Q5V2T3 (PYRB_HALMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	rrnAC1225

Organism

Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) [Complete proteome] [HAMAP]

Taxonomic identifier

272569 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloarcula

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Subunit structure	Heterooligomer of catalytic and regulatory chains.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000113244

Sequences

	Sequence		Length	Mass (Da)
	Q5V2T3 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 50C9F4FDB9F014DF	FASTA	304	33,329
	10 20 30 40 50 60 MRHDHIISAK QLSRGDIETV LDHAADIAAD PGAFADRHSD TLLGLLFFEP STRTKMSFTT 70 80 90 100 110 120 AMKRLGGDIV DMGSVESSSV KKGESLADTV RVVEGYTDAL VLRHPMEGSA KMASEFVDVP 130 140 150 160 170 180 LVNAGDGAGQ HPTQTLLDLY TIRENAGFDD LTIGIMGDLK YGRTVHSLAH ALTTVDASQH 190 200 210 220 230 240 FISPESLQLP RSVRYDLHEA GAGIREHTEL DDILPELDVL YVTRIQAERF PDESEYREVA 250 260 270 280 290 300 GQYQIDGDTL AAAKDDLTVM HPLPRVDEIA HDVDETTHAQ YFQQAHNGVP VRMALLDLML GGDQ

References

[1]

"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea." Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V. Genome Res. 14:2221-2234(2004) [PubMed: 15520287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY596297 Genomic DNA. Translation: AAV46169.1.
RefSeq	YP_135875.1. NC_006396.1.
3D structure databases
ProteinModelPortal	Q5V2T3.
SMR	Q5V2T3. Positions 1-302.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3130100.
GenomeReviews	Gene locus rrnAC1225 in contig AY596297_GR.
KEGG	hma:rrnAC1225.
NMPDR	fig|272569.1.peg.1143.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG579429.
OMA	ASEYSHI.
PhylomeDB	Q5V2T3.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	HMAR272569:RRNAC1225-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_HALMA

Accession

Primary (citable) accession number: Q5V2T3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	December 7, 2004
Last modified:	December 14, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program