ID RPIA_HALMA Reviewed; 228 AA. AC Q5UZD7; DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot. DT 07-DEC-2004, sequence version 1. DT 27-MAR-2024, entry version 92. DE RecName: Full=Ribose-5-phosphate isomerase A {ECO:0000255|HAMAP-Rule:MF_00170}; DE EC=5.3.1.6 {ECO:0000255|HAMAP-Rule:MF_00170}; DE AltName: Full=Phosphoriboisomerase A {ECO:0000255|HAMAP-Rule:MF_00170}; DE Short=PRI {ECO:0000255|HAMAP-Rule:MF_00170}; GN Name=rpiA {ECO:0000255|HAMAP-Rule:MF_00170}; GN OrderedLocusNames=rrnAC2572; OS Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM OS B-1809) (Halobacterium marismortui). OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales; OC Haloarculaceae; Haloarcula. OX NCBI_TaxID=272569; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809; RX PubMed=15520287; DOI=10.1101/gr.2700304; RA Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., RA Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., RA Hood L., Ng W.V.; RT "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the RT Dead Sea."; RL Genome Res. 14:2221-2234(2004). CC -!- FUNCTION: Catalyzes the reversible conversion of ribose-5-phosphate to CC ribulose 5-phosphate. {ECO:0000255|HAMAP-Rule:MF_00170}. CC -!- CATALYTIC ACTIVITY: CC Reaction=aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate; CC Xref=Rhea:RHEA:14657, ChEBI:CHEBI:58121, ChEBI:CHEBI:58273; CC EC=5.3.1.6; Evidence={ECO:0000255|HAMAP-Rule:MF_00170}; CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribose CC 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step CC 1/1. {ECO:0000255|HAMAP-Rule:MF_00170}. CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00170}. CC -!- SIMILARITY: Belongs to the ribose 5-phosphate isomerase family. CC {ECO:0000255|HAMAP-Rule:MF_00170}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY596297; AAV47366.1; -; Genomic_DNA. DR RefSeq; WP_011224305.1; NZ_CP039138.1. DR AlphaFoldDB; Q5UZD7; -. DR SMR; Q5UZD7; -. DR STRING; 272569.rrnAC2572; -. DR PaxDb; 272569-rrnAC2572; -. DR EnsemblBacteria; AAV47366; AAV47366; rrnAC2572. DR GeneID; 40153458; -. DR KEGG; hma:rrnAC2572; -. DR PATRIC; fig|272569.17.peg.3174; -. DR eggNOG; arCOG01122; Archaea. DR HOGENOM; CLU_056590_1_0_2; -. DR UniPathway; UPA00115; UER00412. DR Proteomes; UP000001169; Chromosome I. DR GO; GO:0004751; F:ribose-5-phosphate isomerase activity; IEA:UniProtKB-UniRule. DR GO; GO:0009052; P:pentose-phosphate shunt, non-oxidative branch; IEA:UniProtKB-UniRule. DR CDD; cd01398; RPI_A; 1. DR Gene3D; 3.30.70.260; -; 1. DR Gene3D; 3.40.50.1360; -; 1. DR HAMAP; MF_00170; Rib_5P_isom_A; 1. DR InterPro; IPR037171; NagB/RpiA_transferase-like. DR InterPro; IPR020672; Ribose5P_isomerase_typA_subgr. DR InterPro; IPR004788; Ribose5P_isomerase_type_A. DR NCBIfam; TIGR00021; rpiA; 1. DR PANTHER; PTHR11934; RIBOSE-5-PHOSPHATE ISOMERASE; 1. DR PANTHER; PTHR11934:SF0; RIBOSE-5-PHOSPHATE ISOMERASE; 1. DR Pfam; PF06026; Rib_5-P_isom_A; 1. DR SUPFAM; SSF75445; D-ribose-5-phosphate isomerase (RpiA), lid domain; 1. DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1. PE 3: Inferred from homology; KW Isomerase; Reference proteome. FT CHAIN 1..228 FT /note="Ribose-5-phosphate isomerase A" FT /id="PRO_0000158507" FT ACT_SITE 106 FT /note="Proton acceptor" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00170" FT BINDING 31..34 FT /ligand="substrate" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00170" FT BINDING 85..88 FT /ligand="substrate" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00170" FT BINDING 97..100 FT /ligand="substrate" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00170" FT BINDING 124 FT /ligand="substrate" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00170" SQ SEQUENCE 228 AA; 23080 MW; 87BD40081AE76DD2 CRC64; MKQGGSDAAK QAAGESAAEA VEDATVVGLG TGSTAAYAIR AIGQAVDAGL DVVGVPTSFQ SRQLARDCGI PLADLDDVSV DLAIDGADEV ASGNLIKGGG AAHAREKIVD ASADRFLVVA DPTKEAAVLS YPVPVEVLPM ARSTVVTAVE ELGGDPTLRR AERKDGPVVT DNGNLVLDCD FNSIHDPAAL ASDLAALPGV VEHGLFVGMA DEIHVGTADG VTVRTLSK //