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Protein

Homogentisate 1,2-dioxygenase

Gene

HGO

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.

Cofactori

Fe cationBy similarity

Pathwayi: L-phenylalanine degradation

This protein is involved in step 4 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Homogentisate 1,2-dioxygenase (HGO)
  5. no protein annotated in this organism
  6. no protein annotated in this organism
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi356IronBy similarity1
Metal bindingi362IronBy similarity1
Metal bindingi392IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-OSA-71182. Phenylalanine and tyrosine catabolism.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:HGO
Ordered Locus Names:Os06g0103300Imported, LOC_Os06g01360Curated
ORF Names:OsJ_19811Imported, OSJNBa0075G19.26
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002474781 – 470Homogentisate 1,2-dioxygenaseAdd BLAST470

Proteomic databases

PaxDbiQ5VRH4.

Expressioni

Gene expression databases

ExpressionAtlasiQ5VRH4. baseline and differential.
GenevisibleiQ5VRH4. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os06g01360.1.

Structurei

3D structure databases

ProteinModelPortaliQ5VRH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.Curated

Phylogenomic databases

eggNOGiKOG1417. Eukaryota.
COG3508. LUCA.
HOGENOMiHOG000139824.
InParanoidiQ5VRH4.
KOiK00451.
OMAiRGYLCEN.
OrthoDBiEOG0936072X.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5VRH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMATATPAA QNEQQEKGGL EYVYLSGLGN SLSSEAVAGT LPRGQNSPLV
60 70 80 90 100
CPLGLYAEQL SGTPFTAPRA RNLRTWLYRI KPSVTHEPFH PRRPAHPRLI
110 120 130 140 150
GDFDRTTTDT VATPTQLRWR PADVPPHHPP LDFIDGLYTV CGAGSSFLRH
160 170 180 190 200
GYAIHMYAAN KSMDGCAFCN ADGDFLIVPQ QGKLLITTEC GKLLVPPGEI
210 220 230 240 250
VVIPQGFRFA VDLPDGPSRG YVSEIFGTHF QLPDLGPIGA NGLASARDFL
260 270 280 290 300
SPTAWFEQVH RPGYTIVQKY GGELFTATQD FSPFNVVAWH GNYVPYKYDL
310 320 330 340 350
SKFCPFNTVL FDHADPSVNT VLTAPTDKPG VALLDFVIFP PRWLVAENTF
360 370 380 390 400
RPPYYHRNCM SEFMGLIYGI YEAKADGFLP GGASLHSCMT PHGPDTKTYE
410 420 430 440 450
ATISRPDANE PSRLSGTLAF MFESALIPRV CQWALDSPSR DLDYYQCWIG
460 470
LKSHFSHDNG GATSEEPCRK
Length:470
Mass (Da):51,771
Last modified:December 7, 2004 - v1
Checksum:i9C2148F4ABB079E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti421M → V in AK065189 (PubMed:12869764).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002842 Genomic DNA. Translation: BAD67951.1.
AP008212 Genomic DNA. Translation: BAF18454.1.
AP014962 Genomic DNA. Translation: BAS95715.1.
CM000143 Genomic DNA. Translation: EEE64940.1.
AK065189 mRNA. No translation available.
RefSeqiXP_015643393.1. XM_015787907.1.
UniGeneiOs.11622.

Genome annotation databases

EnsemblPlantsiOS06T0103300-01; OS06T0103300-01; OS06G0103300.
GeneIDi4339844.
GrameneiOS06T0103300-01; OS06T0103300-01; OS06G0103300.
KEGGiosa:4339844.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002842 Genomic DNA. Translation: BAD67951.1.
AP008212 Genomic DNA. Translation: BAF18454.1.
AP014962 Genomic DNA. Translation: BAS95715.1.
CM000143 Genomic DNA. Translation: EEE64940.1.
AK065189 mRNA. No translation available.
RefSeqiXP_015643393.1. XM_015787907.1.
UniGeneiOs.11622.

3D structure databases

ProteinModelPortaliQ5VRH4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os06g01360.1.

Proteomic databases

PaxDbiQ5VRH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS06T0103300-01; OS06T0103300-01; OS06G0103300.
GeneIDi4339844.
GrameneiOS06T0103300-01; OS06T0103300-01; OS06G0103300.
KEGGiosa:4339844.

Phylogenomic databases

eggNOGiKOG1417. Eukaryota.
COG3508. LUCA.
HOGENOMiHOG000139824.
InParanoidiQ5VRH4.
KOiK00451.
OMAiRGYLCEN.
OrthoDBiEOG0936072X.

Enzyme and pathway databases

UniPathwayiUPA00139; UER00339.
ReactomeiR-OSA-71182. Phenylalanine and tyrosine catabolism.

Gene expression databases

ExpressionAtlasiQ5VRH4. baseline and differential.
GenevisibleiQ5VRH4. OS.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHGD_ORYSJ
AccessioniPrimary (citable) accession number: Q5VRH4
Secondary accession number(s): A0A0P0WRA6, Q0DFB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.