Q5V632 (TRPG2_HALMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component II
EC=4.1.3.27

Gene names

Name:	trpG2
Ordered Locus Names:	pNG7325

Encoded on

Plasmid pNG700

Organism

Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) [Complete proteome] [HAMAP]

Taxonomic identifier

272569 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloarcula

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Domain	Glutamine amidotransferase
Molecular function	Lyase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological process	glutamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Anthranilate synthase component II		PRO_0000056881
Regions
	Domain	1 – 190	190	Glutamine amidotransferase type-1
Sites
	Active site	76	1	By similarity
	Active site	167	1	By similarity
	Active site	169	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5V632 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 6752B48DD811FFD8	FASTA	190	20,308
	10 20 30 40 50 60 MILIIDNYDS FAYNLVQYVG EFDDVTVRRN DAIDVEGIHE LDPDGIVVSP GPGTPAEAGV 70 80 90 100 110 120 SIDVFAETEY PALGVCLGHQ ALCAAHGTPV GHAPSVVHGK PSEVRHDGTR LYDGVDDPFE 130 140 150 160 170 180 VGRYHSLAVK ASELPDTLSE TAHTNDEQGI VMGVQHAEKP HIGVQFHPES ILTDAGKQIV 190 ENFCTGIAKA

References

[1]

"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea." Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V. Genome Res. 14:2221-2234(2004) [PubMed: 15520287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY596296 Genomic DNA. Translation: AAV45020.1.
RefSeq	YP_134726.1. NC_006395.1.
3D structure databases
ProteinModelPortal	Q5V632.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3127200.
GenomeReviews	Gene locus pNG7325 in contig AY596296_GR.
KEGG	hma:pNG7325.
NMPDR	fig|272569.1.peg.3516.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG292341.
OMA	ENGHALF.
PhylomeDB	Q5V632.
ProtClustDB	CLSK2766365.
Enzyme and pathway databases
BioCyc	HMAR272569:PNG7325-MONOMER.
Family and domain databases
InterPro	IPR017926. GATASE_1. IPR006221. TrpG_papA. [Graphical view]
KO	K01658.
Pfam	PF00117. GATase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00566. TrpG_papA. 1 hit.
PROSITE	PS51273. GATASE_TYPE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPG2_HALMA

Accession

Primary (citable) accession number: Q5V632

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	December 7, 2004
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program