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Protein

L-tyrosine decarboxylase

Gene

mfnA

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine.UniRule annotation

Catalytic activityi

L-tyrosine = tyramine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: UniProtKB-HAMAP
  2. tyrosine decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tyrosine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-1631-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
L-tyrosine decarboxylaseUniRule annotation (EC:4.1.1.25UniRule annotation)
Short name:
TDCUniRule annotation
Gene namesi
Name:mfnAUniRule annotation
Ordered Locus Names:rrnAC1798
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000001169 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350L-tyrosine decarboxylasePRO_0000147020Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei206 – 2061N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272569.rrnAC1798.

Structurei

3D structure databases

ProteinModelPortaliQ5V1B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000246269.
KOiK18933.
OMAiTEYGMVD.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_01610. Tyr_decarbox.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR020931. Tyr_deCO2ase.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03812. tyr_de_CO2_Arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5V1B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQRAEPQDF ERVLSSMCTV PHPSAREAAE RFLATNPGDP GTYETIAGLE
60 70 80 90 100
REAVEYLGDI TGLSDPAGYV ASGGTEANLQ AIRIARNRAD TDDPNVVAPV
110 120 130 140 150
HAHFSFTKAA DVLGVELRTA PAADYRVNMA AMAELVDEDT VCVVGVAGST
160 170 180 190 200
EYGYVDPIPA IADLAETVDA LCHVDAAWGG FYLPFTDHDW HFGHADIDTM
210 220 230 240 250
TIDPHKVGQA AVPAGGLLAR DRTLLDELAV ETPYLESTDQ LTLTGTRSGA
260 270 280 290 300
GVASAVAAME SLWPAGYRQQ YETSMANADW LADQLSARGH DVVGPELPLV
310 320 330 340 350
AADLSMPMTD ELRDRGWRVS KTGAGEMRVV CMPHVTRSML RSFVADLDWY
Length:350
Mass (Da):37,666
Last modified:December 7, 2004 - v1
Checksum:i63B2A9E21FF87177
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596297 Genomic DNA. Translation: AAV46689.1.
RefSeqiYP_136395.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV46689; AAV46689; rrnAC1798.
GeneIDi3128786.
KEGGihma:rrnAC1798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596297 Genomic DNA. Translation: AAV46689.1.
RefSeqiYP_136395.1. NC_006396.1.

3D structure databases

ProteinModelPortaliQ5V1B4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272569.rrnAC1798.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV46689; AAV46689; rrnAC1798.
GeneIDi3128786.
KEGGihma:rrnAC1798.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000246269.
KOiK18933.
OMAiTEYGMVD.

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-1631-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_01610. Tyr_decarbox.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR020931. Tyr_deCO2ase.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03812. tyr_de_CO2_Arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

Entry informationi

Entry nameiMFNA_HALMA
AccessioniPrimary (citable) accession number: Q5V1B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 7, 2004
Last modified: April 1, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.