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Protein

Protein ABHD17B

Gene

ABHD17B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei170 – 1701Charge relay systemBy similarity
Active sitei235 – 2351Charge relay systemBy similarity
Active sitei264 – 2641Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERihuman-ABHD17B. 5_AlphaBeta_hydrolase.
MEROPSiS09.055.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ABHD17BCurated (EC:3.-.-.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 17BCurated
Short name:
Abhydrolase domain-containing protein 17BImported
Gene namesi
Name:ABHD17BImported
Synonyms:C9orf77, FAM108B1
ORF Names:CGI-67
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:24278. ABHD17B.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162385624.

Chemistry

ChEMBLiCHEMBL2189132.

Polymorphism and mutation databases

BioMutaiABHD17B.
DMDMi74746845.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 288268Protein ABHD17BPRO_0000281111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei282 – 2821PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5VST6.
MaxQBiQ5VST6.
PaxDbiQ5VST6.
PRIDEiQ5VST6.

PTM databases

iPTMnetiQ5VST6.
PhosphoSiteiQ5VST6.
SwissPalmiQ5VST6.

Expressioni

Gene expression databases

BgeeiQ5VST6.
CleanExiHS_FAM108B1.
GenevisibleiQ5VST6. HS.

Organism-specific databases

HPAiHPA047862.

Interactioni

Protein-protein interaction databases

BioGridi119293. 19 interactions.
STRINGi9606.ENSP00000366240.

Structurei

3D structure databases

ProteinModelPortaliQ5VST6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. ABHD17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1552. Eukaryota.
COG1073. LUCA.
GeneTreeiENSGT00390000000948.
HOGENOMiHOG000007142.
HOVERGENiHBG061270.
InParanoidiQ5VST6.
OMAiTGQASEC.
OrthoDBiEOG7V7670.
PhylomeDBiQ5VST6.
TreeFamiTF314365.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR022742. Hydrolase_4.
[Graphical view]
PfamiPF12146. Hydrolase_4. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VST6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNNLSFSELC CLFCCPPCPG KIASKLAFLP PDPTYTLMCD ESGSRWTLHL
60 70 80 90 100
SERADWQYSS REKDAIECFM TRTSKGNRIA CMFVRCSPNA KYTLLFSHGN
110 120 130 140 150
AVDLGQMSSF YIGLGSRINC NIFSYDYSGY GASSGKPTEK NLYADIEAAW
160 170 180 190 200
LALRTRYGIR PENVIIYGQS IGTVPSVDLA ARYESAAVIL HSPLTSGMRV
210 220 230 240 250
AFPDTKKTYC FDAFPNIDKI SKITSPVLII HGTEDEVIDF SHGLALFERC
260 270 280
QRPVEPLWVE GAGHNDVELY GQYLERLKQF VSQELVNL
Length:288
Mass (Da):32,215
Last modified:December 7, 2004 - v1
Checksum:iF315AF711AF532BD
GO
Isoform 2 (identifier: Q5VST6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-288: NL → QKHKEGK

Show »
Length:293
Mass (Da):32,823
Checksum:i239D054DAE87173F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 214CPGK → LSGE in AAD34062 (PubMed:10810093).Curated
Sequence conflicti43 – 442GS → RT in AAD34062 (PubMed:10810093).Curated
Sequence conflicti207 – 2071K → E in AAD34062 (PubMed:10810093).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti154 – 1541R → K.
Corresponds to variant rs12380380 [ dbSNP | Ensembl ].
VAR_054080
Natural varianti169 – 1691Q → K.1 Publication
Corresponds to variant rs17854317 [ dbSNP | Ensembl ].
VAR_031230

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei287 – 2882NL → QKHKEGK in isoform 2. 1 PublicationVSP_023975

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151825 mRNA. Translation: AAD34062.1.
AK293060 mRNA. Translation: BAF85749.1.
AL138751, AL671309 Genomic DNA. Translation: CAH72763.1.
AL138751, AL671309 Genomic DNA. Translation: CAH72764.1.
AL671309, AL138751 Genomic DNA. Translation: CAH73542.1.
AL671309, AL138751 Genomic DNA. Translation: CAH73543.1.
CH471089 Genomic DNA. Translation: EAW62521.1.
BC038390 mRNA. Translation: AAH38390.2.
BC044576 mRNA. Translation: AAH44576.1.
CCDSiCCDS35042.1. [Q5VST6-2]
CCDS35043.1. [Q5VST6-1]
RefSeqiNP_001020951.1. NM_001025780.2. [Q5VST6-1]
NP_057098.2. NM_016014.3. [Q5VST6-2]
XP_006717197.1. XM_006717134.2. [Q5VST6-1]
XP_011517061.1. XM_011518759.1. [Q5VST6-1]
UniGeneiHs.380389.

Genome annotation databases

EnsembliENST00000333421; ENSP00000330222; ENSG00000107362. [Q5VST6-1]
ENST00000377041; ENSP00000366240; ENSG00000107362. [Q5VST6-2]
GeneIDi51104.
KEGGihsa:51104.
UCSCiuc004ail.4. human. [Q5VST6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151825 mRNA. Translation: AAD34062.1.
AK293060 mRNA. Translation: BAF85749.1.
AL138751, AL671309 Genomic DNA. Translation: CAH72763.1.
AL138751, AL671309 Genomic DNA. Translation: CAH72764.1.
AL671309, AL138751 Genomic DNA. Translation: CAH73542.1.
AL671309, AL138751 Genomic DNA. Translation: CAH73543.1.
CH471089 Genomic DNA. Translation: EAW62521.1.
BC038390 mRNA. Translation: AAH38390.2.
BC044576 mRNA. Translation: AAH44576.1.
CCDSiCCDS35042.1. [Q5VST6-2]
CCDS35043.1. [Q5VST6-1]
RefSeqiNP_001020951.1. NM_001025780.2. [Q5VST6-1]
NP_057098.2. NM_016014.3. [Q5VST6-2]
XP_006717197.1. XM_006717134.2. [Q5VST6-1]
XP_011517061.1. XM_011518759.1. [Q5VST6-1]
UniGeneiHs.380389.

3D structure databases

ProteinModelPortaliQ5VST6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119293. 19 interactions.
STRINGi9606.ENSP00000366240.

Chemistry

ChEMBLiCHEMBL2189132.

Protein family/group databases

ESTHERihuman-ABHD17B. 5_AlphaBeta_hydrolase.
MEROPSiS09.055.

PTM databases

iPTMnetiQ5VST6.
PhosphoSiteiQ5VST6.
SwissPalmiQ5VST6.

Polymorphism and mutation databases

BioMutaiABHD17B.
DMDMi74746845.

Proteomic databases

EPDiQ5VST6.
MaxQBiQ5VST6.
PaxDbiQ5VST6.
PRIDEiQ5VST6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333421; ENSP00000330222; ENSG00000107362. [Q5VST6-1]
ENST00000377041; ENSP00000366240; ENSG00000107362. [Q5VST6-2]
GeneIDi51104.
KEGGihsa:51104.
UCSCiuc004ail.4. human. [Q5VST6-1]

Organism-specific databases

CTDi51104.
GeneCardsiABHD17B.
H-InvDBHIX0025709.
HGNCiHGNC:24278. ABHD17B.
HPAiHPA047862.
neXtProtiNX_Q5VST6.
PharmGKBiPA162385624.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1552. Eukaryota.
COG1073. LUCA.
GeneTreeiENSGT00390000000948.
HOGENOMiHOG000007142.
HOVERGENiHBG061270.
InParanoidiQ5VST6.
OMAiTGQASEC.
OrthoDBiEOG7V7670.
PhylomeDBiQ5VST6.
TreeFamiTF314365.

Miscellaneous databases

ChiTaRSiABHD17B. human.
GenomeRNAii51104.
PROiQ5VST6.

Gene expression databases

BgeeiQ5VST6.
CleanExiHS_FAM108B1.
GenevisibleiQ5VST6. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR022742. Hydrolase_4.
[Graphical view]
PfamiPF12146. Hydrolase_4. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-169.
    Tissue: Brain and Skin.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAB17B_HUMAN
AccessioniPrimary (citable) accession number: Q5VST6
Secondary accession number(s): A8KAJ5
, Q5VST7, Q86YB6, Q8IY03, Q9Y377
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 7, 2004
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.