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Protein

Glycoprotein endo-alpha-1,2-mannosidase-like protein

Gene

MANEAL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

CAZyiGH99. Glycoside Hydrolase Family 99.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein endo-alpha-1,2-mannosidase-like protein (EC:3.2.1.-)
Gene namesi
Name:MANEAL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26452. MANEAL.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence analysis
Transmembranei9 – 2921Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini30 – 457428LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671481.

Polymorphism and mutation databases

BioMutaiMANEAL.
DMDMi74746792.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Glycoprotein endo-alpha-1,2-mannosidase-like proteinPRO_0000282320Add
BLAST

Proteomic databases

MaxQBiQ5VSG8.
PaxDbiQ5VSG8.
PRIDEiQ5VSG8.

PTM databases

iPTMnetiQ5VSG8.
PhosphoSiteiQ5VSG8.

Expressioni

Gene expression databases

BgeeiQ5VSG8.
CleanExiHS_MANEAL.
ExpressionAtlasiQ5VSG8. baseline and differential.
GenevisibleiQ5VSG8. HS.

Interactioni

Protein-protein interaction databases

BioGridi127196. 19 interactions.
STRINGi9606.ENSP00000362136.

Structurei

3D structure databases

ProteinModelPortaliQ5VSG8.
SMRiQ5VSG8. Positions 107-452.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 75Poly-Arg
Compositional biasi32 – 9564Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 99 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMQ9. Eukaryota.
ENOG4111PYT. LUCA.
GeneTreeiENSGT00390000016054.
HOGENOMiHOG000223388.
HOVERGENiHBG103563.
InParanoidiQ5VSG8.
OMAiLREHMTQ.
OrthoDBiEOG7NGQB6.
PhylomeDBiQ5VSG8.
TreeFamiTF324051.

Family and domain databases

InterProiIPR026071. Glyco_Hydrolase_99.
[Graphical view]
PANTHERiPTHR13572. PTHR13572. 1 hit.
PfamiPF16317. Glyco_hydro_99. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VSG8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARRRRRACI ALFLVLLFAF GTLMGLRTLK APDGLPALGP GLELAPFERR
60 70 80 90 100
PEGAPAPAAR APAAPAAPPP PPPPPRTADP GGSPGPAPAE AEPAPVQSLR
110 120 130 140 150
VYSDLHAFYY SWYGSPRREG HYIHWDHVMV PHWDPKISAS YPRGRHSPPD
160 170 180 190 200
DLGSSFYPEL GPYSSRDPEV LREHMTQLKE AAIGVLVLSW YPPGMADDNG
210 220 230 240 250
EPSDDLVPAI LDTAHQYSIQ VAFHIQPYKG RDDITVHDNI KYIIDTYGSH
260 270 280 290 300
GAFYRYKNSM GKSLPLFYIY DSYLTSPEAW AHLLTPNGPH SIRNTPYDGV
310 320 330 340 350
FIALLVEEGH THDILAAGFD GMYTYFASNG FSFGSSHQNW KAVKNFCDAN
360 370 380 390 400
NLMFIPSVGP GYIDTSIRPW NNHNTRNRVN GKYYETALQA ALTVRPEIVS
410 420 430 440 450
ITSFNEWHEG TQIEKAIPKK TPTRLYLDYL PHQPSLYLEL TRRWAEHFIK

EKEQWLM
Length:457
Mass (Da):51,317
Last modified:December 7, 2004 - v1
Checksum:i1C7AA38C32FE1A5A
GO
Isoform 2 (identifier: Q5VSG8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.
     223-246: FHIQPYKGRDDITVHDNIKYIIDT → MITGSPQMTWCPPFWTPPISTASR

Show »
Length:235
Mass (Da):27,024
Checksum:i09057B0D65BD5D3C
GO
Isoform 3 (identifier: Q5VSG8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     247-250: YGSH → TGKL
     251-457: Missing.

Show »
Length:250
Mass (Da):27,386
Checksum:i40F26AFB6F18509B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 222222Missing in isoform 2. 1 PublicationVSP_024116Add
BLAST
Alternative sequencei223 – 24624FHIQP…YIIDT → MITGSPQMTWCPPFWTPPIS TASR in isoform 2. 1 PublicationVSP_024117Add
BLAST
Alternative sequencei247 – 2504YGSH → TGKL in isoform 3. 1 PublicationVSP_024118
Alternative sequencei251 – 457207Missing in isoform 3. 1 PublicationVSP_024119Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055996 mRNA. Translation: BAB71068.1.
AL929472 Genomic DNA. Translation: CAH70081.1.
AL929472 Genomic DNA. Translation: CAH70082.1.
BC009952 mRNA. Translation: AAH09952.2.
BC031903 mRNA. Translation: AAH31903.1.
BC063587 mRNA. Translation: AAH63587.1.
BC077730 mRNA. Translation: AAH77730.1.
CCDSiCCDS426.1. [Q5VSG8-2]
CCDS44110.1. [Q5VSG8-1]
CCDS44111.1. [Q5VSG8-3]
RefSeqiNP_001026910.1. NM_001031740.2. [Q5VSG8-3]
NP_001106954.1. NM_001113482.1. [Q5VSG8-1]
NP_689709.1. NM_152496.2. [Q5VSG8-2]
XP_011539090.1. XM_011540788.1. [Q5VSG8-2]
UniGeneiHs.534562.
Hs.706404.

Genome annotation databases

EnsembliENST00000329006; ENSP00000328770; ENSG00000185090. [Q5VSG8-2]
ENST00000373045; ENSP00000362136; ENSG00000185090. [Q5VSG8-1]
ENST00000397631; ENSP00000380755; ENSG00000185090. [Q5VSG8-3]
GeneIDi149175.
KEGGihsa:149175.
UCSCiuc001cbx.3. human. [Q5VSG8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055996 mRNA. Translation: BAB71068.1.
AL929472 Genomic DNA. Translation: CAH70081.1.
AL929472 Genomic DNA. Translation: CAH70082.1.
BC009952 mRNA. Translation: AAH09952.2.
BC031903 mRNA. Translation: AAH31903.1.
BC063587 mRNA. Translation: AAH63587.1.
BC077730 mRNA. Translation: AAH77730.1.
CCDSiCCDS426.1. [Q5VSG8-2]
CCDS44110.1. [Q5VSG8-1]
CCDS44111.1. [Q5VSG8-3]
RefSeqiNP_001026910.1. NM_001031740.2. [Q5VSG8-3]
NP_001106954.1. NM_001113482.1. [Q5VSG8-1]
NP_689709.1. NM_152496.2. [Q5VSG8-2]
XP_011539090.1. XM_011540788.1. [Q5VSG8-2]
UniGeneiHs.534562.
Hs.706404.

3D structure databases

ProteinModelPortaliQ5VSG8.
SMRiQ5VSG8. Positions 107-452.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127196. 19 interactions.
STRINGi9606.ENSP00000362136.

Protein family/group databases

CAZyiGH99. Glycoside Hydrolase Family 99.

PTM databases

iPTMnetiQ5VSG8.
PhosphoSiteiQ5VSG8.

Polymorphism and mutation databases

BioMutaiMANEAL.
DMDMi74746792.

Proteomic databases

MaxQBiQ5VSG8.
PaxDbiQ5VSG8.
PRIDEiQ5VSG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329006; ENSP00000328770; ENSG00000185090. [Q5VSG8-2]
ENST00000373045; ENSP00000362136; ENSG00000185090. [Q5VSG8-1]
ENST00000397631; ENSP00000380755; ENSG00000185090. [Q5VSG8-3]
GeneIDi149175.
KEGGihsa:149175.
UCSCiuc001cbx.3. human. [Q5VSG8-1]

Organism-specific databases

CTDi149175.
GeneCardsiMANEAL.
HGNCiHGNC:26452. MANEAL.
neXtProtiNX_Q5VSG8.
PharmGKBiPA142671481.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMQ9. Eukaryota.
ENOG4111PYT. LUCA.
GeneTreeiENSGT00390000016054.
HOGENOMiHOG000223388.
HOVERGENiHBG103563.
InParanoidiQ5VSG8.
OMAiLREHMTQ.
OrthoDBiEOG7NGQB6.
PhylomeDBiQ5VSG8.
TreeFamiTF324051.

Miscellaneous databases

ChiTaRSiMANEAL. human.
GenomeRNAii149175.
PROiQ5VSG8.

Gene expression databases

BgeeiQ5VSG8.
CleanExiHS_MANEAL.
ExpressionAtlasiQ5VSG8. baseline and differential.
GenevisibleiQ5VSG8. HS.

Family and domain databases

InterProiIPR026071. Glyco_Hydrolase_99.
[Graphical view]
PANTHERiPTHR13572. PTHR13572. 1 hit.
PfamiPF16317. Glyco_hydro_99. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 155-457 (ISOFORM 1).
    Tissue: Brain, Prostate and Skin.

Entry informationi

Entry nameiMANEL_HUMAN
AccessioniPrimary (citable) accession number: Q5VSG8
Secondary accession number(s): Q6DD86
, Q6P497, Q8N5P8, Q96G55, Q96N42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 7, 2004
Last modified: June 8, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.