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Q5V3Z1 (F16A1_HALMA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Fructose-1,6-bisphosphatase class 1 1
Short name=FBPase class 1 1
EC=3.1.3.11
Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 1
Gene names
Name:fbp1
Ordered Locus Names:rrnAC0772
OrganismHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) [Complete proteome] [HAMAP]
Taxonomic identifier272569 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloarcula

Protein attributes

Sequence length291 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP MF_01855

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855

Subunit structure

Homotetramer By similarity. HAMAP MF_01855

Subcellular location

Cytoplasm Potential HAMAP MF_01855.

Sequence similarities

Belongs to the FBPase class 1 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbohydrate metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionfructose 1,6-bisphosphate 1-phosphatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 291291Fructose-1,6-bisphosphatase class 1 1 HAMAP MF_01855
PRO_0000364768

Regions

Region98 – 1014Substrate binding By similarity

Sites

Metal binding781Magnesium 1 By similarity
Metal binding951Magnesium 1 By similarity
Metal binding951Magnesium 2 By similarity
Metal binding971Magnesium 1; via carbonyl oxygen By similarity
Metal binding981Magnesium 2 By similarity
Metal binding2391Magnesium 2 By similarity
Binding site2031Substrate By similarity
Binding site2331Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5V3Z1 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: D030743B13C060E1

FASTA29131,589
        10         20         30         40         50         60 
MSKSLDISTT EAEQTVTEVI DTIVATTPDV RRAVADYRGQ SNSVNPTGDD QLAADLRADE 

        70         80         90        100        110        120 
LFEQRVLGID GVASYASEER ADVKTTDGRL HVAMDPLDGS SNLEPNSGMG TIFGIYSEQP 

       130        140        150        160        170        180 
PTVGTNLLAA GFVIYGPITS MVVARDGSVR EYILEDGDKR VVDDDVTVPE DPTVFGFGGG 

       190        200        210        220        230        240 
VDSWTDEFES YAEAVRHELK LRYGGAMVAD INQVLTYGGI FSYPALESRP EGKLRVQFEG 

       250        260        270        280        290 
HPMAYILESA GGRSSDGDQS LLEIEPDELH ERTPLYLGND DLIDRLEANI D

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References

[1]"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea."
Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V.
Genome Res. 14:2221-2234(2004) [PubMed: 15520287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY596297 Genomic DNA. Translation: AAV45761.1.
RefSeqYP_135467.1. NC_006396.1.

3D structure databases

HSSPHSSP built from PDB template 1DBZ based on UniProtKB P46275.
ProteinModelPortalQ5V3Z1.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3128891.
GenomeReviewsGene locus rrnAC0772 in contig AY596297_GR.
KEGGhma:rrnAC0772.
NMPDRfig|272569.1.peg.728.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG731261.
OMAQLWDDKL.
PhylomeDBQ5V3Z1.
ProtClustDBPRK09293.

Enzyme and pathway databases

BioCycHMAR272569:RRNAC0772-MONOMER.

Family and domain databases

HAMAPMF_01855. FBPase_class1.
[Tree]
InterProIPR000146. FBPase_class-1/SBPase.
[Graphical view]
KOK03841.
PANTHERPTHR11556. In_FB_phphtase. 1 hit.
PfamPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFPIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSPR00115. F16BPHPHTASE.
PROSITEPS00124. FBPASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF16A1_HALMA
AccessionPrimary (citable) accession number: Q5V3Z1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: December 7, 2004
Last modified: December 14, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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