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Q5V574

- HISX_HALMA

UniProt

Q5V574 - HISX_HALMA

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Protein

Histidinol dehydrogenase

Gene
hisD, rrnAC0272
Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231NAD By similarity
Binding sitei183 – 1831NAD By similarity
Binding sitei206 – 2061NAD By similarity
Binding sitei229 – 2291Substrate By similarity
Metal bindingi251 – 2511Zinc By similarity
Binding sitei251 – 2511Substrate By similarity
Metal bindingi254 – 2541Zinc By similarity
Binding sitei254 – 2541Substrate By similarity
Active sitei320 – 3201Proton acceptor By similarity
Active sitei321 – 3211Proton acceptor By similarity
Binding sitei321 – 3211Substrate By similarity
Metal bindingi354 – 3541Zinc By similarity
Binding sitei354 – 3541Substrate By similarity
Binding sitei408 – 4081Substrate By similarity
Metal bindingi413 – 4131Zinc By similarity
Binding sitei413 – 4131Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-247-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:rrnAC0272
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000001169: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Histidinol dehydrogenaseUniRule annotationPRO_0000135891Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272569.rrnAC0272.

Structurei

3D structure databases

ProteinModelPortaliQ5V574.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiNAMSILL.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5V574-1 [UniParc]FASTAAdd to Basket

« Hide

MNVRTIADLG PDERAAFFDR DAGVDAVRDD VRDIVSQVHE EGDVALRRFA    50
EEFDDVSVGN IDITDAAERA YEEIDDDVRE AIEDAAANIR AFHERQVPED 100
WRDDFEGREL GRRFRPLDSA GVYAPGGTAA YPSSALMGVI PAKVAGVEHV 150
AVATPPAEEV NPVTLAAIHV AGADAVYQVG GAQAIAALAY GTETVSATDI 200
VVGPGNRWVT AAKAEVRGDV AIDFLAGPSE VMVVADGDAD PELVAADLIA 250
QAEHDENASV VAVTDDADLA EQVVDAVDEQ ADGREREAVI RAALDNDTSG 300
VLLARSMSEA VLFAEEYAAE HLSIQAADDE SLLERIPSAG SVFLGPYSPV 350
AAGDYATGTN HVLPTGGNAR VTGGLSVDTF VRSTTVQRLS EDSLGDIADT 400
ITTLAEAEGL DAHAESVRKR FE 422
Length:422
Mass (Da):44,466
Last modified:December 7, 2004 - v1
Checksum:iB04AC7EF3AA246D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596297 Genomic DNA. Translation: AAV45328.1.
RefSeqiWP_011222927.1. NC_006396.1.
YP_135034.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV45328; AAV45328; rrnAC0272.
GeneIDi3129583.
KEGGihma:rrnAC0272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596297 Genomic DNA. Translation: AAV45328.1 .
RefSeqi WP_011222927.1. NC_006396.1.
YP_135034.1. NC_006396.1.

3D structure databases

ProteinModelPortali Q5V574.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272569.rrnAC0272.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV45328 ; AAV45328 ; rrnAC0272 .
GeneIDi 3129583.
KEGGi hma:rrnAC0272.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi NAMSILL.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci HMAR272569:GJDH-247-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

Entry informationi

Entry nameiHISX_HALMA
AccessioniPrimary (citable) accession number: Q5V574
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 7, 2004
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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