SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5VSY0

- GKAP1_HUMAN

UniProt

Q5VSY0 - GKAP1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
G kinase-anchoring protein 1
Gene
GKAP1, GKAP42, FKSG21
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. signal transduction Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
G kinase-anchoring protein 1
Alternative name(s):
cGMP-dependent protein kinase-anchoring protein of 42 kDa
Gene namesi
Name:GKAP1
Synonyms:GKAP42
ORF Names:FKSG21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:17496. GKAP1.

Subcellular locationi

Golgi apparatus By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134880503.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366G kinase-anchoring protein 1
PRO_0000315654Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271Phosphoserine2 Publications
Modified residuei106 – 1061Phosphoserine; by PKG By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5VSY0.
PaxDbiQ5VSY0.
PRIDEiQ5VSY0.

PTM databases

PhosphoSiteiQ5VSY0.

Expressioni

Gene expression databases

ArrayExpressiQ5VSY0.
BgeeiQ5VSY0.
CleanExiHS_GKAP1.
GenevestigatoriQ5VSY0.

Organism-specific databases

HPAiHPA035117.
HPA035118.

Interactioni

Subunit structurei

Interacts with PRKG1 By similarity.

Protein-protein interaction databases

BioGridi123231. 7 interactions.
DIPiDIP-47324N.
IntActiQ5VSY0. 7 interactions.
MINTiMINT-1455843.
STRINGi9606.ENSP00000365550.

Structurei

3D structure databases

ProteinModelPortaliQ5VSY0.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili47 – 7731 Reviewed prediction
Add
BLAST
Coiled coili128 – 16033 Reviewed prediction
Add
BLAST
Coiled coili243 – 353111 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the GKAP1 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG39546.
HOGENOMiHOG000088604.
HOVERGENiHBG107948.
OMAiPNPVQKD.
OrthoDBiEOG7GJ6D6.
PhylomeDBiQ5VSY0.
TreeFamiTF328459.

Family and domain databases

InterProiIPR026109. GKAP1.
[Graphical view]
PANTHERiPTHR14899. PTHR14899. 1 hit.
PRINTSiPR02083. GKINASEAP1.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VSY0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASAVLSSVP TTASRFALLQ VDSGSGSDSE PGKGKGRNTG KSQTLGSKST    50
TNEKKREKRR KKKEQQQSEA NELRNLAFKK IPQKSSHAVC NAQHDLPLSN 100
PVQKDSREEN WQEWRQRDEQ LTSEMFEADL EKALLLSKLE YEEHKKEYED 150
AENTSTQSKV MNKKDKRKNH QGKDRPLTVS LKDFHSEDHI SKKTEELSSS 200
QTLSHDGGFF NRLEDDVHKI LIREKRREQL TEYNGTDNCT AHEHNQEVVL 250
KDGRIERLKL ELERKDAEIQ KLKNVITQWE AKYKEVKARN AQLLKMLQEG 300
EMKDKAEILL QVDESQSIKN ELTIQVTSLH AALEQERSKV KVLQAELAKY 350
QGGRKGKRNS ESDQCR 366
Length:366
Mass (Da):42,078
Last modified:January 15, 2008 - v2
Checksum:i973D16361756691B
GO
Isoform 2 (identifier: Q5VSY0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     196-246: Missing.

Show »
Length:315
Mass (Da):36,126
Checksum:i90AEB71AF18F1CEE
GO

Sequence cautioni

The sequence BAB71712.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAH70734.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI16011.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EAW62665.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei196 – 24651Missing in isoform 2.
VSP_030596Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti325 – 3251Q → R in AAG40320. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033131 mRNA. Translation: BAB40454.1.
AB033132 mRNA. Translation: BAB40455.1.
AF319476 mRNA. Translation: AAG40320.1.
AL662787, AL354733 Genomic DNA. Translation: CAH70734.1. Sequence problems.
AL662787, AL354733 Genomic DNA. Translation: CAH70735.1.
AL354733, AL662787 Genomic DNA. Translation: CAI16010.1.
AL354733, AL662787 Genomic DNA. Translation: CAI16011.1. Sequence problems.
CH471089 Genomic DNA. Translation: EAW62665.1. Sequence problems.
CH471089 Genomic DNA. Translation: EAW62666.1.
BC014476 mRNA. Translation: AAH14476.1.
AK058198 mRNA. Translation: BAB71712.1. Different initiation.
CCDSiCCDS35049.1. [Q5VSY0-1]
CCDS47988.1. [Q5VSY0-2]
RefSeqiNP_001129425.1. NM_001135953.1. [Q5VSY0-2]
NP_079487.2. NM_025211.3. [Q5VSY0-1]
XP_005252298.1. XM_005252241.1. [Q5VSY0-1]
UniGeneiHs.522255.

Genome annotation databases

EnsembliENST00000376365; ENSP00000365544; ENSG00000165113. [Q5VSY0-2]
ENST00000376371; ENSP00000365550; ENSG00000165113. [Q5VSY0-1]
GeneIDi80318.
KEGGihsa:80318.
UCSCiuc004amy.3. human. [Q5VSY0-1]
uc004amz.3. human. [Q5VSY0-2]

Polymorphism databases

DMDMi166224631.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033131 mRNA. Translation: BAB40454.1 .
AB033132 mRNA. Translation: BAB40455.1 .
AF319476 mRNA. Translation: AAG40320.1 .
AL662787 , AL354733 Genomic DNA. Translation: CAH70734.1 . Sequence problems.
AL662787 , AL354733 Genomic DNA. Translation: CAH70735.1 .
AL354733 , AL662787 Genomic DNA. Translation: CAI16010.1 .
AL354733 , AL662787 Genomic DNA. Translation: CAI16011.1 . Sequence problems.
CH471089 Genomic DNA. Translation: EAW62665.1 . Sequence problems.
CH471089 Genomic DNA. Translation: EAW62666.1 .
BC014476 mRNA. Translation: AAH14476.1 .
AK058198 mRNA. Translation: BAB71712.1 . Different initiation.
CCDSi CCDS35049.1. [Q5VSY0-1 ]
CCDS47988.1. [Q5VSY0-2 ]
RefSeqi NP_001129425.1. NM_001135953.1. [Q5VSY0-2 ]
NP_079487.2. NM_025211.3. [Q5VSY0-1 ]
XP_005252298.1. XM_005252241.1. [Q5VSY0-1 ]
UniGenei Hs.522255.

3D structure databases

ProteinModelPortali Q5VSY0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123231. 7 interactions.
DIPi DIP-47324N.
IntActi Q5VSY0. 7 interactions.
MINTi MINT-1455843.
STRINGi 9606.ENSP00000365550.

PTM databases

PhosphoSitei Q5VSY0.

Polymorphism databases

DMDMi 166224631.

Proteomic databases

MaxQBi Q5VSY0.
PaxDbi Q5VSY0.
PRIDEi Q5VSY0.

Protocols and materials databases

DNASUi 80318.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376365 ; ENSP00000365544 ; ENSG00000165113 . [Q5VSY0-2 ]
ENST00000376371 ; ENSP00000365550 ; ENSG00000165113 . [Q5VSY0-1 ]
GeneIDi 80318.
KEGGi hsa:80318.
UCSCi uc004amy.3. human. [Q5VSY0-1 ]
uc004amz.3. human. [Q5VSY0-2 ]

Organism-specific databases

CTDi 80318.
GeneCardsi GC09M086354.
HGNCi HGNC:17496. GKAP1.
HPAi HPA035117.
HPA035118.
MIMi 611356. gene.
neXtProti NX_Q5VSY0.
PharmGKBi PA134880503.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39546.
HOGENOMi HOG000088604.
HOVERGENi HBG107948.
OMAi PNPVQKD.
OrthoDBi EOG7GJ6D6.
PhylomeDBi Q5VSY0.
TreeFami TF328459.

Miscellaneous databases

ChiTaRSi GKAP1. human.
GenomeRNAii 80318.
NextBioi 70827.
PROi Q5VSY0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q5VSY0.
Bgeei Q5VSY0.
CleanExi HS_GKAP1.
Genevestigatori Q5VSY0.

Family and domain databases

InterProi IPR026109. GKAP1.
[Graphical view ]
PANTHERi PTHR14899. PTHR14899. 1 hit.
PRINTSi PR02083. GKINASEAP1.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha."
    Yuasa K., Omori K., Yanaka N.
    J. Biol. Chem. 275:4897-4905(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "Cloning of FKSG21, a novel gene located on human chromosome 9."
    Wang Y.-G., Gong L.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 145-366 (ISOFORM 1).
    Tissue: Testis.
  7. "Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia."
    Sweetser D.A., Peniket A.J., Haaland C., Blomberg A.A., Zhang Y., Zaidi S.T., Dayyani F., Zhao Z., Heerema N.A., Boultwood J., Dewald G.W., Paietta E., Slovak M.L., Willman C.L., Wainscoat J.S., Bernstein I.D., Daly S.B.
    Genes Chromosomes Cancer 44:279-291(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiGKAP1_HUMAN
AccessioniPrimary (citable) accession number: Q5VSY0
Secondary accession number(s): Q96LI0
, Q9BYI1, Q9BYI2, Q9H225
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 9, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi