Q5V631 (TRPE3_HALMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component 1 3
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component I 3

Gene names

Name:	trpE3
Ordered Locus Names:	pNG7327

Encoded on

Plasmid pNG700

Organism

Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) [Complete proteome] [HAMAP]

Taxonomic identifier

272569 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloarcula

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.
Sequence caution	The sequence AAV45021.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Anthranilate synthase component 1 3		PRO_0000154124

Sequences

	Sequence		Length	Mass (Da)
	Q5V631 [UniParc]. Last modified June 21, 2005. Version 2. Checksum: 93B3EBE2B2A9AE12	FASTA	503	55,112
	10 20 30 40 50 60 MTEIRFSTDK ESFIETARAA ADGTRVPVEA RVTVADPFEA YRRARDENTD GFYLETTGGQ 70 80 90 100 110 120 SGWGYFGIEP IERVEVSAGA TPAQDGGSPS LEAIDDLLDR EHLERGDCTV PYPCGAFGWL 130 140 150 160 170 180 SYDVARELED IPETTVSDGL PRLQFGVFDC IAAWEEPHDG NVEIHVTACP TVDGSPESAF 190 200 210 220 230 240 ERGRTMAREL AQDAIHGEKH VQSQPTAASQ ATFESECGEA AFADRVRQIK QYVRDGDTFQ 250 260 270 280 290 300 TNVSHRLTAP AAVHPVDTFD AVRRVNPAPY SALLEFPGVD LVSASPELLL DVDGDQLLTE 310 320 330 340 350 360 PIAGTRPRGA TPSEDEDLEV DLCSDEKERA EHAMLVDLER NDLGKVSEYG SVDVAEYRRV 370 380 390 400 410 420 DRYSEVMHLV SLIEGELRDA VSIADAVAAV FPGGTITGAP KPRTMEIIDE VERTRRGPYT 430 440 450 460 470 480 GSIGMFGFDD RATLNITIRT LVHYDDEYRL RVGSGIVHDS VPEAEYRETL DKARALVTAV 490 500 DEALGEQGSF AVESETEPME GMR

References

[1]

"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea." Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V. Genome Res. 14:2221-2234(2004) [PubMed: 15520287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY596296 Genomic DNA. Translation: AAV45021.1. Different initiation.
RefSeq	YP_134727.1. NC_006395.1.
3D structure databases
ProteinModelPortal	Q5V631.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3127203.
GenomeReviews	Gene locus pNG7327 in contig AY596296_GR.
KEGG	hma:pNG7327.
NMPDR	fig|272569.1.peg.3517.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG507440.
PhylomeDB	Q5V631.
ProtClustDB	CLSK511064.
Enzyme and pathway databases
BioCyc	HMAR272569:PNG7327-MONOMER.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
KO	K01657.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE3_HALMA

Accession

Primary (citable) accession number: Q5V631

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	June 21, 2005
Last modified:	December 14, 2011
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program