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Q5V1K0 (GUAAA_HALMA) Reviewed, UniProtKB/Swiss-Prot

Last modified August 10, 2010. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
Customize displayNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Names and origin

Protein namesRecommended name:
GMP synthase [glutamine-hydrolyzing] subunit A

EC=6.3.5.2
Alternative name(s):
Glutamine amidotransferase
Gene names
Name:guaAA
Synonyms:guaA2
Ordered Locus Names:rrnAC1694
OrganismHaloarcula marismortui (Halobacterium marismortui) [Complete proteome] [HAMAP]
Taxonomic identifier2238 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the synthesis of GMP from XMP By similarity. HAMAP MF_01510

Catalytic activity

ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP MF_01510

Pathway

Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP MF_01510

Subunit structure

Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B) Potential.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 189189GMP synthase [glutamine-hydrolyzing] subunit A HAMAP MF_01510
PRO_0000140218

Regions

Domain3 – 187185Glutamine amidotransferase type-1

Sites

Active site731Nucleophile By similarity
Active site1611 By similarity
Active site1631 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5V1K0-1 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: CA137C751FEFA40A

FASTA18920,567
        10         20         30         40         50         60 
MTRIDVIDNH GQFTHLEQRA LRDMGVDVSL RDNTTPPEEI DADGIVLSGG PDMDDIGNCP 

        70         80         90        100        110        120 
EYLDLDVPVL GICLGMQLIA DELGGRVGGG EYGGYADVTV DILDDDDPLL GSLYPETRVW 

       130        140        150        160        170        180 
ASHADEVKEV PPGFERTATS DVCGVEAMSN TDEAIYGVQW HPEVAHTEEG EEVFENFLSV 


CDQQSVARQ 

« Hide

References

[1]"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea."
Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V.
Genome Res. 14:2221-2234(2004) [PubMed: 15520287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43049 / DSM 3752 / JCM 8966.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY596297 Genomic DNA. Translation: AAV46602.1.
RefSeqYP_136308.1.

3D structure databases

ProteinModelPortalQ5V1K0.
SMRQ5V1K0. Positions 4-183.
ModBaseSearch...

Genome annotation databases

GeneID3127927.
GenomeReviewsGene locus rrnAC1694 in contig AY596297_GR.
KEGGhma:rrnAC1694.
NMPDRfig|272569.1.peg.1577.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG292341.
OMAGQYVHRI.
ProtClustDBPRK00758.

Enzyme and pathway databases

BioCycHMAR272569:RRNAC1694-MONOMER.
BRENDA6.3.5.2. 88.

Family and domain databases

HAMAPMF_01510. GMP_synthase_A.
[Tree]
InterProIPR006220. Anth_synthII.
IPR011702. GATASE.
IPR017926. GATASE_1.
IPR000991. GATase_class1_C.
IPR004739. GMP_synth_N.
[Graphical view]
PfamPF00117. GATase. 1 hit.
[Graphical view]
PRINTSPR00097. ANTSNTHASEII.
PR00096. GATASE.
TIGRFAMsTIGR00888. guaA_Nterm. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAAA_HALMA
AccessionPrimary (citable) accession number: Q5V1K0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 7, 2004
Last modified: August 10, 2010
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families