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Reviewed, UniProtKB/Swiss-Prot Q5V4R0 (DNLI_HALMA)

Last modified June 16, 2009. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    DNA ligase
    EC=6.5.1.1
Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]
Gene names
Name: lig
Ordered Locus Names: rrnAC0463
OrganismHaloarcula marismortui (Halobacterium marismortui) [Complete proteome] [HAMAP]
Taxonomic identifier2238 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP MF_00407

Cofactor

Divalent metal cations By similarity.

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 554554DNA ligase HAMAP MF_00407
PRO_1000049866

Sites

Active site2551N6-AMP-lysine intermediate By similarity
Binding site2531ATP By similarity
Binding site2601ATP By similarity
Binding site2751ATP By similarity
Binding site3041ATP By similarity
Binding site3441ATP By similarity
Binding site4181ATP By similarity
Binding site4241ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5V4R0-1 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 6DA9C5DCA84BCF3C

FASTA55459,594
        10         20         30         40         50         60 
MEFAAFADRA EAIESESADT AITEAVTDLF RASGSDLSTL ARFVQGRVFP AYESRTLDIG 

        70         80         90        100        110        120 
PRLCYEAIAR AAGQNVSADD VEQRLADLGE IGAVAASYDL GGQQGLAAFG AGGGGDDALT 

       130        140        150        160        170        180 
VAELDDELRN LAAVDGSGSQ GTKVDILFGL FSRCSSTEAG YLARLVLSEM RIGVGEGTVR 

       190        200        210        220        230        240 
DAAAAAFDVP VEAVERAVQV SNDYGMVAEV ARDEGESGLA TVTLEIGRPV QAMLAQAGTV 

       250        260        270        280        290        300 
AGALEDWDRA AVEWKYDGAR VQVHFDGEDA RLFSRNMEEV TDPLPEVVET VESTLDAPAI 

       310        320        330        340        350        360 
LDGEVVAVDD GGDPLPFQEV LRRFRRKHDV AAAREDVAVR LHAFDCLHAA GEDLLDAALE 

       370        380        390        400        410        420 
TRHDRLESLF PADSDVFSQM WLSDDAEEIE SLEAEALAAG QEGIMLKDPT AAYSPGKRGK 

       430        440        450        460        470        480 
HWRKRKPDVE TLDCVVTGAE WGEGRRANVL GSFELSVRTD DGYATVGNVA TGITDEELDD 

       490        500        510        520        530        540 
LTERFEPYIR SEDGRDVVLD PAVVFEVGYE EIQASQSYAS GYALRFPRFL SVREDKTPDS 

       550 
ADSLARVERL AESQ 

« Hide

References

[1]"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea."
Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V.
Genome Res. 14:2221-2234(2004) [PubMed: 15520287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43049 / DSM 3752 / JCM 8966.

Cross-references

Sequence databases

AY596297 Genomic DNA. Translation: AAV45492.1.
RefSeqYP_135198.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3130622.
GenomeReviewsGene locus rrnAC0463 in contig AY596297_GR.
KEGGhma:rrnAC0463.
NMPDRfig|272569.1.peg.457.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ5V4R0.
OMAQ5V4R0. SNLHLGA.

Enzyme and pathway databases

BioCycHMAR272569:RRNAC0463-MON.
BRENDA6.5.1.1. 88.

Family and domain databases

HAMAPMF_00407.
[Tree]
InterProIPR000977. DNA_ligase.
IPR012309. DNA_ligase_A_C.
IPR012310. DNA_ligase_A_M.
IPR012308. DNA_ligase_A_N.
IPR016059. DNA_ligase_CS.
IPR012340. NA-bd_OB-fold.
[Graphical view]
Gene3DG3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. False negative.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_HALMA
AccessionPrimary (citable) accession number: Q5V4R0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 7, 2004
Last modified: June 16, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents