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Q5VIR6

- VPS53_HUMAN

UniProt

Q5VIR6 - VPS53_HUMAN

Protein

Vacuolar protein sorting-associated protein 53 homolog

Gene

VPS53

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD.2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar protein sorting-associated protein 53 homolog
    Gene namesi
    Name:VPS53
    ORF Names:PP13624
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:25608. VPS53.

    Subcellular locationi

    GO - Cellular componenti

    1. endosome membrane Source: UniProtKB-SubCell
    2. GARP complex Source: MGI

    Keywords - Cellular componenti

    Endosome, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670618.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 699699Vacuolar protein sorting-associated protein 53 homologPRO_0000215189Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei110 – 1101N6-acetyllysine1 Publication
    Modified residuei360 – 3601N6-acetyllysine1 Publication
    Modified residuei377 – 3771Phosphoserine1 Publication
    Modified residuei391 – 3911Phosphothreonine1 Publication
    Modified residuei580 – 5801Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ5VIR6.
    PaxDbiQ5VIR6.
    PRIDEiQ5VIR6.

    PTM databases

    PhosphoSiteiQ5VIR6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5VIR6.
    BgeeiQ5VIR6.
    CleanExiHS_VPS53.
    GenevestigatoriQ5VIR6.

    Organism-specific databases

    HPAiHPA022988.
    HPA024446.

    Interactioni

    Subunit structurei

    Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54.1 Publication

    Protein-protein interaction databases

    BioGridi120563. 13 interactions.
    DIPiDIP-59352N.
    IntActiQ5VIR6. 2 interactions.
    STRINGi9606.ENSP00000401435.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VIR6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili55 – 14288Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the VPS53 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG327715.
    HOGENOMiHOG000265899.
    HOVERGENiHBG092351.
    InParanoidiQ5VIR6.
    OMAiAMSKMPW.
    OrthoDBiEOG70PBWZ.
    PhylomeDBiQ5VIR6.
    TreeFamiTF106150.

    Family and domain databases

    InterProiIPR007234. Vps53_N.
    [Graphical view]
    PfamiPF04100. Vps53_N. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5VIR6-1) [UniParc]FASTAAdd to Basket

    Also known as: long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMEEEELEFV EELEAVLQLT PEVQLAIEQV FPSQDPLDRA DFNAVEYINT    50
    LFPTEQSLAN IDEVVNKIRL KIRRLDDNIR TVVRGQTNVG QDGRQALEEA 100
    QKAIQQLFGK IKDIKDKAEK SEQMVKEITR DIKQLDHAKR HLTTSITTLN 150
    HLHMLAGGVD SLEAMTRRRQ YGEVANLLQG VMNVLEHFHK YMGIPQIRQL 200
    SERVKAAQTE LGQQILADFE EAFPSQGTKR PGGPSNVLRD ACLVANILDP 250
    RIKQEIIKKF IKQHLSEYLV LFQENQDVAW LDKIDRRYAW IKRQLVDYEE 300
    KYGRMFPREW CMAERIAVEF CHVTRAELAK IMRTRAKEIE VKLLLFAIQR 350
    TTNFEGFLAK RFSGCTLTDG TLKKLESPPP STNPFLEDEP TPEMEELATE 400
    KGDLDQPKKP KAPDNPFHGI VSKCFEPHLY VYIESQDKNL GELIDRFVAD 450
    FKAQGPPKPN TDEGGAVLPS CADLFVYYKK CMVQCSQLST GEPMIALTTI 500
    FQKYLREYAW KILSGNLPKT TTSSGGLTIS SLLKEKEGSE VAKFTLEELC 550
    LICNILSTAE YCLATTQQLE EKLKEKVDVS LIERINLTGE MDTFSTVISS 600
    SIQLLVQDLD AACDPALTAM SKMQWQNVEH VGDQSPYVTS VILHIKQNVP 650
    IIRDNLASTR KYFTQFCVKF ANSFIPKFIT HLFKCKPISM VGAEQVRWT 699
    Length:699
    Mass (Da):79,653
    Last modified:December 7, 2004 - v1
    Checksum:i6C07EC07682BF4C6
    GO
    Isoform 2 (identifier: Q5VIR6-2) [UniParc]FASTAAdd to Basket

    Also known as: short

    The sequence of this isoform differs from the canonical sequence as follows:
         96-124: Missing.

    Show »
    Length:670
    Mass (Da):76,352
    Checksum:i8057AAC082136EC7
    GO
    Isoform 3 (identifier: Q5VIR6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         656-673: LASTRKYFTQFCVKFANS → PVASTRKYFTQLCVKFAK
         674-699: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:673
    Mass (Da):76,569
    Checksum:i82C41A7433B5EF79
    GO
    Isoform 4 (identifier: Q5VIR6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         696-699: VRWT → LLLDTHSLKM...KLEKLIKKRL

    Show »
    Length:832
    Mass (Da):94,405
    Checksum:iEA71D35158E9419E
    GO

    Sequence cautioni

    The sequence AAL55842.1 differs from that shown. Reason: Frameshift at position 562.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271I → V in ABW03005. (PubMed:18367545)Curated
    Sequence conflicti115 – 1151K → N in ABW03005. (PubMed:18367545)Curated
    Sequence conflicti466 – 4661A → T in AAK27973. (PubMed:12565177)Curated
    Sequence conflicti520 – 5201T → P in AAK27973. (PubMed:12565177)Curated
    Sequence conflicti525 – 5251G → E in AAK27973. (PubMed:12565177)Curated
    Sequence conflicti658 – 6658STRKYFTQ → NMAKSHLY in AAL55842. (PubMed:15498874)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti328 – 3281L → I.
    Corresponds to variant rs16954056 [ dbSNP | Ensembl ].
    VAR_059959
    Natural varianti375 – 3751L → R.
    Corresponds to variant rs61644407 [ dbSNP | Ensembl ].
    VAR_066561

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei96 – 12429Missing in isoform 2. 2 PublicationsVSP_016236Add
    BLAST
    Alternative sequencei656 – 67318LASTR…KFANS → PVASTRKYFTQLCVKFAK in isoform 3. 1 PublicationVSP_016237Add
    BLAST
    Alternative sequencei674 – 69926Missing in isoform 3. 1 PublicationVSP_016238Add
    BLAST
    Alternative sequencei696 – 6994VRWT → LLLDTHSLKMVLLDLPSISS QVVRKAPASYTKIVVKGMTR AEMILKVVMAPHEPLVVFVD NYIKLLTDCNTETFQKILDM KGLKRSEQSSMLELLRQRLP APPSGAESSGSLSLTAPTPE QESSRIRKLEKLIKKRL in isoform 4. 1 PublicationVSP_042106

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY444797 mRNA. Translation: AAS20944.1.
    AF246287 mRNA. Translation: AAK27973.1.
    EU021218 mRNA. Translation: ABW03005.1.
    AK001841 mRNA. Translation: BAA91935.1.
    AK290343 mRNA. Translation: BAF83032.1.
    AC015853 Genomic DNA. No translation available.
    AC027455 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90661.1.
    BC006116 mRNA. Translation: AAH06116.1.
    AF318335 mRNA. Translation: AAL55842.1. Frameshift.
    CCDSiCCDS10995.1. [Q5VIR6-2]
    CCDS45558.1. [Q5VIR6-4]
    RefSeqiNP_001121631.1. NM_001128159.2. [Q5VIR6-4]
    NP_060759.2. NM_018289.3. [Q5VIR6-2]
    UniGeneiHs.461819.

    Genome annotation databases

    EnsembliENST00000291074; ENSP00000291074; ENSG00000141252. [Q5VIR6-2]
    ENST00000437048; ENSP00000401435; ENSG00000141252. [Q5VIR6-4]
    ENST00000571805; ENSP00000459312; ENSG00000141252. [Q5VIR6-1]
    GeneIDi55275.
    KEGGihsa:55275.
    UCSCiuc002frm.2. human. [Q5VIR6-2]
    uc002frn.2. human. [Q5VIR6-1]
    uc010cjo.2. human. [Q5VIR6-4]

    Polymorphism databases

    DMDMi74746777.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY444797 mRNA. Translation: AAS20944.1 .
    AF246287 mRNA. Translation: AAK27973.1 .
    EU021218 mRNA. Translation: ABW03005.1 .
    AK001841 mRNA. Translation: BAA91935.1 .
    AK290343 mRNA. Translation: BAF83032.1 .
    AC015853 Genomic DNA. No translation available.
    AC027455 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90661.1 .
    BC006116 mRNA. Translation: AAH06116.1 .
    AF318335 mRNA. Translation: AAL55842.1 . Frameshift.
    CCDSi CCDS10995.1. [Q5VIR6-2 ]
    CCDS45558.1. [Q5VIR6-4 ]
    RefSeqi NP_001121631.1. NM_001128159.2. [Q5VIR6-4 ]
    NP_060759.2. NM_018289.3. [Q5VIR6-2 ]
    UniGenei Hs.461819.

    3D structure databases

    ProteinModelPortali Q5VIR6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120563. 13 interactions.
    DIPi DIP-59352N.
    IntActi Q5VIR6. 2 interactions.
    STRINGi 9606.ENSP00000401435.

    PTM databases

    PhosphoSitei Q5VIR6.

    Polymorphism databases

    DMDMi 74746777.

    Proteomic databases

    MaxQBi Q5VIR6.
    PaxDbi Q5VIR6.
    PRIDEi Q5VIR6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000291074 ; ENSP00000291074 ; ENSG00000141252 . [Q5VIR6-2 ]
    ENST00000437048 ; ENSP00000401435 ; ENSG00000141252 . [Q5VIR6-4 ]
    ENST00000571805 ; ENSP00000459312 ; ENSG00000141252 . [Q5VIR6-1 ]
    GeneIDi 55275.
    KEGGi hsa:55275.
    UCSCi uc002frm.2. human. [Q5VIR6-2 ]
    uc002frn.2. human. [Q5VIR6-1 ]
    uc010cjo.2. human. [Q5VIR6-4 ]

    Organism-specific databases

    CTDi 55275.
    GeneCardsi GC17M000381.
    H-InvDB HIX0013386.
    HGNCi HGNC:25608. VPS53.
    HPAi HPA022988.
    HPA024446.
    neXtProti NX_Q5VIR6.
    PharmGKBi PA142670618.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327715.
    HOGENOMi HOG000265899.
    HOVERGENi HBG092351.
    InParanoidi Q5VIR6.
    OMAi AMSKMPW.
    OrthoDBi EOG70PBWZ.
    PhylomeDBi Q5VIR6.
    TreeFami TF106150.

    Miscellaneous databases

    ChiTaRSi VPS53. human.
    GenomeRNAii 55275.
    NextBioi 59405.
    PROi Q5VIR6.

    Gene expression databases

    ArrayExpressi Q5VIR6.
    Bgeei Q5VIR6.
    CleanExi HS_VPS53.
    Genevestigatori Q5VIR6.

    Family and domain databases

    InterProi IPR007234. Vps53_N.
    [Graphical view ]
    Pfami PF04100. Vps53_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
    2. "The minimum LOH region defined on chromosome 17p13.3 in human hepatocellular carcinoma with gene content analysis."
      Zhao X., He M., Wan D., Ye Y., He Y., Han L., Guo M., Huang Y., Qin W., Wang M.W., Chong W., Chen J., Zhang L., Yang N., Xu B., Wu M., Zuo L., Gu J.
      Cancer Lett. 190:221-232(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    3. "Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes."
      Perez-Victoria F.J., Mardones G.A., Bonifacino J.S.
      Mol. Biol. Cell 19:2350-2362(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), SUBCELLULAR LOCATION, FUNCTION.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 332-699.
      Tissue: Placenta and Tongue.
    5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    8. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-665 (ISOFORM 1).
    9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377 AND THR-391, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-110 AND LYS-360, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex."
      Perez-Victoria F.J., Schindler C., Magadan J.G., Mardones G.A., Delevoye C., Romao M., Raposo G., Bonifacino J.S.
      Mol. Biol. Cell 21:3386-3395(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH VPS51.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-580, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiVPS53_HUMAN
    AccessioniPrimary (citable) accession number: Q5VIR6
    Secondary accession number(s): A8K2S8
    , B3FH42, Q8WYW3, Q9BRR2, Q9BY02, Q9NV25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3