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Q5VN19

- MPK11_ORYSJ

UniProt

Q5VN19 - MPK11_ORYSJ

Protein

Mitogen-activated protein kinase 11

Gene

MPK11

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 2 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Activated by threonine and tyrosine phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei55 – 551ATPPROSITE-ProRule annotation
    Active sitei152 – 1521Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi32 – 409ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase 11 (EC:2.7.11.24)
    Short name:
    MAP kinase 11
    Gene namesi
    Name:MPK11
    Ordered Locus Names:Os06g0367900, LOC_Os06g26340
    ORF Names:OSJNBa0015G09.36-1, OSJNBa0015G09.36-2
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 6

    Organism-specific databases

    GrameneiQ5VN19.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570Mitogen-activated protein kinase 11PRO_0000239754Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei188 – 1881PhosphothreonineBy similarity
    Modified residuei190 – 1901PhosphotyrosineBy similarity

    Post-translational modificationi

    Dually phosphorylated on Thr-188 and Tyr-190, which activates the enzyme.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ5VN19.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VN19.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 317292Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi188 – 1903TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    OMAiARKYLTC.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5VN19-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQTSNFRKKN AAEVDFFMGY GDVNRYEVLE VIGKGSYGLV CSANDIHTGE    50
    KVAIKKIHNI FEHISDAARI LREIKLLRLL RHPDIVEIKH IMLPPSKMDF 100
    RDIYVVFELM ESDLHQVIKA NDDLTREHYQ FFLYQMLRAL KYIHTANVYH 150
    RDLKPKNILA NANCKLKICD FGLARVAFTD APTTVFWTDY VATRWYRAPE 200
    LCGSFYSKYT PAIDIWSIGC IFAEVLIGKP LFPGKNVVHQ LDLITDLLGT 250
    PSLDAISQVR NDKARKYLTC MRKKQPASFS HKFLKADPLA LQLLRKLLAF 300
    DPKDRPSAQE ALADPYFNGL AKVEREPSCQ PIPKMEFEFE RRRATKEDIK 350
    ELIFQEILEY HPQLLKEHIS GTERPNFHHL SVVDQFRKQF TQVEENLNGS 400
    GAAVSLQRKH SSLPRSTIVH SAAIPAKDYK HVASSSTKLA VDGSWNAQIQ 450
    GVHANIAGEP STIVRPAVSS ERSLAPTLQW QPNMTHFLNH ALCYQNTVFS 500
    GSLLDATGPA QAIPRTTPYV DYRSGNLDLY QHHVSREDVQ SDTATAQAHA 550
    ASHGPVPAVS YSLPGTYRIT 570
    Length:570
    Mass (Da):64,524
    Last modified:June 13, 2006 - v2
    Checksum:i56B9FDFF251177ED
    GO
    Isoform 2 (identifier: Q5VN19-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         416-421: STIVHS → RAFNYR
         422-570: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:421
    Mass (Da):48,760
    Checksum:i89E740497AAC5654
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei416 – 4216STIVHS → RAFNYR in isoform 2. 1 PublicationVSP_019262
    Alternative sequencei422 – 570149Missing in isoform 2. 1 PublicationVSP_019263Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP005763 Genomic DNA. Translation: BAD69155.1.
    AP005763 Genomic DNA. Translation: BAD69156.1.
    AK065641 mRNA. No translation available.
    AK066968 mRNA. No translation available.
    RefSeqiNP_001057613.1. NM_001064148.1. [Q5VN19-1]
    UniGeneiOs.24552.

    Genome annotation databases

    EnsemblPlantsiOS06T0367900-01; OS06T0367900-01; OS06G0367900. [Q5VN19-1]
    GeneIDi4341010.
    KEGGiosa:4341010.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP005763 Genomic DNA. Translation: BAD69155.1 .
    AP005763 Genomic DNA. Translation: BAD69156.1 .
    AK065641 mRNA. No translation available.
    AK066968 mRNA. No translation available.
    RefSeqi NP_001057613.1. NM_001064148.1. [Q5VN19-1 ]
    UniGenei Os.24552.

    3D structure databases

    ProteinModelPortali Q5VN19.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5VN19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS06T0367900-01 ; OS06T0367900-01 ; OS06G0367900 . [Q5VN19-1 ]
    GeneIDi 4341010.
    KEGGi osa:4341010.

    Organism-specific databases

    Gramenei Q5VN19.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    OMAi ARKYLTC.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: cv. Nipponbare.
    3. "Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
      Reyna N.S., Yang Y.
      Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiMPK11_ORYSJ
    AccessioniPrimary (citable) accession number: Q5VN19
    Secondary accession number(s): Q5VN20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 68 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3