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Q5V1B4 (MFNA_HALMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
L-tyrosine decarboxylase
Short name=TDC
EC=4.1.1.25
Gene names
Name:mfnA
Ordered Locus Names:rrnAC1798
OrganismHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) [Complete proteome] [HAMAP]
Taxonomic identifier272569 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloarcula ›

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine By similarity. HAMAP-Rule MF_01610

Catalytic activity

L-tyrosine = tyramine + CO2. HAMAP-Rule MF_01610

Cofactor

Pyridoxal phosphate By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtyrosine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionpyridoxal phosphate binding

Inferred from electronic annotation. Source: HAMAP

tyrosine decarboxylase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350L-tyrosine decarboxylase HAMAP-Rule MF_01610
PRO_0000147020

Amino acid modifications

Modified residue2061N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5V1B4 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 63B2A9E21FF87177

FASTA35037,666
        10         20         30         40         50         60 
MLQRAEPQDF ERVLSSMCTV PHPSAREAAE RFLATNPGDP GTYETIAGLE REAVEYLGDI 

        70         80         90        100        110        120 
TGLSDPAGYV ASGGTEANLQ AIRIARNRAD TDDPNVVAPV HAHFSFTKAA DVLGVELRTA 

       130        140        150        160        170        180 
PAADYRVNMA AMAELVDEDT VCVVGVAGST EYGYVDPIPA IADLAETVDA LCHVDAAWGG 

       190        200        210        220        230        240 
FYLPFTDHDW HFGHADIDTM TIDPHKVGQA AVPAGGLLAR DRTLLDELAV ETPYLESTDQ 

       250        260        270        280        290        300 
LTLTGTRSGA GVASAVAAME SLWPAGYRQQ YETSMANADW LADQLSARGH DVVGPELPLV 

       310        320        330        340        350 
AADLSMPMTD ELRDRGWRVS KTGAGEMRVV CMPHVTRSML RSFVADLDWY

« Hide

References

[1]"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea."
Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V.
Genome Res. 14:2221-2234(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY596297 Genomic DNA. Translation: AAV46689.1.
RefSeqYP_136395.1. NC_006396.1.

3D structure databases

ProteinModelPortalQ5V1B4.
ModBaseSearch...

Protein-protein interaction databases

STRING272569.rrnAC1798.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV46689; AAV46689; rrnAC1798.
GeneID3128786.
KEGGhma:rrnAC1798.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0076.
HOGENOMHOG000246269.
KOK01592.
OMADAPYLTE.
ProtClustDBPRK13520.

Enzyme and pathway databases

BioCycHMAR272569:GJDH-1631-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_01610. Tyr_decarbox.
InterProIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR020931. Tyr_deCO2ase.
[Graphical view]
PfamPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR03812. tyr_de_CO2_Arch. 1 hit.
PROSITEPS00392. DDC_GAD_HDC_YDC. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMFNA_HALMA
AccessionPrimary (citable) accession number: Q5V1B4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 7, 2004
Last modified: May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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