ID   HTR2_HALMA              Reviewed;         773 AA.
AC   Q5V5V4;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   27-MAR-2024, entry version 101.
DE   RecName: Full=Sensory rhodopsin II transducer;
DE   AltName: Full=MCP domain signal transducer 2;
DE            Short=HmHtrII;
GN   Name=htr2; OrderedLocusNames=rrnAC0013;
OS   Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM
OS   B-1809) (Halobacterium marismortui).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Haloarcula.
OX   NCBI_TaxID=272569;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809;
RX   PubMed=15520287; DOI=10.1101/gr.2700304;
RA   Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W.,
RA   Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E.,
RA   Hood L., Ng W.V.;
RT   "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the
RT   Dead Sea.";
RL   Genome Res. 14:2221-2234(2004).
RN   [2]
RP   INDUCTION.
RX   PubMed=20802037; DOI=10.1128/jb.00642-10;
RA   Fu H.Y., Lin Y.C., Chang Y.N., Tseng H., Huang C.C., Liu K.C., Huang C.S.,
RA   Su C.W., Weng R.R., Lee Y.Y., Ng W.V., Yang C.S.;
RT   "A novel six-rhodopsin system in a single archaeon.";
RL   J. Bacteriol. 192:5866-5873(2010).
CC   -!- FUNCTION: Transduces signals from the phototaxis receptor sensory
CC       rhodopsin II (Sop2). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Expressed constitutively throughout the growth phases, both
CC       in presence and absence of white light. {ECO:0000269|PubMed:20802037}.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000305}.
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DR   EMBL; AY596297; AAV45098.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5V5V4; -.
DR   SMR; Q5V5V4; -.
DR   STRING; 272569.rrnAC0013; -.
DR   PaxDb; 272569-rrnAC0013; -.
DR   EnsemblBacteria; AAV45098; AAV45098; rrnAC0013.
DR   KEGG; hma:rrnAC0013; -.
DR   PATRIC; fig|272569.17.peg.827; -.
DR   eggNOG; arCOG02320; Archaea.
DR   HOGENOM; CLU_000445_107_19_2; -.
DR   Proteomes; UP000001169; Chromosome I.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd11386; MCP_signal; 1.
DR   CDD; cd18774; PDC2_HK_sensor; 1.
DR   Gene3D; 6.10.250.1910; -; 1.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR   InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   PANTHER; PTHR32089:SF92; LYSOZYME-LIKE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   PRINTS; PR00260; CHEMTRNSDUCR.
DR   SMART; SM00304; HAMP; 2.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF158472; HAMP domain-like; 1.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Membrane; Reference proteome; Repeat; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..773
FT                   /note="Sensory rhodopsin II transducer"
FT                   /id="PRO_0000428858"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          311..363
FT                   /note="HAMP 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          398..451
FT                   /note="HAMP 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          470..706
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
FT   REGION          717..740
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          727..760
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        717..735
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   773 AA;  82593 MW;  9CFBFFF01183AC6A CRC64;
     MDSNRDSPLP SFIAGSYAAR LGVALSFAIL VIIAAGVLTS VQASATLEED VADDITALSE
     TQAVQLDDWL TTSRRNVRST SRLPVFTDGT DTEKQQRLEE LRSNEELPPG VVAVHYFDTE
     TSEIRASSNQ DFIGVNAAEQ GAPFATDPPQ FDGPDDTHVT EPFSVSVVDH PIVAVVSPVP
     GDEDRALVYM IDLREKADQI SSHREGSFTT VVNTDGEFVS HPNHSMIGST APISQMESDP
     LGTLEPGQRM FHETDSMLMG LTRLESHDWV VMVHSDREAA YALSDQINSD LIGLILLAVV
     NLGLIGVTIG GNTIASLRRL SVKAEAMADG ELDVDLDTSR EDEFGTLYAA FDNMRANLRT
     QISEAETAKQ EAEAAKEQAQ AAREDVESER NEMEALTGHL ELKAQQYSDA LDAAANGDLT
     ARVKTDSMND AMAEVGEDIN TTLDALEDTI ADMKAFATNV IQSSDRVNSN AERVDRASKQ
     VSKSINEIFE GTTEQNEGLE SAAAEMQNLS ATAQQVASSA QQVADTSQSA AKVGEDGREA
     AQEAIAEMSA IEAETGETVE EINALDDELD EIGEIVGVIT SIVEQTNMLA LNASIEAAHA
     DGDGEGFAVV ADEIKGLAEE TKEAAADIEG RIEAIQEQAG DTVETMESTS TRITEGVSTV
     EETVDALETI VEYTEEVDTG IQEIDRATEE QARTAQDVMG TIDDLTTISQ QTATEADTVA
     GAAQDQSASI EEVSDSATEL RQRADDLESL LDRFTVENSA GTGTDSTAAV GDD
//