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Protein

Striatin-interacting protein 1

Gene

STRIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.1 Publication

GO - Biological processi

  • cortical actin cytoskeleton organization Source: UniProtKB
  • regulation of cell morphogenesis Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Striatin-interacting protein 1
Alternative name(s):
Protein FAM40A
Gene namesi
Name:STRIP1
Synonyms:FAM40A, KIAA1761
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143093.14.
HGNCiHGNC:25916. STRIP1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143093.
PharmGKBiPA134939426.

Polymorphism and mutation databases

DMDMi71648671.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001870171 – 837Striatin-interacting protein 1Add BLAST837

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei59PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei339PhosphoserineBy similarity1
Modified residuei788PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5VSL9.
MaxQBiQ5VSL9.
PaxDbiQ5VSL9.
PeptideAtlasiQ5VSL9.
PRIDEiQ5VSL9.

PTM databases

iPTMnetiQ5VSL9.
PhosphoSitePlusiQ5VSL9.

Expressioni

Gene expression databases

BgeeiENSG00000143093.
CleanExiHS_FAM40A.
GenevisibleiQ5VSL9. HS.

Organism-specific databases

HPAiHPA060302.
HPA060498.

Interactioni

Subunit structurei

Component of striatin-interacting phosphatase and kinase (STRIPAK) complex (By similarity). Interacts with CDC42BPB (PubMed:25743393). Interacts with CTTNBP2NL (PubMed:18782753).By similarity2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124497. 61 interactors.
DIPiDIP-51621N.
IntActiQ5VSL9. 30 interactors.
STRINGi9606.ENSP00000358810.

Structurei

3D structure databases

ProteinModelPortaliQ5VSL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 36Pro-richAdd BLAST34

Sequence similaritiesi

Belongs to the STRIP family.Curated

Phylogenomic databases

eggNOGiKOG3680. Eukaryota.
ENOG410XRAB. LUCA.
GeneTreeiENSGT00400000022095.
HOVERGENiHBG081506.
InParanoidiQ5VSL9.
OMAiGMITRFC.
OrthoDBiEOG091G02GC.
PhylomeDBiQ5VSL9.
TreeFamiTF314205.

Family and domain databases

InterProiView protein in InterPro
IPR021819. DUF3402.
IPR012486. N1221.
PfamiView protein in Pfam
PF11882. DUF3402. 2 hits.
PF07923. N1221. 1 hit.
SMARTiView protein in SMART
SM01293. DUF3402. 1 hit.
SM01292. N1221. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VSL9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPAVGGPGP LIVNNKQPQP PPPPPPAAAQ PPPGAPRAAA GLLPGGKARE
60 70 80 90 100
FNRNQRKDSE GYSESPDLEF EYADTDKWAA ELSELYSYTE GPEFLMNRKC
110 120 130 140 150
FEEDFRIHVT DKKWTELDTN QHRTHAMRLL DGLEVTAREK RLKVARAILY
160 170 180 190 200
VAQGTFGECS SEAEVQSWMR YNIFLLLEVG TFNALVELLN MEIDNSAACS
210 220 230 240 250
SAVRKPAISL ADSTDLRVLL NIMYLIVETV HQECEGDKAE WRTMRQTFRA
260 270 280 290 300
ELGSPLYNNE PFAIMLFGMV TKFCSGHAPH FPMKKVLLLL WKTVLCTLGG
310 320 330 340 350
FEELQSMKAE KRSILGLPPL PEDSIKVIRN MRAASPPASA SDLIEQQQKR
360 370 380 390 400
GRREHKALIK QDNLDAFNER DPYKADDSRE EEEENDDDNS LEGETFPLER
410 420 430 440 450
DEVMPPPLQH PQTDRLTCPK GLPWAPKVRE KDIEMFLESS RSKFIGYTLG
460 470 480 490 500
SDTNTVVGLP RPIHESIKTL KQHKYTSIAE VQAQMEEEYL RSPLSGGEEE
510 520 530 540 550
VEQVPAETLY QGLLPSLPQY MIALLKILLA AAPTSKAKTD SINILADVLP
560 570 580 590 600
EEMPTTVLQS MKLGVDVNRH KEVIVKAISA VLLLLLKHFK LNHVYQFEYM
610 620 630 640 650
AQHLVFANCI PLILKFFNQN IMSYITAKNS ISVLDYPHCV VHELPELTAE
660 670 680 690 700
SLEAGDSNQF CWRNLFSCIN LLRILNKLTK WKHSRTMMLV VFKSAPILKR
710 720 730 740 750
ALKVKQAMMQ LYVLKLLKVQ TKYLGRQWRK SNMKTMSAIY QKVRHRLNDD
760 770 780 790 800
WAYGNDLDAR PWDFQAEECA LRANIERFNA RRYDRAHSNP DFLPVDNCLQ
810 820 830
SVLGQRVDLP EDFQMNYDLW LEREVFSKPI SWEELLQ
Length:837
Mass (Da):95,576
Last modified:December 7, 2004 - v1
Checksum:i5F9BA1D4C7DE6925
GO
Isoform 2 (identifier: Q5VSL9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Note: No experimental confirmation available.
Show »
Length:742
Mass (Da):85,451
Checksum:iA4C208A05F910919
GO
Isoform 3 (identifier: Q5VSL9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-264: Missing.
     596-596: Q → QVPTGLSLLS...FFFFFSCWLQ
     630-630: S → R
     631-837: Missing.

Note: No experimental confirmation available.
Show »
Length:440
Mass (Da):49,699
Checksum:iB1ADA0F87A30303E
GO
Isoform 4 (identifier: Q5VSL9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     194-212: DNSAACSSAVRKPAISLAD → EHCCVRPAVSALAGGQAQD
     213-837: Missing.

Note: No experimental confirmation available.
Show »
Length:212
Mass (Da):23,540
Checksum:i636A065B51CB3595
GO

Sequence cautioni

The sequence AAH32644 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti397P → L in BAC86034 (PubMed:14702039).Curated1
Sequence conflicti744R → Q in BAB55265 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076430628K → N1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0148561 – 264Missing in isoform 3. 1 PublicationAdd BLAST264
Alternative sequenceiVSP_0148571 – 95Missing in isoform 2. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_014858194 – 212DNSAA…ISLAD → EHCCVRPAVSALAGGQAQD in isoform 4. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_014859213 – 837Missing in isoform 4. 1 PublicationAdd BLAST625
Alternative sequenceiVSP_014860596Q → QVPTGLSLLSCGLGPRALLL LQPTRTGALAFDPLELCMNV LRHGPSAKAFHPWRKEGKVP RAAPFFFFFFSCWLQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_014861630S → R in isoform 3. 1 Publication1
Alternative sequenceiVSP_014862631 – 837Missing in isoform 3. 1 PublicationAdd BLAST207

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051548 mRNA. Translation: BAB21852.2.
AK027649 mRNA. Translation: BAB55265.1.
AK125054 mRNA. Translation: BAC86034.1.
AL834196 mRNA. Translation: CAH56368.1.
AL772411, AL160006 Genomic DNA. Translation: CAH70967.1.
AL772411, AL160006 Genomic DNA. Translation: CAH70968.1.
AL160006, AL772411 Genomic DNA. Translation: CAI22715.1.
AL160006, AL772411 Genomic DNA. Translation: CAI22716.1.
BC032644 mRNA. Translation: AAH32644.1. Different initiation.
BC094786 mRNA. Translation: AAH94786.1.
BC119814 mRNA. Translation: AAI19815.1.
BC121793 mRNA. Translation: AAI21794.1.
CCDSiCCDS30798.1. [Q5VSL9-1]
CCDS59197.1. [Q5VSL9-2]
RefSeqiNP_001257697.1. NM_001270768.1. [Q5VSL9-2]
NP_149079.2. NM_033088.3. [Q5VSL9-1]
UniGeneiHs.584996.

Genome annotation databases

EnsembliENST00000369795; ENSP00000358810; ENSG00000143093. [Q5VSL9-1]
ENST00000369796; ENSP00000358811; ENSG00000143093. [Q5VSL9-2]
ENST00000485775; ENSP00000476025; ENSG00000143093. [Q5VSL9-4]
GeneIDi85369.
KEGGihsa:85369.
UCSCiuc001dyz.2. human. [Q5VSL9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTRP1_HUMAN
AccessioniPrimary (citable) accession number: Q5VSL9
Secondary accession number(s): Q0V925
, Q5VSL8, Q658K2, Q6ZV31, Q8N598, Q96SN2, Q9C0A2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: December 7, 2004
Last modified: September 27, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families