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Protein

Ribonuclease Z

Gene

rnz

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61Zinc 1; catalyticUniRule annotation1
Metal bindingi63Zinc 1; catalyticUniRule annotation1
Active sitei65Proton acceptorUniRule annotation1
Metal bindingi65Zinc 2; catalyticUniRule annotation1
Metal bindingi66Zinc 2; catalyticUniRule annotation1
Metal bindingi139Zinc 1; catalyticUniRule annotation1
Metal bindingi210Zinc 1; catalyticUniRule annotation1
Metal bindingi210Zinc 2; catalyticUniRule annotation1
Metal bindingi268Zinc 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processtRNA processing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:rrnAC2500
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHaloarculaceaeHaloarcula
Proteomesi
  • UP000001169 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001559211 – 311Ribonuclease ZAdd BLAST311

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272569.rrnAC2500.

Structurei

3D structure databases

ProteinModelPortaliQ5UZJ9.
SMRiQ5UZJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00501. Archaea.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiGTQRQMM.
OrthoDBiPOG093Z04VY.

Family and domain databases

CDDicd07717. RNaseZ_ZiPD-like_MBL-fold. 1 hit.
Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiView protein in InterPro
IPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
PfamiView protein in Pfam
PF00753. Lactamase_B. 1 hit.
SMARTiView protein in SMART
SM00849. Lactamase_B. 1 hit.
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5UZJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMRVTFLGT SGAVPTTQRN TSSIFVNRDG DYLLFDCGEG TQRQMMRYGT
60 70 80 90 100
GFAIDHLFVT HLHGDHVLGI PGLLQTWDFN ERERAIAIHT PAGTRGNIKQ
110 120 130 140 150
LIQANGTTPS FPVRINEVSA GDVVLDRSEY EIRAIETAHR CASVGYVLDE
160 170 180 190 200
DDRKGKFDRE KAEEEFGIPP GPKYSKLHRG EAVEHEGETI QPEAVVGPAR
210 220 230 240 250
PGRRFVYTGD TLPTESVIEA SEDADLLVHD ATFAEDRKER AKATAHSTAR
260 270 280 290 300
EAADVARQAG ASTLALTHIS TRYAASADEL VDEARDAFDG EVVLAEDGME
310
RRVEFPDADE Y
Length:311
Mass (Da):34,236
Last modified:December 7, 2004 - v1
Checksum:i022E49E38BE2AE8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596297 Genomic DNA. Translation: AAV47304.1.
RefSeqiWP_004959414.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV47304; AAV47304; rrnAC2500.
GeneIDi3129599.
KEGGihma:rrnAC2500.
PATRICifig|272569.17.peg.3109.

Similar proteinsi

Entry informationi

Entry nameiRNZ_HALMA
AccessioniPrimary (citable) accession number: Q5UZJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: December 7, 2004
Last modified: August 30, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families