Reviewed, UniProtKB/Swiss-Prot Q5VAN0 (CD38_MACFA)

Names and origin

Protein names

Recommended name:
    ADP-ribosyl cyclase 1
    EC=3.2.2.5
Alternative name(s):
    Cyclic ADP-ribose hydrolase 1
      Short name=cADPr hydrolase 1
    CD_antigen=CD38

Gene names

Name:

CD38

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system By similarity.
Catalytic activity	NAD+ + H2O = ADP-ribose + nicotinamide.
Enzyme regulation	ATP inhibits the hydrolyzing activity By similarity.
Subcellular location	Membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the ADP-ribosyl cyclase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal-anchor Transmembrane
Ligand	NAD
Molecular function	Hydrolase Receptor
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD+ nucleosidase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	ADP-ribosyl cyclase 1		PRO_0000144067
Regions
	Topological domain	1 – 21	21	Cytoplasmic Potential
	Transmembrane	22 – 43	22	Signal-anchor for type II membrane protein Potential
	Topological domain	44 – 301	258	Extracellular Potential
Sites
	Active site	120	1	By similarity
	Active site	202	1	By similarity
Amino acid modifications
	Glycosylation	101	1	N-linked (GlcNAc...) Potential
	Glycosylation	121	1	N-linked (GlcNAc...) Potential
	Glycosylation	210	1	N-linked (GlcNAc...) Potential
	Glycosylation	220	1	N-linked (GlcNAc...) Potential
	Disulfide bond	68 ↔ 83		By similarity
	Disulfide bond	100 ↔ 181		By similarity
	Disulfide bond	161 ↔ 174		By similarity
	Disulfide bond	255 ↔ 276		By similarity
	Disulfide bond	288 ↔ 297		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5VAN0-1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: E659212B926165B1	FASTA	301	34,422
	10 20 30 40 50 60 MANCEFSPVS GDKPCCRLSR RAQVCLGVCL LVLLILVVVV AVVLPRWRQQ WSGSGTTSRF 70 80 90 100 110 120 PETVLARCVK YTEVHPEMRH VDCQSVWDAF KGAFISKYPC NITEEDYQPL VKLGTQTVPC 130 140 150 160 170 180 NKTLLWSRIK DLAHQFTQVQ RDMFTLEDML LGYLADDLTW CGEFNTFEIN YQSCPDWRKD 190 200 210 220 230 240 CSNNPVSVFW KTVSRRFAET ACGVVHVMLN GSRSKIFDKN STFGSVEVHN LQPEKVQALE 250 260 270 280 290 300 AWVIHGGRED SRDLCQDPTI KELESIISKR NIRFFCKNIY RPDKFLQCVK NPEDSSCLSG I

References

[1]	"Characterization and phylogenetic epitope mapping of CD38 ADPR cyclase in the cynomolgus macaque." Ferrero E., Orciani M., Vacca P., Ortolan E., Crovella S., Titti F., Saccucci F., Malavasi F. BMC Immunol. 5:21-21(2004) [PubMed: 15383153] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY555148 mRNA. Translation: AAT36330.1.
3D structure databases
SMR	Q5VAN0. Positions 47-299.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q5VAN0.
OrthoDB	EOG93N9ZW.
Enzyme and pathway databases
BRENDA	3.2.2.5. 3438.
Family and domain databases
InterPro	IPR003193. ADP-ribosyl_cyclase. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR10912. Rib_hydrolayse. 1 hit.
Pfam	PF02267. Rib_hydrolayse. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CD38_MACFA

Accession

Primary (citable) accession number: Q5VAN0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	December 7, 2004
Last modified:	January 19, 2010
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)