Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5VRH4

- HGD_ORYSJ

UniProt

Q5VRH4 - HGD_ORYSJ

Protein

Homogentisate 1,2-dioxygenase

Gene

HGO

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Homogentisate + O2 = 4-maleylacetoacetate.

    Cofactori

    Iron.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi356 – 3561IronBy similarity
    Metal bindingi362 – 3621IronBy similarity
    Metal bindingi392 – 3921IronBy similarity

    GO - Molecular functioni

    1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. homogentisate catabolic process Source: EnsemblPlants/Gramene
    2. L-phenylalanine catabolic process Source: UniProtKB-UniPathway
    3. tyrosine catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Phenylalanine catabolism, Tyrosine catabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00139; UER00339.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
    Alternative name(s):
    Homogentisate oxygenase
    Homogentisic acid oxidase
    Homogentisicase
    Gene namesi
    Name:HGO
    Ordered Locus Names:Os06g0103300, LOC_Os06g01360
    ORF Names:OSJNBa0075G19.26
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 6

    Organism-specific databases

    GrameneiQ5VRH4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: EnsemblPlants/Gramene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 470470Homogentisate 1,2-dioxygenasePRO_0000247478Add
    BLAST

    Proteomic databases

    PRIDEiQ5VRH4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VRH4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the homogentisate dioxygenase family.Curated

    Phylogenomic databases

    eggNOGiCOG3508.
    HOGENOMiHOG000139824.
    KOiK00451.
    OMAiSITTECG.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    InterProiIPR005708. Homogentis_dOase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR11056. PTHR11056. 1 hit.
    PfamiPF04209. HgmA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR01015. hmgA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5VRH4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMATATPAA QNEQQEKGGL EYVYLSGLGN SLSSEAVAGT LPRGQNSPLV    50
    CPLGLYAEQL SGTPFTAPRA RNLRTWLYRI KPSVTHEPFH PRRPAHPRLI 100
    GDFDRTTTDT VATPTQLRWR PADVPPHHPP LDFIDGLYTV CGAGSSFLRH 150
    GYAIHMYAAN KSMDGCAFCN ADGDFLIVPQ QGKLLITTEC GKLLVPPGEI 200
    VVIPQGFRFA VDLPDGPSRG YVSEIFGTHF QLPDLGPIGA NGLASARDFL 250
    SPTAWFEQVH RPGYTIVQKY GGELFTATQD FSPFNVVAWH GNYVPYKYDL 300
    SKFCPFNTVL FDHADPSVNT VLTAPTDKPG VALLDFVIFP PRWLVAENTF 350
    RPPYYHRNCM SEFMGLIYGI YEAKADGFLP GGASLHSCMT PHGPDTKTYE 400
    ATISRPDANE PSRLSGTLAF MFESALIPRV CQWALDSPSR DLDYYQCWIG 450
    LKSHFSHDNG GATSEEPCRK 470
    Length:470
    Mass (Da):51,771
    Last modified:December 7, 2004 - v1
    Checksum:i9C2148F4ABB079E4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti421 – 4211M → V(PubMed:12869764)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP002842 Genomic DNA. Translation: BAD67951.1.
    AK065189 mRNA. No translation available.
    RefSeqiNP_001056540.1. NM_001063075.1.
    UniGeneiOs.11622.

    Genome annotation databases

    EnsemblPlantsiOS06T0103300-01; OS06T0103300-01; OS06G0103300.
    GeneIDi4339844.
    KEGGiosa:4339844.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP002842 Genomic DNA. Translation: BAD67951.1 .
    AK065189 mRNA. No translation available.
    RefSeqi NP_001056540.1. NM_001063075.1.
    UniGenei Os.11622.

    3D structure databases

    ProteinModelPortali Q5VRH4.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5VRH4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS06T0103300-01 ; OS06T0103300-01 ; OS06G0103300 .
    GeneIDi 4339844.
    KEGGi osa:4339844.

    Organism-specific databases

    Gramenei Q5VRH4.

    Phylogenomic databases

    eggNOGi COG3508.
    HOGENOMi HOG000139824.
    KOi K00451.
    OMAi SITTECG.

    Enzyme and pathway databases

    UniPathwayi UPA00139 ; UER00339 .

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    InterProi IPR005708. Homogentis_dOase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR11056. PTHR11056. 1 hit.
    Pfami PF04209. HgmA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR01015. hmgA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiHGD_ORYSJ
    AccessioniPrimary (citable) accession number: Q5VRH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3