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Protein

Mitogen-activated protein kinase 11

Gene

MPK11

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei55ATPPROSITE-ProRule annotation1
Active sitei152Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 40ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-OSA-4086398 Ca2+ pathway
R-OSA-5687128 MAPK6/MAPK4 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 11 (EC:2.7.11.24)
Short name:
MAP kinase 11
Gene namesi
Name:MPK11
Ordered Locus Names:Os06g0367900, LOC_Os06g26340
ORF Names:OSJNBa0015G09.36-1, OSJNBa0015G09.36-2
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397541 – 570Mitogen-activated protein kinase 11Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188PhosphothreonineBy similarity1
Modified residuei190PhosphotyrosineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-188 and Tyr-190, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5VN19
PRIDEiQ5VN19

Expressioni

Gene expression databases

ExpressionAtlasiQ5VN19 differential
GenevisibleiQ5VN19 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os06g26340.1

Structurei

3D structure databases

ProteinModelPortaliQ5VN19
SMRiQ5VN19
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 317Protein kinasePROSITE-ProRule annotationAdd BLAST292

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi188 – 190TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
HOGENOMiHOG000233024
InParanoidiQ5VN19
OMAiKQFTQVE
OrthoDBiEOG093605CF

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VN19-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQTSNFRKKN AAEVDFFMGY GDVNRYEVLE VIGKGSYGLV CSANDIHTGE
60 70 80 90 100
KVAIKKIHNI FEHISDAARI LREIKLLRLL RHPDIVEIKH IMLPPSKMDF
110 120 130 140 150
RDIYVVFELM ESDLHQVIKA NDDLTREHYQ FFLYQMLRAL KYIHTANVYH
160 170 180 190 200
RDLKPKNILA NANCKLKICD FGLARVAFTD APTTVFWTDY VATRWYRAPE
210 220 230 240 250
LCGSFYSKYT PAIDIWSIGC IFAEVLIGKP LFPGKNVVHQ LDLITDLLGT
260 270 280 290 300
PSLDAISQVR NDKARKYLTC MRKKQPASFS HKFLKADPLA LQLLRKLLAF
310 320 330 340 350
DPKDRPSAQE ALADPYFNGL AKVEREPSCQ PIPKMEFEFE RRRATKEDIK
360 370 380 390 400
ELIFQEILEY HPQLLKEHIS GTERPNFHHL SVVDQFRKQF TQVEENLNGS
410 420 430 440 450
GAAVSLQRKH SSLPRSTIVH SAAIPAKDYK HVASSSTKLA VDGSWNAQIQ
460 470 480 490 500
GVHANIAGEP STIVRPAVSS ERSLAPTLQW QPNMTHFLNH ALCYQNTVFS
510 520 530 540 550
GSLLDATGPA QAIPRTTPYV DYRSGNLDLY QHHVSREDVQ SDTATAQAHA
560 570
ASHGPVPAVS YSLPGTYRIT
Length:570
Mass (Da):64,524
Last modified:June 13, 2006 - v2
Checksum:i56B9FDFF251177ED
GO
Isoform 2 (identifier: Q5VN19-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     416-421: STIVHS → RAFNYR
     422-570: Missing.

Note: No experimental confirmation available.
Show »
Length:421
Mass (Da):48,760
Checksum:i89E740497AAC5654
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019262416 – 421STIVHS → RAFNYR in isoform 2. 1 Publication6
Alternative sequenceiVSP_019263422 – 570Missing in isoform 2. 1 PublicationAdd BLAST149

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP005763 Genomic DNA Translation: BAD69155.1
AP005763 Genomic DNA Translation: BAD69156.1
AP008212 Genomic DNA Translation: BAF19527.1
AP014962 Genomic DNA Translation: BAS97726.1
AP014962 Genomic DNA Translation: BAS97727.1
AK065641 mRNA No translation available.
AK066968 mRNA Translation: BAG90204.1
AK100081 mRNA Translation: BAG94435.1
RefSeqiXP_015643951.1, XM_015788465.1 [Q5VN19-1]
XP_015643953.1, XM_015788467.1 [Q5VN19-2]
UniGeneiOs.24552

Genome annotation databases

EnsemblPlantsiOs06t0367900-01; Os06t0367900-01; Os06g0367900 [Q5VN19-1]
Os06t0367900-02; Os06t0367900-02; Os06g0367900 [Q5VN19-2]
GeneIDi4341010
GrameneiOs06t0367900-01; Os06t0367900-01; Os06g0367900 [Q5VN19-1]
Os06t0367900-02; Os06t0367900-02; Os06g0367900 [Q5VN19-2]
KEGGiosa:4341010

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMPK11_ORYSJ
AccessioniPrimary (citable) accession number: Q5VN19
Secondary accession number(s): Q0DC96, Q5VN20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: May 23, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

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