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Q5V574

- HISX_HALMA

UniProt

Q5V574 - HISX_HALMA

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei123 – 1231NADUniRule annotation
    Binding sitei183 – 1831NADUniRule annotation
    Binding sitei206 – 2061NADUniRule annotation
    Binding sitei229 – 2291SubstrateUniRule annotation
    Metal bindingi251 – 2511ZincUniRule annotation
    Binding sitei251 – 2511SubstrateUniRule annotation
    Metal bindingi254 – 2541ZincUniRule annotation
    Binding sitei254 – 2541SubstrateUniRule annotation
    Active sitei320 – 3201Proton acceptorUniRule annotation
    Active sitei321 – 3211Proton acceptorUniRule annotation
    Binding sitei321 – 3211SubstrateUniRule annotation
    Metal bindingi354 – 3541ZincUniRule annotation
    Binding sitei354 – 3541SubstrateUniRule annotation
    Binding sitei408 – 4081SubstrateUniRule annotation
    Metal bindingi413 – 4131ZincUniRule annotation
    Binding sitei413 – 4131SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciHMAR272569:GJDH-247-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:rrnAC0272
    OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
    Taxonomic identifieri272569 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
    ProteomesiUP000001169: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422Histidinol dehydrogenasePRO_0000135891Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272569.rrnAC0272.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5V574.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiNAMSILL.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5V574-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNVRTIADLG PDERAAFFDR DAGVDAVRDD VRDIVSQVHE EGDVALRRFA    50
    EEFDDVSVGN IDITDAAERA YEEIDDDVRE AIEDAAANIR AFHERQVPED 100
    WRDDFEGREL GRRFRPLDSA GVYAPGGTAA YPSSALMGVI PAKVAGVEHV 150
    AVATPPAEEV NPVTLAAIHV AGADAVYQVG GAQAIAALAY GTETVSATDI 200
    VVGPGNRWVT AAKAEVRGDV AIDFLAGPSE VMVVADGDAD PELVAADLIA 250
    QAEHDENASV VAVTDDADLA EQVVDAVDEQ ADGREREAVI RAALDNDTSG 300
    VLLARSMSEA VLFAEEYAAE HLSIQAADDE SLLERIPSAG SVFLGPYSPV 350
    AAGDYATGTN HVLPTGGNAR VTGGLSVDTF VRSTTVQRLS EDSLGDIADT 400
    ITTLAEAEGL DAHAESVRKR FE 422
    Length:422
    Mass (Da):44,466
    Last modified:December 7, 2004 - v1
    Checksum:iB04AC7EF3AA246D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV45328.1.
    RefSeqiWP_011222927.1. NC_006396.1.
    YP_135034.1. NC_006396.1.

    Genome annotation databases

    EnsemblBacteriaiAAV45328; AAV45328; rrnAC0272.
    GeneIDi3129583.
    KEGGihma:rrnAC0272.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV45328.1 .
    RefSeqi WP_011222927.1. NC_006396.1.
    YP_135034.1. NC_006396.1.

    3D structure databases

    ProteinModelPortali Q5V574.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272569.rrnAC0272.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV45328 ; AAV45328 ; rrnAC0272 .
    GeneIDi 3129583.
    KEGGi hma:rrnAC0272.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi NAMSILL.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci HMAR272569:GJDH-247-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

    Entry informationi

    Entry nameiHISX_HALMA
    AccessioniPrimary (citable) accession number: Q5V574
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3