Reviewed, UniProtKB/Swiss-Prot Q5V213 (TRPE2_HALMA)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1 2
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I 2

Gene names

Name:	trpE2
Ordered Locus Names:	rrnAC1518

Organism

Haloarcula marismortui (Halobacterium marismortui) [Complete proteome] [HAMAP]

Taxonomic identifier

2238 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloarcula

Protein attributes

Sequence length	536 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 536	536	Anthranilate synthase component 1 2		PRO_0000154123

Sequences

	Sequence		Length	Mass (Da)
	Q5V213-1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: B6E6E61722F155A4	FASTA	536	58,526
	10 20 30 40 50 60 MTLDISREEF VEHAKADRPV VVRTAAELDV DVEPLTAYAA LTGRTSDVAA NDYTFLLESA 70 80 90 100 110 120 EKVASSDPDG AFAPETDDRH ARFSFVGYDP RAVVTVTGDE SEVEAFDDRY ADLVTTDGGD 130 140 150 160 170 180 VVDDLRAAMP DVALRNFPAM DRQHLEGGLV GFLSYDAVYD LWLDEVGLDR PDSRFPDAQF 190 200 210 220 230 240 VLTTSTVRFD HVEDTVSLVF TPVVRQGEDA GERYGELVAE AERVEAVLSD LSPLSTGGFR 250 260 270 280 290 300 REDEVAGPRD EYEDAVERAK EYVLSGDIYQ GVISRTRELY GDVDPLGFYE ALRAVNPSPY 310 320 330 340 350 360 MYLLGYDDLT IVGASPETLV SVAGDHVVSN PIAGTCPRGN SPVEDRRLAG EMLADGKERA 370 380 390 400 410 420 EHTMLVDLAR NDVRRVAEAG SVRVPEFMNV LKYSHVQHIE STVTGRLAED KDAFDAARAT 430 440 450 460 470 480 FPAGTLSGAP KIRAMEIIDE LERSPRGPYG GGVGYFDWDG DTDFAIVIRS ATVEDEGDRD 490 500 510 520 530 RITVQAGAGI VADSDPESEY VETEQKMDGV LTALEEIEGE PVDVAERAAG HEEVTR

References

[1]

"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea." Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V. Genome Res. 14:2221-2234(2004) [PubMed: 15520287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43049 / DSM 3752 / JCM 8966.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY596297 Genomic DNA. Translation: AAV46439.1.
RefSeq	YP_136145.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3127581.
GenomeReviews	Gene locus rrnAC1518 in contig AY596297_GR.
KEGG	hma:rrnAC1518.
NMPDR	fig|272569.1.peg.1410.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG507440.
OMA	IAGTCPR.
Enzyme and pathway databases
BioCyc	HMAR272569:RRNAC1518-MONOMER.
BRENDA	4.1.3.27. 88.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR010116. Anthranilate_synth_I_arc. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
TIGRFAMs	TIGR01820. TrpE-arch. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE2_HALMA

Accession

Primary (citable) accession number: Q5V213

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	December 7, 2004
Last modified:	February 9, 2010
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)