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Protein

Glucose-6-phosphate isomerase

Gene

gpi

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathway:iglycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (gpi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. Fructose-bisphosphate aldolase (fba)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei366 – 3661Proton donorBy similarity
Active sitei397 – 3971By similarity
Active sitei525 – 5251By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

ReactomeiREACT_298380. Glycolysis.
REACT_350266. Gluconeogenesis.
REACT_360616. TP53 Regulates Metabolic Genes.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:gpi
Synonyms:g6pi, pgi
ORF Names:DDB_G0283673
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0283673. gpi.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Glucose-6-phosphate isomerasePRO_0000315252Add
BLAST

Proteomic databases

PRIDEiQ5V9E9.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231026.

Structurei

3D structure databases

ProteinModelPortaliQ5V9E9.
SMRiQ5V9E9. Positions 3-556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
InParanoidiQ5V9E9.
KOiK01810.
OMAiCETQAML.
PhylomeDBiQ5V9E9.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5V9E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEFKNLKEH YENIGKNINM RKEFESNYGA TRFKDFSKEV NISKQVGTIL
60 70 80 90 100
LDYSKNRINK ETMDLLFELA RASKVEEMRN SMFQGEKINI TEDRAVLHTA
110 120 130 140 150
LRNRDPSAVI KVDGENVIPS VRKVLDKMRS FSERVRSGQW KGYTGKTITD
160 170 180 190 200
VVNIGIGGSD LGPVMVTQAL KNYANDKVMR AHFVSNIDGT HLAETVKHLC
210 220 230 240 250
PETTLFIVAS KTFTTQETIT NAQSARSWFL EKIGGSSVSA DVQKHAIGQH
260 270 280 290 300
FVALSTNEQE VTKFGILKEN MFEFWDWVGG RYSVWSAIGL SVALYVGMDH
310 320 330 340 350
FESFLEGAYH MDQHFLNTPL ELNLPVIMGL LGVWYNNFFG CQTQAILPYD
360 370 380 390 400
QYLSRFPAYF QQGDMESNGK SVQRNGERVT HSTGPIIWGE PGTNGQHAFY
410 420 430 440 450
QLIHQGQKII PCDFIASVES HNPLGKHHQI LLSNFFAQTE ALMKGKNEQE
460 470 480 490 500
VTNELTKEGL SQEKIKQLLP HKVFEGNRPT NSIFLHKLTP HSLGALIALY
510 520 530 540 550
EHKIFVQGII WNINSFDQWG VELGKQLAKS ILPELSDNNE VSTHDSSTNG
560
LINFYKSNSK L
Length:561
Mass (Da):63,465
Last modified:December 7, 2004 - v1
Checksum:iB49E0503E55D7F77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY581146 Genomic DNA. Translation: AAT92030.1.
AAFI02000056 Genomic DNA. Translation: EAL65603.1.
RefSeqiXP_638957.1. XM_633865.1.

Genome annotation databases

EnsemblProtistsiDDB0231026; DDB0231026; DDB_G0283673.
GeneIDi8624197.
KEGGiddi:DDB_G0283673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY581146 Genomic DNA. Translation: AAT92030.1.
AAFI02000056 Genomic DNA. Translation: EAL65603.1.
RefSeqiXP_638957.1. XM_633865.1.

3D structure databases

ProteinModelPortaliQ5V9E9.
SMRiQ5V9E9. Positions 3-556.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231026.

Proteomic databases

PRIDEiQ5V9E9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0231026; DDB0231026; DDB_G0283673.
GeneIDi8624197.
KEGGiddi:DDB_G0283673.

Organism-specific databases

dictyBaseiDDB_G0283673. gpi.

Phylogenomic databases

eggNOGiCOG0166.
InParanoidiQ5V9E9.
KOiK01810.
OMAiCETQAML.
PhylomeDBiQ5V9E9.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
ReactomeiREACT_298380. Glycolysis.
REACT_350266. Gluconeogenesis.
REACT_360616. TP53 Regulates Metabolic Genes.

Miscellaneous databases

PROiQ5V9E9.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cryptosporidium parvum: phylogenomic evidence for organelle loss, intracellular and horizontal gene transfer."
    Huang J., Mullapudi N., Lancto C., Scott M., Abrahamsen M., Kissinger J.C.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiG6PI_DICDI
AccessioniPrimary (citable) accession number: Q5V9E9
Secondary accession number(s): Q54QR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 7, 2004
Last modified: June 24, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.