ID   Q5V7L8_HALMA            Unreviewed;       549 AA.
AC   Q5V7L8;
DT   07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT   07-DEC-2004, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   SubName: Full=Exo-alpha-sialidase {ECO:0000313|EMBL:AAV44485.1};
DE            EC=3.2.1.18 {ECO:0000313|EMBL:AAV44485.1};
GN   OrderedLocusNames=pNG5066 {ECO:0000313|EMBL:AAV44485.1};
OS   Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM
OS   B-1809) (Halobacterium marismortui).
OG   Plasmid pNG500 {ECO:0000313|EMBL:AAV44485.1,
OG   ECO:0000313|Proteomes:UP000001169}.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Haloarcula.
OX   NCBI_TaxID=272569 {ECO:0000313|EMBL:AAV44485.1, ECO:0000313|Proteomes:UP000001169};
RN   [1] {ECO:0000313|EMBL:AAV44485.1, ECO:0000313|Proteomes:UP000001169}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809
RC   {ECO:0000313|Proteomes:UP000001169};
RC   PLASMID=Plasmid pNG500 {ECO:0000313|Proteomes:UP000001169};
RX   PubMed=15520287; DOI=10.1101/gr.2700304;
RA   Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W.,
RA   Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E.,
RA   Hood L., Ng W.V.;
RT   "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the
RT   Dead Sea.";
RL   Genome Res. 14:2221-2234(2004).
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DR   EMBL; AY596294; AAV44485.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5V7L8; -.
DR   EnsemblBacteria; AAV44485; AAV44485; pNG5066.
DR   KEGG; hma:pNG5066; -.
DR   PATRIC; fig|272569.17.peg.228; -.
DR   HOGENOM; CLU_028008_1_0_2; -.
DR   Proteomes; UP000001169; Plasmid pNG500.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR35902:SF3; ALPHA-GALACTOSIDASE NEW3 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR35902; S-LAYER DOMAIN-LIKE PROTEIN-RELATED; 1.
PE   4: Predicted;
KW   Glycosidase {ECO:0000313|EMBL:AAV44485.1};
KW   Hydrolase {ECO:0000313|EMBL:AAV44485.1};
KW   Membrane {ECO:0000256|SAM:Phobius}; Plasmid {ECO:0000313|EMBL:AAV44485.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001169};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        525..545
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          217..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        217..241
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   549 AA;  58478 MW;  DC6F8C0DBD53E780 CRC64;
     MTQNTLPNPP SLTTVLTAVL LVGFVVSAVP SIATAQASES GDVVGNPDVT FTTSSEPLSA
     DTADELTVSI VNYGQIIQHG PSQYEDSVMT ARGLSFEIDD GDTPIDVQTG QVSVGNFPTG
     SIEKTVSVIV PDNAEPGTYK LPVNYEYSYT RHIRYGPSGP TEGSDSTKTK TGSITVQVRE
     DARFEIVEAN ATTQVGDNND VSFTLKNTGS EIARGANINA ESQSSSLTFE SGDTSSTASV
     GDWEPGEIRT VSYNAALESD APVRGYSVNL KINYDDIDGI DRTSDPITTT VQSIREQDFI
     LSNVESQLRV GEDGDLIGTV HNDGPLPARN VVVQYTGEDQ SVIPTEDSTA VGTLDPGQSE
     SFSLPIAISG SAESGLRSLD MAIKYRNDEG ETRTFDELAV DAEVASERDR FDATIENRTI
     QAGGSRAVDV AVTNNLNEVA SDVEVRLFAD DPLDTGDTDT GYVQSLDPGE TKTVTFELTT
     TGSATVGSTY PISLDFRYDD TEGDSHLTKT YRLPIDVIES QEGGLPLPVI AVALLVIGTA
     ALVIYRRQQ
//