Q5UZL2 (Q5UZL2_HALMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
NH(3)-dependent NAD(+) synthetase HAMAP MF_00193
EC=6.3.1.5 HAMAP MF_00193

Gene names

Name:	nadE1 EMBL AAV47291.1
Synonyms:	nadE HAMAP MF_00193
Ordered Locus Names:	rrnAC2486

Organism

Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) [Complete proteome] [HAMAP] EMBL AAV47291.1

Taxonomic identifier

272569 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloarcula

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. HAMAP MF_00193
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1. HAMAP MF_00193
Sequence similarities	Belongs to the NAD synthetase family. HAMAP MF_00193

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_00193 NAD HAMAP MF_00193 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00193 EMBL AAV47291.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP NAD+ synthase (glutamine-hydrolyzing) activity Inferred from electronic annotation. Source: InterPro NAD+ synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	49 – 56	8	ATP By similarity HAMAP MF_00193
Sites
	Active site	51	1	By similarity HAMAP MF_00193

Sequences

	Sequence		Length	Mass (Da)
	Q5UZL2 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 9C38D8879B4B631E	FASTA	277	29,643
	10 20 30 40 50 60 MATAESIVRA DEPLNLTFSE AELEAHRDHI TSFIEAQVDA AGVDTVVMGL SGGIDSTLVS 70 80 90 100 110 120 HLAVEALGRD AVHGLVMPSE VNRADNMSDA ERVANDLLGI EYDVIEINPL VDTFLDAYPD 130 140 150 160 170 180 AEGDQLAVGN LRVRCRAVLN YLVGNHEQAL VLGTGNRSEA LVGYYTKYGD GAVDCHPIAA 190 200 210 220 230 240 LYKQQVRQLA KHVGVPDDLA EKTASAEMWA GQTDADEMGM DYDTLDSILA LHIDGGVPAA 250 260 270 GTADQLGVPL DVVETVREMY ESSAHKRAMP PGPDPLY

References

[1]

"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea." Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V. Genome Res. 14:2221-2234(2004) [PubMed: 15520287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY596297 Genomic DNA. Translation: AAV47291.1.
RefSeq	YP_136997.1. NC_006396.1.
3D structure databases
ProteinModelPortal	Q5UZL2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3130290.
GenomeReviews	Gene locus rrnAC2486 in contig AY596297_GR.
KEGG	hma:rrnAC2486.
NMPDR	fig|272569.1.peg.2278.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG351567.
OMA	DGAVDCH.
PhylomeDB	Q5UZL2.
ProtClustDB	PRK13980.
Family and domain databases
HAMAP	MF_00193. NadE. [Tree]
InterPro	IPR022310. NAD/GMP_synthase. IPR003694. NAD_synthase. IPR022926. NH(3)-dep_NAD(+)_synth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01916.
Pfam	PF02540. NAD_synthase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00552. NadE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q5UZL2_HALMA

Accession

Primary (citable) accession number: Q5UZL2

Entry history

Integrated into UniProtKB/TrEMBL:	December 7, 2004
Last sequence update:	December 7, 2004
Last modified:	December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)