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Protein

Alpha/beta hydrolase domain-containing protein 17B

Gene

ABHD17B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed:26701913).By similarity1 Publication

Catalytic activityi

Palmitoyl-[protein] + H2O = palmitate + [protein].1 Publication

Enzyme regulationi

Inhibited by palmostatin-B.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei170Charge relay systemBy similarity1
Active sitei235Charge relay systemBy similarity1
Active sitei264Charge relay systemBy similarity1

GO - Molecular functioni

  • palmitoyl-(protein) hydrolase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Protein family/group databases

ESTHERihuman-ABHD17B. ABHD17-depalmitoylase.
MEROPSiS09.055.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha/beta hydrolase domain-containing protein 17BCurated (EC:3.1.2.221 Publication)
Short name:
Abhydrolase domain-containing protein 17BImported
Gene namesi
Name:ABHD17BImported
Synonyms:C9orf77, FAM108B1
ORF Names:CGI-67
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000107362.13.
HGNCiHGNC:24278. ABHD17B.
neXtProtiNX_Q5VST6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Endosome, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000107362.
PharmGKBiPA162385624.

Chemistry databases

ChEMBLiCHEMBL2189132.

Polymorphism and mutation databases

BioMutaiABHD17B.
DMDMi74746845.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002811111 – 288Alpha/beta hydrolase domain-containing protein 17BAdd BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei282PhosphoserineBy similarity1

Post-translational modificationi

Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization. Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ5VST6.
MaxQBiQ5VST6.
PaxDbiQ5VST6.
PeptideAtlasiQ5VST6.
PRIDEiQ5VST6.

PTM databases

iPTMnetiQ5VST6.
PhosphoSitePlusiQ5VST6.
SwissPalmiQ5VST6.

Expressioni

Gene expression databases

BgeeiENSG00000107362.
CleanExiHS_FAM108B1.
GenevisibleiQ5VST6. HS.

Organism-specific databases

HPAiHPA047862.

Interactioni

Protein-protein interaction databases

BioGridi119293. 31 interactors.
STRINGi9606.ENSP00000366240.

Structurei

3D structure databases

ProteinModelPortaliQ5VST6.
SMRiQ5VST6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. ABHD17 family.Curated

Phylogenomic databases

eggNOGiKOG1552. Eukaryota.
COG1073. LUCA.
GeneTreeiENSGT00390000000948.
HOGENOMiHOG000007142.
HOVERGENiHBG061270.
InParanoidiQ5VST6.
OMAiKQFVAHE.
OrthoDBiEOG091G0EV3.
PhylomeDBiQ5VST6.
TreeFamiTF314365.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR022742. Hydrolase_4.
PfamiView protein in Pfam
PF12146. Hydrolase_4. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VST6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNNLSFSELC CLFCCPPCPG KIASKLAFLP PDPTYTLMCD ESGSRWTLHL
60 70 80 90 100
SERADWQYSS REKDAIECFM TRTSKGNRIA CMFVRCSPNA KYTLLFSHGN
110 120 130 140 150
AVDLGQMSSF YIGLGSRINC NIFSYDYSGY GASSGKPTEK NLYADIEAAW
160 170 180 190 200
LALRTRYGIR PENVIIYGQS IGTVPSVDLA ARYESAAVIL HSPLTSGMRV
210 220 230 240 250
AFPDTKKTYC FDAFPNIDKI SKITSPVLII HGTEDEVIDF SHGLALFERC
260 270 280
QRPVEPLWVE GAGHNDVELY GQYLERLKQF VSQELVNL
Length:288
Mass (Da):32,215
Last modified:December 7, 2004 - v1
Checksum:iF315AF711AF532BD
GO
Isoform 2 (identifier: Q5VST6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-288: NL → QKHKEGK

Show »
Length:293
Mass (Da):32,823
Checksum:i239D054DAE87173F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18 – 21CPGK → LSGE in AAD34062 (PubMed:10810093).Curated4
Sequence conflicti43 – 44GS → RT in AAD34062 (PubMed:10810093).Curated2
Sequence conflicti207K → E in AAD34062 (PubMed:10810093).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054080154R → K. Corresponds to variant dbSNP:rs12380380Ensembl.1
Natural variantiVAR_031230169Q → K1 PublicationCorresponds to variant dbSNP:rs17854317Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023975287 – 288NL → QKHKEGK in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151825 mRNA. Translation: AAD34062.1.
AK293060 mRNA. Translation: BAF85749.1.
AL138751 Genomic DNA. No translation available.
AL671309 Genomic DNA. No translation available.
CH471089 Genomic DNA. Translation: EAW62521.1.
BC038390 mRNA. Translation: AAH38390.2.
BC044576 mRNA. Translation: AAH44576.1.
CCDSiCCDS35042.1. [Q5VST6-2]
CCDS35043.1. [Q5VST6-1]
RefSeqiNP_001020951.1. NM_001025780.2. [Q5VST6-1]
NP_057098.2. NM_016014.3. [Q5VST6-2]
XP_006717197.2. XM_006717134.3. [Q5VST6-2]
XP_016870276.1. XM_017014787.1. [Q5VST6-2]
XP_016870277.1. XM_017014788.1. [Q5VST6-1]
XP_016870278.1. XM_017014789.1. [Q5VST6-1]
UniGeneiHs.380389.

Genome annotation databases

EnsembliENST00000333421; ENSP00000330222; ENSG00000107362. [Q5VST6-1]
ENST00000377041; ENSP00000366240; ENSG00000107362. [Q5VST6-2]
GeneIDi51104.
KEGGihsa:51104.
UCSCiuc004ail.4. human. [Q5VST6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAB17B_HUMAN
AccessioniPrimary (citable) accession number: Q5VST6
Secondary accession number(s): A8KAJ5
, Q5VST7, Q86YB6, Q8IY03, Q9Y377
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 7, 2004
Last modified: February 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome