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Q5VP69

- MPK16_ORYSJ

UniProt

Q5VP69 - MPK16_ORYSJ

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Protein

Mitogen-activated protein kinase 16

Gene

MPK16

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511ATPPROSITE-ProRule annotation
Active sitei148 – 1481Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi28 – 369ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 16 (EC:2.7.11.24)
Short name:
MAP kinase 16
Gene namesi
Name:MPK16
Ordered Locus Names:Os01g0643800, LOC_Os01g45620
ORF Names:P0510C12.37, P0707D10.2
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 1

Organism-specific databases

GrameneiQ5VP69.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Mitogen-activated protein kinase 16PRO_0000239759Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei184 – 1841PhosphothreonineBy similarity
Modified residuei186 – 1861PhosphotyrosineBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-184 and Tyr-186, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5VP69.
PRIDEiQ5VP69.

Expressioni

Gene expression databases

ExpressionAtlasiQ5VP69. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ5VP69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 313292Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi184 – 1863TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ5VP69.
OMAiASAVNTH.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VP69-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDAKKGSGEP EFFSEYGDAS RYEVTEVVGK GSYGVVAAAV DTHTGGRVAI
60 70 80 90 100
KKINDVFEHI SDATRILREI KLLRLLRHPD IVEIKHIMLP PSRREFRDIY
110 120 130 140 150
IIFELMESDL HQVIKANDDL TPEHHQFFLY QLLRGMKYIH AASVFHRDLK
160 170 180 190 200
PKNILANADC KVKICDFGLA RVSFDDTPSA IFWTDYVATR WYRAPELCGS
210 220 230 240 250
FFSKYTPAID IWSVGCIFAE MLMGKPLFPG KNVVHQLDLM TDLLGSPSGE
260 270 280 290 300
TISRIRNEKA RRYLGNMRKK PRVPFSQKFP GADPMALHLL ERLLAFDPKD
310 320 330 340 350
RPTAAEALTD PYFTGLANSE REPIAQPISK LEFEFERRKL AKDDVRELIY
360 370 380 390 400
REILEYHPQM MQKYLRGGDQ SNFLYPSGVD RFKRQFAHLE EGVAQGDKTS
410 420 430 440 450
PQLRQHVSLP RERVVRNGDE PDPTADYCIK LHVGEQPGHS SVTDGLNKPL
460 470 480 490 500
LSARNFLKSE SIGASQCVVI KEKREKDEES MSEYMNEAAD GVPHKIAQLK

T
Length:501
Mass (Da):57,099
Last modified:December 7, 2004 - v1
Checksum:i291499BB20C5C959
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002910 Genomic DNA. Translation: BAD67997.1.
AP003725 Genomic DNA. Translation: BAD68756.1.
AK069424 mRNA. No translation available.
RefSeqiNP_001043694.1. NM_001050229.1.
UniGeneiOs.34984.

Genome annotation databases

EnsemblPlantsiOS01T0643800-01; OS01T0643800-01; OS01G0643800.
GeneIDi4326567.
KEGGiosa:4326567.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002910 Genomic DNA. Translation: BAD67997.1 .
AP003725 Genomic DNA. Translation: BAD68756.1 .
AK069424 mRNA. No translation available.
RefSeqi NP_001043694.1. NM_001050229.1.
UniGenei Os.34984.

3D structure databases

ProteinModelPortali Q5VP69.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q5VP69.
PRIDEi Q5VP69.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS01T0643800-01 ; OS01T0643800-01 ; OS01G0643800 .
GeneIDi 4326567.
KEGGi osa:4326567.

Organism-specific databases

Gramenei Q5VP69.

Phylogenomic databases

eggNOGi COG0515.
InParanoidi Q5VP69.
OMAi ASAVNTH.

Gene expression databases

ExpressionAtlasi Q5VP69. baseline.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence and structure of rice chromosome 1."
    Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.
    , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
    Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.
  3. "Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
    Reyna N.S., Yang Y.
    Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiMPK16_ORYSJ
AccessioniPrimary (citable) accession number: Q5VP69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 7, 2004
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3