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Q5V5Y2 (FTHS_HALMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:pNG7380
Encoded onPlasmid pNG700
OrganismHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) [Complete proteome] [HAMAP]
Taxonomic identifier272569 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Sequence caution

The sequence AAV45070.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 553553Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199413

Regions

Nucleotide binding56 – 638ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5V5Y2 [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: 6FDA27CFF8595A76

FASTA55359,251
        10         20         30         40         50         60 
MEPIWELVEP WGLGLDDLQY FGEYTAKVKQ HAIERLREQA ENREQNLVLV TGMTPTPKGE 

        70         80         90        100        110        120 
GKTVTTVGLG QTLNHVGEEA MIAIREPSLG PVFGVKGGAA GGGRSQVLPM EDINLHFTGD 

       130        140        150        160        170        180 
LHALTSAHNL IAAMLDAKIS QGDDLNIDIN NVSWPRAIDM NDRALRETVV GLGGKTGGTP 

       190        200        210        220        230        240 
REDSFILTAA SELMAVLCLA SDIGDLKERV SRIIVAYDED GDPVTVEDIE ATGPATMLLR 

       250        260        270        280        290        300 
DAIKPNVVQT IEGTPALVHG GPFANIAHGT NSLVADKTAF GMGDYLVTEA GFGSDLGAEK 

       310        320        330        340        350        360 
FMDVVCRKGD MTPNAVVLVA SVRALKYHGL NQWPVDYDEI GEAGVEAVEA GFSNLDKHAR 

       370        380        390        400        410        420 
NLQKFGVPVV VSVNRFPDDT DEEVQAVLDH CREDLGVRAA ESNVFSDGSE GGVDLAENVI 

       430        440        450        460        470        480 
EATEESNEED FRMLYDDDDS IKEKIHTVAT EIYGADDVKY TGGALDDIEQ MNDLDFDDYP 

       490        500        510        520        530        540 
VVMSKTFHSL SDDASQKGAP EGWELEISEV YPSAGAGFLV ALTADALTMP GLPARPAAAD 

       550 
MDIDGDGNIS GLF 

« Hide

References

[1]"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea."
Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V.
Genome Res. 14:2221-2234(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY596296 Genomic DNA. Translation: AAV45070.1. Different initiation.
RefSeqYP_134776.1. NC_006395.1.

3D structure databases

ProteinModelPortalQ5V5Y2.
SMRQ5V5Y2. Positions 1-551.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272569.pNG7380.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV45070; AAV45070; pNG7380.
GeneID3127410.
KEGGhma:pNG7380.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.

Enzyme and pathway databases

BioCycHMAR272569:GJDH-3537-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_HALMA
AccessionPrimary (citable) accession number: Q5V5Y2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways