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Q5VSY0

- GKAP1_HUMAN

UniProt

Q5VSY0 - GKAP1_HUMAN

Protein

G kinase-anchoring protein 1

Gene

GKAP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. signal transduction Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G kinase-anchoring protein 1
    Alternative name(s):
    cGMP-dependent protein kinase-anchoring protein of 42 kDa
    Gene namesi
    Name:GKAP1
    Synonyms:GKAP42
    ORF Names:FKSG21
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:17496. GKAP1.

    Subcellular locationi

    Golgi apparatus By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB

    Keywords - Cellular componenti

    Golgi apparatus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134880503.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 366366G kinase-anchoring protein 1PRO_0000315654Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei27 – 271Phosphoserine2 Publications
    Modified residuei106 – 1061Phosphoserine; by PKGBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ5VSY0.
    PaxDbiQ5VSY0.
    PRIDEiQ5VSY0.

    PTM databases

    PhosphoSiteiQ5VSY0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5VSY0.
    BgeeiQ5VSY0.
    CleanExiHS_GKAP1.
    GenevestigatoriQ5VSY0.

    Organism-specific databases

    HPAiHPA035117.
    HPA035118.

    Interactioni

    Subunit structurei

    Interacts with PRKG1.By similarity

    Protein-protein interaction databases

    BioGridi123231. 8 interactions.
    DIPiDIP-47324N.
    IntActiQ5VSY0. 8 interactions.
    MINTiMINT-1455843.
    STRINGi9606.ENSP00000365550.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VSY0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili47 – 7731Sequence AnalysisAdd
    BLAST
    Coiled coili128 – 16033Sequence AnalysisAdd
    BLAST
    Coiled coili243 – 353111Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GKAP1 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG39546.
    HOGENOMiHOG000088604.
    HOVERGENiHBG107948.
    OMAiPNPVQKD.
    OrthoDBiEOG7GJ6D6.
    PhylomeDBiQ5VSY0.
    TreeFamiTF328459.

    Family and domain databases

    InterProiIPR026109. GKAP1.
    [Graphical view]
    PANTHERiPTHR14899. PTHR14899. 1 hit.
    PRINTSiPR02083. GKINASEAP1.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5VSY0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASAVLSSVP TTASRFALLQ VDSGSGSDSE PGKGKGRNTG KSQTLGSKST    50
    TNEKKREKRR KKKEQQQSEA NELRNLAFKK IPQKSSHAVC NAQHDLPLSN 100
    PVQKDSREEN WQEWRQRDEQ LTSEMFEADL EKALLLSKLE YEEHKKEYED 150
    AENTSTQSKV MNKKDKRKNH QGKDRPLTVS LKDFHSEDHI SKKTEELSSS 200
    QTLSHDGGFF NRLEDDVHKI LIREKRREQL TEYNGTDNCT AHEHNQEVVL 250
    KDGRIERLKL ELERKDAEIQ KLKNVITQWE AKYKEVKARN AQLLKMLQEG 300
    EMKDKAEILL QVDESQSIKN ELTIQVTSLH AALEQERSKV KVLQAELAKY 350
    QGGRKGKRNS ESDQCR 366
    Length:366
    Mass (Da):42,078
    Last modified:January 15, 2008 - v2
    Checksum:i973D16361756691B
    GO
    Isoform 2 (identifier: Q5VSY0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         196-246: Missing.

    Show »
    Length:315
    Mass (Da):36,126
    Checksum:i90AEB71AF18F1CEE
    GO

    Sequence cautioni

    The sequence BAB71712.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAH70734.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI16011.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence EAW62665.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti325 – 3251Q → R in AAG40320. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei196 – 24651Missing in isoform 2. 1 PublicationVSP_030596Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033131 mRNA. Translation: BAB40454.1.
    AB033132 mRNA. Translation: BAB40455.1.
    AF319476 mRNA. Translation: AAG40320.1.
    AL662787, AL354733 Genomic DNA. Translation: CAH70734.1. Sequence problems.
    AL662787, AL354733 Genomic DNA. Translation: CAH70735.1.
    AL354733, AL662787 Genomic DNA. Translation: CAI16010.1.
    AL354733, AL662787 Genomic DNA. Translation: CAI16011.1. Sequence problems.
    CH471089 Genomic DNA. Translation: EAW62665.1. Sequence problems.
    CH471089 Genomic DNA. Translation: EAW62666.1.
    BC014476 mRNA. Translation: AAH14476.1.
    AK058198 mRNA. Translation: BAB71712.1. Different initiation.
    CCDSiCCDS35049.1. [Q5VSY0-1]
    CCDS47988.1. [Q5VSY0-2]
    RefSeqiNP_001129425.1. NM_001135953.1. [Q5VSY0-2]
    NP_079487.2. NM_025211.3. [Q5VSY0-1]
    XP_005252298.1. XM_005252241.1. [Q5VSY0-1]
    UniGeneiHs.522255.

    Genome annotation databases

    EnsembliENST00000376365; ENSP00000365544; ENSG00000165113. [Q5VSY0-2]
    ENST00000376371; ENSP00000365550; ENSG00000165113. [Q5VSY0-1]
    GeneIDi80318.
    KEGGihsa:80318.
    UCSCiuc004amy.3. human. [Q5VSY0-1]
    uc004amz.3. human. [Q5VSY0-2]

    Polymorphism databases

    DMDMi166224631.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033131 mRNA. Translation: BAB40454.1 .
    AB033132 mRNA. Translation: BAB40455.1 .
    AF319476 mRNA. Translation: AAG40320.1 .
    AL662787 , AL354733 Genomic DNA. Translation: CAH70734.1 . Sequence problems.
    AL662787 , AL354733 Genomic DNA. Translation: CAH70735.1 .
    AL354733 , AL662787 Genomic DNA. Translation: CAI16010.1 .
    AL354733 , AL662787 Genomic DNA. Translation: CAI16011.1 . Sequence problems.
    CH471089 Genomic DNA. Translation: EAW62665.1 . Sequence problems.
    CH471089 Genomic DNA. Translation: EAW62666.1 .
    BC014476 mRNA. Translation: AAH14476.1 .
    AK058198 mRNA. Translation: BAB71712.1 . Different initiation.
    CCDSi CCDS35049.1. [Q5VSY0-1 ]
    CCDS47988.1. [Q5VSY0-2 ]
    RefSeqi NP_001129425.1. NM_001135953.1. [Q5VSY0-2 ]
    NP_079487.2. NM_025211.3. [Q5VSY0-1 ]
    XP_005252298.1. XM_005252241.1. [Q5VSY0-1 ]
    UniGenei Hs.522255.

    3D structure databases

    ProteinModelPortali Q5VSY0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123231. 8 interactions.
    DIPi DIP-47324N.
    IntActi Q5VSY0. 8 interactions.
    MINTi MINT-1455843.
    STRINGi 9606.ENSP00000365550.

    PTM databases

    PhosphoSitei Q5VSY0.

    Polymorphism databases

    DMDMi 166224631.

    Proteomic databases

    MaxQBi Q5VSY0.
    PaxDbi Q5VSY0.
    PRIDEi Q5VSY0.

    Protocols and materials databases

    DNASUi 80318.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376365 ; ENSP00000365544 ; ENSG00000165113 . [Q5VSY0-2 ]
    ENST00000376371 ; ENSP00000365550 ; ENSG00000165113 . [Q5VSY0-1 ]
    GeneIDi 80318.
    KEGGi hsa:80318.
    UCSCi uc004amy.3. human. [Q5VSY0-1 ]
    uc004amz.3. human. [Q5VSY0-2 ]

    Organism-specific databases

    CTDi 80318.
    GeneCardsi GC09M086354.
    HGNCi HGNC:17496. GKAP1.
    HPAi HPA035117.
    HPA035118.
    MIMi 611356. gene.
    neXtProti NX_Q5VSY0.
    PharmGKBi PA134880503.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39546.
    HOGENOMi HOG000088604.
    HOVERGENi HBG107948.
    OMAi PNPVQKD.
    OrthoDBi EOG7GJ6D6.
    PhylomeDBi Q5VSY0.
    TreeFami TF328459.

    Miscellaneous databases

    ChiTaRSi GKAP1. human.
    GenomeRNAii 80318.
    NextBioi 70827.
    PROi Q5VSY0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5VSY0.
    Bgeei Q5VSY0.
    CleanExi HS_GKAP1.
    Genevestigatori Q5VSY0.

    Family and domain databases

    InterProi IPR026109. GKAP1.
    [Graphical view ]
    PANTHERi PTHR14899. PTHR14899. 1 hit.
    PRINTSi PR02083. GKINASEAP1.
    ProtoNeti Search...

    Publicationsi

    1. "Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha."
      Yuasa K., Omori K., Yanaka N.
      J. Biol. Chem. 275:4897-4905(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. "Cloning of FKSG21, a novel gene located on human chromosome 9."
      Wang Y.-G., Gong L.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 145-366 (ISOFORM 1).
      Tissue: Testis.
    7. "Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia."
      Sweetser D.A., Peniket A.J., Haaland C., Blomberg A.A., Zhang Y., Zaidi S.T., Dayyani F., Zhao Z., Heerema N.A., Boultwood J., Dewald G.W., Paietta E., Slovak M.L., Willman C.L., Wainscoat J.S., Bernstein I.D., Daly S.B.
      Genes Chromosomes Cancer 44:279-291(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiGKAP1_HUMAN
    AccessioniPrimary (citable) accession number: Q5VSY0
    Secondary accession number(s): Q96LI0
    , Q9BYI1, Q9BYI2, Q9H225
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3