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Protein

Sperm protein associated with the nucleus on the X chromosome N1

Gene

SPANXN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm protein associated with the nucleus on the X chromosome N1
Alternative name(s):
Nuclear-associated protein SPAN-Xn1
Short name:
SPANX-N1
SPANX family member N1
Gene namesi
Name:SPANXN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:33174. SPANXN1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162404376.

Polymorphism and mutation databases

BioMutaiSPANXN1.
DMDMi74746835.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7272Sperm protein associated with the nucleus on the X chromosome N1PRO_0000285538Add
BLAST

Proteomic databases

PaxDbiQ5VSR9.
PRIDEiQ5VSR9.

Expressioni

Gene expression databases

BgeeiQ5VSR9.
CleanExiHS_SPANXN1.

Structurei

3D structure databases

ProteinModelPortaliQ5VSR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPAN-X family.Curated

Phylogenomic databases

eggNOGiNOG136441.
GeneTreeiENSGT00530000064247.
HOGENOMiHOG000015252.
HOVERGENiHBG097736.
OMAiAFCYRKA.
OrthoDBiEOG7C2R2W.
PhylomeDBiQ5VSR9.
TreeFamiTF341404.

Family and domain databases

InterProiIPR010007. SPANX_prot.
[Graphical view]
PANTHERiPTHR23425. PTHR23425. 1 hit.
PfamiPF07458. SPAN-X. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VSR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQPTSSING EKRKSPCESN NENDEMQETP NRDLAPEPSL KKMKTSEYST
60 70
VLAFCYRKAK KIHSNQLEND QS
Length:72
Mass (Da):8,263
Last modified:December 7, 2004 - v1
Checksum:i9248A461D75DDA5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY825029 Genomic DNA. Translation: AAV97585.1.
DQ336121 mRNA. Translation: ABC61872.1.
DQ336118 mRNA. Translation: ABC61869.1.
DQ336119 mRNA. Translation: ABC61870.1.
DQ336120 mRNA. Translation: ABC61871.1.
AL356499, AL713923 Genomic DNA. Translation: CAI42585.1.
AL713923, AL356499 Genomic DNA. Translation: CAH70536.1.
CCDSiCCDS35421.1.
RefSeqiNP_001009614.1. NM_001009614.2.
UniGeneiHs.551270.

Genome annotation databases

EnsembliENST00000370493; ENSP00000359524; ENSG00000203923.
GeneIDi494118.
KEGGihsa:494118.
UCSCiuc004fcb.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY825029 Genomic DNA. Translation: AAV97585.1.
DQ336121 mRNA. Translation: ABC61872.1.
DQ336118 mRNA. Translation: ABC61869.1.
DQ336119 mRNA. Translation: ABC61870.1.
DQ336120 mRNA. Translation: ABC61871.1.
AL356499, AL713923 Genomic DNA. Translation: CAI42585.1.
AL713923, AL356499 Genomic DNA. Translation: CAH70536.1.
CCDSiCCDS35421.1.
RefSeqiNP_001009614.1. NM_001009614.2.
UniGeneiHs.551270.

3D structure databases

ProteinModelPortaliQ5VSR9.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiSPANXN1.
DMDMi74746835.

Proteomic databases

PaxDbiQ5VSR9.
PRIDEiQ5VSR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370493; ENSP00000359524; ENSG00000203923.
GeneIDi494118.
KEGGihsa:494118.
UCSCiuc004fcb.2. human.

Organism-specific databases

CTDi494118.
GeneCardsiGC0XP144328.
HGNCiHGNC:33174. SPANXN1.
MIMi300664. gene.
neXtProtiNX_Q5VSR9.
PharmGKBiPA162404376.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG136441.
GeneTreeiENSGT00530000064247.
HOGENOMiHOG000015252.
HOVERGENiHBG097736.
OMAiAFCYRKA.
OrthoDBiEOG7C2R2W.
PhylomeDBiQ5VSR9.
TreeFamiTF341404.

Miscellaneous databases

GenomeRNAii494118.
NextBioi111806.
PROiQ5VSR9.
SOURCEiSearch...

Gene expression databases

BgeeiQ5VSR9.
CleanExiHS_SPANXN1.

Family and domain databases

InterProiIPR010007. SPANX_prot.
[Graphical view]
PANTHERiPTHR23425. PTHR23425. 1 hit.
PfamiPF07458. SPAN-X. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids."
    Kouprina N., Mullokandov M., Rogozin I.B., Collins N.K., Solomon G., Otstot J., Risinger J.I., Koonin E.V., Barrett J.C., Larionov V.
    Proc. Natl. Acad. Sci. U.S.A. 101:3077-3082(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27."
    Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W., Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J., Larionov V.
    Genome Res. 15:1477-1486(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSPXN1_HUMAN
AccessioniPrimary (citable) accession number: Q5VSR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 7, 2004
Last modified: July 22, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.