Reviewed, UniProtKB/Swiss-Prot Q5V448 (TRPE1_HALMA)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I 1

Gene names

Name:	trpE1
Ordered Locus Names:	rrnAC0709

Organism

Haloarcula marismortui (Halobacterium marismortui) [Complete proteome] [HAMAP]

Taxonomic identifier

2238 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloarcula

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	Anthranilate synthase component 1 1		PRO_0000154122

Sequences

	Sequence		Length	Mass (Da)
	Q5V448-1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 41533472289C120D	FASTA	489	53,790
	10 20 30 40 50 60 MQSVETDRTT FTDLAADAHP AARVPVEVRV DVDDPFLAYR RARDETGGVY LATTGGQSGW 70 80 90 100 110 120 GYFGTAPADF REVDPRAGGT LAALTEFLDG ERLVRGDCDV PYPCGAVGWL SYDVARELES 130 140 150 160 170 180 LPDSADADRA LPNLQVARYD RFAAWEEPRG ESVTLRVTAC PRVDDFETPE LAYEFGKQHA 190 200 210 220 230 240 LDLARAAAQG DPSVEDPPVE TDEATFESDC TRESFADRVQ TVKQYIRDGD TFQANVSQRL 250 260 270 280 290 300 RAPAAVHPVE AFDALRTVNP APYSALLEFP GVDLVSASPE LLLHRDGDRI ETEPIAGTRP 310 320 330 340 350 360 RGETPDADDR LETDLLDDEK ERAEHAMLVD LERNDLGKVS KFGSVEVSDY RRVDRYSEVM 370 380 390 400 410 420 HLVSVVEGRL RDGASLQDAI AAVFPGGTIT GAPKPRTMEI IDEVEATRRG PYTGSIGLFG 430 440 450 460 470 480 FDGRATLNIV IRTLVRYAEE YHLRVGAGVV HDSDPDREYQ ETLDKGRALV NAVDEALGRR VDLAMEDQQ

References

[1]

"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea." Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V. Genome Res. 14:2221-2234(2004) [PubMed: 15520287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43049 / DSM 3752 / JCM 8966.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY596297 Genomic DNA. Translation: AAV45704.1.
RefSeq	YP_135410.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3130370.
GenomeReviews	Gene locus rrnAC0709 in contig AY596297_GR.
KEGG	hma:rrnAC0709.
NMPDR	fig|272569.1.peg.669.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5V448.
OMA	IAVARRC.
Enzyme and pathway databases
BioCyc	HMAR272569:RRNAC0709-MON.
BRENDA	4.1.3.27. 88.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. IPR010118. Para-NH2Bz/anthranilate_synth. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
ProDom	PD000779. Anth_synth_chor. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01824. PabB-clade2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE1_HALMA

Accession

Primary (citable) accession number: Q5V448

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	December 7, 2004
Last modified:	November 3, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)