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Q5VRH4 (HGD_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homogentisate 1,2-dioxygenase

EC=1.13.11.5
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene names
Name:HGO
Ordered Locus Names:Os06g0103300, LOC_Os06g01360
ORF Names:OSJNBa0075G19.26
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Homogentisate + O2 = 4-maleylacetoacetate.

Cofactor

Iron By similarity.

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Homogentisate 1,2-dioxygenase
PRO_0000247478

Sites

Metal binding3561Iron By similarity
Metal binding3621Iron By similarity
Metal binding3921Iron By similarity

Experimental info

Sequence conflict4211M → V Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q5VRH4 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 9C2148F4ABB079E4

FASTA47051,771
        10         20         30         40         50         60 
MAMATATPAA QNEQQEKGGL EYVYLSGLGN SLSSEAVAGT LPRGQNSPLV CPLGLYAEQL 

        70         80         90        100        110        120 
SGTPFTAPRA RNLRTWLYRI KPSVTHEPFH PRRPAHPRLI GDFDRTTTDT VATPTQLRWR 

       130        140        150        160        170        180 
PADVPPHHPP LDFIDGLYTV CGAGSSFLRH GYAIHMYAAN KSMDGCAFCN ADGDFLIVPQ 

       190        200        210        220        230        240 
QGKLLITTEC GKLLVPPGEI VVIPQGFRFA VDLPDGPSRG YVSEIFGTHF QLPDLGPIGA 

       250        260        270        280        290        300 
NGLASARDFL SPTAWFEQVH RPGYTIVQKY GGELFTATQD FSPFNVVAWH GNYVPYKYDL 

       310        320        330        340        350        360 
SKFCPFNTVL FDHADPSVNT VLTAPTDKPG VALLDFVIFP PRWLVAENTF RPPYYHRNCM 

       370        380        390        400        410        420 
SEFMGLIYGI YEAKADGFLP GGASLHSCMT PHGPDTKTYE ATISRPDANE PSRLSGTLAF 

       430        440        450        460        470 
MFESALIPRV CQWALDSPSR DLDYYQCWIG LKSHFSHDNG GATSEEPCRK 

« Hide

References

[1]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[2]"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
The rice full-length cDNA consortium
Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Nipponbare.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP002842 Genomic DNA. Translation: BAD67951.1.
AK065189 mRNA. No translation available.
RefSeqNP_001056540.1. NM_001063075.1.
UniGeneOs.11622.

3D structure databases

ProteinModelPortalQ5VRH4.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5VRH4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsOS06T0103300-01; OS06T0103300-01; OS06G0103300.
GeneID4339844.
KEGGosa:4339844.

Organism-specific databases

GrameneQ5VRH4.

Phylogenomic databases

eggNOGCOG3508.
HOGENOMHOG000139824.
KOK00451.
OMATESIAFM.
ProtClustDBPLN02658.

Enzyme and pathway databases

UniPathwayUPA00139; UER00339.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
InterProIPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR11056. PTHR11056. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHGD_ORYSJ
AccessionPrimary (citable) accession number: Q5VRH4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 7, 2004
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

PATHWAY comments

Index of metabolic and biosynthesis pathways