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Q5V574

- HISX_HALMA

UniProt

Q5V574 - HISX_HALMA

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231NADUniRule annotation
Binding sitei183 – 1831NADUniRule annotation
Binding sitei206 – 2061NADUniRule annotation
Binding sitei229 – 2291SubstrateUniRule annotation
Metal bindingi251 – 2511ZincUniRule annotation
Binding sitei251 – 2511SubstrateUniRule annotation
Metal bindingi254 – 2541ZincUniRule annotation
Binding sitei254 – 2541SubstrateUniRule annotation
Active sitei320 – 3201Proton acceptorUniRule annotation
Active sitei321 – 3211Proton acceptorUniRule annotation
Binding sitei321 – 3211SubstrateUniRule annotation
Metal bindingi354 – 3541ZincUniRule annotation
Binding sitei354 – 3541SubstrateUniRule annotation
Binding sitei408 – 4081SubstrateUniRule annotation
Metal bindingi413 – 4131ZincUniRule annotation
Binding sitei413 – 4131SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-247-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:rrnAC0272
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000001169: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Histidinol dehydrogenasePRO_0000135891Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272569.rrnAC0272.

Structurei

3D structure databases

ProteinModelPortaliQ5V574.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiNAMSILL.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5V574-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNVRTIADLG PDERAAFFDR DAGVDAVRDD VRDIVSQVHE EGDVALRRFA
60 70 80 90 100
EEFDDVSVGN IDITDAAERA YEEIDDDVRE AIEDAAANIR AFHERQVPED
110 120 130 140 150
WRDDFEGREL GRRFRPLDSA GVYAPGGTAA YPSSALMGVI PAKVAGVEHV
160 170 180 190 200
AVATPPAEEV NPVTLAAIHV AGADAVYQVG GAQAIAALAY GTETVSATDI
210 220 230 240 250
VVGPGNRWVT AAKAEVRGDV AIDFLAGPSE VMVVADGDAD PELVAADLIA
260 270 280 290 300
QAEHDENASV VAVTDDADLA EQVVDAVDEQ ADGREREAVI RAALDNDTSG
310 320 330 340 350
VLLARSMSEA VLFAEEYAAE HLSIQAADDE SLLERIPSAG SVFLGPYSPV
360 370 380 390 400
AAGDYATGTN HVLPTGGNAR VTGGLSVDTF VRSTTVQRLS EDSLGDIADT
410 420
ITTLAEAEGL DAHAESVRKR FE
Length:422
Mass (Da):44,466
Last modified:December 7, 2004 - v1
Checksum:iB04AC7EF3AA246D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596297 Genomic DNA. Translation: AAV45328.1.
RefSeqiWP_011222927.1. NC_006396.1.
YP_135034.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV45328; AAV45328; rrnAC0272.
GeneIDi3129583.
KEGGihma:rrnAC0272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596297 Genomic DNA. Translation: AAV45328.1 .
RefSeqi WP_011222927.1. NC_006396.1.
YP_135034.1. NC_006396.1.

3D structure databases

ProteinModelPortali Q5V574.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272569.rrnAC0272.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV45328 ; AAV45328 ; rrnAC0272 .
GeneIDi 3129583.
KEGGi hma:rrnAC0272.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi NAMSILL.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci HMAR272569:GJDH-247-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

Entry informationi

Entry nameiHISX_HALMA
AccessioniPrimary (citable) accession number: Q5V574
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 7, 2004
Last modified: November 26, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3