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Q5V3W8 (Q5V3W8_HALMA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Amidophosphoribosyltransferase PIRNR PIRNR000485
Short name=ATase PIRNR PIRNR000485
EC=2.4.2.14 PIRNR PIRNR000485
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase PIRNR PIRNR000485
Gene names
Name:purF EMBL AAV45784.1
Ordered Locus Names:rrnAC0797
OrganismHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) [Complete proteome] [HAMAP] EMBL AAV45784.1
Taxonomic identifier272569 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloarcula

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. PIRNR PIRNR000485

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. PIRSR PIRSR000485-3

Binds 1 magnesium ion per subunit By similarity. PIRNR PIRNR000485

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. PIRNR PIRNR000485

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. PIRNR PIRNR000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site51For GATase activity By similarity PIRSR PIRSR000485-1
Metal binding2431Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding3941Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4451Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4481Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3

Sequences

Sequence LengthMass (Da)Tools
Q5V3W8 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 054CDB8980D0ED8D

FASTA48052,210
        10         20         30         40         50         60 
MHEKCGVVGI SLEDRDAARP LYYSLYALQH RGQESAGIVT HDGFQQYSHV EMGLVGDAFD 

        70         80         90        100        110        120 
PGDLEALNGS NGIGHVRYPT AGSVNACCAQ PFSVSFKSGS LGLSHNGNLV NADEIGDELA 

       130        140        150        160        170        180 
DLGHAFTSDG DTEVIAHDLA RNLLEEDLVR AVKRTMNRIH GSYSLTIMHD ETVLGVRDPQ 

       190        200        210        220        230        240 
GNRPLCIGEL KDGYVLASES AAIDTLDGEL IRDVKPGELV VLHADGTGYD TYQLVEPENT 

       250        260        270        280        290        300 
ANCFFEHVYF ARPDSTIDEN LVYEVRRELG RKLWEESGVE SDVVLPVPDS GRAFASGYAE 

       310        320        330        340        350        360 
AAQDDGSDIE FAEGLMKNRY VGRTFIMPTQ DERERAVRLK LNPIKSTIEG KSVTIIDDSI 

       370        380        390        400        410        420 
VRGTTSTQLI KLLKDAGAEE VNVRIGAPPI VAPCYMGIDM ASRDELIAGN QSVEEIRDEI 

       430        440        450        460        470        480 
EADSLSYLSI DAIAETLDKS RTDLCLGCVT GEYPYDIEGE ATDRDVVRPD IGTQSSPADD

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References

[1]"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea."
Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V.
Genome Res. 14:2221-2234(2004) [PubMed: 15520287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY596297 Genomic DNA. Translation: AAV45784.1.
RefSeqYP_135490.1. NC_006396.1.

3D structure databases

ProteinModelPortalQ5V3W8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3129889.
GenomeReviewsGene locus rrnAC0797 in contig AY596297_GR.
KEGGhma:rrnAC0797.
NMPDRfig|272569.1.peg.751.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG392416.
OMAVWAPGEE.
PhylomeDBQ5V3W8.
ProtClustDBCLSK511436.

Family and domain databases

InterProIPR005854. Amd_phspho_trans.
IPR000583. GATase_2.
IPR017932. GATase_II.
IPR000836. PRibTrfase.
[Graphical view]
KOK00764.
PANTHERPTHR11907. Amd_phspho_trans. 1 hit.
PfamPF00310. GATase_2. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFPIRSF000485. Amd_phspho_trans. 1 hit.
TIGRFAMsTIGR01134. PurF. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ5V3W8_HALMA
AccessionPrimary (citable) accession number: Q5V3W8
Entry history
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info