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Q5V3T2

- MEND_HALMA

UniProt

Q5V3T2 - MEND_HALMA

Protein

2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

Gene

menD

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).UniRule annotation

    Catalytic activityi

    Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2.UniRule annotation

    Cofactori

    Magnesium or manganese.UniRule annotation
    Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW
    3. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. menaquinone biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Menaquinone biosynthesis

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciHMAR272569:GJDH-745-MONOMER.
    UniPathwayiUPA00079; UER00164.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthaseUniRule annotation (EC:2.2.1.9UniRule annotation)
    Short name:
    SEPHCHC synthaseUniRule annotation
    Alternative name(s):
    Menaquinone biosynthesis protein MenDUniRule annotation
    Gene namesi
    Name:menDUniRule annotation
    Ordered Locus Names:rrnAC0838
    OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
    Taxonomic identifieri272569 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
    ProteomesiUP000001169: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5925922-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthasePRO_0000341896Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272569.rrnAC0838.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5V3T2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TPP enzyme family. MenD subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1165.
    HOGENOMiHOG000218359.
    KOiK02551.

    Family and domain databases

    Gene3Di3.40.50.1220. 1 hit.
    3.40.50.970. 2 hits.
    HAMAPiMF_01659. MenD.
    InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
    IPR004433. MenaQ_synth_MenD.
    IPR029061. THDP-binding.
    IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
    IPR011766. TPP_enzyme-bd_C.
    [Graphical view]
    PfamiPF02775. TPP_enzyme_C. 1 hit.
    PF02776. TPP_enzyme_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004983. MenD. 1 hit.
    SUPFAMiSSF52467. SSF52467. 1 hit.
    SSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00173. menD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5V3T2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAPNVNTLW AETLVGELVA GGVDAVCLSP GSRSTPLTVA FAEHPDIEVF    50
    SHLDERSAAF FALGRARRTG EPTPLVCTSG TAAANYHPAV IEANQSGVPL 100
    LLLTADRPPE LIDSGANQTV DQEKLYGDAV RWYRDMPEPE AEPRKVRMLR 150
    TTAARALAES TGSDPGPVHL NCRFRKPLEP TPMPEDDPAG VPADWAGGDN 200
    GAKIGRDGPF VTTSEGVETP DEQTVRRVQD ALEAAERGLI VAGPADQGLS 250
    ADSLERLAAA TGFPVLADPL SDLRFGPHVD RLDVPVCGGY DGYLGSDSVD 300
    QWDDPDVVVR FGASPTSKPL RHYLRDADCQ QFLVDPAGGW SEAEFTATNL 350
    LVANPDATAD ALAGETLGGV AASWREQFIR AEQTHWDAVT ETASETYWEG 400
    GVLSDVTALA PDPATLFISN SMPIRDMDRF GGPRDADLTV LGNRGASGID 450
    GITSTALGAG SATSDPLVLV TGDLAYYHDM NGLLALGRCA VDATVVLLNN 500
    DGGGIFHMLP IEDHPTFEDQ FRTPHGLDFE PTEALYSLQF ERVADRRQFR 550
    ERFAESVQTD GTQVIEVRFD AGDSHAVRDQ LTEQVAETLA GD 592
    Length:592
    Mass (Da):63,302
    Last modified:July 1, 2008 - v2
    Checksum:i1CD9A0AC89160526
    GO

    Sequence cautioni

    The sequence AAV45820.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV45820.1. Different initiation.
    RefSeqiYP_135526.1. NC_006396.1.

    Genome annotation databases

    EnsemblBacteriaiAAV45820; AAV45820; rrnAC0838.
    GeneIDi3129325.
    KEGGihma:rrnAC0838.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV45820.1 . Different initiation.
    RefSeqi YP_135526.1. NC_006396.1.

    3D structure databases

    ProteinModelPortali Q5V3T2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272569.rrnAC0838.

    Protocols and materials databases

    DNASUi 3129325.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV45820 ; AAV45820 ; rrnAC0838 .
    GeneIDi 3129325.
    KEGGi hma:rrnAC0838.

    Phylogenomic databases

    eggNOGi COG1165.
    HOGENOMi HOG000218359.
    KOi K02551.

    Enzyme and pathway databases

    UniPathwayi UPA00079 ; UER00164 .
    BioCyci HMAR272569:GJDH-745-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1220. 1 hit.
    3.40.50.970. 2 hits.
    HAMAPi MF_01659. MenD.
    InterProi IPR029035. DHS-like_NAD/FAD-binding_dom.
    IPR004433. MenaQ_synth_MenD.
    IPR029061. THDP-binding.
    IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
    IPR011766. TPP_enzyme-bd_C.
    [Graphical view ]
    Pfami PF02775. TPP_enzyme_C. 1 hit.
    PF02776. TPP_enzyme_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004983. MenD. 1 hit.
    SUPFAMi SSF52467. SSF52467. 1 hit.
    SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00173. menD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

    Entry informationi

    Entry nameiMEND_HALMA
    AccessioniPrimary (citable) accession number: Q5V3T2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3