Reviewed, UniProtKB/Swiss-Prot Q5V214 (TRPG1_HALMA)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component II
    EC=4.1.3.27

Gene names

Name:	trpG1
Ordered Locus Names:	rrnAC1517

Organism

Haloarcula marismortui (Halobacterium marismortui) [Complete proteome] [HAMAP]

Taxonomic identifier

2238 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloarcula

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Domain	Glutamine amidotransferase
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glutamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Anthranilate synthase component II		PRO_0000056880
Regions
	Domain	17 – 207	191	Glutamine amidotransferase type-1
Sites
	Active site	96	1	By similarity
	Active site	187	1	By similarity
	Active site	189	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5V214-1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: C9DBC7C50BD983B7	FASTA	207	22,292
	10 20 30 40 50 60 MSTAQPAGAD AVRDDLRVLF VDNFDSFTYN LVEYVSEHAE TEVVRNTASL DDVEAFDPDA 70 80 90 100 110 120 IILSPGPGHP KNERDVGVTL DVLREVSPDV PTLGVCLGLE SAVYAYGGTI GRAPEPIHGK 130 140 150 160 170 180 AFPIDHDGKG VFAGLEQGFQ GGRYHSLIAD DVPEEFVVSA TTETEDGTEL VMGVRHREHP 190 200 IEAVQFHPES VLTAVGHDVI RNFLAGL

References

[1]

"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea." Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V. Genome Res. 14:2221-2234(2004) [PubMed: 15520287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43049 / DSM 3752 / JCM 8966.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY596297 Genomic DNA. Translation: AAV46438.1.
RefSeq	YP_136144.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3127597.
GenomeReviews	Gene locus rrnAC1517 in contig AY596297_GR.
KEGG	hma:rrnAC1517.
NMPDR	fig|272569.1.peg.1408.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG292341.
OMA	DIGNCLE.
Enzyme and pathway databases
BioCyc	HMAR272569:RRNAC1517-MONOMER.
BRENDA	4.1.3.27. 88.
Family and domain databases
InterPro	IPR006220. Anth_synthII. IPR001317. CarbamoylP_synth_GATase_dom. IPR011702. GATASE. IPR017926. GATASE_1. IPR000991. GATase_class1_C. IPR006221. TrpG_papA. [Graphical view]
Pfam	PF00117. GATase. 1 hit. [Graphical view]
PRINTS	PR00097. ANTSNTHASEII. PR00099. CPSGATASE. PR00096. GATASE.
TIGRFAMs	TIGR00566. trpG_papA. 1 hit.
PROSITE	PS51273. GATASE_TYPE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPG1_HALMA

Accession

Primary (citable) accession number: Q5V214

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	December 7, 2004
Last modified:	February 9, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)