Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Catalase-peroxidase 1

Gene

katG1

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei89Transition state stabilizerUniRule annotation1
Active sitei93Proton acceptorUniRule annotation1
Metal bindingi258Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei3064. HmaCP02.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 1UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 1UniRule annotation
Alternative name(s):
Peroxidase/catalase 1UniRule annotation
Gene namesi
Name:katG1UniRule annotation
Ordered Locus Names:rrnAC2018
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
Proteomesi
  • UP000001169 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003549651 – 730Catalase-peroxidase 1Add BLAST730

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki92 ↔ 217Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-243)UniRule annotation
Cross-linki217 ↔ 243Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-92)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ5V0S5.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi272569.rrnAC2018.

Structurei

3D structure databases

ProteinModelPortaliQ5V0S5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04487. Archaea.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5V0S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKTVLMPSP SKCSLMAKRD QDWSPNQLRL DILDQNARDA DPRGTGFDYA
60 70 80 90 100
EEFQELDLDA VKADLEELMT SSQDWWPADY GHYGPLFIRM AWHSAGTYRT
110 120 130 140 150
TDGRGGASGG RQRFAPLNSW PDNANLDKAR RLLWPIKKKY GRKLSWADLI
160 170 180 190 200
VLAGNHAIES MGLKTFGWAG GREDAFEPDE AVDWGPEDEM EAHQSERRTD
210 220 230 240 250
DGELKEPLGA AVMGLIYVDP EGPNGNPDPL ASAENIRESF GRMAMNDEET
260 270 280 290 300
AALIAGGHTF GKVHGADDPE ENLGDVPEDA PIEQMGLGWE NDYGSGKAGD
310 320 330 340 350
TITSGIEGPW TQAPIEWDNG YIDNLLDYEW EPEKGPGGAW QWTPTDEALA
360 370 380 390 400
NTVPDAHDPS EKQTPMMLTT DIALKRDPDY REVMERFQEN PMEFGINFAR
410 420 430 440 450
AWYKLIHRDM GPPERFLGPD APDEEMIWQD PVPDVDHDLI GDEEVAELKT
460 470 480 490 500
DILETDLTVS QLVKTAWASA STYRDSDKRG GANGARIRLE PQKNWEVNEP
510 520 530 540 550
AQLETVLATL EEIQAEFNSA RTDDTRVSLA DLIVLGGNAA VEQAAADAGY
560 570 580 590 600
DVTVPFEPGR TDATPEQTDV DSFEALKPRA DGFRNYARDD VDVPAEELLV
610 620 630 640 650
DRADLLDLTP EEMTVLVGGL RSLGATYQDS DLGVFTDEPG TLTNDFFEVV
660 670 680 690 700
LGMDTEWEPV SESKDVFEGY DRETGEQTWA ASRVDLIFGS HSRLRAIAEV
710 720 730
YGADGAEAEL VDDFVDAWHK VMRLDRFDLE
Length:730
Mass (Da):81,147
Last modified:December 7, 2004 - v1
Checksum:i490649C67F89CCA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596297 Genomic DNA. Translation: AAV46878.1.

Genome annotation databases

EnsemblBacteriaiAAV46878; AAV46878; rrnAC2018.
KEGGihma:rrnAC2018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596297 Genomic DNA. Translation: AAV46878.1.

3D structure databases

ProteinModelPortaliQ5V0S5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272569.rrnAC2018.

Protein family/group databases

PeroxiBasei3064. HmaCP02.

Proteomic databases

PRIDEiQ5V0S5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV46878; AAV46878; rrnAC2018.
KEGGihma:rrnAC2018.

Phylogenomic databases

eggNOGiarCOG04487. Archaea.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG1_HALMA
AccessioniPrimary (citable) accession number: Q5V0S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.