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Q5V467

- GMSS1_HALMA

UniProt

Q5V467 - GMSS1_HALMA

Protein

Glutamate mutase sigma subunit 1

Gene

glmS1

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).1 Publication

    Catalytic activityi

    L-threo-3-methylaspartate = L-glutamate.UniRule annotation

    Cofactori

    Adenosylcobalamin.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi20 – 201Cobalt (cobalamin axial ligand)UniRule annotation

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. methylaspartate mutase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. anaerobic glutamate catabolic process Source: UniProtKB-HAMAP
    2. glutamate catabolic process via L-citramalate Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Cobalamin, Cobalt, Metal-binding

    Enzyme and pathway databases

    BioCyciHMAR272569:GJDH-607-MONOMER.
    MetaCyc:MONOMER-16253.
    UniPathwayiUPA00561; UER00617.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate mutase sigma subunit 1UniRule annotation (EC:5.4.99.1UniRule annotation)
    Alternative name(s):
    Glutamate mutase S chain 1UniRule annotation
    Glutamate mutase small subunit 1UniRule annotation
    Methylaspartate mutase 1UniRule annotation
    Gene namesi
    Name:glmS1UniRule annotation
    Synonyms:mamA1
    Ordered Locus Names:rrnAC0684
    OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
    Taxonomic identifieri272569 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
    ProteomesiUP000001169: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 151151Glutamate mutase sigma subunit 1PRO_0000278195Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272569.rrnAC0684.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5V467.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 140134B12-bindingUniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni17 – 215Adenosylcobalamin bindingUniRule annotation
    Regioni65 – 673Adenosylcobalamin bindingUniRule annotation
    Regioni96 – 1005Adenosylcobalamin bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the methylaspartate mutase GlmS subunit family.UniRule annotation
    Contains 1 B12-binding domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2185.
    HOGENOMiHOG000011065.
    KOiK01846.
    OMAiTSQEEFA.

    Family and domain databases

    Gene3Di3.40.50.280. 1 hit.
    HAMAPiMF_00526. Me_Asp_mutase_S.
    InterProiIPR006158. Cobalamin-bd.
    IPR006394. Me_Asp_mutase.
    [Graphical view]
    PfamiPF02310. B12-binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF52242. SSF52242. 1 hit.
    TIGRFAMsiTIGR01501. MthylAspMutase. 1 hit.
    PROSITEiPS51332. B12_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5V467-1 [UniParc]FASTAAdd to Basket

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    MTGKYMPRTV ILGVIGSDAH VVGITILEQA LSAAGFEVIN LGVQTAQDEF    50
    VSAAKSHDAE AVLVSSLYGH ARQDCEGLHD ELDDAGLDVL TYVGGNLAVG 100
    QSDFEETQAT FRQMGFDRVF DAETDPEEAI EMLREDLQLT TTEAEQIRVD 150
    G 151
    Length:151
    Mass (Da):16,306
    Last modified:December 7, 2004 - v1
    Checksum:i3812223A02A9142A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV45685.1.
    RefSeqiYP_135391.1. NC_006396.1.

    Genome annotation databases

    EnsemblBacteriaiAAV45685; AAV45685; rrnAC0684.
    GeneIDi3130384.
    KEGGihma:rrnAC0684.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV45685.1 .
    RefSeqi YP_135391.1. NC_006396.1.

    3D structure databases

    ProteinModelPortali Q5V467.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272569.rrnAC0684.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV45685 ; AAV45685 ; rrnAC0684 .
    GeneIDi 3130384.
    KEGGi hma:rrnAC0684.

    Phylogenomic databases

    eggNOGi COG2185.
    HOGENOMi HOG000011065.
    KOi K01846.
    OMAi TSQEEFA.

    Enzyme and pathway databases

    UniPathwayi UPA00561 ; UER00617 .
    BioCyci HMAR272569:GJDH-607-MONOMER.
    MetaCyc:MONOMER-16253.

    Family and domain databases

    Gene3Di 3.40.50.280. 1 hit.
    HAMAPi MF_00526. Me_Asp_mutase_S.
    InterProi IPR006158. Cobalamin-bd.
    IPR006394. Me_Asp_mutase.
    [Graphical view ]
    Pfami PF02310. B12-binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52242. SSF52242. 1 hit.
    TIGRFAMsi TIGR01501. MthylAspMutase. 1 hit.
    PROSITEi PS51332. B12_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    2. Cited for: FUNCTION.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

    Entry informationi

    Entry nameiGMSS1_HALMA
    AccessioniPrimary (citable) accession number: Q5V467
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3