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Q5V1B4

- MFNA_HALMA

UniProt

Q5V1B4 - MFNA_HALMA

Protein

L-tyrosine decarboxylase

Gene

mfnA

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine.UniRule annotation

    Catalytic activityi

    L-tyrosine = tyramine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: UniProtKB-HAMAP
    2. tyrosine decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tyrosine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciHMAR272569:GJDH-1631-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-tyrosine decarboxylaseUniRule annotation (EC:4.1.1.25UniRule annotation)
    Short name:
    TDCUniRule annotation
    Gene namesi
    Name:mfnAUniRule annotation
    Ordered Locus Names:rrnAC1798
    OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
    Taxonomic identifieri272569 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
    ProteomesiUP000001169: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350L-tyrosine decarboxylasePRO_0000147020Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei206 – 2061N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272569.rrnAC1798.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5V1B4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0076.
    HOGENOMiHOG000246269.
    KOiK01592.
    OMAiKLVWAEL.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_01610. Tyr_decarbox.
    InterProiIPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR020931. Tyr_deCO2ase.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR03812. tyr_de_CO2_Arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5V1B4-1 [UniParc]FASTAAdd to Basket

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    MLQRAEPQDF ERVLSSMCTV PHPSAREAAE RFLATNPGDP GTYETIAGLE    50
    REAVEYLGDI TGLSDPAGYV ASGGTEANLQ AIRIARNRAD TDDPNVVAPV 100
    HAHFSFTKAA DVLGVELRTA PAADYRVNMA AMAELVDEDT VCVVGVAGST 150
    EYGYVDPIPA IADLAETVDA LCHVDAAWGG FYLPFTDHDW HFGHADIDTM 200
    TIDPHKVGQA AVPAGGLLAR DRTLLDELAV ETPYLESTDQ LTLTGTRSGA 250
    GVASAVAAME SLWPAGYRQQ YETSMANADW LADQLSARGH DVVGPELPLV 300
    AADLSMPMTD ELRDRGWRVS KTGAGEMRVV CMPHVTRSML RSFVADLDWY 350
    Length:350
    Mass (Da):37,666
    Last modified:December 7, 2004 - v1
    Checksum:i63B2A9E21FF87177
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV46689.1.
    RefSeqiYP_136395.1. NC_006396.1.

    Genome annotation databases

    EnsemblBacteriaiAAV46689; AAV46689; rrnAC1798.
    GeneIDi3128786.
    KEGGihma:rrnAC1798.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV46689.1 .
    RefSeqi YP_136395.1. NC_006396.1.

    3D structure databases

    ProteinModelPortali Q5V1B4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272569.rrnAC1798.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV46689 ; AAV46689 ; rrnAC1798 .
    GeneIDi 3128786.
    KEGGi hma:rrnAC1798.

    Phylogenomic databases

    eggNOGi COG0076.
    HOGENOMi HOG000246269.
    KOi K01592.
    OMAi KLVWAEL.

    Enzyme and pathway databases

    BioCyci HMAR272569:GJDH-1631-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_01610. Tyr_decarbox.
    InterProi IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR020931. Tyr_deCO2ase.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR03812. tyr_de_CO2_Arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

    Entry informationi

    Entry nameiMFNA_HALMA
    AccessioniPrimary (citable) accession number: Q5V1B4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3