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Q5V9E9 (G6PI_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:gpi
Synonyms:g6pi, pgi
ORF Names:DDB_G0283673
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length561 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 561561Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000315252

Sites

Active site3661Proton donor By similarity
Active site3971 By similarity
Active site5251 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5V9E9 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: B49E0503E55D7F77

FASTA56163,465
        10         20         30         40         50         60 
MEEFKNLKEH YENIGKNINM RKEFESNYGA TRFKDFSKEV NISKQVGTIL LDYSKNRINK 

        70         80         90        100        110        120 
ETMDLLFELA RASKVEEMRN SMFQGEKINI TEDRAVLHTA LRNRDPSAVI KVDGENVIPS 

       130        140        150        160        170        180 
VRKVLDKMRS FSERVRSGQW KGYTGKTITD VVNIGIGGSD LGPVMVTQAL KNYANDKVMR 

       190        200        210        220        230        240 
AHFVSNIDGT HLAETVKHLC PETTLFIVAS KTFTTQETIT NAQSARSWFL EKIGGSSVSA 

       250        260        270        280        290        300 
DVQKHAIGQH FVALSTNEQE VTKFGILKEN MFEFWDWVGG RYSVWSAIGL SVALYVGMDH 

       310        320        330        340        350        360 
FESFLEGAYH MDQHFLNTPL ELNLPVIMGL LGVWYNNFFG CQTQAILPYD QYLSRFPAYF 

       370        380        390        400        410        420 
QQGDMESNGK SVQRNGERVT HSTGPIIWGE PGTNGQHAFY QLIHQGQKII PCDFIASVES 

       430        440        450        460        470        480 
HNPLGKHHQI LLSNFFAQTE ALMKGKNEQE VTNELTKEGL SQEKIKQLLP HKVFEGNRPT 

       490        500        510        520        530        540 
NSIFLHKLTP HSLGALIALY EHKIFVQGII WNINSFDQWG VELGKQLAKS ILPELSDNNE 

       550        560 
VSTHDSSTNG LINFYKSNSK L 

« Hide

References

« Hide 'large scale' references
[1]"Cryptosporidium parvum: phylogenomic evidence for organelle loss, intracellular and horizontal gene transfer."
Huang J., Mullapudi N., Lancto C., Scott M., Abrahamsen M., Kissinger J.C.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY581146 Genomic DNA. Translation: AAT92030.1.
AAFI02000056 Genomic DNA. Translation: EAL65603.1.

3D structure databases

ProteinModelPortalQ5V9E9.
SMRQ5V9E9. Positions 3-556.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231026.

Proteomic databases

PRIDEQ5V9E9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231026; DDB0231026; DDB_G0283673.
KEGGddi:DDB_G0283673.

Organism-specific databases

dictyBaseDDB_G0283673. gpi.

Phylogenomic databases

eggNOGCOG0166.
KOK01810.
OMALKMHFVS.
PhylomeDBQ5V9E9.
ProtClustDBCLSZ2430346.

Enzyme and pathway databases

UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ5V9E9.

Entry information

Entry nameG6PI_DICDI
AccessionPrimary (citable) accession number: Q5V9E9
Secondary accession number(s): Q54QR6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 7, 2004
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase