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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei185UniRule annotation1
Active sitei212UniRule annotation1
Active sitei309UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:rrnAC2204
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHaloarculaceaeHaloarcula
Proteomesi
  • UP000001169 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001580491 – 369Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei564-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi272569.rrnAC2204.

Structurei

3D structure databases

ProteinModelPortaliQ5V0B3.
SMRiQ5V0B3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 122Response regulatoryPROSITE-ProRule annotationAdd BLAST117
Domaini173 – 367CheB-type methylesteraseUniRule annotationAdd BLAST195

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02382. Archaea.
COG2201. LUCA.
HOGENOMiHOG000151424.
KOiK03412.
OMAiMLEMHRA.
OrthoDBiPOG093Z00HE.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5V0B3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGVRAVVA DDSHFMRSVI SDILSDGGID VVAQARDGEE AVSAVIEHRP
60 70 80 90 100
DVVTMDVEMP VMNGIEATER IMAESPTPVL MLSAHTDENA DVTFEALDKG
110 120 130 140 150
AVDFFTKPGG EVSMEMSRLK DQLVEMVSSV AAVDVGATGS RSGTGSDSGT
160 170 180 190 200
APTTAGGSAT DRRGTGGSSG QTTYVANPTL VIGSSTGGPK MVEQVMENLP
210 220 230 240 250
IEADLRVLII QHMPEGFTGR FAERINTRSD YEVQEATDGA RIGGGEGLVA
260 270 280 290 300
AGDRHMEVKN YRNGRLRTKL TQDEPVNSVR PAVDVTMQTA AETIDDPLVG
310 320 330 340 350
LILTGMGEDG ADGIRRIKQA GGKTIAQDEA TSAVYGMPKR AAETGCVDTV
360
LPIDDIADGV IDTITTEVT
Length:369
Mass (Da):38,673
Last modified:December 7, 2004 - v1
Checksum:i7FE06D0C908C5129
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596297 Genomic DNA. Translation: AAV47040.1.
RefSeqiWP_007189315.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV47040; AAV47040; rrnAC2204.
GeneIDi3128994.
KEGGihma:rrnAC2204.
PATRICifig|272569.17.peg.2838.

Similar proteinsi

Entry informationi

Entry nameiCHEB_HALMA
AccessioniPrimary (citable) accession number: Q5V0B3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 7, 2004
Last modified: November 22, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome