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Q5VN19

- MPK11_ORYSJ

UniProt

Q5VN19 - MPK11_ORYSJ

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Protein

Mitogen-activated protein kinase 11

Gene
MPK11, Os06g0367900, LOC_Os06g26340, OSJNBa0015G09.36-1, OSJNBa0015G09.36-2
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei55 – 551ATP By similarity
Active sitei152 – 1521Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi32 – 409ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 11 (EC:2.7.11.24)
Short name:
MAP kinase 11
Gene namesi
Name:MPK11
Ordered Locus Names:Os06g0367900, LOC_Os06g26340
ORF Names:OSJNBa0015G09.36-1, OSJNBa0015G09.36-2
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 6

Organism-specific databases

GrameneiQ5VN19.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Mitogen-activated protein kinase 11PRO_0000239754Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei188 – 1881Phosphothreonine By similarity
Modified residuei190 – 1901Phosphotyrosine By similarity

Post-translational modificationi

Dually phosphorylated on Thr-188 and Tyr-190, which activates the enzyme By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5VN19.

Structurei

3D structure databases

ProteinModelPortaliQ5VN19.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 317292Protein kinaseAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi188 – 1903TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
OMAiARKYLTC.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VN19-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQTSNFRKKN AAEVDFFMGY GDVNRYEVLE VIGKGSYGLV CSANDIHTGE    50
KVAIKKIHNI FEHISDAARI LREIKLLRLL RHPDIVEIKH IMLPPSKMDF 100
RDIYVVFELM ESDLHQVIKA NDDLTREHYQ FFLYQMLRAL KYIHTANVYH 150
RDLKPKNILA NANCKLKICD FGLARVAFTD APTTVFWTDY VATRWYRAPE 200
LCGSFYSKYT PAIDIWSIGC IFAEVLIGKP LFPGKNVVHQ LDLITDLLGT 250
PSLDAISQVR NDKARKYLTC MRKKQPASFS HKFLKADPLA LQLLRKLLAF 300
DPKDRPSAQE ALADPYFNGL AKVEREPSCQ PIPKMEFEFE RRRATKEDIK 350
ELIFQEILEY HPQLLKEHIS GTERPNFHHL SVVDQFRKQF TQVEENLNGS 400
GAAVSLQRKH SSLPRSTIVH SAAIPAKDYK HVASSSTKLA VDGSWNAQIQ 450
GVHANIAGEP STIVRPAVSS ERSLAPTLQW QPNMTHFLNH ALCYQNTVFS 500
GSLLDATGPA QAIPRTTPYV DYRSGNLDLY QHHVSREDVQ SDTATAQAHA 550
ASHGPVPAVS YSLPGTYRIT 570
Length:570
Mass (Da):64,524
Last modified:June 13, 2006 - v2
Checksum:i56B9FDFF251177ED
GO
Isoform 2 (identifier: Q5VN19-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     416-421: STIVHS → RAFNYR
     422-570: Missing.

Note: No experimental confirmation available.

Show »
Length:421
Mass (Da):48,760
Checksum:i89E740497AAC5654
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei416 – 4216STIVHS → RAFNYR in isoform 2. VSP_019262
Alternative sequencei422 – 570149Missing in isoform 2. VSP_019263Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP005763 Genomic DNA. Translation: BAD69155.1.
AP005763 Genomic DNA. Translation: BAD69156.1.
AK065641 mRNA. No translation available.
AK066968 mRNA. No translation available.
RefSeqiNP_001057613.1. NM_001064148.1. [Q5VN19-1]
UniGeneiOs.24552.

Genome annotation databases

EnsemblPlantsiOS06T0367900-01; OS06T0367900-01; OS06G0367900. [Q5VN19-1]
GeneIDi4341010.
KEGGiosa:4341010.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP005763 Genomic DNA. Translation: BAD69155.1 .
AP005763 Genomic DNA. Translation: BAD69156.1 .
AK065641 mRNA. No translation available.
AK066968 mRNA. No translation available.
RefSeqi NP_001057613.1. NM_001064148.1. [Q5VN19-1 ]
UniGenei Os.24552.

3D structure databases

ProteinModelPortali Q5VN19.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5VN19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS06T0367900-01 ; OS06T0367900-01 ; OS06G0367900 . [Q5VN19-1 ]
GeneIDi 4341010.
KEGGi osa:4341010.

Organism-specific databases

Gramenei Q5VN19.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
OMAi ARKYLTC.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: cv. Nipponbare.
  3. "Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
    Reyna N.S., Yang Y.
    Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiMPK11_ORYSJ
AccessioniPrimary (citable) accession number: Q5VN19
Secondary accession number(s): Q5VN20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: May 14, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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