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Protein

Glucose-6-phosphate isomerase

Gene

gpi

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (gpi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. Fructose-bisphosphate aldolase (fba)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei366Proton donorBy similarity1
Active sitei397By similarity1
Active sitei525By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

ReactomeiR-DDI-5628897 TP53 Regulates Metabolic Genes
R-DDI-6798695 Neutrophil degranulation
R-DDI-70171 Glycolysis
R-DDI-70263 Gluconeogenesis
UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:gpi
Synonyms:g6pi, pgi
ORF Names:DDB_G0283673
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0283673 gpi

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003152521 – 561Glucose-6-phosphate isomeraseAdd BLAST561

Proteomic databases

PaxDbiQ5V9E9

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231026

Structurei

3D structure databases

ProteinModelPortaliQ5V9E9
SMRiQ5V9E9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiKOG2446 Eukaryota
COG0166 LUCA
InParanoidiQ5V9E9
KOiK01810
OMAiQAETHAM
PhylomeDBiQ5V9E9

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5V9E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEFKNLKEH YENIGKNINM RKEFESNYGA TRFKDFSKEV NISKQVGTIL
60 70 80 90 100
LDYSKNRINK ETMDLLFELA RASKVEEMRN SMFQGEKINI TEDRAVLHTA
110 120 130 140 150
LRNRDPSAVI KVDGENVIPS VRKVLDKMRS FSERVRSGQW KGYTGKTITD
160 170 180 190 200
VVNIGIGGSD LGPVMVTQAL KNYANDKVMR AHFVSNIDGT HLAETVKHLC
210 220 230 240 250
PETTLFIVAS KTFTTQETIT NAQSARSWFL EKIGGSSVSA DVQKHAIGQH
260 270 280 290 300
FVALSTNEQE VTKFGILKEN MFEFWDWVGG RYSVWSAIGL SVALYVGMDH
310 320 330 340 350
FESFLEGAYH MDQHFLNTPL ELNLPVIMGL LGVWYNNFFG CQTQAILPYD
360 370 380 390 400
QYLSRFPAYF QQGDMESNGK SVQRNGERVT HSTGPIIWGE PGTNGQHAFY
410 420 430 440 450
QLIHQGQKII PCDFIASVES HNPLGKHHQI LLSNFFAQTE ALMKGKNEQE
460 470 480 490 500
VTNELTKEGL SQEKIKQLLP HKVFEGNRPT NSIFLHKLTP HSLGALIALY
510 520 530 540 550
EHKIFVQGII WNINSFDQWG VELGKQLAKS ILPELSDNNE VSTHDSSTNG
560
LINFYKSNSK L
Length:561
Mass (Da):63,465
Last modified:December 7, 2004 - v1
Checksum:iB49E0503E55D7F77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY581146 Genomic DNA Translation: AAT92030.1
AAFI02000056 Genomic DNA Translation: EAL65603.1
RefSeqiXP_638957.1, XM_633865.1

Genome annotation databases

EnsemblProtistsiEAL65603; EAL65603; DDB_G0283673
GeneIDi8624197
KEGGiddi:DDB_G0283673

Similar proteinsi

Entry informationi

Entry nameiG6PI_DICDI
AccessioniPrimary (citable) accession number: Q5V9E9
Secondary accession number(s): Q54QR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 7, 2004
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health