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Protein

Obscurin

Gene

OBSCN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle. Isoform 3 together with ANK1 isoform Mu17/Ank1.5 may provide a molecular link between the sarcoplasmic reticulum and myofibrils.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei6497ATPPROSITE-ProRule annotation1
Active sitei6587Proton acceptorBy similarity1
Binding sitei7701ATPPROSITE-ProRule annotation1
Active sitei7791Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6474 – 6482ATPPROSITE-ProRule annotation9
Nucleotide bindingi7678 – 7686ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ankyrin binding Source: BHF-UCL
  • ATP binding Source: UniProtKB-KW
  • guanyl-nucleotide exchange factor activity Source: Reactome
  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: UniProtKB-KW
  • Rho guanyl-nucleotide exchange factor activity Source: Reactome
  • structural constituent of muscle Source: BHF-UCL
  • titin binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Muscle protein, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Differentiation

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS07976-MONOMER.
ReactomeiR-HSA-193648. NRAGE signals death through JNK.
R-HSA-194840. Rho GTPase cycle.
R-HSA-416482. G alpha (12/13) signalling events.
SignaLinkiQ5VST9.

Names & Taxonomyi

Protein namesi
Recommended name:
Obscurin (EC:2.7.11.1)
Alternative name(s):
Obscurin-RhoGEF
Obscurin-myosin light chain kinase
Short name:
Obscurin-MLCK
Gene namesi
Name:OBSCN
Synonyms:KIAA1556, KIAA1639
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15719. OBSCN.

Subcellular locationi

Isoform 3 :

GO - Cellular componenti

  • cytosol Source: Reactome
  • M band Source: BHF-UCL
  • myofibril Source: BHF-UCL
  • Z disc Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving OBSCN has been found in Wilms tumor. Translocation t(1;7)(q42;p15) with PTHB1.

Organism-specific databases

DisGeNETi84033.
OpenTargetsiENSG00000154358.
PharmGKBiPA31888.

Polymorphism and mutation databases

DMDMi215274225.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352981 – 7968ObscurinAdd BLAST7968

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 82PROSITE-ProRule annotation
Disulfide bondi259 ↔ 311PROSITE-ProRule annotation
Disulfide bondi354 ↔ 404PROSITE-ProRule annotation
Modified residuei395PhosphoserineBy similarity1
Disulfide bondi819 ↔ 870PROSITE-ProRule annotation
Disulfide bondi912 ↔ 962PROSITE-ProRule annotation
Disulfide bondi1004 ↔ 1054PROSITE-ProRule annotation
Disulfide bondi1096 ↔ 1146PROSITE-ProRule annotation
Disulfide bondi1188 ↔ 1238PROSITE-ProRule annotation
Disulfide bondi1280 ↔ 1330PROSITE-ProRule annotation
Disulfide bondi1372 ↔ 1422PROSITE-ProRule annotation
Disulfide bondi1464 ↔ 1514PROSITE-ProRule annotation
Disulfide bondi1556 ↔ 1606PROSITE-ProRule annotation
Disulfide bondi1648 ↔ 1698PROSITE-ProRule annotation
Disulfide bondi1723 ↔ 1791PROSITE-ProRule annotation
Disulfide bondi1830 ↔ 1880PROSITE-ProRule annotation
Disulfide bondi2187 ↔ 2237PROSITE-ProRule annotation
Disulfide bondi2311 ↔ 2361PROSITE-ProRule annotation
Disulfide bondi2490 ↔ 2540PROSITE-ProRule annotation
Disulfide bondi2668 ↔ 2718PROSITE-ProRule annotation
Disulfide bondi2848 ↔ 2898PROSITE-ProRule annotation
Modified residuei2889PhosphoserineBy similarity1
Disulfide bondi2937 ↔ 2987PROSITE-ProRule annotation
Disulfide bondi3117 ↔ 3167PROSITE-ProRule annotation
Disulfide bondi3206 ↔ 3256PROSITE-ProRule annotation
Disulfide bondi3295 ↔ 3344PROSITE-ProRule annotation
Disulfide bondi3383 ↔ 3432PROSITE-ProRule annotation
Disulfide bondi3471 ↔ 3520PROSITE-ProRule annotation
Disulfide bondi3559 ↔ 3608PROSITE-ProRule annotation
Disulfide bondi3647 ↔ 3696PROSITE-ProRule annotation
Disulfide bondi3735 ↔ 3784PROSITE-ProRule annotation
Disulfide bondi3823 ↔ 3872PROSITE-ProRule annotation
Disulfide bondi3911 ↔ 3961PROSITE-ProRule annotation
Disulfide bondi4000 ↔ 4050PROSITE-ProRule annotation
Modified residuei4015PhosphoserineBy similarity1
Disulfide bondi4089 ↔ 4141PROSITE-ProRule annotation
Disulfide bondi4453 ↔ 4508PROSITE-ProRule annotation
Modified residuei4750PhosphoserineBy similarity1
Modified residuei4754PhosphothreonineBy similarity1
Modified residuei4757PhosphoserineBy similarity1
Modified residuei4788PhosphothreonineBy similarity1
Modified residuei4805PhosphoserineBy similarity1
Disulfide bondi4919 ↔ 4971PROSITE-ProRule annotation
Disulfide bondi5147 ↔ 5199PROSITE-ProRule annotation
Modified residuei5563PhosphoserineBy similarity1
Modified residuei5569PhosphothreonineBy similarity1
Modified residuei5571PhosphoserineBy similarity1
Modified residuei5573PhosphoserineBy similarity1
Disulfide bondi6035 ↔ 6087PROSITE-ProRule annotation
Disulfide bondi6129 ↔ 6182PROSITE-ProRule annotation
Modified residuei6831PhosphoserineCombined sources1
Modified residuei7244PhosphoserineCombined sources1
Disulfide bondi7484 ↔ 7536PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ5VST9.
PeptideAtlasiQ5VST9.
PRIDEiQ5VST9.

PTM databases

iPTMnetiQ5VST9.
PhosphoSitePlusiQ5VST9.

Expressioni

Gene expression databases

BgeeiENSG00000154358.
ExpressionAtlasiQ5VST9. baseline and differential.
GenevisibleiQ5VST9. HS.

Organism-specific databases

HPAiHPA019497.
HPA021186.

Interactioni

Subunit structurei

Isoform 3 interacts with TTN/titin, ANK1 isoform Mu17/ank1.5, and with calmodulin in a Ca2+-independent manner. Associates with fast skeletal muscle myosin (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ANK1P161573EBI-941921,EBI-941686
ANK1P16157-178EBI-941921,EBI-941819
TTNQ8WZ4211EBI-941850,EBI-681210

GO - Molecular functioni

  • ankyrin binding Source: BHF-UCL
  • titin binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi123847. 23 interactors.
DIPiDIP-35727N.
IntActiQ5VST9. 24 interactors.
MINTiMINT-254901.

Structurei

Secondary structure

17968
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 14Combined sources6
Beta strandi17 – 19Combined sources3
Beta strandi27 – 37Combined sources11
Beta strandi40 – 45Combined sources6
Beta strandi53 – 61Combined sources9
Beta strandi64 – 69Combined sources6
Helixi74 – 76Combined sources3
Beta strandi78 – 85Combined sources8
Beta strandi87 – 97Combined sources11
Beta strandi1634 – 1639Combined sources6
Beta strandi1644 – 1646Combined sources3
Beta strandi1653 – 1655Combined sources3
Beta strandi1658 – 1661Combined sources4
Beta strandi1670 – 1677Combined sources8
Beta strandi1680 – 1685Combined sources6
Turni1690 – 1692Combined sources3
Beta strandi1696 – 1700Combined sources5
Beta strandi1707 – 1712Combined sources6
Beta strandi2745 – 2750Combined sources6
Beta strandi2753 – 2758Combined sources6
Beta strandi2771 – 2776Combined sources6
Beta strandi2784 – 2788Combined sources5
Beta strandi2791 – 2796Combined sources6
Turni2801 – 2803Combined sources3
Beta strandi2807 – 2811Combined sources5
Beta strandi2814 – 2818Combined sources5
Beta strandi2820 – 2823Combined sources4
Beta strandi2829 – 2831Combined sources3
Beta strandi2836 – 2838Combined sources3
Beta strandi2844 – 2846Combined sources3
Beta strandi2849 – 2854Combined sources6
Beta strandi2859 – 2863Combined sources5
Beta strandi2869 – 2877Combined sources9
Beta strandi2880 – 2887Combined sources8
Turni2890 – 2892Combined sources3
Beta strandi2894 – 2899Combined sources6
Beta strandi2904 – 2911Combined sources8
Beta strandi2925 – 2928Combined sources4
Beta strandi2931 – 2938Combined sources8
Beta strandi2947 – 2952Combined sources6
Beta strandi2957 – 2966Combined sources10
Beta strandi2969 – 2976Combined sources8
Turni2979 – 2981Combined sources3
Beta strandi2983 – 2988Combined sources6
Beta strandi2996 – 3001Combined sources6
Beta strandi3006 – 3009Combined sources4
Beta strandi3013 – 3017Combined sources5
Beta strandi3027 – 3030Combined sources4
Beta strandi3037 – 3042Combined sources6
Beta strandi3048 – 3050Combined sources3
Turni3057 – 3059Combined sources3
Beta strandi3063 – 3065Combined sources3
Turni3070 – 3072Combined sources3
Beta strandi3074 – 3080Combined sources7
Beta strandi3087 – 3092Combined sources6
Beta strandi3187 – 3189Combined sources3
Beta strandi3194 – 3197Combined sources4
Beta strandi3202 – 3210Combined sources9
Beta strandi3216 – 3219Combined sources4
Beta strandi3227 – 3235Combined sources9
Beta strandi3238 – 3243Combined sources6
Helixi3248 – 3250Combined sources3
Beta strandi3252 – 3258Combined sources7
Beta strandi3261 – 3270Combined sources10
Beta strandi3371 – 3374Combined sources4
Beta strandi3386 – 3388Combined sources3
Beta strandi3392 – 3397Combined sources6
Beta strandi3402 – 3405Combined sources4
Beta strandi3407 – 3410Combined sources4
Beta strandi3412 – 3421Combined sources10
Turni3424 – 3426Combined sources3
Beta strandi3430 – 3433Combined sources4
Beta strandi3438 – 3441Combined sources4
Beta strandi3443 – 3446Combined sources4
Beta strandi3452 – 3454Combined sources3
Beta strandi3459 – 3462Combined sources4
Beta strandi3467 – 3475Combined sources9
Beta strandi3480 – 3483Combined sources4
Beta strandi3490 – 3509Combined sources20
Turni3512 – 3514Combined sources3
Beta strandi3516 – 3522Combined sources7
Beta strandi3525 – 3534Combined sources10
Beta strandi3555 – 3564Combined sources10
Beta strandi3568 – 3575Combined sources8
Beta strandi3578 – 3581Combined sources4
Beta strandi3583 – 3587Combined sources5
Beta strandi3590 – 3597Combined sources8
Turni3600 – 3602Combined sources3
Beta strandi3604 – 3610Combined sources7
Beta strandi3613 – 3618Combined sources6
Beta strandi3620 – 3622Combined sources3
Beta strandi3628 – 3630Combined sources3
Beta strandi3643 – 3651Combined sources9
Beta strandi3656 – 3663Combined sources8
Beta strandi3667 – 3675Combined sources9
Beta strandi3678 – 3683Combined sources6
Beta strandi3692 – 3698Combined sources7
Beta strandi3701 – 3709Combined sources9
Beta strandi3716 – 3718Combined sources3
Beta strandi3723 – 3726Combined sources4
Beta strandi3731 – 3739Combined sources9
Beta strandi3744 – 3751Combined sources8
Beta strandi3754 – 3757Combined sources4
Beta strandi3759 – 3763Combined sources5
Beta strandi3766 – 3773Combined sources8
Turni3776 – 3778Combined sources3
Beta strandi3780 – 3788Combined sources9
Beta strandi3790 – 3798Combined sources9
Beta strandi3811 – 3814Combined sources4
Beta strandi3820 – 3824Combined sources5
Beta strandi3826 – 3828Combined sources3
Beta strandi3831 – 3837Combined sources7
Beta strandi3842 – 3848Combined sources7
Beta strandi3852 – 3861Combined sources10
Helixi3864 – 3866Combined sources3
Beta strandi3870 – 3874Combined sources5
Beta strandi3877 – 3880Combined sources4
Beta strandi3883 – 3886Combined sources4
Beta strandi4342 – 4344Combined sources3
Beta strandi4349 – 4351Combined sources3
Beta strandi4353 – 4365Combined sources13
Beta strandi4369 – 4375Combined sources7
Beta strandi4386 – 4391Combined sources6
Helixi4392 – 4394Combined sources3
Beta strandi4396 – 4403Combined sources8
Helixi4406 – 4408Combined sources3
Beta strandi4410 – 4416Combined sources7
Beta strandi4419 – 4427Combined sources9
Beta strandi4449 – 4454Combined sources6
Beta strandi4461 – 4463Combined sources3
Beta strandi4465 – 4468Combined sources4
Beta strandi4478 – 4485Combined sources8
Beta strandi4488 – 4495Combined sources8
Beta strandi4502 – 4507Combined sources6
Beta strandi4512 – 4518Combined sources7
Beta strandi5604 – 5609Combined sources6
Beta strandi5628 – 5636Combined sources9
Beta strandi5639 – 5644Combined sources6
Beta strandi5654 – 5657Combined sources4
Helixi5659 – 5661Combined sources3
Beta strandi5662 – 5665Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V1CNMR-A5601-5668[»]
2CR6NMR-A2999-3100[»]
2DKUNMR-A2915-3004[»]
2DM7NMR-A3551-3631[»]
2E7BNMR-A3184-3273[»]
2EDFNMR-A2826-2915[»]
2EDHNMR-A3614-3713[»]
2EDLNMR-A3801-3887[»]
2EDQNMR-A3713-3806[»]
2EDRNMR-A3361-3449[»]
2EDTNMR-A3449-3537[»]
2EDWNMR-A3537-3630[»]
2ENYNMR-A2735-2825[»]
2EO1NMR-A1623-1712[»]
2GQHNMR-A3450-3543[»]
2MWCNMR-A4337-4429[»]
2N56NMR-A4430-4524[»]
2YZ8X-ray2.00A3184-3273[»]
4C4KX-ray1.95O9-103[»]
4RSVX-ray2.41A4337-4429[»]
ProteinModelPortaliQ5VST9.
SMRiQ5VST9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5VST9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 100Ig-like 1Add BLAST91
Domaini110 – 202Ig-like 2Add BLAST93
Domaini236 – 322Ig-like 3Add BLAST87
Domaini331 – 414Ig-like 4Add BLAST84
Domaini420 – 508Ig-like 5Add BLAST89
Domaini515 – 612Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST98
Domaini619 – 698Ig-like 6Add BLAST80
Domaini701 – 790Ig-like 7Add BLAST90
Domaini798 – 884Ig-like 8Add BLAST87
Domaini886 – 977Ig-like 9Add BLAST92
Domaini978 – 1066Ig-like 10Add BLAST89
Domaini1070 – 1161Ig-like 11Add BLAST92
Domaini1162 – 1252Ig-like 12Add BLAST91
Domaini1254 – 1345Ig-like 13Add BLAST92
Domaini1346 – 1432Ig-like 14Add BLAST87
Domaini1438 – 1524Ig-like 15Add BLAST87
Domaini1530 – 1621Ig-like 16Add BLAST92
Domaini1622 – 1719Ig-like 17Add BLAST98
Domaini1731 – 1808Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST78
Domaini1809 – 1894Ig-like 18Add BLAST86
Domaini1896 – 1982Ig-like 19Add BLAST87
Domaini1987 – 2071Ig-like 20Add BLAST85
Domaini2077 – 2162Ig-like 21Add BLAST86
Domaini2165 – 2249Ig-like 22Add BLAST85
Domaini2289 – 2380Ig-like 23Add BLAST92
Domaini2468 – 2559Ig-like 24Add BLAST92
Domaini2564 – 2643Ig-like 25Add BLAST80
Domaini2646 – 2730Ig-like 26Add BLAST85
Domaini2736 – 2823Ig-like 27Add BLAST88
Domaini2826 – 2908Ig-like 28Add BLAST83
Domaini2920 – 2999Ig-like 29Add BLAST80
Domaini3003 – 3092Ig-like 30Add BLAST90
Domaini3095 – 3183Ig-like 31Add BLAST89
Domaini3184 – 3268Ig-like 32Add BLAST85
Domaini3273 – 3356Ig-like 33Add BLAST84
Domaini3359 – 3444Ig-like 34Add BLAST86
Domaini3449 – 3532Ig-like 35Add BLAST84
Domaini3537 – 3620Ig-like 36Add BLAST84
Domaini3625 – 3708Ig-like 37Add BLAST84
Domaini3713 – 3796Ig-like 38Add BLAST84
Domaini3801 – 3884Ig-like 39Add BLAST84
Domaini3890 – 3973Ig-like 40Add BLAST84
Domaini3978 – 4062Ig-like 41Add BLAST85
Domaini4068 – 4160Ig-like 42Add BLAST93
Domaini4171 – 4239Ig-like 43Add BLAST69
Domaini4248 – 4337Ig-like 44Add BLAST90
Domaini4340 – 4427Ig-like 45Add BLAST88
Domaini4430 – 4518Ig-like 46Add BLAST89
Domaini4525 – 4619Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST95
Domaini4624 – 4714Ig-like 47Add BLAST91
Domaini4872 – 4901IQPROSITE-ProRule annotationAdd BLAST30
Domaini4898 – 4989Ig-like 48Add BLAST92
Domaini5126 – 5215Ig-like 49Add BLAST90
Domaini5260 – 5349Ig-like 50Add BLAST90
Domaini5371 – 5467Ig-like 51Add BLAST97
Domaini5601 – 5668SH3Add BLAST68
Domaini5693 – 5877DHPROSITE-ProRule annotationAdd BLAST185
Domaini5895 – 6004PHPROSITE-ProRule annotationAdd BLAST110
Domaini6014 – 6097Ig-like 52Add BLAST84
Domaini6108 – 6200Ig-like 53Add BLAST93
Domaini6357 – 6445Ig-like 54Add BLAST89
Domaini6468 – 6721Protein kinase 1PROSITE-ProRule annotationAdd BLAST254
Domaini7463 – 7552Ig-like 55Add BLAST90
Domaini7557 – 7649Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST93
Domaini7672 – 7924Protein kinase 2PROSITE-ProRule annotationAdd BLAST253

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi192 – 198Poly-Ala7
Compositional biasi710 – 713Poly-Ala4
Compositional biasi931 – 934Poly-Ser4
Compositional biasi1115 – 1118Poly-Ser4
Compositional biasi1207 – 1210Poly-Ser4
Compositional biasi1299 – 1302Poly-Ser4
Compositional biasi1391 – 1394Poly-Ser4
Compositional biasi1575 – 1578Poly-Ser4
Compositional biasi1667 – 1670Poly-Ser4
Compositional biasi4398 – 4401Poly-Leu4
Compositional biasi4846 – 4849Poly-Gln4
Compositional biasi6789 – 6796Poly-Ser8
Compositional biasi6969 – 7117Pro-richAdd BLAST149

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 2 protein kinase domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, SH3 domain

Phylogenomic databases

GeneTreeiENSGT00860000133679.
HOVERGENiHBG108206.
InParanoidiQ5VST9.
KOiK17531.
PhylomeDBiQ5VST9.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.10. 60 hits.
InterProiIPR000219. DH-domain.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR000048. IQ_motif_EF-hand-BS.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 51 hits.
PF00612. IQ. 1 hit.
PF00069. Pkinase. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 56 hits.
SM00408. IGc2. 49 hits.
SM00406. IGv. 14 hits.
SM00015. IQ. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48726. SSF48726. 57 hits.
SSF49265. SSF49265. 3 hits.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50010. DH_2. 1 hit.
PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 47 hits.
PS50096. IQ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q5VST9-1) [UniParc]FASTAAdd to basket
Also known as: B, obscurin-MLCK giant kinase

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDQPQFSGAP RFLTRPKAFV VSVGKDATLS CQIVGNPTPQ VSWEKDQQPV
60 70 80 90 100
AAGARFRLAQ DGDLYRLTIL DLALGDSGQY VCRARNAIGE AFAAVGLQVD
110 120 130 140 150
AEAACAEQAP HFLLRPTSIR VREGSEATFR CRVGGSPRPA VSWSKDGRRL
160 170 180 190 200
GEPDGPRVRV EELGEASALR IRAARPRDGG TYEVRAENPL GAASAAAALV
210 220 230 240 250
VDSDAADTAS RPGTSTAALL AHLQRRREAM RAEGAPASPP STGTRTCTVT
260 270 280 290 300
EGKHARLSCY VTGEPKPETV WKKDGQLVTE GRRHVVYEDA QENFVLKILF
310 320 330 340 350
CKQSDRGLYT CTASNLVGQT YSSVLVVVRE PAVPFKKRLQ DLEVREKESA
360 370 380 390 400
TFLCEVPQPS TEAAWFKEET RLWASAKYGI EEEGTERRLT VRNVSADDDA
410 420 430 440 450
VYICETPEGS RTVAELAVQG NLLRKLPRKT AVRVGDTAMF CVELAVPVGP
460 470 480 490 500
VHWLRNQEEV VAGGRVAISA EGTRHTLTIS QCCLEDVGQV AFMAGDCQTS
510 520 530 540 550
TQFCVSAPRK PPLQPPVDPV VKARMESSVI LSWSPPPHGE RPVTIDGYLV
560 570 580 590 600
EKKKLGTYTW IRCHEAEWVA TPELTVADVA EEGNFQFRVS ALNSFGQSPY
610 620 630 640 650
LEFPGTVHLA PKLAVRTPLK AVQAVEGGEV TFSVDLTVAS AGEWFLDGQA
660 670 680 690 700
LKASSVYEIH CDRTRHTLTI REVPASLHGA QLKFVANGIE SSIRMEVRAA
710 720 730 740 750
PGLTANKPPA AAAREVLARL HEEAQLLAEL SDQAAAVTWL KDGRTLSPGP
760 770 780 790 800
KYEVQASAGR RVLLVRDVAR DDAGLYECVS RGGRIAYQLS VQGLARFLHK
810 820 830 840 850
DMAGSCVDAV AGGPAQFECE TSEAHVHVHW YKDGMELGHS GERFLQEDVG
860 870 880 890 900
TRHRLVAATV TRQDEGTYSC RVGEDSVDFR LRVSEPKVVF AKEQLARRKL
910 920 930 940 950
QAEAGASATL SCEVAQAQTE VTWYKDGKKL SSSSKVCMEA TGCTRRLVVQ
960 970 980 990 1000
QAGQADAGEY SCEAGGQRLS FHLDVKEPKV VFAKDQVAHS EVQAEAGASA
1010 1020 1030 1040 1050
TLSCEVAQAQ TEVMWYKDGK KLSSSLKVHV EAKGCRRRLV VQQAGKTDAG
1060 1070 1080 1090 1100
DYSCEARGQR VSFRLHITEP KMMFAKEQSV HNEVQAEAGA SAMLSCEVAQ
1110 1120 1130 1140 1150
AQTEVTWYKD GKKLSSSSKV GMEVKGCTRR LVLPQAGKAD AGEYSCEAGG
1160 1170 1180 1190 1200
QRVSFHLHIT EPKGVFAKEQ SVHNEVQAEA GTTAMLSCEV AQPQTEVTWY
1210 1220 1230 1240 1250
KDGKKLSSSS KVRMEVKGCT RRLVVQQVGK ADAGEYSCEA GGQRVSFQLH
1260 1270 1280 1290 1300
ITEPKAVFAK EQLVHNEVRT EAGASATLSC EVAQAQTEVT WYKDGKKLSS
1310 1320 1330 1340 1350
SSKVRIEAAG CMRQLVVQQA GQADAGEYTC EAGGQRLSFH LDVSEPKAVF
1360 1370 1380 1390 1400
AKEQLAHRKV QAEAGAIATL SCEVAQAQTE VTWYKDGKKL SSSSKVRMEA
1410 1420 1430 1440 1450
VGCTRRLVVQ QACQADTGEY SCEAGGQRLS FSLDVAEPKV VFAKEQPVHR
1460 1470 1480 1490 1500
EVQAQAGAST TLSCEVAQAQ TEVMWYKDGK KLSFSSKVRM EAVGCTRRLV
1510 1520 1530 1540 1550
VQQAGQAVAG EYSCEAGSQR LSFHLHVAEP KAVFAKEQPA SREVQAEAGT
1560 1570 1580 1590 1600
SATLSCEVAQ AQTEVTWYKD GKKLSSSSKV RMEAVGCTRR LVVQEAGQAD
1610 1620 1630 1640 1650
AGEYSCKAGD QRLSFHLHVA EPKVVFAKEQ PAHREVQAEA GASATLSCEV
1660 1670 1680 1690 1700
AQAQTEVTWY KDGKKLSSSS KVRVEAVGCT RRLVVQQAGQ AEAGEYSCEA
1710 1720 1730 1740 1750
GGQQLSFRLQ VAELEPQISE RPCRREPLVV KEHEDIILTA TLATPSAATV
1760 1770 1780 1790 1800
TWLKDGVEIR RSKRHETASQ GDTHTLTVHG AQVLDSAIYS CRVGAEGQDF
1810 1820 1830 1840 1850
PVQVEEVAAK FCRLLEPVCG ELGGTVTLAC ELSPACAEVV WRCGNTQLRV
1860 1870 1880 1890 1900
GKRFQMVAEG PVRSLTVLGL RAEDAGEYVC ESRDDHTSAQ LTVSVPRVVK
1910 1920 1930 1940 1950
FMSGLSTVVA EEGGEATFQC VVSPSDVAVV WFRDGALLQP SEKFAISQSG
1960 1970 1980 1990 2000
ASHSLTISDL VLEDAGQITV EAEGASSSAA LRVREAPVLF KKKLEPQTVE
2010 2020 2030 2040 2050
ERSSVTLEVE LTRPWPELRW TRNATALAPG KNVEIHAEGA RHRLVLHNVG
2060 2070 2080 2090 2100
FADRGFFGCE TPDDKTQAKL TVEMRQVRLV RGLQAVEARE QGTATMEVQL
2110 2120 2130 2140 2150
SHADVDGSWT RDGLRFQQGP TCHLAVRGPM HTLTLSGLRP EDSGLMVFKA
2160 2170 2180 2190 2200
EGVHTSARLV VTELPVSFSR PLQDVVTTEK EKVTLECELS RPNVDVRWLK
2210 2220 2230 2240 2250
DGVELRAGKT MAIAAQGACR SLTIYRCEFA DQGVYVCDAH DAQSSASVKV
2260 2270 2280 2290 2300
QGRTYTLIYR RVLAEDAGEI QFVAENAESR AQLRVKELPV TLVRPLRDKI
2310 2320 2330 2340 2350
AMEKHRGVLE CQVSRASAQV RWFKGSQELQ PGPKYELVSD GLYRKLIISD
2360 2370 2380 2390 2400
VHAEDEDTYT CDAGDVKTSA QFFVEEQSIT IVRGLQDVTV MEPAPAWFEC
2410 2420 2430 2440 2450
ETSIPSVRPP KWLLGKTVLQ AGGNVGLEQE GTVHRLMLRR TCSTMTGPVH
2460 2470 2480 2490 2500
FTVGKSRSSA RLVVSDIPVV LTRPLEPKTG RELQSVVLSC DFRPAPKAVQ
2510 2520 2530 2540 2550
WYKDDTPLSP SEKFKMSLEG QMAELRILRL MPADAGVYRC QAGSAHSSTE
2560 2570 2580 2590 2600
VTVEAREVTV TGPLQDAEAT EEGWASFSCE LSHEDEEVEW SLNGMPLYND
2610 2620 2630 2640 2650
SFHEISHKGR RHTLVLKSIQ RADAGIVRAS SLKVSTSARL EVRVKPVVFL
2660 2670 2680 2690 2700
KALDDLSAEE RGTLALQCEV SDPEAHVVWR KDGVQLGPSD KYDFLHTAGT
2710 2720 2730 2740 2750
RGLVVHDVSP EDAGLYTCHV GSEETRARVR VHDLHVGITK RLKTMEVLEG
2760 2770 2780 2790 2800
ESCSFECVLS HESASDPAMW TVGGKTVGSS SRFQATRQGR KYILVVREAA
2810 2820 2830 2840 2850
PSDAGEVVFS VRGLTSKASL IVRERPAAII KPLEDQWVAP GEDVELRCEL
2860 2870 2880 2890 2900
SRAGTPVHWL KDRKAIRKSQ KYDVVCEGTM AMLVIRGASL KDAGEYTCEV
2910 2920 2930 2940 2950
EASKSTASLH VEEKANCFTE ELTNLQVEEK GTAVFTCKTE HPAATVTWRK
2960 2970 2980 2990 3000
GLLELRASGK HQPSQEGLTL RLTISALEKA DSDTYTCDIG QAQSRAQLLV
3010 3020 3030 3040 3050
QGRRVHIIED LEDVDVQEGS SATFRCRISP ANYEPVHWFL DKTPLHANEL
3060 3070 3080 3090 3100
NEIDAQPGGY HVLTLRQLAL KDSGTIYFEA GDQRASAALR VTEKPSVFSR
3110 3120 3130 3140 3150
ELTDATITEG EDLTLVCETS TCDIPVCWTK DGKTLRGSAR CQLSHEGHRA
3160 3170 3180 3190 3200
QLLITGATLQ DSGRYKCEAG GACSSSIVRV HARPVRFQEA LKDLEVLEGG
3210 3220 3230 3240 3250
AATLRCVLSS VAAPVKWCYG NNVLRPGDKY SLRQEGAMLE LVVRNLRPQD
3260 3270 3280 3290 3300
SGRYSCSFGD QTTSATLTVT ALPAQFIGKL RNKEATEGAT ATLRCELSKA
3310 3320 3330 3340 3350
APVEWRKGSE TLRDGDRYCL RQDGAMCELQ IRGLAMVDAA EYSCVCGEER
3360 3370 3380 3390 3400
TSASLTIRPM PAHFIGRLRH QESIEGATAT LRCELSKAAP VEWRKGRESL
3410 3420 3430 3440 3450
RDGDRHSLRQ DGAVCELQIC GLAVADAGEY SCVCGEERTS ATLTVKALPA
3460 3470 3480 3490 3500
KFTEGLRNEE AVEGATAMLW CELSKVAPVE WRKGPENLRD GDRYILRQEG
3510 3520 3530 3540 3550
TRCELQICGL AMADAGEYLC VCGQERTSAT LTIRALPARF IEDVKNQEAR
3560 3570 3580 3590 3600
EGATAVLQCE LNSAAPVEWR KGSETLRDGD RYSLRQDGTK CELQIRGLAM
3610 3620 3630 3640 3650
ADTGEYSCVC GQERTSAMLT VRALPIKFTE GLRNEEATEG ATAVLRCELS
3660 3670 3680 3690 3700
KMAPVEWWKG HETLRDGDRH SLRQDGARCE LQIRGLVAED AGEYLCMCGK
3710 3720 3730 3740 3750
ERTSAMLTVR AMPSKFIEGL RNEEATEGDT ATLWCELSKA APVEWRKGHE
3760 3770 3780 3790 3800
TLRDGDRHSL RQDGSRCELQ IRGLAVVDAG EYSCVCGQER TSATLTVRAL
3810 3820 3830 3840 3850
PARFIEDVKN QEAREGATAV LQCELSKAAP VEWRKGSETL RGGDRYSLRQ
3860 3870 3880 3890 3900
DGTRCELQIH GLSVADTGEY SCVCGQERTS ATLTVRAPQP VFREPLQSLQ
3910 3920 3930 3940 3950
AEEGSTATLQ CELSEPTATV VWSKGGLQLQ ANGRREPRLQ GCTAELVLQD
3960 3970 3980 3990 4000
LQREDTGEYT CTCGSQATSA TLTVTAAPVR FLRELQHQEV DEGGTAHLCC
4010 4020 4030 4040 4050
ELSRAGASVE WRKGSLQLFP CAKYQMVQDG AAAELLVRGV EQEDAGDYTC
4060 4070 4080 4090 4100
DTGHTQSMAS LSVRVPRPKF KTRLQSLEQE TGDIARLCCQ LSDAESGAVV
4110 4120 4130 4140 4150
QWLKEGVELH AGPKYEMRSQ GATRELLIHQ LEAKDTGEYA CVTGGQKTAA
4160 4170 4180 4190 4200
SLRVTEPEVT IVRGLVDAEV TADEDVEFSC EVSRAGATGV QWCLQGLPLQ
4210 4220 4230 4240 4250
SNEVTEVAVR DGRIHTLRLK GVTPEDAGTV SFHLGNHASS AQLTVRAPEV
4260 4270 4280 4290 4300
TILEPLQDVQ LSEGQDASFQ CRLSRASGQE ARWALGGVPL QANEMNDITV
4310 4320 4330 4340 4350
EQGTLHLLTL HKVTLEDAGT VSFHVGTCSS EAQLKVTAKN TVVRGLENVE
4360 4370 4380 4390 4400
ALEGGEALFE CQLSQPEVAA HTWLLDDEPV HTSENAEVVF FENGLRHLLL
4410 4420 4430 4440 4450
LKNLRPQDSC RVTFLAGDMV TSAFLTVRGW RLEILEPLKN AAVRAGAQAC
4460 4470 4480 4490 4500
FTCTLSEAVP VGEASWYING AAVQPDDSDW TVTADGSHHA LLLRSAQPHH
4510 4520 4530 4540 4550
AGEVTFACRD AVASARLTVL GLPDPPEDAE VVARSSHTVT LSWAAPMSDG
4560 4570 4580 4590 4600
GGGLCGYRVE VKEGATGQWR LCHELVPGPE CVVDGLAPGE TYRFRVAAVG
4610 4620 4630 4640 4650
PVGAGEPVHL PQTVRLAEPP KPVPPQPSAP ESRQVAAGED VSLELEVVAE
4660 4670 4680 4690 4700
AGEVIWHKGM ERIQPGGRFE VVSQGRQQML VIKGFTAEDQ GEYHCGLAQG
4710 4720 4730 4740 4750
SICPAAATFQ VALSPASVDE APQPSLPPEA AQEGDLHLLW EALARKRRMS
4760 4770 4780 4790 4800
REPTLDSISE LPEEDGRSQR LPQEAEEVAP DLSEGYSTAD ELARTGDADL
4810 4820 4830 4840 4850
SHTSSDDESR AGTPSLVTYL KKAGRPGTSP LASKVGAPAA PSVKPQQQQE
4860 4870 4880 4890 4900
PLAAVRPPLG DLSTKDLGDP SMDKAAVKIQ AAFKGYKVRK EMKQQEGPMF
4910 4920 4930 4940 4950
SHTFGDTEAQ VGDALRLECV VASKADVRAR WLKDGVELTD GRHHHIDQLG
4960 4970 4980 4990 5000
DGTCSLLITG LDRADAGCYT CQVSNKFGQV THSACVVVSG SESEAESSSG
5010 5020 5030 5040 5050
GELDDAFRRA ARRLHRLFRT KSPAEVSDEE LFLSADEGPA EPEEPADWQT
5060 5070 5080 5090 5100
YREDEHFICI RFEALTEARQ AVTRFQEMFA TLGIGVEIKL VEQGPRRVEM
5110 5120 5130 5140 5150
CISKETPAPV VPPEPLPSLL TSDAAPVFLT ELQNQEVQDG YPVSFDCVVT
5160 5170 5180 5190 5200
GQPMPSVRWF KDGKLLEEDD HYMINEDQQG GHQLIITAVV PADMGVYRCL
5210 5220 5230 5240 5250
AENSMGVSST KAELRVDLTS TDYDTAADAT ESSSYFSAQG YLSSREQEGT
5260 5270 5280 5290 5300
ESTTDEGQLP QVVEELRDLQ VAPGTRLAKF QLKVKGYPAP RLYWFKDGQP
5310 5320 5330 5340 5350
LTASAHIRMT DKKILHTLEI ISVTREDSGQ YAAYISNAMG AAYSSARLLV
5360 5370 5380 5390 5400
RGPDEPEEKP ASDVHEQLVP PRMLERFTPK KVKKGSSITF SVKVEGRPVP
5410 5420 5430 5440 5450
TVHWLREEAE RGVLWIGPDT PGYTVASSAQ QHSLVLLDVG RQHQGTYTCI
5460 5470 5480 5490 5500
ASNAAGQALC SASLHVSGLP KVEEQEKVKE ALISTFLQGT TQAISAQGLE
5510 5520 5530 5540 5550
TASFADLGGQ RKEEPLAAKE ALGHLSLAEV GTEEFLQKLT SQITEMVSAK
5560 5570 5580 5590 5600
ITQAKLQVPG GDSDEDSKTP SASPRHGRSR PSSSIQESSS ESEDGDARGE
5610 5620 5630 5640 5650
IFDIYVVTAD YLPLGAEQDA ITLREGQYVE VLDAAHPLRW LVRTKPTKSS
5660 5670 5680 5690 5700
PSRQGWVSPA YLDRRLKLSP EWGAAEAPEF PGEAVSEDEY KARLSSVIQE
5710 5720 5730 5740 5750
LLSSEQAFVE ELQFLQSHHL QHLERCPHVP IAVAGQKAVI FRNVRDIGRF
5760 5770 5780 5790 5800
HSSFLQELQQ CDTDDDVAMC FIKNQAAFEQ YLEFLVGRVQ AESVVVSTAI
5810 5820 5830 5840 5850
QEFYKKYAEE ALLAGDPSQP PPPPLQHYLE QPVERVQRYQ ALLKELIRNK
5860 5870 5880 5890 5900
ARNRQNCALL EQAYAVVSAL PQRAENKLHV SLMENYPGTL QALGEPIRQG
5910 5920 5930 5940 5950
HFIVWEGAPG ARMPWKGHNR HVFLFRNHLV ICKPRRDSRT DTVSYVFRNM
5960 5970 5980 5990 6000
MKLSSIDLND QVEGDDRAFE VWQEREDSVR KYLLQARTAI IKSSWVKEIC
6010 6020 6030 6040 6050
GIQQRLALPV WRPPDFEEEL ADCTAELGET VKLACRVTGT PKPVISWYKD
6060 6070 6080 6090 6100
GKAVQVDPHH ILIEDPDGSC ALILDSLTGV DSGQYMCFAA SAAGNCSTLG
6110 6120 6130 6140 6150
KILVQVPPRF VNKVRASPFV EGEDAQFTCT IEGAPYPQIR WYKDGALLTT
6160 6170 6180 6190 6200
GNKFQTLSEP RSGLLVLVIR AASKEDLGLY ECELVNRLGS ARASAELRIQ
6210 6220 6230 6240 6250
SPMLQAQEQC HREQLVAAVE DTTLERADQE VTSVLKRLLG PKAPGPSTGD
6260 6270 6280 6290 6300
LTGPGPCPRG APALQETGSQ PPVTGTSEAP AVPPRVPQPL LHEGPEQEPE
6310 6320 6330 6340 6350
AIARAQEWTV PIRMEGAAWP GAGTGELLWD VHSHVVRETT QRTYTYQAID
6360 6370 6380 6390 6400
THTARPPSMQ VTIEDVQAQT GGTAQFEAII EGDPQPSVTW YKDSVQLVDS
6410 6420 6430 6440 6450
TRLSQQQEGT TYSLVLRHVA SKDAGVYTCL AQNTGGQVLC KAELLVLGGD
6460 6470 6480 6490 6500
NEPDSEKQSH RRKLHSFYEV KEEIGRGVFG FVKRVQHKGN KILCAAKFIP
6510 6520 6530 6540 6550
LRSRTRAQAY RERDILAALS HPLVTGLLDQ FETRKTLILI LELCSSEELL
6560 6570 6580 6590 6600
DRLYRKGVVT EAEVKVYIQQ LVEGLHYLHS HGVLHLDIKP SNILMVHPAR
6610 6620 6630 6640 6650
EDIKICDFGF AQNITPAELQ FSQYGSPEFV SPEIIQQNPV SEASDIWAMG
6660 6670 6680 6690 6700
VISYLSLTCS SPFAGESDRA TLLNVLEGRV SWSSPMAAHL SEDAKDFIKA
6710 6720 6730 6740 6750
TLQRAPQARP SAAQCLSHPW FLKSMPAEEA HFINTKQLKF LLARSRWQRS
6760 6770 6780 6790 6800
LMSYKSILVM RSIPELLRGP PDSPSLGVAR HLCRDTGGSS SSSSSSDNEL
6810 6820 6830 6840 6850
APFARAKSLP PSPVTHSPLL HPRGFLRPSA SLPEEAEASE RSTEAPAPPA
6860 6870 6880 6890 6900
SPEGAGPPAA QGCVPRHSVI RSLFYHQAGE SPEHGALAPG SRRHPARRRH
6910 6920 6930 6940 6950
LLKGGYIAGA LPGLREPLME HRVLEEEAAR EEQATLLAKA PSFETALRLP
6960 6970 6980 6990 7000
ASGTHLAPGH SHSLEHDSPS TPRPSSEACG EAQRLPSAPS GGAPIRDMGH
7010 7020 7030 7040 7050
PQGSKQLPST GGHPGTAQPE RPSPDSPWGQ PAPFCHPKQG SAPQEGCSPH
7060 7070 7080 7090 7100
PAVAPCPPGS FPPGSCKEAP LVPSSPFLGQ PQAPPAPAKA SPPLDSKMGP
7110 7120 7130 7140 7150
GDISLPGRPK PGPCSSPGSA SQASSSQVSS LRVGSSQVGT EPGPSLDAEG
7160 7170 7180 7190 7200
WTQEAEDLSD STPTLQRPQE QATMRKFSLG GRGGYAGVAG YGTFAFGGDA
7210 7220 7230 7240 7250
GGMLGQGPMW ARIAWAVSQS EEEEQEEARA ESQSEEQQEA RAESPLPQVS
7260 7270 7280 7290 7300
ARPVPEVGRA PTRSSPEPTP WEDIGQVSLV QIRDLSGDAE AADTISLDIS
7310 7320 7330 7340 7350
EVDPAYLNLS DLYDIKYLPF EFMIFRKVPK SAQPEPPSPM AEEELAEFPE
7360 7370 7380 7390 7400
PTWPWPGELG PHAGLEITEE SEDVDALLAE AAVGRKRKWS SPSRSLFHFP
7410 7420 7430 7440 7450
GRHLPLDEPA ELGLRERVKA SVEHISRILK GRPEGLEKEG PPRKKPGLAS
7460 7470 7480 7490 7500
FRLSGLKSWD RAPTFLRELS DETVVLGQSV TLACQVSAQP AAQATWSKDG
7510 7520 7530 7540 7550
APLESSSRVL ISATLKNFQL LTILVVVAED LGVYTCSVSN ALGTVTTTGV
7560 7570 7580 7590 7600
LRKAERPSSS PCPDIGEVYA DGVLLVWKPV ESYGPVTYIV QCSLEGGSWT
7610 7620 7630 7640 7650
TLASDIFDCC YLTSKLSRGG TYTFRTACVS KAGMGPYSSP SEQVLLGGPS
7660 7670 7680 7690 7700
HLASEEESQG RSAQPLPSTK TFAFQTQIQR GRFSVVRQCW EKASGRALAA
7710 7720 7730 7740 7750
KIIPYHPKDK TAVLREYEAL KGLRHPHLAQ LHAAYLSPRH LVLILELCSG
7760 7770 7780 7790 7800
PELLPCLAER ASYSESEVKD YLWQMLSATQ YLHNQHILHL DLRSENMIIT
7810 7820 7830 7840 7850
EYNLLKVVDL GNAQSLSQEK VLPSDKFKDY LETMAPELLE GQGAVPQTDI
7860 7870 7880 7890 7900
WAIGVTAFIM LSAEYPVSSE GARDLQRGLR KGLVRLSRCY AGLSGGAVAF
7910 7920 7930 7940 7950
LRSTLCAQPW GRPCASSCLQ CPWLTEEGPA CSRPAPVTFP TARLRVFVRN
7960
REKRRALLYK RHNLAQVR
Length:7,968
Mass (Da):868,484
Last modified:November 25, 2008 - v3
Checksum:i46550B34565CAC76
GO
Isoform 2 (identifier: Q5VST9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     5753-5753: S → SS

Show »
Length:7,969
Mass (Da):868,571
Checksum:i6FB22EBF680A4EF0
GO
Isoform 3 (identifier: Q5VST9-3) [UniParc]FASTAAdd to basket
Also known as: unc-89-like

The sequence of this isoform differs from the canonical sequence as follows:
     6221-6620: DTTLERADQE...AQNITPAELQ → VTEQETKVPK...DRDGDEAAQP
     6621-7968: Missing.

Note: Lacks the kinase domain. Initially described as obscurin.
Show »
Length:6,620
Mass (Da):721,547
Checksum:iAAD71899C0D7D0ED
GO
Isoform 4 (identifier: Q5VST9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3888-3913: PQPVFREPLQSLQAEEGSTATLQCEL → LPARIHSRSEDQGGLRRGHSYTAV
     3914-7968: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:3,911
Mass (Da):427,046
Checksum:i1BA7C12914F8C063
GO
Isoform 5 (identifier: Q5VST9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3886-3886: R → RALPARFTQD...EKTSATLTVK

Show »
Length:8,483
Mass (Da):924,971
Checksum:i9CACA6907978C3B6
GO

Sequence cautioni

Isoform 4 : The sequence BAB13382 differs from that shown. Reason: Frameshift at positions 3891, 5061, 5093, 5268, 6352 and 6919.Curated
The sequence CAC85746 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAC85749 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAC85750 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAH71670 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI19283 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI19284 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti888V → A in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti895L → P in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti897R → C in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti899 – 900KL → EV in CAC85746 (PubMed:11448995).Curated2
Sequence conflicti904A → V in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti917A → D in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti919T → M in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti937 – 938CM → HV in CAC85746 (PubMed:11448995).Curated2
Sequence conflicti941T → V in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti944T → M in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti952A → V in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti957A → S in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti965G → R in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti969L → V in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti972H → R in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti999S → N in CAC44768 (PubMed:11448995).Curated1
Sequence conflicti1011T → A in CAC44768 (PubMed:11448995).Curated1
Sequence conflicti1348A → V in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti1355L → P in CAC85749 (PubMed:11448995).Curated1
Sequence conflicti1357H → R in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti1359K → E in CAC85749 (PubMed:11448995).Curated1
Sequence conflicti1360V → L in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti1367I → S in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti1367I → S in CAC85749 (PubMed:11448995).Curated1
Sequence conflicti1394S → L in CAC85749 (PubMed:11448995).Curated1
Sequence conflicti1397 – 1398RM → HV in CAC85749 (PubMed:11448995).Curated2
Sequence conflicti1397R → C in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti1401V → A in CAC85749 (PubMed:11448995).Curated1
Sequence conflicti1401V → T in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti1413C → G in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti1413C → G in CAC85749 (PubMed:11448995).Curated1
Sequence conflicti1417T → A in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti1428R → Q in CAC85749 (PubMed:11448995).Curated1
Sequence conflicti1432S → H in CAC85746 (PubMed:11448995).Curated1
Sequence conflicti1445E → D in CAC85750 (PubMed:11448995).Curated1
Sequence conflicti1455Q → E in CAC85750 (PubMed:11448995).Curated1
Sequence conflicti1458A → T in CAC85750 (PubMed:11448995).Curated1
Sequence conflicti1461T → M in CAC85750 (PubMed:11448995).Curated1
Sequence conflicti1524H → R in CAC85749 (PubMed:11448995).Curated1
Sequence conflicti1526H → Q in CAC85749 (PubMed:11448995).Curated1
Sequence conflicti1580 – 1582VRM → MRV in CAC85750 (PubMed:11448995).Curated3
Sequence conflicti1607K → E in CAC85750 (PubMed:11448995).Curated1
Sequence conflicti1610D → G in CAC85750 (PubMed:11448995).Curated1
Sequence conflicti1633H → C in CAC85750 (PubMed:11448995).Curated1
Sequence conflicti1653 – 1655AQT → GQM in CAC85750 (PubMed:11448995).Curated3
Sequence conflicti1673 – 1674RV → HM in CAC85750 (PubMed:11448995).Curated2
Sequence conflicti1677 – 1679VGC → SGY in CAC85750 (PubMed:11448995).Curated3
Sequence conflicti1692E → D in CAC44768 (PubMed:11448995).Curated1
Sequence conflicti1692E → D in CAC85750 (PubMed:11448995).Curated1
Sequence conflicti1704Q → R in CAC44768 (PubMed:11448995).Curated1
Sequence conflicti1704Q → R in CAC85750 (PubMed:11448995).Curated1
Sequence conflicti1710Q → H in CAC44768 (PubMed:11448995).Curated1
Sequence conflicti1710Q → H in CAC85750 (PubMed:11448995).Curated1
Sequence conflicti1848L → P in CAC44768 (PubMed:11448995).Curated1
Sequence conflicti2014P → A in CAC85750 (PubMed:11448995).Curated1
Sequence conflicti3126V → M in CAC44768 (PubMed:11448995).Curated1
Sequence conflicti4155T → TG in CAC85752 (PubMed:16625316).Curated1
Sequence conflicti4489H → Q in CAC44768 (PubMed:11448995).Curated1
Sequence conflicti4959T → A in CAC44768 (PubMed:11448995).Curated1
Sequence conflicti5243S → ST in CAC85753 (PubMed:11448995).Curated1
Sequence conflicti5391S → F in BAB13465 (PubMed:10997877).Curated1
Sequence conflicti5499 – 5500LE → FQ in CAC44768 (PubMed:11448995).Curated2
Sequence conflicti6115R → L in CAC44768 (PubMed:11448995).Curated1
Sequence conflicti6570Q → E in CAJ76912 (PubMed:16625316).Curated1
Sequence conflicti6710 – 6711PS → SG in CAJ76912 (PubMed:16625316).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02640951A → T.1 PublicationCorresponds to variant rs1771487dbSNPEnsembl.1
Natural variantiVAR_034618502Q → R.2 PublicationsCorresponds to variant rs1771487dbSNPEnsembl.1
Natural variantiVAR_042276804G → S.1 PublicationCorresponds to variant rs55950009dbSNPEnsembl.1
Natural variantiVAR_047743908A → T.Corresponds to variant rs1757153dbSNPEnsembl.1
Natural variantiVAR_0422771027K → R.1 PublicationCorresponds to variant rs55760713dbSNPEnsembl.1
Natural variantiVAR_0422781086A → S.1 PublicationCorresponds to variant rs117147433dbSNPEnsembl.1
Natural variantiVAR_0422791090A → T.1 Publication1
Natural variantiVAR_0422801091S → T.1 Publication1
Natural variantiVAR_0422811101A → P.1 Publication1
Natural variantiVAR_0422821121G → R.1 Publication1
Natural variantiVAR_0422831133L → V.1 PublicationCorresponds to variant rs777214598dbSNPEnsembl.1
Natural variantiVAR_0355301136A → V in a colorectal cancer sample; somatic mutation. 2 Publications1
Natural variantiVAR_0422841156H → Q.1 Publication1
Natural variantiVAR_0422851248Q → H.1 PublicationCorresponds to variant rs199523598dbSNPEnsembl.1
Natural variantiVAR_0346191508V → D.Corresponds to variant rs7532342dbSNPEnsembl.1
Natural variantiVAR_0422861532A → V.1 PublicationCorresponds to variant rs453140dbSNPEnsembl.1
Natural variantiVAR_0422871566T → M.1 PublicationCorresponds to variant rs56217040dbSNPEnsembl.1
Natural variantiVAR_0422881601A → T.1 PublicationCorresponds to variant rs55706639dbSNPEnsembl.1
Natural variantiVAR_0355311792R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs750681123dbSNPEnsembl.1
Natural variantiVAR_0355321930V → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs545316651dbSNPEnsembl.1
Natural variantiVAR_0355332090E → K in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0477442106D → E.Corresponds to variant rs1188721dbSNPEnsembl.1
Natural variantiVAR_0477452116F → L.Corresponds to variant rs1188722dbSNPEnsembl.1
Natural variantiVAR_0355342314S → F in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0477462529R → Q.Corresponds to variant rs3795783dbSNPEnsembl.1
Natural variantiVAR_0477472720V → M.Corresponds to variant rs1188697dbSNPEnsembl.1
Natural variantiVAR_0477482812R → W.Corresponds to variant rs3795785dbSNPEnsembl.1
Natural variantiVAR_0346203300A → T.1 PublicationCorresponds to variant rs437129dbSNPEnsembl.1
Natural variantiVAR_0477493372E → D.Corresponds to variant rs3795789dbSNPEnsembl.1
Natural variantiVAR_0477503373S → C.Corresponds to variant rs3795790dbSNPEnsembl.1
Natural variantiVAR_0422893389A → V.1 PublicationCorresponds to variant rs770177081dbSNPEnsembl.1
Natural variantiVAR_0422903426D → E.1 Publication1
Natural variantiVAR_0422913834R → G.1 Publication1
Natural variantiVAR_0355353983R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs539154039dbSNPEnsembl.1
Natural variantiVAR_0477514039G → R.Corresponds to variant rs435776dbSNPEnsembl.1
Natural variantiVAR_0346214381H → R.1 PublicationCorresponds to variant rs1150912dbSNPEnsembl.1
Natural variantiVAR_0346224450C → R.1 PublicationCorresponds to variant rs1188732dbSNPEnsembl.1
Natural variantiVAR_0742954492L → R.1 PublicationCorresponds to variant rs369570923dbSNPEnsembl.1
Natural variantiVAR_0594294516R → W.Corresponds to variant rs11810627dbSNPEnsembl.1
Natural variantiVAR_0264104534R → H.1 PublicationCorresponds to variant rs4653942dbSNPEnsembl.1
Natural variantiVAR_0355364558R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs199865640dbSNPEnsembl.1
Natural variantiVAR_0561024642S → C.Corresponds to variant rs1188729dbSNPEnsembl.1
Natural variantiVAR_0561034662R → C.Corresponds to variant rs3795800dbSNPEnsembl.1
Natural variantiVAR_0561044666G → S.Corresponds to variant rs3795801dbSNPEnsembl.1
Natural variantiVAR_0355374810R → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs570805670dbSNPEnsembl.1
Natural variantiVAR_0422924823A → S.1 Publication1
Natural variantiVAR_0561054962D → G.Corresponds to variant rs373610dbSNPEnsembl.1
Natural variantiVAR_0355385071A → T in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0561065269L → V.Corresponds to variant rs369909dbSNPEnsembl.1
Natural variantiVAR_0561075575R → H.Corresponds to variant rs3795809dbSNPEnsembl.1
Natural variantiVAR_0422935598R → Q.1 Publication1
Natural variantiVAR_0561085891Q → E.Corresponds to variant rs1188710dbSNPEnsembl.1
Natural variantiVAR_0422946473E → Q.1 Publication1
Natural variantiVAR_0561097172A → V.1 PublicationCorresponds to variant rs500049dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0269703886R → RALPARFTQDLKTKEASEGA TATLQCELSKVAPVEWKKGP ETLRDGGRYSLKQDGTRCEL QIHDLSVADAGEYSCMCGQE RTSATLTVRALPARFTEGLR NEEAMEGATATLQCELSKAA PVEWRKGLEALRDGDKYSLR QDGAVCELQIHGLAMADNGV YSCVCGQERTSATLTVRALP ARFIEDMRNQKATEGATVTL QCKLRKAAPVEWRKGPNTLK DGDRYSLKQDGTSCELQIRG LVIADAGEYSCICEQERTSA TLTVRALPARFIEDVRNHEA TEGATAVLQCELSKAAPVEW RKGSETLRDGDRYSLRQDGT RCELQIRGLAVEDTGEYLCV CGQERTSATLTVRALPARFI DNMTNQEAREGATATLHCEL SKVAPVEWRKGPETLRDGDR HSLRQDGTRCELQIRGLSVA DAGEYSCVCGQERTSATLTI REATEGATAMLQCELSKVAP VEWRKGPETLRDGDRYNLRQ DGTRCELQIHGLSVADTGEY SCVCGQEKTSATLTVK in isoform 5. Curated1
Alternative sequenceiVSP_0200863888 – 3913PQPVF…LQCEL → LPARIHSRSEDQGGLRRGHS YTAV in isoform 4. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_0200873914 – 7968Missing in isoform 4. 1 PublicationAdd BLAST4055
Alternative sequenceiVSP_0184365753S → SS in isoform 2. 1 Publication1
Alternative sequenceiVSP_0184376221 – 6620DTTLE…PAELQ → VTEQETKVPKKTVIIEETIT TVVKSPRGQRRSPSKSPSRS PSRCSASPLRPGLLAPDLLY LPGAGQPRRPEAEPGQKPVV PTLYVTEAEAHSPALPGLSG PQPKWVEVEETIEVRVKKMG PQGVSPTTEVPRSSSGHLFT LPGATPGGDPNSNNSNNKLL AQEAWAQGTAMVGVREPLVF RVDARGSVDWAASGMGSLEE EGTMEEAGEEEGEDGDAFVT EESQDTHSLGDRDPKILTHN GRMLTLADLEDYVPGEGETF HCGGPGPGAPDDPPCEVSVI QREIGEPTVGQPVLLSVGHA LGPRGPLGLFRPEPRGASPP GPQVRSLEGTSFLLREAPAR PVGSAPWTQSFCTRIRRSAD SGQSSFTTELSTQTVNFGTV GETVTLHICPDRDGDEAAQP in isoform 3. 1 PublicationAdd BLAST400
Alternative sequenceiVSP_0184386621 – 7968Missing in isoform 3. 1 PublicationAdd BLAST1348

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002535 mRNA. Translation: