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Q5V600 (DYR2_HALMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydrofolate reductase 2

EC=1.5.1.3
Gene names
Name:folA2
Ordered Locus Names:pNG7359
Encoded onPlasmid pNG700
OrganismHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) [Complete proteome] [HAMAP]
Taxonomic identifier272569 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula

Protein attributes

Sequence length167 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis By similarity.

Catalytic activity

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.

Sequence similarities

Belongs to the dihydrofolate reductase family.

Contains 1 DHFR (dihydrofolate reductase) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 167167Dihydrofolate reductase 2
PRO_0000186432

Regions

Domain4 – 167164DHFR

Sequences

Sequence LengthMass (Da)Tools
Q5V600 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 37176A5FE13B17EC

FASTA16718,093
        10         20         30         40         50         60 
MCMKLSLIAA VAANGVIGAG GDIPWQYPED LTHFKETTVG HPVIMGRRTF ESIRRDLDGP 

        70         80         90        100        110        120 
LPERLNIVLT TTPHQLPDSV TAVTSTTAAV AEAADSDAST TYVIGGATVY EQFLPQADEL 

       130        140        150        160 
ILTELAAAFD GDTVFPTVDW SNWTEMERTT HSEFAIVRYT RTSSDSA 

« Hide

References

[1]"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea."
Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V.
Genome Res. 14:2221-2234(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY596296 Genomic DNA. Translation: AAV45052.1.
RefSeqYP_134758.1. NC_006395.1.

3D structure databases

ProteinModelPortalQ5V600.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272569.pNG7359.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV45052; AAV45052; pNG7359.
GeneID3127320.
KEGGhma:pNG7359.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0262.
HOGENOMHOG000040233.
KOK00287.
OMALVAHDQQ.

Enzyme and pathway databases

BioCycHMAR272569:GJDH-3519-MONOMER.
UniPathwayUPA00077; UER00158.

Family and domain databases

Gene3D3.40.430.10. 1 hit.
InterProIPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view]
PfamPF00186. DHFR_1. 1 hit.
[Graphical view]
PIRSFPIRSF000194. DHFR. 1 hit.
PRINTSPR00070. DHFR.
SUPFAMSSF53597. SSF53597. 1 hit.
PROSITEPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDYR2_HALMA
AccessionPrimary (citable) accession number: Q5V600
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 7, 2004
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways