Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5V1B4

- MFNA_HALMA

UniProt

Q5V1B4 - MFNA_HALMA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

L-tyrosine decarboxylase

Gene

mfnA

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine.UniRule annotation

Catalytic activityi

L-tyrosine = tyramine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: UniProtKB-HAMAP
  2. tyrosine decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tyrosine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-1631-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
L-tyrosine decarboxylaseUniRule annotation (EC:4.1.1.25UniRule annotation)
Short name:
TDCUniRule annotation
Gene namesi
Name:mfnAUniRule annotation
Ordered Locus Names:rrnAC1798
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000001169: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350L-tyrosine decarboxylasePRO_0000147020Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei206 – 2061N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272569.rrnAC1798.

Structurei

3D structure databases

ProteinModelPortaliQ5V1B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000246269.
KOiK01592.
OMAiKLVWAEL.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_01610. Tyr_decarbox.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR020931. Tyr_deCO2ase.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03812. tyr_de_CO2_Arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5V1B4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLQRAEPQDF ERVLSSMCTV PHPSAREAAE RFLATNPGDP GTYETIAGLE
60 70 80 90 100
REAVEYLGDI TGLSDPAGYV ASGGTEANLQ AIRIARNRAD TDDPNVVAPV
110 120 130 140 150
HAHFSFTKAA DVLGVELRTA PAADYRVNMA AMAELVDEDT VCVVGVAGST
160 170 180 190 200
EYGYVDPIPA IADLAETVDA LCHVDAAWGG FYLPFTDHDW HFGHADIDTM
210 220 230 240 250
TIDPHKVGQA AVPAGGLLAR DRTLLDELAV ETPYLESTDQ LTLTGTRSGA
260 270 280 290 300
GVASAVAAME SLWPAGYRQQ YETSMANADW LADQLSARGH DVVGPELPLV
310 320 330 340 350
AADLSMPMTD ELRDRGWRVS KTGAGEMRVV CMPHVTRSML RSFVADLDWY
Length:350
Mass (Da):37,666
Last modified:December 7, 2004 - v1
Checksum:i63B2A9E21FF87177
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596297 Genomic DNA. Translation: AAV46689.1.
RefSeqiYP_136395.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV46689; AAV46689; rrnAC1798.
GeneIDi3128786.
KEGGihma:rrnAC1798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596297 Genomic DNA. Translation: AAV46689.1 .
RefSeqi YP_136395.1. NC_006396.1.

3D structure databases

ProteinModelPortali Q5V1B4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272569.rrnAC1798.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV46689 ; AAV46689 ; rrnAC1798 .
GeneIDi 3128786.
KEGGi hma:rrnAC1798.

Phylogenomic databases

eggNOGi COG0076.
HOGENOMi HOG000246269.
KOi K01592.
OMAi KLVWAEL.

Enzyme and pathway databases

BioCyci HMAR272569:GJDH-1631-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_01610. Tyr_decarbox.
InterProi IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR020931. Tyr_deCO2ase.
[Graphical view ]
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR03812. tyr_de_CO2_Arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

Entry informationi

Entry nameiMFNA_HALMA
AccessioniPrimary (citable) accession number: Q5V1B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 7, 2004
Last modified: October 1, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3