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Q5VST9 (OBSCN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Obscurin

EC=2.7.11.1
Alternative name(s):
Obscurin-RhoGEF
Obscurin-myosin light chain kinase
Short name=Obscurin-MLCK
Gene names
Name:OBSCN
Synonyms:KIAA1556, KIAA1639
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length7968 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle. Isoform 3 together with ANK1 isoform Mu17/Ank15 may provide a molecular link between the sarcoplasmic reticulum and myofibrils. Ref.1 Ref.9

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Subunit structure

Isoform 3 interacts with TTN/titin, ANK1 isoform Mu17/ank15, and with calmodulin in a Ca2+-independent manner. Associates with fast skeletal muscle myosin By similarity. Ref.1 Ref.5 Ref.7

Subcellular location

Isoform 3: CytoplasmmyofibrilsarcomereM line. CytoplasmmyofibrilsarcomereZ line. Note: In differentiating skeletal muscle cells, isoform 3 primarily localizes to the sarcomeric M-line and less frequently to the Z-disk. Isoform 3 colocalizes with ANK1 isoform Mu17/ank15 at the M-line in differentiated skeletal muscle cells. Ref.7

Involvement in disease

A chromosomal aberration involving OBSCN has been found in Wilms tumor. Translocation t(1;7)(q42;p15) with PTHB1.

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

Contains 1 DH (DBL-homology) domain.

Contains 4 fibronectin type-III domains.

Contains 55 Ig-like (immunoglobulin-like) domains.

Contains 1 IQ domain.

Contains 1 PH domain.

Contains 2 protein kinase domains.

Contains 1 SH3 domain.

Caution

Initially the name obscurin was used to describe isoform 3 which lacks the kinase domains.

Sequence caution

The sequence CAC85746.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAC85749.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAC85750.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAH71670.2 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI19283.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI19284.1 differs from that shown. Reason: Erroneous gene model prediction.

Isoform 4: The sequence BAB13382.1 differs from that shown. Reason: Frameshift at positions 3891, 5061, 5093, 5268, 6352 and 6919.

Ontologies

Keywords
   Biological processDifferentiation
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
Chromosomal rearrangement
Polymorphism
   DomainImmunoglobulin domain
Repeat
SH3 domain
   LigandATP-binding
Calmodulin-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionDevelopmental protein
Kinase
Muscle protein
Serine/threonine-protein kinase
Transferase
   PTMDisulfide bond
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic signaling pathway

Traceable author statement. Source: Reactome

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

neurotrophin TRK receptor signaling pathway

Traceable author statement. Source: Reactome

positive regulation of apoptotic process

Traceable author statement. Source: Reactome

protein localization to M-band

Inferred from sequence or structural similarity PubMed 18782775. Source: BHF-UCL

regulation of small GTPase mediated signal transduction

Traceable author statement. Source: Reactome

sarcomere organization

Traceable author statement PubMed 18782775. Source: BHF-UCL

small GTPase mediated signal transduction

Traceable author statement. Source: Reactome

   Cellular_componentM band

Inferred from sequence or structural similarity Ref.5PubMed 18782775. Source: BHF-UCL

Z disc

Inferred from sequence or structural similarity Ref.5. Source: BHF-UCL

cytosol

Traceable author statement. Source: Reactome

myofibril

Non-traceable author statement Ref.5. Source: BHF-UCL

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Rho guanyl-nucleotide exchange factor activity

Inferred from electronic annotation. Source: InterPro

ankyrin binding

Inferred from physical interaction PubMed 18782775. Source: BHF-UCL

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction Ref.1Ref.7PubMed 16962094PubMed 20489725PubMed 23414517. Source: IntAct

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

protein tyrosine kinase activity

Inferred from electronic annotation. Source: InterPro

structural constituent of muscle

Non-traceable author statement Ref.5. Source: BHF-UCL

titin binding

Inferred from physical interaction Ref.5. Source: BHF-UCL

Complete GO annotation...

Binary interactions

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q5VST9-1)

Also known as: B; obscurin-MLCK giant kinase;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5VST9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     5753-5753: S → SS
Isoform 3 (identifier: Q5VST9-3)

Also known as: unc-89-like;

The sequence of this isoform differs from the canonical sequence as follows:
     6221-6620: DTTLERADQE...AQNITPAELQ → VTEQETKVPK...DRDGDEAAQP
     6621-7968: Missing.
Note: Lacks the kinase domain. Initially described as obscurin.
Isoform 4 (identifier: Q5VST9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     3888-3913: PQPVFREPLQSLQAEEGSTATLQCEL → LPARIHSRSEDQGGLRRGHSYTAV
     3914-7968: Missing.
Note: No experimental confirmation available.
Isoform 5 (identifier: Q5VST9-6)

The sequence of this isoform differs from the canonical sequence as follows:
     3886-3886: R → RALPARFTQD...EKTSATLTVK

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 79687968Obscurin
PRO_0000235298

Regions

Domain10 – 10091Ig-like 1
Domain110 – 20293Ig-like 2
Domain236 – 32287Ig-like 3
Domain331 – 41484Ig-like 4
Domain420 – 50889Ig-like 5
Domain515 – 61298Fibronectin type-III 1
Domain619 – 69880Ig-like 6
Domain701 – 79090Ig-like 7
Domain798 – 88487Ig-like 8
Domain886 – 97792Ig-like 9
Domain978 – 106689Ig-like 10
Domain1070 – 116192Ig-like 11
Domain1162 – 125291Ig-like 12
Domain1254 – 134592Ig-like 13
Domain1346 – 143287Ig-like 14
Domain1438 – 152487Ig-like 15
Domain1530 – 162192Ig-like 16
Domain1622 – 171998Ig-like 17
Domain1731 – 180878Fibronectin type-III 2
Domain1809 – 189486Ig-like 18
Domain1896 – 198287Ig-like 19
Domain1987 – 207185Ig-like 20
Domain2077 – 216286Ig-like 21
Domain2165 – 224985Ig-like 22
Domain2289 – 238092Ig-like 23
Domain2468 – 255992Ig-like 24
Domain2564 – 264380Ig-like 25
Domain2646 – 273085Ig-like 26
Domain2736 – 282388Ig-like 27
Domain2826 – 290883Ig-like 28
Domain2920 – 299980Ig-like 29
Domain3003 – 309290Ig-like 30
Domain3095 – 318389Ig-like 31
Domain3184 – 326885Ig-like 32
Domain3273 – 335684Ig-like 33
Domain3359 – 344486Ig-like 34
Domain3449 – 353284Ig-like 35
Domain3537 – 362084Ig-like 36
Domain3625 – 370884Ig-like 37
Domain3713 – 379684Ig-like 38
Domain3801 – 388484Ig-like 39
Domain3890 – 397384Ig-like 40
Domain3978 – 406285Ig-like 41
Domain4068 – 416093Ig-like 42
Domain4171 – 423969Ig-like 43
Domain4248 – 433790Ig-like 44
Domain4340 – 442788Ig-like 45
Domain4430 – 451889Ig-like 46
Domain4525 – 461995Fibronectin type-III 3
Domain4624 – 471491Ig-like 47
Domain4872 – 490130IQ
Domain4898 – 498992Ig-like 48
Domain5126 – 521590Ig-like 49
Domain5260 – 534990Ig-like 50
Domain5371 – 546797Ig-like 51
Domain5601 – 566868SH3
Domain5693 – 5877185DH
Domain5895 – 6004110PH
Domain6014 – 609784Ig-like 52
Domain6108 – 620093Ig-like 53
Domain6357 – 644589Ig-like 54
Domain6468 – 6721254Protein kinase 1
Domain7463 – 755290Ig-like 55
Domain7557 – 764993Fibronectin type-III 4
Domain7672 – 7924253Protein kinase 2
Nucleotide binding6474 – 64829ATP By similarity
Nucleotide binding7678 – 76869ATP By similarity
Compositional bias192 – 1987Poly-Ala
Compositional bias710 – 7134Poly-Ala
Compositional bias931 – 9344Poly-Ser
Compositional bias1115 – 11184Poly-Ser
Compositional bias1207 – 12104Poly-Ser
Compositional bias1299 – 13024Poly-Ser
Compositional bias1391 – 13944Poly-Ser
Compositional bias1575 – 15784Poly-Ser
Compositional bias1667 – 16704Poly-Ser
Compositional bias4398 – 44014Poly-Leu
Compositional bias4846 – 48494Poly-Gln
Compositional bias6789 – 67968Poly-Ser
Compositional bias6969 – 7117149Pro-rich

Sites

Active site65871Proton acceptor By similarity
Active site77911Proton acceptor By similarity
Binding site64971ATP By similarity
Binding site77011ATP By similarity

Amino acid modifications

Disulfide bond31 ↔ 82 By similarity
Disulfide bond259 ↔ 311 By similarity
Disulfide bond354 ↔ 404 By similarity
Disulfide bond819 ↔ 870 By similarity
Disulfide bond912 ↔ 962 By similarity
Disulfide bond1004 ↔ 1054 By similarity
Disulfide bond1096 ↔ 1146 By similarity
Disulfide bond1188 ↔ 1238 By similarity
Disulfide bond1280 ↔ 1330 By similarity
Disulfide bond1372 ↔ 1422 By similarity
Disulfide bond1464 ↔ 1514 By similarity
Disulfide bond1556 ↔ 1606 By similarity
Disulfide bond1648 ↔ 1698 By similarity
Disulfide bond1723 ↔ 1791 By similarity
Disulfide bond1830 ↔ 1880 By similarity
Disulfide bond2187 ↔ 2237 By similarity
Disulfide bond2311 ↔ 2361 By similarity
Disulfide bond2490 ↔ 2540 By similarity
Disulfide bond2668 ↔ 2718 By similarity
Disulfide bond2848 ↔ 2898 By similarity
Disulfide bond2937 ↔ 2987 By similarity
Disulfide bond3117 ↔ 3167 By similarity
Disulfide bond3206 ↔ 3256 By similarity
Disulfide bond3295 ↔ 3344 By similarity
Disulfide bond3383 ↔ 3432 By similarity
Disulfide bond3471 ↔ 3520 By similarity
Disulfide bond3559 ↔ 3608 By similarity
Disulfide bond3647 ↔ 3696 By similarity
Disulfide bond3735 ↔ 3784 By similarity
Disulfide bond3823 ↔ 3872 By similarity
Disulfide bond3911 ↔ 3961 By similarity
Disulfide bond4000 ↔ 4050 By similarity
Disulfide bond4089 ↔ 4141 By similarity
Disulfide bond4453 ↔ 4508 By similarity
Disulfide bond4919 ↔ 4971 By similarity
Disulfide bond5147 ↔ 5199 By similarity
Disulfide bond6035 ↔ 6087 By similarity
Disulfide bond6129 ↔ 6182 By similarity
Disulfide bond7484 ↔ 7536 By similarity

Natural variations

Alternative sequence38861R → RALPARFTQDLKTKEASEGA TATLQCELSKVAPVEWKKGP ETLRDGGRYSLKQDGTRCEL QIHDLSVADAGEYSCMCGQE RTSATLTVRALPARFTEGLR NEEAMEGATATLQCELSKAA PVEWRKGLEALRDGDKYSLR QDGAVCELQIHGLAMADNGV YSCVCGQERTSATLTVRALP ARFIEDMRNQKATEGATVTL QCKLRKAAPVEWRKGPNTLK DGDRYSLKQDGTSCELQIRG LVIADAGEYSCICEQERTSA TLTVRALPARFIEDVRNHEA TEGATAVLQCELSKAAPVEW RKGSETLRDGDRYSLRQDGT RCELQIRGLAVEDTGEYLCV CGQERTSATLTVRALPARFI DNMTNQEAREGATATLHCEL SKVAPVEWRKGPETLRDGDR HSLRQDGTRCELQIRGLSVA DAGEYSCVCGQERTSATLTI REATEGATAMLQCELSKVAP VEWRKGPETLRDGDRYNLRQ DGTRCELQIHGLSVADTGEY SCVCGQEKTSATLTVK in isoform 5.
VSP_026970
Alternative sequence3888 – 391326PQPVF…LQCEL → LPARIHSRSEDQGGLRRGHS YTAV in isoform 4.
VSP_020086
Alternative sequence3914 – 79684055Missing in isoform 4.
VSP_020087
Alternative sequence57531S → SS in isoform 2.
VSP_018436
Alternative sequence6221 – 6620400DTTLE…PAELQ → VTEQETKVPKKTVIIEETIT TVVKSPRGQRRSPSKSPSRS PSRCSASPLRPGLLAPDLLY LPGAGQPRRPEAEPGQKPVV PTLYVTEAEAHSPALPGLSG PQPKWVEVEETIEVRVKKMG PQGVSPTTEVPRSSSGHLFT LPGATPGGDPNSNNSNNKLL AQEAWAQGTAMVGVREPLVF RVDARGSVDWAASGMGSLEE EGTMEEAGEEEGEDGDAFVT EESQDTHSLGDRDPKILTHN GRMLTLADLEDYVPGEGETF HCGGPGPGAPDDPPCEVSVI QREIGEPTVGQPVLLSVGHA LGPRGPLGLFRPEPRGASPP GPQVRSLEGTSFLLREAPAR PVGSAPWTQSFCTRIRRSAD SGQSSFTTELSTQTVNFGTV GETVTLHICPDRDGDEAAQP in isoform 3.
VSP_018437
Alternative sequence6621 – 79681348Missing in isoform 3.
VSP_018438
Natural variant511A → T. Ref.1
Corresponds to variant rs1771487 [ dbSNP | Ensembl ].
VAR_026409
Natural variant5021Q → R. Ref.1 Ref.13
Corresponds to variant rs1771487 [ dbSNP | Ensembl ].
VAR_034618
Natural variant8041G → S. Ref.13
Corresponds to variant rs55950009 [ dbSNP | Ensembl ].
VAR_042276
Natural variant9081A → T.
Corresponds to variant rs1757153 [ dbSNP | Ensembl ].
VAR_047743
Natural variant10271K → R. Ref.13
Corresponds to variant rs55760713 [ dbSNP | Ensembl ].
VAR_042277
Natural variant10861A → S. Ref.13
VAR_042278
Natural variant10901A → T. Ref.13
VAR_042279
Natural variant10911S → T. Ref.13
VAR_042280
Natural variant11011A → P. Ref.13
VAR_042281
Natural variant11211G → R. Ref.13
VAR_042282
Natural variant11331L → V. Ref.13
VAR_042283
Natural variant11361A → V in a colorectal cancer sample; somatic mutation. Ref.12 Ref.13
VAR_035530
Natural variant11561H → Q. Ref.13
VAR_042284
Natural variant12481Q → H. Ref.13
VAR_042285
Natural variant15081V → D. Ref.1
Corresponds to variant rs7532342 [ dbSNP | Ensembl ].
VAR_034619
Natural variant15321A → V. Ref.13
Corresponds to variant rs453140 [ dbSNP | Ensembl ].
VAR_042286
Natural variant15661T → M. Ref.13
Corresponds to variant rs56217040 [ dbSNP | Ensembl ].
VAR_042287
Natural variant16011A → T. Ref.13
Corresponds to variant rs55706639 [ dbSNP | Ensembl ].
VAR_042288
Natural variant17921R → H in a colorectal cancer sample; somatic mutation. Ref.12
VAR_035531
Natural variant19301V → M in a colorectal cancer sample; somatic mutation. Ref.12
VAR_035532
Natural variant20901E → K in a colorectal cancer sample; somatic mutation. Ref.12
VAR_035533
Natural variant21061D → E.
Corresponds to variant rs1188721 [ dbSNP | Ensembl ].
VAR_047744
Natural variant21161F → L.
Corresponds to variant rs1188722 [ dbSNP | Ensembl ].
VAR_047745
Natural variant23141S → F in a breast cancer sample; somatic mutation. Ref.12
VAR_035534
Natural variant25291R → Q.
Corresponds to variant rs3795783 [ dbSNP | Ensembl ].
VAR_047746
Natural variant27201V → M.
Corresponds to variant rs1188697 [ dbSNP | Ensembl ].
VAR_047747
Natural variant28121R → W.
Corresponds to variant rs3795785 [ dbSNP | Ensembl ].
VAR_047748
Natural variant33001A → T. Ref.1
Corresponds to variant rs437129 [ dbSNP | Ensembl ].
VAR_034620
Natural variant33721E → D.
Corresponds to variant rs3795789 [ dbSNP | Ensembl ].
VAR_047749
Natural variant33731S → C.
Corresponds to variant rs3795790 [ dbSNP | Ensembl ].
VAR_047750
Natural variant33891A → V. Ref.13
VAR_042289
Natural variant34261D → E. Ref.13
VAR_042290
Natural variant38341R → G. Ref.13
VAR_042291
Natural variant39831R → Q in a colorectal cancer sample; somatic mutation. Ref.12
VAR_035535
Natural variant40391G → R.
Corresponds to variant rs435776 [ dbSNP | Ensembl ].
VAR_047751
Natural variant43811H → R. Ref.1
Corresponds to variant rs1150912 [ dbSNP | Ensembl ].
VAR_034621
Natural variant44501C → R. Ref.1
Corresponds to variant rs1188732 [ dbSNP | Ensembl ].
VAR_034622
Natural variant45161R → W.
Corresponds to variant rs11810627 [ dbSNP | Ensembl ].
VAR_059429
Natural variant45341R → H. Ref.1
Corresponds to variant rs4653942 [ dbSNP | Ensembl ].
VAR_026410
Natural variant45581R → H in a colorectal cancer sample; somatic mutation. Ref.12
VAR_035536
Natural variant46421S → C.
Corresponds to variant rs1188729 [ dbSNP | Ensembl ].
VAR_056102
Natural variant46621R → C.
Corresponds to variant rs3795800 [ dbSNP | Ensembl ].
VAR_056103
Natural variant46661G → S.
Corresponds to variant rs3795801 [ dbSNP | Ensembl ].
VAR_056104
Natural variant48101R → Q in a breast cancer sample; somatic mutation. Ref.12
VAR_035537
Natural variant48231A → S. Ref.13
VAR_042292
Natural variant49621D → G.
Corresponds to variant rs373610 [ dbSNP | Ensembl ].
VAR_056105
Natural variant50711A → T in a breast cancer sample; somatic mutation. Ref.12
VAR_035538
Natural variant52691L → V.
Corresponds to variant rs369909 [ dbSNP | Ensembl ].
VAR_056106
Natural variant55751R → H.
Corresponds to variant rs3795809 [ dbSNP | Ensembl ].
VAR_056107
Natural variant55981R → Q. Ref.13
VAR_042293
Natural variant58911Q → E.
Corresponds to variant rs1188710 [ dbSNP | Ensembl ].
VAR_056108
Natural variant64731E → Q. Ref.13
VAR_042294
Natural variant71721A → V. Ref.4
Corresponds to variant rs500049 [ dbSNP | Ensembl ].
VAR_056109

Experimental info

Sequence conflict8881V → A in CAC85746. Ref.1
Sequence conflict8951L → P in CAC85746. Ref.1
Sequence conflict8971R → C in CAC85746. Ref.1
Sequence conflict899 – 9002KL → EV in CAC85746. Ref.1
Sequence conflict9041A → V in CAC85746. Ref.1
Sequence conflict9171A → D in CAC85746. Ref.1
Sequence conflict9191T → M in CAC85746. Ref.1
Sequence conflict937 – 9382CM → HV in CAC85746. Ref.1
Sequence conflict9411T → V in CAC85746. Ref.1
Sequence conflict9441T → M in CAC85746. Ref.1
Sequence conflict9521A → V in CAC85746. Ref.1
Sequence conflict9571A → S in CAC85746. Ref.1
Sequence conflict9651G → R in CAC85746. Ref.1
Sequence conflict9691L → V in CAC85746. Ref.1
Sequence conflict9721H → R in CAC85746. Ref.1
Sequence conflict9991S → N in CAC44768. Ref.1
Sequence conflict10111T → A in CAC44768. Ref.1
Sequence conflict13481A → V in CAC85746. Ref.1
Sequence conflict13551L → P in CAC85749. Ref.1
Sequence conflict13571H → R in CAC85746. Ref.1
Sequence conflict13591K → E in CAC85749. Ref.1
Sequence conflict13601V → L in CAC85746. Ref.1
Sequence conflict13671I → S in CAC85746. Ref.1
Sequence conflict13671I → S in CAC85749. Ref.1
Sequence conflict13941S → L in CAC85749. Ref.1
Sequence conflict1397 – 13982RM → HV in CAC85749. Ref.1
Sequence conflict13971R → C in CAC85746. Ref.1
Sequence conflict14011V → A in CAC85749. Ref.1
Sequence conflict14011V → T in CAC85746. Ref.1
Sequence conflict14131C → G in CAC85746. Ref.1
Sequence conflict14131C → G in CAC85749. Ref.1
Sequence conflict14171T → A in CAC85746. Ref.1
Sequence conflict14281R → Q in CAC85749. Ref.1
Sequence conflict14321S → H in CAC85746. Ref.1
Sequence conflict14451E → D in CAC85750. Ref.1
Sequence conflict14551Q → E in CAC85750. Ref.1
Sequence conflict14581A → T in CAC85750. Ref.1
Sequence conflict14611T → M in CAC85750. Ref.1
Sequence conflict15241H → R in CAC85749. Ref.1
Sequence conflict15261H → Q in CAC85749. Ref.1
Sequence conflict1580 – 15823VRM → MRV in CAC85750. Ref.1
Sequence conflict16071K → E in CAC85750. Ref.1
Sequence conflict16101D → G in CAC85750. Ref.1
Sequence conflict16331H → C in CAC85750. Ref.1
Sequence conflict1653 – 16553AQT → GQM in CAC85750. Ref.1
Sequence conflict1673 – 16742RV → HM in CAC85750. Ref.1
Sequence conflict1677 – 16793VGC → SGY in CAC85750. Ref.1
Sequence conflict16921E → D in CAC44768. Ref.1
Sequence conflict16921E → D in CAC85750. Ref.1
Sequence conflict17041Q → R in CAC44768. Ref.1
Sequence conflict17041Q → R in CAC85750. Ref.1
Sequence conflict17101Q → H in CAC44768. Ref.1
Sequence conflict17101Q → H in CAC85750. Ref.1
Sequence conflict18481L → P in CAC44768. Ref.1
Sequence conflict20141P → A in CAC85750. Ref.1
Sequence conflict31261V → M in CAC44768. Ref.1
Sequence conflict41551T → TG in CAC85752. Ref.3
Sequence conflict44891H → Q in CAC44768. Ref.1
Sequence conflict49591T → A in CAC44768. Ref.1
Sequence conflict52431S → ST in CAC85753. Ref.1
Sequence conflict53911S → F in BAB13465. Ref.4
Sequence conflict5499 – 55002LE → FQ in CAC44768. Ref.1
Sequence conflict61151R → L in CAC44768. Ref.1
Sequence conflict65701Q → E in CAJ76912. Ref.3
Sequence conflict6710 – 67112PS → SG in CAJ76912. Ref.3

Secondary structure

...................................................................................................................................................................................................................................... 7968
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (B) (obscurin-MLCK giant kinase) [UniParc].

Last modified November 25, 2008. Version 3.
Checksum: 46550B34565CAC76

FASTA7,968868,484
        10         20         30         40         50         60 
MDQPQFSGAP RFLTRPKAFV VSVGKDATLS CQIVGNPTPQ VSWEKDQQPV AAGARFRLAQ 

        70         80         90        100        110        120 
DGDLYRLTIL DLALGDSGQY VCRARNAIGE AFAAVGLQVD AEAACAEQAP HFLLRPTSIR 

       130        140        150        160        170        180 
VREGSEATFR CRVGGSPRPA VSWSKDGRRL GEPDGPRVRV EELGEASALR IRAARPRDGG 

       190        200        210        220        230        240 
TYEVRAENPL GAASAAAALV VDSDAADTAS RPGTSTAALL AHLQRRREAM RAEGAPASPP 

       250        260        270        280        290        300 
STGTRTCTVT EGKHARLSCY VTGEPKPETV WKKDGQLVTE GRRHVVYEDA QENFVLKILF 

       310        320        330        340        350        360 
CKQSDRGLYT CTASNLVGQT YSSVLVVVRE PAVPFKKRLQ DLEVREKESA TFLCEVPQPS 

       370        380        390        400        410        420 
TEAAWFKEET RLWASAKYGI EEEGTERRLT VRNVSADDDA VYICETPEGS RTVAELAVQG 

       430        440        450        460        470        480 
NLLRKLPRKT AVRVGDTAMF CVELAVPVGP VHWLRNQEEV VAGGRVAISA EGTRHTLTIS 

       490        500        510        520        530        540 
QCCLEDVGQV AFMAGDCQTS TQFCVSAPRK PPLQPPVDPV VKARMESSVI LSWSPPPHGE 

       550        560        570        580        590        600 
RPVTIDGYLV EKKKLGTYTW IRCHEAEWVA TPELTVADVA EEGNFQFRVS ALNSFGQSPY 

       610        620        630        640        650        660 
LEFPGTVHLA PKLAVRTPLK AVQAVEGGEV TFSVDLTVAS AGEWFLDGQA LKASSVYEIH 

       670        680        690        700        710        720 
CDRTRHTLTI REVPASLHGA QLKFVANGIE SSIRMEVRAA PGLTANKPPA AAAREVLARL 

       730        740        750        760        770        780 
HEEAQLLAEL SDQAAAVTWL KDGRTLSPGP KYEVQASAGR RVLLVRDVAR DDAGLYECVS 

       790        800        810        820        830        840 
RGGRIAYQLS VQGLARFLHK DMAGSCVDAV AGGPAQFECE TSEAHVHVHW YKDGMELGHS 

       850        860        870        880        890        900 
GERFLQEDVG TRHRLVAATV TRQDEGTYSC RVGEDSVDFR LRVSEPKVVF AKEQLARRKL 

       910        920        930        940        950        960 
QAEAGASATL SCEVAQAQTE VTWYKDGKKL SSSSKVCMEA TGCTRRLVVQ QAGQADAGEY 

       970        980        990       1000       1010       1020 
SCEAGGQRLS FHLDVKEPKV VFAKDQVAHS EVQAEAGASA TLSCEVAQAQ TEVMWYKDGK 

      1030       1040       1050       1060       1070       1080 
KLSSSLKVHV EAKGCRRRLV VQQAGKTDAG DYSCEARGQR VSFRLHITEP KMMFAKEQSV 

      1090       1100       1110       1120       1130       1140 
HNEVQAEAGA SAMLSCEVAQ AQTEVTWYKD GKKLSSSSKV GMEVKGCTRR LVLPQAGKAD 

      1150       1160       1170       1180       1190       1200 
AGEYSCEAGG QRVSFHLHIT EPKGVFAKEQ SVHNEVQAEA GTTAMLSCEV AQPQTEVTWY 

      1210       1220       1230       1240       1250       1260 
KDGKKLSSSS KVRMEVKGCT RRLVVQQVGK ADAGEYSCEA GGQRVSFQLH ITEPKAVFAK 

      1270       1280       1290       1300       1310       1320 
EQLVHNEVRT EAGASATLSC EVAQAQTEVT WYKDGKKLSS SSKVRIEAAG CMRQLVVQQA 

      1330       1340       1350       1360       1370       1380 
GQADAGEYTC EAGGQRLSFH LDVSEPKAVF AKEQLAHRKV QAEAGAIATL SCEVAQAQTE 

      1390       1400       1410       1420       1430       1440 
VTWYKDGKKL SSSSKVRMEA VGCTRRLVVQ QACQADTGEY SCEAGGQRLS FSLDVAEPKV 

      1450       1460       1470       1480       1490       1500 
VFAKEQPVHR EVQAQAGAST TLSCEVAQAQ TEVMWYKDGK KLSFSSKVRM EAVGCTRRLV 

      1510       1520       1530       1540       1550       1560 
VQQAGQAVAG EYSCEAGSQR LSFHLHVAEP KAVFAKEQPA SREVQAEAGT SATLSCEVAQ 

      1570       1580       1590       1600       1610       1620 
AQTEVTWYKD GKKLSSSSKV RMEAVGCTRR LVVQEAGQAD AGEYSCKAGD QRLSFHLHVA 

      1630       1640       1650       1660       1670       1680 
EPKVVFAKEQ PAHREVQAEA GASATLSCEV AQAQTEVTWY KDGKKLSSSS KVRVEAVGCT 

      1690       1700       1710       1720       1730       1740 
RRLVVQQAGQ AEAGEYSCEA GGQQLSFRLQ VAELEPQISE RPCRREPLVV KEHEDIILTA 

      1750       1760       1770       1780       1790       1800 
TLATPSAATV TWLKDGVEIR RSKRHETASQ GDTHTLTVHG AQVLDSAIYS CRVGAEGQDF 

      1810       1820       1830       1840       1850       1860 
PVQVEEVAAK FCRLLEPVCG ELGGTVTLAC ELSPACAEVV WRCGNTQLRV GKRFQMVAEG 

      1870       1880       1890       1900       1910       1920 
PVRSLTVLGL RAEDAGEYVC ESRDDHTSAQ LTVSVPRVVK FMSGLSTVVA EEGGEATFQC 

      1930       1940       1950       1960       1970       1980 
VVSPSDVAVV WFRDGALLQP SEKFAISQSG ASHSLTISDL VLEDAGQITV EAEGASSSAA 

      1990       2000       2010       2020       2030       2040 
LRVREAPVLF KKKLEPQTVE ERSSVTLEVE LTRPWPELRW TRNATALAPG KNVEIHAEGA 

      2050       2060       2070       2080       2090       2100 
RHRLVLHNVG FADRGFFGCE TPDDKTQAKL TVEMRQVRLV RGLQAVEARE QGTATMEVQL 

      2110       2120       2130       2140       2150       2160 
SHADVDGSWT RDGLRFQQGP TCHLAVRGPM HTLTLSGLRP EDSGLMVFKA EGVHTSARLV 

      2170       2180       2190       2200       2210       2220 
VTELPVSFSR PLQDVVTTEK EKVTLECELS RPNVDVRWLK DGVELRAGKT MAIAAQGACR 

      2230       2240       2250       2260       2270       2280 
SLTIYRCEFA DQGVYVCDAH DAQSSASVKV QGRTYTLIYR RVLAEDAGEI QFVAENAESR 

      2290       2300       2310       2320       2330       2340 
AQLRVKELPV TLVRPLRDKI AMEKHRGVLE CQVSRASAQV RWFKGSQELQ PGPKYELVSD 

      2350       2360       2370       2380       2390       2400 
GLYRKLIISD VHAEDEDTYT CDAGDVKTSA QFFVEEQSIT IVRGLQDVTV MEPAPAWFEC 

      2410       2420       2430       2440       2450       2460 
ETSIPSVRPP KWLLGKTVLQ AGGNVGLEQE GTVHRLMLRR TCSTMTGPVH FTVGKSRSSA 

      2470       2480       2490       2500       2510       2520 
RLVVSDIPVV LTRPLEPKTG RELQSVVLSC DFRPAPKAVQ WYKDDTPLSP SEKFKMSLEG 

      2530       2540       2550       2560       2570       2580 
QMAELRILRL MPADAGVYRC QAGSAHSSTE VTVEAREVTV TGPLQDAEAT EEGWASFSCE 

      2590       2600       2610       2620       2630       2640 
LSHEDEEVEW SLNGMPLYND SFHEISHKGR RHTLVLKSIQ RADAGIVRAS SLKVSTSARL 

      2650       2660       2670       2680       2690       2700 
EVRVKPVVFL KALDDLSAEE RGTLALQCEV SDPEAHVVWR KDGVQLGPSD KYDFLHTAGT 

      2710       2720       2730       2740       2750       2760 
RGLVVHDVSP EDAGLYTCHV GSEETRARVR VHDLHVGITK RLKTMEVLEG ESCSFECVLS 

      2770       2780       2790       2800       2810       2820 
HESASDPAMW TVGGKTVGSS SRFQATRQGR KYILVVREAA PSDAGEVVFS VRGLTSKASL 

      2830       2840       2850       2860       2870       2880 
IVRERPAAII KPLEDQWVAP GEDVELRCEL SRAGTPVHWL KDRKAIRKSQ KYDVVCEGTM 

      2890       2900       2910       2920       2930       2940 
AMLVIRGASL KDAGEYTCEV EASKSTASLH VEEKANCFTE ELTNLQVEEK GTAVFTCKTE 

      2950       2960       2970       2980       2990       3000 
HPAATVTWRK GLLELRASGK HQPSQEGLTL RLTISALEKA DSDTYTCDIG QAQSRAQLLV 

      3010       3020       3030       3040       3050       3060 
QGRRVHIIED LEDVDVQEGS SATFRCRISP ANYEPVHWFL DKTPLHANEL NEIDAQPGGY 

      3070       3080       3090       3100       3110       3120 
HVLTLRQLAL KDSGTIYFEA GDQRASAALR VTEKPSVFSR ELTDATITEG EDLTLVCETS 

      3130       3140       3150       3160       3170       3180 
TCDIPVCWTK DGKTLRGSAR CQLSHEGHRA QLLITGATLQ DSGRYKCEAG GACSSSIVRV 

      3190       3200       3210       3220       3230       3240 
HARPVRFQEA LKDLEVLEGG AATLRCVLSS VAAPVKWCYG NNVLRPGDKY SLRQEGAMLE 

      3250       3260       3270       3280       3290       3300 
LVVRNLRPQD SGRYSCSFGD QTTSATLTVT ALPAQFIGKL RNKEATEGAT ATLRCELSKA 

      3310       3320       3330       3340       3350       3360 
APVEWRKGSE TLRDGDRYCL RQDGAMCELQ IRGLAMVDAA EYSCVCGEER TSASLTIRPM 

      3370       3380       3390       3400       3410       3420 
PAHFIGRLRH QESIEGATAT LRCELSKAAP VEWRKGRESL RDGDRHSLRQ DGAVCELQIC 

      3430       3440       3450       3460       3470       3480 
GLAVADAGEY SCVCGEERTS ATLTVKALPA KFTEGLRNEE AVEGATAMLW CELSKVAPVE 

      3490       3500       3510       3520       3530       3540 
WRKGPENLRD GDRYILRQEG TRCELQICGL AMADAGEYLC VCGQERTSAT LTIRALPARF 

      3550       3560       3570       3580       3590       3600 
IEDVKNQEAR EGATAVLQCE LNSAAPVEWR KGSETLRDGD RYSLRQDGTK CELQIRGLAM 

      3610       3620       3630       3640       3650       3660 
ADTGEYSCVC GQERTSAMLT VRALPIKFTE GLRNEEATEG ATAVLRCELS KMAPVEWWKG 

      3670       3680       3690       3700       3710       3720 
HETLRDGDRH SLRQDGARCE LQIRGLVAED AGEYLCMCGK ERTSAMLTVR AMPSKFIEGL 

      3730       3740       3750       3760       3770       3780 
RNEEATEGDT ATLWCELSKA APVEWRKGHE TLRDGDRHSL RQDGSRCELQ IRGLAVVDAG 

      3790       3800       3810       3820       3830       3840 
EYSCVCGQER TSATLTVRAL PARFIEDVKN QEAREGATAV LQCELSKAAP VEWRKGSETL 

      3850       3860       3870       3880       3890       3900 
RGGDRYSLRQ DGTRCELQIH GLSVADTGEY SCVCGQERTS ATLTVRAPQP VFREPLQSLQ 

      3910       3920       3930       3940       3950       3960 
AEEGSTATLQ CELSEPTATV VWSKGGLQLQ ANGRREPRLQ GCTAELVLQD LQREDTGEYT 

      3970       3980       3990       4000       4010       4020 
CTCGSQATSA TLTVTAAPVR FLRELQHQEV DEGGTAHLCC ELSRAGASVE WRKGSLQLFP 

      4030       4040       4050       4060       4070       4080 
CAKYQMVQDG AAAELLVRGV EQEDAGDYTC DTGHTQSMAS LSVRVPRPKF KTRLQSLEQE 

      4090       4100       4110       4120       4130       4140 
TGDIARLCCQ LSDAESGAVV QWLKEGVELH AGPKYEMRSQ GATRELLIHQ LEAKDTGEYA 

      4150       4160       4170       4180       4190       4200 
CVTGGQKTAA SLRVTEPEVT IVRGLVDAEV TADEDVEFSC EVSRAGATGV QWCLQGLPLQ 

      4210       4220       4230       4240       4250       4260 
SNEVTEVAVR DGRIHTLRLK GVTPEDAGTV SFHLGNHASS AQLTVRAPEV TILEPLQDVQ 

      4270       4280       4290       4300       4310       4320 
LSEGQDASFQ CRLSRASGQE ARWALGGVPL QANEMNDITV EQGTLHLLTL HKVTLEDAGT 

      4330       4340       4350       4360       4370       4380 
VSFHVGTCSS EAQLKVTAKN TVVRGLENVE ALEGGEALFE CQLSQPEVAA HTWLLDDEPV 

      4390       4400       4410       4420       4430       4440 
HTSENAEVVF FENGLRHLLL LKNLRPQDSC RVTFLAGDMV TSAFLTVRGW RLEILEPLKN 

      4450       4460       4470       4480       4490       4500 
AAVRAGAQAC FTCTLSEAVP VGEASWYING AAVQPDDSDW TVTADGSHHA LLLRSAQPHH 

      4510       4520       4530       4540       4550       4560 
AGEVTFACRD AVASARLTVL GLPDPPEDAE VVARSSHTVT LSWAAPMSDG GGGLCGYRVE 

      4570       4580       4590       4600       4610       4620 
VKEGATGQWR LCHELVPGPE CVVDGLAPGE TYRFRVAAVG PVGAGEPVHL PQTVRLAEPP 

      4630       4640       4650       4660       4670       4680 
KPVPPQPSAP ESRQVAAGED VSLELEVVAE AGEVIWHKGM ERIQPGGRFE VVSQGRQQML 

      4690       4700       4710       4720       4730       4740 
VIKGFTAEDQ GEYHCGLAQG SICPAAATFQ VALSPASVDE APQPSLPPEA AQEGDLHLLW 

      4750       4760       4770       4780       4790       4800 
EALARKRRMS REPTLDSISE LPEEDGRSQR LPQEAEEVAP DLSEGYSTAD ELARTGDADL 

      4810       4820       4830       4840       4850       4860 
SHTSSDDESR AGTPSLVTYL KKAGRPGTSP LASKVGAPAA PSVKPQQQQE PLAAVRPPLG 

      4870       4880       4890       4900       4910       4920 
DLSTKDLGDP SMDKAAVKIQ AAFKGYKVRK EMKQQEGPMF SHTFGDTEAQ VGDALRLECV 

      4930       4940       4950       4960       4970       4980 
VASKADVRAR WLKDGVELTD GRHHHIDQLG DGTCSLLITG LDRADAGCYT CQVSNKFGQV 

      4990       5000       5010       5020       5030       5040 
THSACVVVSG SESEAESSSG GELDDAFRRA ARRLHRLFRT KSPAEVSDEE LFLSADEGPA 

      5050       5060       5070       5080       5090       5100 
EPEEPADWQT YREDEHFICI RFEALTEARQ AVTRFQEMFA TLGIGVEIKL VEQGPRRVEM 

      5110       5120       5130       5140       5150       5160 
CISKETPAPV VPPEPLPSLL TSDAAPVFLT ELQNQEVQDG YPVSFDCVVT GQPMPSVRWF 

      5170       5180       5190       5200       5210       5220 
KDGKLLEEDD HYMINEDQQG GHQLIITAVV PADMGVYRCL AENSMGVSST KAELRVDLTS 

      5230       5240       5250       5260       5270       5280 
TDYDTAADAT ESSSYFSAQG YLSSREQEGT ESTTDEGQLP QVVEELRDLQ VAPGTRLAKF 

      5290       5300       5310       5320       5330       5340 
QLKVKGYPAP RLYWFKDGQP LTASAHIRMT DKKILHTLEI ISVTREDSGQ YAAYISNAMG 

      5350       5360       5370       5380       5390       5400 
AAYSSARLLV RGPDEPEEKP ASDVHEQLVP PRMLERFTPK KVKKGSSITF SVKVEGRPVP 

      5410       5420       5430       5440       5450       5460 
TVHWLREEAE RGVLWIGPDT PGYTVASSAQ QHSLVLLDVG RQHQGTYTCI ASNAAGQALC 

      5470       5480       5490       5500       5510       5520 
SASLHVSGLP KVEEQEKVKE ALISTFLQGT TQAISAQGLE TASFADLGGQ RKEEPLAAKE 

      5530       5540       5550       5560       5570       5580 
ALGHLSLAEV GTEEFLQKLT SQITEMVSAK ITQAKLQVPG GDSDEDSKTP SASPRHGRSR 

      5590       5600       5610       5620       5630       5640 
PSSSIQESSS ESEDGDARGE IFDIYVVTAD YLPLGAEQDA ITLREGQYVE VLDAAHPLRW 

      5650       5660       5670       5680       5690       5700 
LVRTKPTKSS PSRQGWVSPA YLDRRLKLSP EWGAAEAPEF PGEAVSEDEY KARLSSVIQE 

      5710       5720       5730       5740       5750       5760 
LLSSEQAFVE ELQFLQSHHL QHLERCPHVP IAVAGQKAVI FRNVRDIGRF HSSFLQELQQ 

      5770       5780       5790       5800       5810       5820 
CDTDDDVAMC FIKNQAAFEQ YLEFLVGRVQ AESVVVSTAI QEFYKKYAEE ALLAGDPSQP 

      5830       5840       5850       5860       5870       5880 
PPPPLQHYLE QPVERVQRYQ ALLKELIRNK ARNRQNCALL EQAYAVVSAL PQRAENKLHV 

      5890       5900       5910       5920       5930       5940 
SLMENYPGTL QALGEPIRQG HFIVWEGAPG ARMPWKGHNR HVFLFRNHLV ICKPRRDSRT 

      5950       5960       5970       5980       5990       6000 
DTVSYVFRNM MKLSSIDLND QVEGDDRAFE VWQEREDSVR KYLLQARTAI IKSSWVKEIC 

      6010       6020       6030       6040       6050       6060 
GIQQRLALPV WRPPDFEEEL ADCTAELGET VKLACRVTGT PKPVISWYKD GKAVQVDPHH 

      6070       6080       6090       6100       6110       6120 
ILIEDPDGSC ALILDSLTGV DSGQYMCFAA SAAGNCSTLG KILVQVPPRF VNKVRASPFV 

      6130       6140       6150       6160       6170       6180 
EGEDAQFTCT IEGAPYPQIR WYKDGALLTT GNKFQTLSEP RSGLLVLVIR AASKEDLGLY 

      6190       6200       6210       6220       6230       6240 
ECELVNRLGS ARASAELRIQ SPMLQAQEQC HREQLVAAVE DTTLERADQE VTSVLKRLLG 

      6250       6260       6270       6280       6290       6300 
PKAPGPSTGD LTGPGPCPRG APALQETGSQ PPVTGTSEAP AVPPRVPQPL LHEGPEQEPE 

      6310       6320       6330       6340       6350       6360 
AIARAQEWTV PIRMEGAAWP GAGTGELLWD VHSHVVRETT QRTYTYQAID THTARPPSMQ 

      6370       6380       6390       6400       6410       6420 
VTIEDVQAQT GGTAQFEAII EGDPQPSVTW YKDSVQLVDS TRLSQQQEGT TYSLVLRHVA 

      6430       6440       6450       6460       6470       6480 
SKDAGVYTCL AQNTGGQVLC KAELLVLGGD NEPDSEKQSH RRKLHSFYEV KEEIGRGVFG 

      6490       6500       6510       6520       6530       6540 
FVKRVQHKGN KILCAAKFIP LRSRTRAQAY RERDILAALS HPLVTGLLDQ FETRKTLILI 

      6550       6560       6570       6580       6590       6600 
LELCSSEELL DRLYRKGVVT EAEVKVYIQQ LVEGLHYLHS HGVLHLDIKP SNILMVHPAR 

      6610       6620       6630       6640       6650       6660 
EDIKICDFGF AQNITPAELQ FSQYGSPEFV SPEIIQQNPV SEASDIWAMG VISYLSLTCS 

      6670       6680       6690       6700       6710       6720 
SPFAGESDRA TLLNVLEGRV SWSSPMAAHL SEDAKDFIKA TLQRAPQARP SAAQCLSHPW 

      6730       6740       6750       6760       6770       6780 
FLKSMPAEEA HFINTKQLKF LLARSRWQRS LMSYKSILVM RSIPELLRGP PDSPSLGVAR 

      6790       6800       6810       6820       6830       6840 
HLCRDTGGSS SSSSSSDNEL APFARAKSLP PSPVTHSPLL HPRGFLRPSA SLPEEAEASE 

      6850       6860       6870       6880       6890       6900 
RSTEAPAPPA SPEGAGPPAA QGCVPRHSVI RSLFYHQAGE SPEHGALAPG SRRHPARRRH 

      6910       6920       6930       6940       6950       6960 
LLKGGYIAGA LPGLREPLME HRVLEEEAAR EEQATLLAKA PSFETALRLP ASGTHLAPGH 

      6970       6980       6990       7000       7010       7020 
SHSLEHDSPS TPRPSSEACG EAQRLPSAPS GGAPIRDMGH PQGSKQLPST GGHPGTAQPE 

      7030       7040       7050       7060       7070       7080 
RPSPDSPWGQ PAPFCHPKQG SAPQEGCSPH PAVAPCPPGS FPPGSCKEAP LVPSSPFLGQ 

      7090       7100       7110       7120       7130       7140 
PQAPPAPAKA SPPLDSKMGP GDISLPGRPK PGPCSSPGSA SQASSSQVSS LRVGSSQVGT 

      7150       7160       7170       7180       7190       7200 
EPGPSLDAEG WTQEAEDLSD STPTLQRPQE QATMRKFSLG GRGGYAGVAG YGTFAFGGDA 

      7210       7220       7230       7240       7250       7260 
GGMLGQGPMW ARIAWAVSQS EEEEQEEARA ESQSEEQQEA RAESPLPQVS ARPVPEVGRA 

      7270       7280       7290       7300       7310       7320 
PTRSSPEPTP WEDIGQVSLV QIRDLSGDAE AADTISLDIS EVDPAYLNLS DLYDIKYLPF 

      7330       7340       7350       7360       7370       7380 
EFMIFRKVPK SAQPEPPSPM AEEELAEFPE PTWPWPGELG PHAGLEITEE SEDVDALLAE 

      7390       7400       7410       7420       7430       7440 
AAVGRKRKWS SPSRSLFHFP GRHLPLDEPA ELGLRERVKA SVEHISRILK GRPEGLEKEG 

      7450       7460       7470       7480       7490       7500 
PPRKKPGLAS FRLSGLKSWD RAPTFLRELS DETVVLGQSV TLACQVSAQP AAQATWSKDG 

      7510       7520       7530       7540       7550       7560 
APLESSSRVL ISATLKNFQL LTILVVVAED LGVYTCSVSN ALGTVTTTGV LRKAERPSSS 

      7570       7580       7590       7600       7610       7620 
PCPDIGEVYA DGVLLVWKPV ESYGPVTYIV QCSLEGGSWT TLASDIFDCC YLTSKLSRGG 

      7630       7640       7650       7660       7670       7680 
TYTFRTACVS KAGMGPYSSP SEQVLLGGPS HLASEEESQG RSAQPLPSTK TFAFQTQIQR 

      7690       7700       7710       7720       7730       7740 
GRFSVVRQCW EKASGRALAA KIIPYHPKDK TAVLREYEAL KGLRHPHLAQ LHAAYLSPRH 

      7750       7760       7770       7780       7790       7800 
LVLILELCSG PELLPCLAER ASYSESEVKD YLWQMLSATQ YLHNQHILHL DLRSENMIIT 

      7810       7820       7830       7840       7850       7860 
EYNLLKVVDL GNAQSLSQEK VLPSDKFKDY LETMAPELLE GQGAVPQTDI WAIGVTAFIM 

      7870       7880       7890       7900       7910       7920 
LSAEYPVSSE GARDLQRGLR KGLVRLSRCY AGLSGGAVAF LRSTLCAQPW GRPCASSCLQ 

      7930       7940       7950       7960 
CPWLTEEGPA CSRPAPVTFP TARLRVFVRN REKRRALLYK RHNLAQVR 

« Hide

Isoform 2 [UniParc].

Checksum: 6FB22EBF680A4EF0
Show »

FASTA7,969868,571
Isoform 3 (unc-89-like) [UniParc].

Checksum: AAD71899C0D7D0ED
Show »

FASTA6,620721,547
Isoform 4 [UniParc].

Checksum: 1BA7C12914F8C063
Show »

FASTA3,911427,046
Isoform 5 [UniParc].

Checksum: 9CACA6907978C3B6
Show »

FASTA8,483924,971

References

« Hide 'large scale' references
[1]"Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly."
Young P.W., Ehler E., Gautel M.
J. Cell Biol. 154:123-136(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 3), VARIANTS THR-51; ARG-502; ASP-1508 THR-3300; ARG-4381; ARG-4450 AND HIS-4534, FUNCTION, INTERACTION WITH TTN AND CALMODULIN.
Tissue: Heart.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Complete human gene structure of obscurin: implications for isoform generation by differential splicing."
Fukuzawa A., Idowu S., Gautel M.
J. Muscle Res. Cell Motil. 26:427-434(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2734-4428 (ISOFORM 5), NUCLEOTIDE SEQUENCE [MRNA] OF 6009-7968 (ISOFORM 1).
Tissue: Cardiac myocyte.
[4]"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5386-7968 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2726-7968 (ISOFORM 4), VARIANT VAL-7172.
Tissue: Brain.
[5]"The complete gene sequence of titin, expression of an unusual ~700 kDa titin isoform and its interaction with obscurin identify a novel Z-line to I-band linking system."
Bang M.-L., Centner T., Fornoff F., Geach A.J., Gotthardt M., McNabb M., Witt C.C., Labeit D., Gregorio C.C., Granzier H., Labeit S.
Circ. Res. 89:1065-1072(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TTN.
[6]"Identification, tissue expression and chromosomal localization of human obscurin-MLCK, a member of the titin and Dbl families of myosin light chain kinases."
Russell M.W., Raeker M.O., Korytkowski K.A., Sonneman K.J.
Gene 282:237-246(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[7]"Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles."
Bagnato P., Barone V., Giacomello E., Rossi D., Sorrentino V.
J. Cell Biol. 160:245-253(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH ANK1.
[8]"The parathyroid hormone-responsive B1 gene is interrupted by a t(1;7)(q42;p15) breakpoint associated with Wilms' tumour."
Vernon E.G., Malik K., Reynolds P., Powlesland R., Dallosso A.R., Jackson S., Henthorn K., Green E.D., Brown K.W.
Oncogene 22:1371-1380(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: CHROMOSOMAL TRANSLOCATION WITH PTHB1.
[9]"Essential role of obscurin in cardiac myofibrillogenesis and hypertrophic response: evidence from small interfering RNA-mediated gene silencing."
Borisov A.B., Sutter S.B., Kontrogianni-Konstantopoulos A., Bloch R.J., Westfall M.V., Russell M.W.
Histochem. Cell Biol. 125:227-238(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[10]"Solution structure of the Ig domains of human obscurin."
RIKEN structural genomics initiative (RSGI)
Submitted (AUG-2007) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 2826-3806.
[11]"Solution structure of the SH3 domain of obscurin."
Pfuhl M., Gautel M.
Submitted (APR-2005) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 5601-5668.
[12]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-1136; HIS-1792; MET-1930; LYS-2090; PHE-2314; GLN-3983; HIS-4558; GLN-4810 AND THR-5071.
[13]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-502; SER-804; ARG-1027; SER-1086; THR-1090; THR-1091; PRO-1101; ARG-1121; VAL-1133; VAL-1136; GLN-1156; HIS-1248; VAL-1532; MET-1566; THR-1601; VAL-3389; GLU-3426; GLY-3834; SER-4823; GLN-5598 AND GLN-6473.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ002535 mRNA. Translation: CAC44768.1.
AJ314896 Genomic DNA. Translation: CAC85745.1.
AJ314898 Genomic DNA. Translation: CAC85746.1. Sequence problems.
AJ314900 Genomic DNA. Translation: CAC85747.1.
AJ314901 Genomic DNA. Translation: CAC85749.1. Sequence problems.
AJ314903 Genomic DNA. Translation: CAC85750.1. Sequence problems.
AJ314904 Genomic DNA. Translation: CAC85751.1.
AJ314905 Genomic DNA. Translation: CAC85752.1.
AJ314906 Genomic DNA. Translation: CAC85753.1.
AJ314907 Genomic DNA. Translation: CAC85754.1.
AJ314908 Genomic DNA. Translation: CAC85755.1.
AL670729, AL353593, AL359510 Genomic DNA. Translation: CAH71673.1.
AL359510, AL670729, AL353593 Genomic DNA. Translation: CAI15072.1.
AL353593 Genomic DNA. Translation: CAI19283.1. Sequence problems.
AL353593 Genomic DNA. Translation: CAI19284.1. Sequence problems.
AL353593, AL670729, AL359510 Genomic DNA. Translation: CAI19285.1.
AL670729 Genomic DNA. Translation: CAH71670.2. Sequence problems.
AM231061 mRNA. Translation: CAJ76912.1.
AB046776 mRNA. Translation: BAB13382.1. Frameshift.
AB046859 mRNA. Translation: BAB13465.2.
CCDSCCDS1570.2. [Q5VST9-3]
CCDS58065.1. [Q5VST9-1]
RefSeqNP_001092093.2. NM_001098623.2. [Q5VST9-1]
NP_443075.3. NM_052843.3. [Q5VST9-3]
UniGeneHs.650039.
Hs.656999.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1V1CNMR-A5601-5668[»]
2CR6NMR-A2999-3100[»]
2DKUNMR-A2915-3004[»]
2DM7NMR-A3551-3631[»]
2E7BNMR-A3184-3273[»]
2EDFNMR-A2826-2915[»]
2EDHNMR-A3614-3713[»]
2EDLNMR-A3801-3887[»]
2EDQNMR-A3713-3806[»]
2EDRNMR-A3361-3449[»]
2EDTNMR-A3449-3537[»]
2EDWNMR-A3537-3630[»]
2ENYNMR-A2735-2825[»]
2EO1NMR-A1623-1712[»]
2GQHNMR-A3450-3543[»]
2YZ8X-ray2.00A3184-3273[»]
ProteinModelPortalQ5VST9.
SMRQ5VST9. Positions 884-975, 979-1067, 1071-1159, 1163-1251, 1255-1436, 1439-1528, 1531-1620, 1623-1712, 2735-3100, 3184-3273, 3275-3898, 5601-5668.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123847. 6 interactions.
DIPDIP-35727N.
IntActQ5VST9. 9 interactions.
MINTMINT-254901.

PTM databases

PhosphoSiteQ5VST9.

Polymorphism databases

DMDM215274225.

Proteomic databases

MaxQBQ5VST9.
PaxDbQ5VST9.
PRIDEQ5VST9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000284548; ENSP00000284548; ENSG00000154358. [Q5VST9-3]
ENST00000422127; ENSP00000409493; ENSG00000154358. [Q5VST9-1]
GeneID84033.
KEGGhsa:84033.
UCSCuc001hsn.4. human. [Q5VST9-3]
uc009xez.2. human. [Q5VST9-1]

Organism-specific databases

CTD84033.
GeneCardsGC01P228395.
H-InvDBHIX0001664.
HIX0159663.
HIX0159975.
HIX0160154.
HGNCHGNC:15719. OBSCN.
HPAHPA019497.
HPA021186.
MIM608616. gene.
neXtProtNX_Q5VST9.
PharmGKBPA31888.
HUGESearch...
Search...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOVERGENHBG108206.
InParanoidQ5VST9.
KOK17531.
OrthoDBEOG7HHWR6.
PhylomeDBQ5VST9.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
SignaLinkQ5VST9.

Gene expression databases

ArrayExpressQ5VST9.
BgeeQ5VST9.
GenevestigatorQ5VST9.

Family and domain databases

Gene3D1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.10. 60 hits.
InterProIPR000219. DH-domain.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR000048. IQ_motif_EF-hand-BS.
IPR011009. Kinase-like_dom.
IPR020682. Obscurin-myosin_light-ch_kin.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PANTHERPTHR19897:SF17. PTHR19897:SF17. 1 hit.
PfamPF00041. fn3. 2 hits.
PF07679. I-set. 51 hits.
PF00612. IQ. 1 hit.
PF00069. Pkinase. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 3 hits.
SM00409. IG. 33 hits.
SM00408. IGc2. 20 hits.
SM00015. IQ. 1 hit.
SM00233. PH. 1 hit.
SM00220. S_TKc. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF48065. SSF48065. 1 hit.
SSF49265. SSF49265. 3 hits.
SSF50044. SSF50044. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEPS50010. DH_2. 1 hit.
PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 47 hits.
PS50096. IQ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ5VST9.
GeneWikiOBSCN.
Obscurin.
GenomeRNAi84033.
NextBio73174.
PROQ5VST9.
SOURCESearch...

Entry information

Entry nameOBSCN_HUMAN
AccessionPrimary (citable) accession number: Q5VST9
Secondary accession number(s): Q2A664 expand/collapse secondary AC list , Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN3, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM