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Protein

Mitogen-activated protein kinase 16

Gene

MPK16

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51ATPPROSITE-ProRule annotation1
Active sitei148Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 36ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-OSA-4086398 Ca2+ pathway
R-OSA-5687128 MAPK6/MAPK4 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 16 (EC:2.7.11.24)
Short name:
MAP kinase 16
Gene namesi
Name:MPK16
Ordered Locus Names:Os01g0643800, LOC_Os01g45620
ORF Names:P0510C12.37, P0707D10.2
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397591 – 501Mitogen-activated protein kinase 16Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184PhosphothreonineBy similarity1
Modified residuei186PhosphotyrosineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-184 and Tyr-186, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5VP69
PRIDEiQ5VP69

Expressioni

Gene expression databases

ExpressionAtlasiQ5VP69 differential
GenevisibleiQ5VP69 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os01g45620.1

Structurei

3D structure databases

ProteinModelPortaliQ5VP69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 313Protein kinasePROSITE-ProRule annotationAdd BLAST292

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi184 – 186TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
InParanoidiQ5VP69
OMAiSGEPEFF
OrthoDBiEOG093605CF

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Q5VP69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKKGSGEP EFFSEYGDAS RYEVTEVVGK GSYGVVAAAV DTHTGGRVAI
60 70 80 90 100
KKINDVFEHI SDATRILREI KLLRLLRHPD IVEIKHIMLP PSRREFRDIY
110 120 130 140 150
IIFELMESDL HQVIKANDDL TPEHHQFFLY QLLRGMKYIH AASVFHRDLK
160 170 180 190 200
PKNILANADC KVKICDFGLA RVSFDDTPSA IFWTDYVATR WYRAPELCGS
210 220 230 240 250
FFSKYTPAID IWSVGCIFAE MLMGKPLFPG KNVVHQLDLM TDLLGSPSGE
260 270 280 290 300
TISRIRNEKA RRYLGNMRKK PRVPFSQKFP GADPMALHLL ERLLAFDPKD
310 320 330 340 350
RPTAAEALTD PYFTGLANSE REPIAQPISK LEFEFERRKL AKDDVRELIY
360 370 380 390 400
REILEYHPQM MQKYLRGGDQ SNFLYPSGVD RFKRQFAHLE EGVAQGDKTS
410 420 430 440 450
PQLRQHVSLP RERVVRNGDE PDPTADYCIK LHVGEQPGHS SVTDGLNKPL
460 470 480 490 500
LSARNFLKSE SIGASQCVVI KEKREKDEES MSEYMNEAAD GVPHKIAQLK

T
Length:501
Mass (Da):57,099
Last modified:December 7, 2004 - v1
Checksum:i291499BB20C5C959
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002910 Genomic DNA Translation: BAD67997.1
AP003725 Genomic DNA Translation: BAD68756.1
AP008207 Genomic DNA Translation: BAF05608.1
AP014957 Genomic DNA Translation: BAS73384.1
AK069424 mRNA Translation: BAG91427.1
UniGeneiOs.34984

Genome annotation databases

EnsemblPlantsiOs01t0643800-01; Os01t0643800-01; Os01g0643800
GrameneiOs01t0643800-01; Os01t0643800-01; Os01g0643800

Similar proteinsi

Entry informationi

Entry nameiMPK16_ORYSJ
AccessioniPrimary (citable) accession number: Q5VP69
Secondary accession number(s): Q0JKX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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