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Q5VSR9

- SPXN1_HUMAN

UniProt

Q5VSR9 - SPXN1_HUMAN

Protein

Sperm protein associated with the nucleus on the X chromosome N1

Gene

SPANXN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome N1
    Alternative name(s):
    Nuclear-associated protein SPAN-Xn1
    Short name:
    SPANX-N1
    SPANX family member N1
    Gene namesi
    Name:SPANXN1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:33174. SPANXN1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162404376.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7272Sperm protein associated with the nucleus on the X chromosome N1PRO_0000285538Add
    BLAST

    Proteomic databases

    PaxDbiQ5VSR9.
    PRIDEiQ5VSR9.

    Expressioni

    Gene expression databases

    BgeeiQ5VSR9.
    CleanExiHS_SPANXN1.
    GenevestigatoriQ5VSR9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VSR9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SPAN-X family.Curated

    Phylogenomic databases

    eggNOGiNOG136441.
    HOGENOMiHOG000015252.
    HOVERGENiHBG097736.
    OMAiEYSTVLA.
    OrthoDBiEOG7C2R2W.
    PhylomeDBiQ5VSR9.
    TreeFamiTF341404.

    Family and domain databases

    InterProiIPR010007. SPANX_prot.
    [Graphical view]
    PANTHERiPTHR23425. PTHR23425. 1 hit.
    PfamiPF07458. SPAN-X. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5VSR9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQPTSSING EKRKSPCESN NENDEMQETP NRDLAPEPSL KKMKTSEYST   50
    VLAFCYRKAK KIHSNQLEND QS 72
    Length:72
    Mass (Da):8,263
    Last modified:December 7, 2004 - v1
    Checksum:i9248A461D75DDA5F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY825029 Genomic DNA. Translation: AAV97585.1.
    DQ336121 mRNA. Translation: ABC61872.1.
    DQ336118 mRNA. Translation: ABC61869.1.
    DQ336119 mRNA. Translation: ABC61870.1.
    DQ336120 mRNA. Translation: ABC61871.1.
    AL356499, AL713923 Genomic DNA. Translation: CAI42585.1.
    AL713923, AL356499 Genomic DNA. Translation: CAH70536.1.
    CCDSiCCDS35421.1.
    RefSeqiNP_001009614.1. NM_001009614.2.
    UniGeneiHs.551270.

    Genome annotation databases

    EnsembliENST00000370493; ENSP00000359524; ENSG00000203923.
    GeneIDi494118.
    KEGGihsa:494118.
    UCSCiuc004fcb.2. human.

    Polymorphism databases

    DMDMi74746835.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY825029 Genomic DNA. Translation: AAV97585.1 .
    DQ336121 mRNA. Translation: ABC61872.1 .
    DQ336118 mRNA. Translation: ABC61869.1 .
    DQ336119 mRNA. Translation: ABC61870.1 .
    DQ336120 mRNA. Translation: ABC61871.1 .
    AL356499 , AL713923 Genomic DNA. Translation: CAI42585.1 .
    AL713923 , AL356499 Genomic DNA. Translation: CAH70536.1 .
    CCDSi CCDS35421.1.
    RefSeqi NP_001009614.1. NM_001009614.2.
    UniGenei Hs.551270.

    3D structure databases

    ProteinModelPortali Q5VSR9.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 74746835.

    Proteomic databases

    PaxDbi Q5VSR9.
    PRIDEi Q5VSR9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370493 ; ENSP00000359524 ; ENSG00000203923 .
    GeneIDi 494118.
    KEGGi hsa:494118.
    UCSCi uc004fcb.2. human.

    Organism-specific databases

    CTDi 494118.
    GeneCardsi GC0XP144328.
    HGNCi HGNC:33174. SPANXN1.
    MIMi 300664. gene.
    neXtProti NX_Q5VSR9.
    PharmGKBi PA162404376.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG136441.
    HOGENOMi HOG000015252.
    HOVERGENi HBG097736.
    OMAi EYSTVLA.
    OrthoDBi EOG7C2R2W.
    PhylomeDBi Q5VSR9.
    TreeFami TF341404.

    Miscellaneous databases

    NextBioi 111806.
    PROi Q5VSR9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5VSR9.
    CleanExi HS_SPANXN1.
    Genevestigatori Q5VSR9.

    Family and domain databases

    InterProi IPR010007. SPANX_prot.
    [Graphical view ]
    PANTHERi PTHR23425. PTHR23425. 1 hit.
    Pfami PF07458. SPAN-X. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids."
      Kouprina N., Mullokandov M., Rogozin I.B., Collins N.K., Solomon G., Otstot J., Risinger J.I., Koonin E.V., Barrett J.C., Larionov V.
      Proc. Natl. Acad. Sci. U.S.A. 101:3077-3082(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27."
      Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W., Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J., Larionov V.
      Genome Res. 15:1477-1486(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiSPXN1_HUMAN
    AccessioniPrimary (citable) accession number: Q5VSR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3