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Q5V5Y2

- FTHS_HALMA

UniProt

Q5V5Y2 - FTHS_HALMA

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, pNG7380
Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi56 – 638ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-3537-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:pNG7380
Encoded oniPlasmid pNG7000 Publication
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000001169: Plasmid pNG700

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199413Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272569.pNG7380.

Structurei

3D structure databases

ProteinModelPortaliQ5V5Y2.
SMRiQ5V5Y2. Positions 1-551.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5V5Y2-1 [UniParc]FASTAAdd to Basket

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MEPIWELVEP WGLGLDDLQY FGEYTAKVKQ HAIERLREQA ENREQNLVLV    50
TGMTPTPKGE GKTVTTVGLG QTLNHVGEEA MIAIREPSLG PVFGVKGGAA 100
GGGRSQVLPM EDINLHFTGD LHALTSAHNL IAAMLDAKIS QGDDLNIDIN 150
NVSWPRAIDM NDRALRETVV GLGGKTGGTP REDSFILTAA SELMAVLCLA 200
SDIGDLKERV SRIIVAYDED GDPVTVEDIE ATGPATMLLR DAIKPNVVQT 250
IEGTPALVHG GPFANIAHGT NSLVADKTAF GMGDYLVTEA GFGSDLGAEK 300
FMDVVCRKGD MTPNAVVLVA SVRALKYHGL NQWPVDYDEI GEAGVEAVEA 350
GFSNLDKHAR NLQKFGVPVV VSVNRFPDDT DEEVQAVLDH CREDLGVRAA 400
ESNVFSDGSE GGVDLAENVI EATEESNEED FRMLYDDDDS IKEKIHTVAT 450
EIYGADDVKY TGGALDDIEQ MNDLDFDDYP VVMSKTFHSL SDDASQKGAP 500
EGWELEISEV YPSAGAGFLV ALTADALTMP GLPARPAAAD MDIDGDGNIS 550
GLF 553
Length:553
Mass (Da):59,251
Last modified:December 6, 2005 - v2
Checksum:i6FDA27CFF8595A76
GO

Sequence cautioni

The sequence AAV45070.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596296 Genomic DNA. Translation: AAV45070.1. Different initiation.
RefSeqiYP_134776.1. NC_006395.1.

Genome annotation databases

EnsemblBacteriaiAAV45070; AAV45070; pNG7380.
GeneIDi3127410.
KEGGihma:pNG7380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596296 Genomic DNA. Translation: AAV45070.1 . Different initiation.
RefSeqi YP_134776.1. NC_006395.1.

3D structure databases

ProteinModelPortali Q5V5Y2.
SMRi Q5V5Y2. Positions 1-551.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272569.pNG7380.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV45070 ; AAV45070 ; pNG7380 .
GeneIDi 3127410.
KEGGi hma:pNG7380.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci HMAR272569:GJDH-3537-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

Entry informationi

Entry nameiFTHS_HALMA
AccessioniPrimary (citable) accession number: Q5V5Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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