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Q5VP69

- MPK16_ORYSJ

UniProt

Q5VP69 - MPK16_ORYSJ

Protein

Mitogen-activated protein kinase 16

Gene

MPK16

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Activated by threonine and tyrosine phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei51 – 511ATPPROSITE-ProRule annotation
    Active sitei148 – 1481Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi28 – 369ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase 16 (EC:2.7.11.24)
    Short name:
    MAP kinase 16
    Gene namesi
    Name:MPK16
    Ordered Locus Names:Os01g0643800, LOC_Os01g45620
    ORF Names:P0510C12.37, P0707D10.2
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 1

    Organism-specific databases

    GrameneiQ5VP69.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 501501Mitogen-activated protein kinase 16PRO_0000239759Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei184 – 1841PhosphothreonineBy similarity
    Modified residuei186 – 1861PhosphotyrosineBy similarity

    Post-translational modificationi

    Dually phosphorylated on Thr-184 and Tyr-186, which activates the enzyme.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ5VP69.
    PRIDEiQ5VP69.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VP69.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 313292Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi184 – 1863TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    OMAiASAVNTH.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5VP69-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDAKKGSGEP EFFSEYGDAS RYEVTEVVGK GSYGVVAAAV DTHTGGRVAI    50
    KKINDVFEHI SDATRILREI KLLRLLRHPD IVEIKHIMLP PSRREFRDIY 100
    IIFELMESDL HQVIKANDDL TPEHHQFFLY QLLRGMKYIH AASVFHRDLK 150
    PKNILANADC KVKICDFGLA RVSFDDTPSA IFWTDYVATR WYRAPELCGS 200
    FFSKYTPAID IWSVGCIFAE MLMGKPLFPG KNVVHQLDLM TDLLGSPSGE 250
    TISRIRNEKA RRYLGNMRKK PRVPFSQKFP GADPMALHLL ERLLAFDPKD 300
    RPTAAEALTD PYFTGLANSE REPIAQPISK LEFEFERRKL AKDDVRELIY 350
    REILEYHPQM MQKYLRGGDQ SNFLYPSGVD RFKRQFAHLE EGVAQGDKTS 400
    PQLRQHVSLP RERVVRNGDE PDPTADYCIK LHVGEQPGHS SVTDGLNKPL 450
    LSARNFLKSE SIGASQCVVI KEKREKDEES MSEYMNEAAD GVPHKIAQLK 500
    T 501
    Length:501
    Mass (Da):57,099
    Last modified:December 7, 2004 - v1
    Checksum:i291499BB20C5C959
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP002910 Genomic DNA. Translation: BAD67997.1.
    AP003725 Genomic DNA. Translation: BAD68756.1.
    AK069424 mRNA. No translation available.
    RefSeqiNP_001043694.1. NM_001050229.1.
    UniGeneiOs.34984.

    Genome annotation databases

    EnsemblPlantsiOS01T0643800-01; OS01T0643800-01; OS01G0643800.
    GeneIDi4326567.
    KEGGiosa:4326567.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP002910 Genomic DNA. Translation: BAD67997.1 .
    AP003725 Genomic DNA. Translation: BAD68756.1 .
    AK069424 mRNA. No translation available.
    RefSeqi NP_001043694.1. NM_001050229.1.
    UniGenei Os.34984.

    3D structure databases

    ProteinModelPortali Q5VP69.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q5VP69.
    PRIDEi Q5VP69.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS01T0643800-01 ; OS01T0643800-01 ; OS01G0643800 .
    GeneIDi 4326567.
    KEGGi osa:4326567.

    Organism-specific databases

    Gramenei Q5VP69.

    Phylogenomic databases

    eggNOGi COG0515.
    OMAi ASAVNTH.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence and structure of rice chromosome 1."
      Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.
      , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
      Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.
    3. "Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
      Reyna N.S., Yang Y.
      Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiMPK16_ORYSJ
    AccessioniPrimary (citable) accession number: Q5VP69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3