PaxDbQ5VSY0.
PRIDEQ5VSY0.

Protocols and materials databases

DNASU80318.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376365; ENSP00000365544; ENSG00000165113. [Q5VSY0-2]
ENST00000376371; ENSP00000365550; ENSG00000165113. [Q5VSY0-1]
GeneID80318.
KEGGhsa:80318.
UCSCuc004amy.3. human. [Q5VSY0-1]
uc004amz.3. human. [Q5VSY0-2]

Organism-specific databases

CTD80318.
GeneCardsGC09M086354.
HGNCHGNC:17496. GKAP1.
HPAHPA035117.
HPA035118.
MIM611356. gene.
neXtProtNX_Q5VSY0.
PharmGKBPA134880503.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39546.
HOGENOMHOG000088604.
HOVERGENHBG107948.
OMAPNPVQKD.
OrthoDBEOG7GJ6D6.
PhylomeDBQ5VSY0.
TreeFamTF328459.

Gene expression databases

ArrayExpressQ5VSY0.
BgeeQ5VSY0.
CleanExHS_GKAP1.
GenevestigatorQ5VSY0.

Family and domain databases

InterProIPR026109. GKAP1.
[Graphical view]
PANTHERPTHR14899. PTHR14899. 1 hit.
PRINTSPR02083. GKINASEAP1.
ProtoNetSearch...

Other

ChiTaRSGKAP1. human.
GenomeRNAi80318.
NextBio70827.
PROQ5VSY0.
SOURCESearch...

Entry information

Entry nameGKAP1_HUMAN
AccessionPrimary (citable) accession number: Q5VSY0
Secondary accession number(s): Q96LI0 expand/collapse secondary AC list , Q9BYI1, Q9BYI2, Q9H225
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 9, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM