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Q5V9E9

- G6PI_DICDI

UniProt

Q5V9E9 - G6PI_DICDI

Protein

Glucose-6-phosphate isomerase

Gene

gpi

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei366 – 3661Proton donorBy similarity
    Active sitei397 – 3971By similarity
    Active sitei525 – 5251By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-KW
    2. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:gpi
    Synonyms:g6pi, pgi
    ORF Names:DDB_G0283673
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0283673. gpi.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 561561Glucose-6-phosphate isomerasePRO_0000315252Add
    BLAST

    Proteomic databases

    PRIDEiQ5V9E9.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0231026.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5V9E9.
    SMRiQ5V9E9. Positions 3-556.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Phylogenomic databases

    eggNOGiCOG0166.
    KOiK01810.
    OMAiCGNELDN.
    PhylomeDBiQ5V9E9.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5V9E9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEFKNLKEH YENIGKNINM RKEFESNYGA TRFKDFSKEV NISKQVGTIL    50
    LDYSKNRINK ETMDLLFELA RASKVEEMRN SMFQGEKINI TEDRAVLHTA 100
    LRNRDPSAVI KVDGENVIPS VRKVLDKMRS FSERVRSGQW KGYTGKTITD 150
    VVNIGIGGSD LGPVMVTQAL KNYANDKVMR AHFVSNIDGT HLAETVKHLC 200
    PETTLFIVAS KTFTTQETIT NAQSARSWFL EKIGGSSVSA DVQKHAIGQH 250
    FVALSTNEQE VTKFGILKEN MFEFWDWVGG RYSVWSAIGL SVALYVGMDH 300
    FESFLEGAYH MDQHFLNTPL ELNLPVIMGL LGVWYNNFFG CQTQAILPYD 350
    QYLSRFPAYF QQGDMESNGK SVQRNGERVT HSTGPIIWGE PGTNGQHAFY 400
    QLIHQGQKII PCDFIASVES HNPLGKHHQI LLSNFFAQTE ALMKGKNEQE 450
    VTNELTKEGL SQEKIKQLLP HKVFEGNRPT NSIFLHKLTP HSLGALIALY 500
    EHKIFVQGII WNINSFDQWG VELGKQLAKS ILPELSDNNE VSTHDSSTNG 550
    LINFYKSNSK L 561
    Length:561
    Mass (Da):63,465
    Last modified:December 7, 2004 - v1
    Checksum:iB49E0503E55D7F77
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY581146 Genomic DNA. Translation: AAT92030.1.
    AAFI02000056 Genomic DNA. Translation: EAL65603.1.
    RefSeqiXP_638957.1. XM_633865.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231026; DDB0231026; DDB_G0283673.
    GeneIDi8624197.
    KEGGiddi:DDB_G0283673.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY581146 Genomic DNA. Translation: AAT92030.1 .
    AAFI02000056 Genomic DNA. Translation: EAL65603.1 .
    RefSeqi XP_638957.1. XM_633865.1.

    3D structure databases

    ProteinModelPortali Q5V9E9.
    SMRi Q5V9E9. Positions 3-556.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0231026.

    Proteomic databases

    PRIDEi Q5V9E9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231026 ; DDB0231026 ; DDB_G0283673 .
    GeneIDi 8624197.
    KEGGi ddi:DDB_G0283673.

    Organism-specific databases

    dictyBasei DDB_G0283673. gpi.

    Phylogenomic databases

    eggNOGi COG0166.
    KOi K01810.
    OMAi CGNELDN.
    PhylomeDBi Q5V9E9.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .

    Miscellaneous databases

    PROi Q5V9E9.

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cryptosporidium parvum: phylogenomic evidence for organelle loss, intracellular and horizontal gene transfer."
      Huang J., Mullapudi N., Lancto C., Scott M., Abrahamsen M., Kissinger J.C.
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiG6PI_DICDI
    AccessioniPrimary (citable) accession number: Q5V9E9
    Secondary accession number(s): Q54QR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3