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Q5V5Y2

- FTHS_HALMA

UniProt

Q5V5Y2 - FTHS_HALMA

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi56 – 638ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHMAR272569:GJDH-3537-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:pNG7380
    Encoded oniPlasmid pNG7000 Publication
    OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
    Taxonomic identifieri272569 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
    ProteomesiUP000001169: Plasmid pNG700

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Formate--tetrahydrofolate ligasePRO_0000199413Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272569.pNG7380.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5V5Y2.
    SMRiQ5V5Y2. Positions 1-551.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5V5Y2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPIWELVEP WGLGLDDLQY FGEYTAKVKQ HAIERLREQA ENREQNLVLV    50
    TGMTPTPKGE GKTVTTVGLG QTLNHVGEEA MIAIREPSLG PVFGVKGGAA 100
    GGGRSQVLPM EDINLHFTGD LHALTSAHNL IAAMLDAKIS QGDDLNIDIN 150
    NVSWPRAIDM NDRALRETVV GLGGKTGGTP REDSFILTAA SELMAVLCLA 200
    SDIGDLKERV SRIIVAYDED GDPVTVEDIE ATGPATMLLR DAIKPNVVQT 250
    IEGTPALVHG GPFANIAHGT NSLVADKTAF GMGDYLVTEA GFGSDLGAEK 300
    FMDVVCRKGD MTPNAVVLVA SVRALKYHGL NQWPVDYDEI GEAGVEAVEA 350
    GFSNLDKHAR NLQKFGVPVV VSVNRFPDDT DEEVQAVLDH CREDLGVRAA 400
    ESNVFSDGSE GGVDLAENVI EATEESNEED FRMLYDDDDS IKEKIHTVAT 450
    EIYGADDVKY TGGALDDIEQ MNDLDFDDYP VVMSKTFHSL SDDASQKGAP 500
    EGWELEISEV YPSAGAGFLV ALTADALTMP GLPARPAAAD MDIDGDGNIS 550
    GLF 553
    Length:553
    Mass (Da):59,251
    Last modified:December 6, 2005 - v2
    Checksum:i6FDA27CFF8595A76
    GO

    Sequence cautioni

    The sequence AAV45070.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596296 Genomic DNA. Translation: AAV45070.1. Different initiation.
    RefSeqiYP_134776.1. NC_006395.1.

    Genome annotation databases

    EnsemblBacteriaiAAV45070; AAV45070; pNG7380.
    GeneIDi3127410.
    KEGGihma:pNG7380.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596296 Genomic DNA. Translation: AAV45070.1 . Different initiation.
    RefSeqi YP_134776.1. NC_006395.1.

    3D structure databases

    ProteinModelPortali Q5V5Y2.
    SMRi Q5V5Y2. Positions 1-551.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272569.pNG7380.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV45070 ; AAV45070 ; pNG7380 .
    GeneIDi 3127410.
    KEGGi hma:pNG7380.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci HMAR272569:GJDH-3537-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

    Entry informationi

    Entry nameiFTHS_HALMA
    AccessioniPrimary (citable) accession number: Q5V5Y2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3