Q5V5K5 (AROC_HALMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	rrnAC0124

Organism

Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) [Complete proteome] [HAMAP]

Taxonomic identifier

272569 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloarcula

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 399	399	Chorismate synthase HAMAP MF_00300		PRO_0000322431

Sequences

	Sequence		Length	Mass (Da)
	Q5V5K5 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 3BACF4B62C502881	FASTA	399	43,362
	10 20 30 40 50 60 MNGNEFGRLF RMTTYGESHG EAMGCTVSGV PAGVELSEEE IQKDLDRRKP GQSMITTSRG 70 80 90 100 110 120 EPDKVTINSG IQDGYTTGTP IGMVIQNKDA RSGKYEPFIT APRPSHGDYT YSAKFGTRNW 130 140 150 160 170 180 GGGGRSSARE TVNWVAAGGV AKQVLEQSDY DVQIKAHVCQ IGDVEAGPVT FEDMLEHSEE 190 200 210 220 230 240 NEVRCADPEA AEEMRDVADQ HQKEGDSIGG AIYFECRGVP SGLGAPRFDS FPSRLGQAMY 250 260 270 280 290 300 SIPAVNDFEY GIGREARTTK GSEYTENWEF DEDGHPTPVG NDHGGIQGGI TTGQPIYGEV 310 320 330 340 350 360 SWHAPVSIPK TQETVDWETG EGKEITVTGR HDPVLPPRAV PVVEAMLACT VLDFMLLGGR 370 380 390 INPDRLDGRP GEYDTDYHPS SPQNDPEDAD THAKTIDDD

References

[1]

"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea." Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V. Genome Res. 14:2221-2234(2004) [PubMed: 15520287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY596297 Genomic DNA. Translation: AAV45197.1.
RefSeq	YP_134903.1. NC_006396.1.
3D structure databases
HSSP	HSSP built from PDB template 1R53 based on UniProtKB P28777.
ProteinModelPortal	Q5V5K5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3130074.
GenomeReviews	Gene locus rrnAC0124 in contig AY596297_GR.
KEGG	hma:rrnAC0124.
NMPDR	fig|272569.1.peg.153.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG292336.
OMA	SRFTTQR.
PhylomeDB	Q5V5K5.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	HMAR272569:RRNAC0124-MONOMER.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. False negative. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_HALMA

Accession

Primary (citable) accession number: Q5V5K5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	December 7, 2004
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program