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Protein

Homogentisate 1,2-dioxygenase

Gene

HGO

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.

Cofactori

Fe cationBy similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi356 – 3561IronBy similarity
Metal bindingi362 – 3621IronBy similarity
Metal bindingi392 – 3921IronBy similarity

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. chlorophyll catabolic process Source: EnsemblPlants/Gramene
  2. fatty acid beta-oxidation Source: EnsemblPlants/Gramene
  3. homogentisate catabolic process Source: EnsemblPlants/Gramene
  4. L-phenylalanine catabolic process Source: UniProtKB-UniPathway
  5. protein import into peroxisome matrix Source: EnsemblPlants/Gramene
  6. response to fructose Source: EnsemblPlants/Gramene
  7. response to sucrose Source: EnsemblPlants/Gramene
  8. tyrosine catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_262012. Phenylalanine and tyrosine catabolism.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:HGO
Ordered Locus Names:Os06g0103300, LOC_Os06g01360
ORF Names:OSJNBa0075G19.26
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 6

Organism-specific databases

GrameneiQ5VRH4.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: EnsemblPlants/Gramene
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Homogentisate 1,2-dioxygenasePRO_0000247478Add
BLAST

Proteomic databases

PRIDEiQ5VRH4.

Expressioni

Gene expression databases

ExpressionAtlasiQ5VRH4. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ5VRH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.Curated

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
InParanoidiQ5VRH4.
KOiK00451.
OMAiRGYLCEN.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5VRH4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAMATATPAA QNEQQEKGGL EYVYLSGLGN SLSSEAVAGT LPRGQNSPLV
60 70 80 90 100
CPLGLYAEQL SGTPFTAPRA RNLRTWLYRI KPSVTHEPFH PRRPAHPRLI
110 120 130 140 150
GDFDRTTTDT VATPTQLRWR PADVPPHHPP LDFIDGLYTV CGAGSSFLRH
160 170 180 190 200
GYAIHMYAAN KSMDGCAFCN ADGDFLIVPQ QGKLLITTEC GKLLVPPGEI
210 220 230 240 250
VVIPQGFRFA VDLPDGPSRG YVSEIFGTHF QLPDLGPIGA NGLASARDFL
260 270 280 290 300
SPTAWFEQVH RPGYTIVQKY GGELFTATQD FSPFNVVAWH GNYVPYKYDL
310 320 330 340 350
SKFCPFNTVL FDHADPSVNT VLTAPTDKPG VALLDFVIFP PRWLVAENTF
360 370 380 390 400
RPPYYHRNCM SEFMGLIYGI YEAKADGFLP GGASLHSCMT PHGPDTKTYE
410 420 430 440 450
ATISRPDANE PSRLSGTLAF MFESALIPRV CQWALDSPSR DLDYYQCWIG
460 470
LKSHFSHDNG GATSEEPCRK
Length:470
Mass (Da):51,771
Last modified:December 7, 2004 - v1
Checksum:i9C2148F4ABB079E4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti421 – 4211M → V(PubMed:12869764)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002842 Genomic DNA. Translation: BAD67951.1.
AK065189 mRNA. No translation available.
RefSeqiNP_001056540.1. NM_001063075.1.
UniGeneiOs.11622.

Genome annotation databases

EnsemblPlantsiOS06T0103300-01; OS06T0103300-01; OS06G0103300.
GeneIDi4339844.
KEGGiosa:4339844.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002842 Genomic DNA. Translation: BAD67951.1.
AK065189 mRNA. No translation available.
RefSeqiNP_001056540.1. NM_001063075.1.
UniGeneiOs.11622.

3D structure databases

ProteinModelPortaliQ5VRH4.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5VRH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS06T0103300-01; OS06T0103300-01; OS06G0103300.
GeneIDi4339844.
KEGGiosa:4339844.

Organism-specific databases

GrameneiQ5VRH4.

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
InParanoidiQ5VRH4.
KOiK00451.
OMAiRGYLCEN.

Enzyme and pathway databases

UniPathwayiUPA00139; UER00339.
ReactomeiREACT_262012. Phenylalanine and tyrosine catabolism.

Gene expression databases

ExpressionAtlasiQ5VRH4. baseline.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiHGD_ORYSJ
AccessioniPrimary (citable) accession number: Q5VRH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 7, 2004
Last modified: January 7, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.