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Q5VN19 (MPK11_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase 11

Short name=MAP kinase 11
EC=2.7.11.24
Gene names
Name:MPK11
Ordered Locus Names:Os06g0367900, LOC_Os06g26340
ORF Names:OSJNBa0015G09.36-1, OSJNBa0015G09.36-2
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Activated by threonine and tyrosine phosphorylation By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-188 and Tyr-190, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

MAP kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5VN19-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5VN19-2)

The sequence of this isoform differs from the canonical sequence as follows:
     416-421: STIVHS → RAFNYR
     422-570: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Mitogen-activated protein kinase 11
PRO_0000239754

Regions

Domain26 – 317292Protein kinase
Nucleotide binding32 – 409ATP By similarity
Motif188 – 1903TXY

Sites

Active site1521Proton acceptor By similarity
Binding site551ATP By similarity

Amino acid modifications

Modified residue1881Phosphothreonine By similarity
Modified residue1901Phosphotyrosine By similarity

Natural variations

Alternative sequence416 – 4216STIVHS → RAFNYR in isoform 2.
VSP_019262
Alternative sequence422 – 570149Missing in isoform 2.
VSP_019263

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 13, 2006. Version 2.
Checksum: 56B9FDFF251177ED

FASTA57064,524
        10         20         30         40         50         60 
MQTSNFRKKN AAEVDFFMGY GDVNRYEVLE VIGKGSYGLV CSANDIHTGE KVAIKKIHNI 

        70         80         90        100        110        120 
FEHISDAARI LREIKLLRLL RHPDIVEIKH IMLPPSKMDF RDIYVVFELM ESDLHQVIKA 

       130        140        150        160        170        180 
NDDLTREHYQ FFLYQMLRAL KYIHTANVYH RDLKPKNILA NANCKLKICD FGLARVAFTD 

       190        200        210        220        230        240 
APTTVFWTDY VATRWYRAPE LCGSFYSKYT PAIDIWSIGC IFAEVLIGKP LFPGKNVVHQ 

       250        260        270        280        290        300 
LDLITDLLGT PSLDAISQVR NDKARKYLTC MRKKQPASFS HKFLKADPLA LQLLRKLLAF 

       310        320        330        340        350        360 
DPKDRPSAQE ALADPYFNGL AKVEREPSCQ PIPKMEFEFE RRRATKEDIK ELIFQEILEY 

       370        380        390        400        410        420 
HPQLLKEHIS GTERPNFHHL SVVDQFRKQF TQVEENLNGS GAAVSLQRKH SSLPRSTIVH 

       430        440        450        460        470        480 
SAAIPAKDYK HVASSSTKLA VDGSWNAQIQ GVHANIAGEP STIVRPAVSS ERSLAPTLQW 

       490        500        510        520        530        540 
QPNMTHFLNH ALCYQNTVFS GSLLDATGPA QAIPRTTPYV DYRSGNLDLY QHHVSREDVQ 

       550        560        570 
SDTATAQAHA ASHGPVPAVS YSLPGTYRIT 

« Hide

Isoform 2 [UniParc].

Checksum: 89E740497AAC5654
Show »

FASTA42148,760

References

« Hide 'large scale' references
[1]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[2]"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
The rice full-length cDNA consortium
Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: cv. Nipponbare.
[3]"Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
Reyna N.S., Yang Y.
Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP005763 Genomic DNA. Translation: BAD69155.1.
AP005763 Genomic DNA. Translation: BAD69156.1.
AK065641 mRNA. No translation available.
AK066968 mRNA. No translation available.
RefSeqNP_001057613.1. NM_001064148.1. [Q5VN19-1]
UniGeneOs.24552.

3D structure databases

ProteinModelPortalQ5VN19.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5VN19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsOS06T0367900-01; OS06T0367900-01; OS06G0367900. [Q5VN19-1]
GeneID4341010.
KEGGosa:4341010.

Organism-specific databases

GrameneQ5VN19.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
OMAARKYLTC.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPK11_ORYSJ
AccessionPrimary (citable) accession number: Q5VN19
Secondary accession number(s): Q5VN20
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: May 14, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations