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Protein

Cell division protein FtsZ

Gene

ftsZ3

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei157GTPUniRule annotation1
Binding sitei160GTPUniRule annotation1
Binding sitei203GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 43GTPUniRule annotation5
Nucleotide bindingi126 – 128GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZ3Imported
Synonyms:ftsZUniRule annotation
Ordered Locus Names:rrnAC2004Imported
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)Imported
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHaloarculaceaeHaloarcula
Proteomesi
  • UP000001169 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi272569.rrnAC2004

Structurei

3D structure databases

ProteinModelPortaliQ5V0T7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 221TubulinInterPro annotationAdd BLAST191
Domaini223 – 340Tubulin_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02201 Archaea
COG0206 LUCA
HOGENOMiHOG000049094
KOiK03531
OMAiIMNQGGV
OrthoDBiPOG093Z0942

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit
PS01135 FTSZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5V0T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDIVNEALE RDEQEQKQLS DSDVDGFGDP RIVIVGCGGA GNNTVNRLYN
60 70 80 90 100
IGVEGADTVA INTDKQHLKM IEADTKILVG KSLTNGLGAG GDPSMGERAT
110 120 130 140 150
EMAQGTIKEV LGDADLVFVT AGMGGGTGTG AAPVVSKIAK EQGAIVVGMV
160 170 180 190 200
STPFNVERAR TVKAEEGLEK LRNEADSIIV LDNNRLLDYV PNLPIGKAFS
210 220 230 240 250
VMDQIIAETV KGISETITQP SLINLDYADM TSIMNQGGVA VMLVGETQDK
260 270 280 290 300
NKTEEVVKDA MNHPLLDVDY RGASGGLVHI TGGPDLTLKE AEGIAQNITE
310 320 330 340 350
RLEADANVIW GARIQEEYKG KVRVMAIMTG VQSAQVLGPT TQKQANKSRE
360 370 380 390 400
AIQEVGDDTS FDASDNVESF DSPAPNSGSQ SSGGRTTGYS ETDGGQDQRE
410
KNNGLDVIRT NK
Length:412
Mass (Da):43,641
Last modified:December 7, 2004 - v1
Checksum:i144B624CA77341CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596297 Genomic DNA Translation: AAV46866.1
RefSeqiWP_007188698.1, NC_006396.1

Genome annotation databases

EnsemblBacteriaiAAV46866; AAV46866; rrnAC2004
GeneIDi3128186
KEGGihma:rrnAC2004
PATRICifig|272569.17.peg.2659

Similar proteinsi

Entry informationi

Entry nameiQ5V0T7_HALMA
AccessioniPrimary (citable) accession number: Q5V0T7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health