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Q5UZH9 (Q5UZH9_HALMA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE1 EMBL AAV47324.1
Synonyms:pyrE HAMAP MF_01208
Ordered Locus Names:rrnAC2521
OrganismHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) [Complete proteome] [HAMAP] EMBL AAV47324.1
Taxonomic identifier272569 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloarcula

Protein attributes

Sequence length183 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity. HAMAP MF_01208

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region117 – 12595-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site9115-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site9215-phosphoribose 1-diphosphate By similarity HAMAP MF_01208
Binding site9515-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1211Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
Q5UZH9 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 2EF83E05E551713F

FASTA18319,416
        10         20         30         40         50         60 
MANDELIAAL RDADAVKFGE FELSHGGTSN YYVDKYVFET NPDCLDLIAG AFAERIAEWD 

        70         80         90        100        110        120 
MDATLAGVAL GAVPLVAVTS VETDIPYVIA RKQAKEYGTG NRIEGDLTDG EEVIILEDIA 

       130        140        150        160        170        180 
TTGQSAVDAA EALREAGAVV NRVLVVVDRE EGASENLADH DLELSSLVTA SDLLADAPDD 


IDV

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References

[1]"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea."
Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V.
Genome Res. 14:2221-2234(2004) [PubMed: 15520287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY596297 Genomic DNA. Translation: AAV47324.1.
RefSeqYP_137030.1. NC_006396.1.

3D structure databases

ProteinModelPortalQ5UZH9.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3129578.
GenomeReviewsGene locus rrnAC2521 in contig AY596297_GR.
KEGGhma:rrnAC2521.
NMPDRfig|272569.1.peg.2311.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG404341.
OMAQTCLVIN.
PhylomeDBQ5UZH9.
ProtClustDBPRK13812.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ5UZH9_HALMA
AccessionPrimary (citable) accession number: Q5UZH9
Entry history
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: December 14, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info